response surface methodology

Open Access Article

1 - Optimization and modeling of growth conditions for Lactobacillus brevis IBRC10818 for biosynthesis of gamma-aminobutyric acid, affected by ultrasonic shock
Mahboobe Rezaei Younes Ghasemi Anousheh Sharifan Hossein Bakhoda

10.30495/fh.2023.73163.1135

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2 - Optimization of methanol-water solvent extraction of anthocyanins from Roselle (Hibiscus sabdariffa L.) petals using response surface methodology
Mahboobeh Eksiri Seyed Ahmad Shahidi Leila Nateghi

10.30495/fh.2023.69777.1121

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3 - Evaluation of the Antimicrobial Potential of Astragalus fasciculifolius Gum Extract Against Clostridium perfringens in Meatball Formulations Using Response Surface Methodology
Najmeh Khademi Pour Anousheh Sharifan Hossein Bakhoda

10.30495/fh.2023.73979.1142

Astragalus fasciculifolius Boiss. is a native medicinal plant of Iran with a long history of traditional use. This study investigated the phenolic composition, antimicrobial activity, and growth dynamics of Clostridium perfringens when treated with ethanolic extracts More

Astragalus fasciculifolius Boiss. is a native medicinal plant of Iran with a long history of traditional use. This study investigated the phenolic composition, antimicrobial activity, and growth dynamics of Clostridium perfringens when treated with ethanolic extracts of A. fasciculifolius gum. Phenolic profiling revealed hesperidin as the most abundant compound (17.61%). Extracts showed antimicrobial activity, with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of 156 and 78 mg/g against C. perfringens, respectively. Microscopy indicated membrane shrinkage and changes upon treatment. A quadratic model was developed to describe C. perfringens growth in meat over time at different extract concentrations and temperatures. Optimization predicted the lowest bacterial numbers at 7200.8 ppm extract concentration, 14.29 h storage time, and 4.0°C temperature. These results demonstrate that A. fasciculifolius gum possesses bioactive compounds with antimicrobial properties against foodborne pathogens. The extract could potentially be developed as a natural preservative for the food, cosmetics, and pharmaceutical industries. Manuscript profile

Open Access Article

4 - Evaluation and statistical optimization of process variables for xylitol production by Candida kefyr
Fatemeh Hedayati Rad Anousheh Sharifan

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5 - The potential of compost-based organic nano-adsorbent (Compost/Fe3O4NPs) for contaminated soil remediation
laleh Ghafghazi Lobat Taghavi Behnam Rasekh Hadi Farahani Amir hesam Hassani

10.30495/jrnr.2023.75130.10299

One of the most important emerging pollutants in human health, food safety, and environmental protection challenges is phthalate esters. Among these, the contamination of agricultural soils with the endocrine-disrupting chemical Di (2-ethylhexyl) phthalate (DEHP) has be More

One of the most important emerging pollutants in human health, food safety, and environmental protection challenges is phthalate esters. Among these, the contamination of agricultural soils with the endocrine-disrupting chemical Di (2-ethylhexyl) phthalate (DEHP) has been confirmed globally. In this research, the DEHP-absorption potential of compost enriched with Fe3O4 NPs was identified. The effects of the sorbent dose in the range of 2–5 g.L-1, 3–11 pH, and DEHP concentration at 5–10 mg.L-1 on absorption efficiency (%) were optimized via response surface methodology in design expert software. The kinetic equilibrium experiment results showed a two-step process, requiring 6 hours of equilibrium time for the exothermic adsorption process at 25ºC. The adsorption process of DEHP fitted best to the pseudo-second-order kinetic (R2 = 0.9932) and the linear form of the Freundlich isotherm models. In the central composite design, the significant quadratic model was validated and used to predict the interaction of variables (P-value <0.0001, adjusted R2 = 0.9753). The optimum conditions of absorption efficiency (74.173%) were obtained at a sorbent dosage of 4.157 g.L-1, pH 5.85, and a DEHP concentration of 4.88 mg.L-1 with a desirability of 0.987. The comparison of FTIR absorption spectra confirmed the active participation of O-H bands (functional groups of phenol, alcohol, and carboxyl) and primary amine (N-H) in the DEHP absorption through interaction with the oxygen atom of the phthalate ester group (C=O). As a result of its successful and acceptable efficiency, using compost/Fe3O4 NP absorbent based on organic wastes is a low-cost and eco-friendly technique for DEHP removal from sensitive ecosystems and also to improve the efficiency of bioremediation in agricultural soils amended by compost. Manuscript profile

Open Access Article

6 - Ultrasonic Assisted Removal of humic acids (HAs) from aqueous solutions on Uultrasonically polysulfone/ X% Fe2O3 mixed matrix membrane, An Experimental Design Methodology
Fereydoon Khazali Shahnaz Davoudi

10.30495/jptc.2023.72322.1258

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7 - Ultrasonic Assisted Removal of Methyl Paraben on Ultrasonically Synthesized Zn(OH)2-NPs-AC: Experimental Design Methodology
Amir Abbas Ghazali

10.30495/jptc.2021.20874

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8 - حذف رنگ بنفش کریستال با استفاده از جاذب سنتزی سیکلودکسترین اصلاح شده با نانو ذرات اکسید آهن و به کمک امواج فراصوت؛ با متدلوژی طراحی تجربی
Ali Omaniziarati Gholamhossein Vatankhah

10.30495/jptc.2021.20426

در این پژوهش، کاربرد جاذب سیکلو دکسترین/نانو ذرات اکسید آهن سنتز شده به عنوان یک جاذب جدید برای حذف رنگ بنفش کریستال از محیط های آبی مورد بررسی قرار گرفت. این مقاله بر توسعه یک روش موثر برای به دست آوردن شرایط بهینه حذف با کمک امواج فراصوت برای حذف حداکثر رنگ بنفش کریست More

در این پژوهش، کاربرد جاذب سیکلو دکسترین/نانو ذرات اکسید آهن سنتز شده به عنوان یک جاذب جدید برای حذف رنگ بنفش کریستال از محیط های آبی مورد بررسی قرار گرفت. این مقاله بر توسعه یک روش موثر برای به دست آوردن شرایط بهینه حذف با کمک امواج فراصوت برای حذف حداکثر رنگ بنفش کریستال بر روی CM-β-CD-Fe3O4NPs  در یک محلول آبی با استفاده از روش سطح پاسخ (RSM) تمرکز دارد. این جاذب جدید با تکنیکهای مختلف مانند FT-IR ،XRD  و SEM مشخصه یابی و ارزیابی گردید. تأثیر متغیرهایی مانند غلظت اولیه رنگ(X1) ،pH (X2) ، دوز جاذب (X3) و زمان فراصوت (X4)  با طراحی مرکب مرکزی (CCD) تحت روش سطح پاسخ مورد بررسی قرار گرفت. این فرآیند به صورت تجربی مدلسازی شد تا متغیرهای مهم و فعل و انفعالات احتمالی آنها آشکار شود. شرایط بهینه سازی برای زمان تابش امواج فراصوت،pH ، مقدار جاذب وغلظت رنگ به ترتیب، 10 میلیگرم بر لیتر، 6، 5 دقیقه و 025/0 گرم تعیین شد. در نهایت، نشان داده شد که حذف رنگ بنفش کریستالی توسط جاذب در pH برابر با 6 اتفاق افتاد. به وضوح ثابت شد که جذب رنگ مورد مطالعه با معادله سینتیکی شبه درجه دوم مطابقت دارد و همدمای لانگمویر داده های تعادل را توضیح میدهد. حداکثر ظرفیت تک لایه جذب توسط جاذب  (qmax)برای رنگ مورد مطالعه در شرایط بهینه 100 میلیگرم بر گرم بدست آمد. گرمازا بودن این فرآیند با مقدار منفی (ΔG˚، ΔH˚ وΔS˚) ثابت شد که نشان از میل جاذب سنتز شده  CM-β-CD-Fe3O4NPs برای حذف رنگ بنفش کریستال دارد. Manuscript profile

Open Access Article

9 - Response Surface Methodology for Removal of Butyl Paraben Dye Using Zeolitic Imidazolate-67 Modified by Fe3O4 Nanoparticles from Aqueous Solutions
Arezoo Ghadi Mohammad Pourmohammad Ali Aghababai Beni

10.30495/jptc.2023.71309.1250

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10 - Consolidated Technique of Response Surface Methodology and Data Envelopment Analysis for setting the parameters of meta-heuristic algorithms - Case study: Production Scheduling Problem
Seyed Esmail Najafi Reza Behnoud

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11 - Development of an Optimal Formulation for Flavored Doogh-Based Soft Drink Using Response Surface Methodology and Evaluate the Resulting Powder
Z. Sarlak F. Garavand R. Mohammadi M. Hosseini M. Rouhi

Introduction: Doogh is a fermented drink that is consumed in Iran and other Middle Eastern countries. Due to the increased awareness of the harmful effects of carbonated drinks, Doogh consumption have been increased considerably because of its nutritional benefits. Usin More

Introduction: Doogh is a fermented drink that is consumed in Iran and other Middle Eastern countries. Due to the increased awareness of the harmful effects of carbonated drinks, Doogh consumption have been increased considerably because of its nutritional benefits. Using healthy and antibacterial flavoring agents such as lime extract and mint distillate, in certain concentrations, can reduce the viability of traditional yoghurt starters and be a good alternative to industrial thermal processes (in heated Doogh). In addition, the powder of these products under certain conditions will contribute to ease maintenance and transportation. Materials and Methods: In the present study, Doogh-based soft drink optimized with lime extract (0-6% v/v) and mint distillate (0-4% v/v) for sensorial and antioxidant properties, using response surface methodology (RSM) and studied during refrigerated storage at 5°C. Soft drink powder was produced by spray dryer in different input air temperatures to increase the product’s shelf life and weight loss. Results: The results showed that the the best model fitted on the sensory total score and IC50 was quadratic. The addition of 3.382% (v/v) lime extract and 2.484% (v/v) mint distillate to drink led to the highest sensory total score and lowest IC50 (the highest antioxidant activity). The optimized formulated drink was stable for 42 days with non-significant loss of sensory quality (p>0.05). For long term storage and production of powder by spray dryer, input hot air temperature at 170°C caused the highest percentage of solubility and sensory acceptability. The resulting powder also had acceptable moisture content, water activity (aw) and color total changes (ΔE). Conclusion: The consumption of Doogh-based products with traditional flavors, might be a strategy to increase the variety of soft drink market. The results of present study showed that Doogh formulated with 3.382% (v/v) lime extract and 2.484% (v/v) mint distillate had desirable sensorial and antioxidant properties. Moreover, the novel Doogh-based drink was transformed to powder that have high solubility and sensory score using spray drier at 170°C. Manuscript profile

Open Access Article

12 - Synthesis, Optimization and Modeling of Curdlan Gum Production from Paenibacillus polymyxaUsing Response Surface Methodology (RSM)
S.M. Rafigh M. Vossoughi A. Vaziri A.A. Safekordi M. Ardjomand

Introduction: Curdlan gum is a bacterial polysaccharidic biopolymer that is the result of β-(1→3)-D-glycosidic linkages. Due to its ability to curdle and the water-holding capacity, curdlan has applications in the manufacture of food products such as jelly, no More

Introduction: Curdlan gum is a bacterial polysaccharidic biopolymer that is the result of β-(1→3)-D-glycosidic linkages. Due to its ability to curdle and the water-holding capacity, curdlan has applications in the manufacture of food products such as jelly, noodles, edible fibers. Curdlan is biodegradable, nontoxic and it has applications in the pharmaceutical industry because of its potent biological activities. For the first time, the present study is concerned with the synthesis, characterization, optimization of cultural conditions and modeling of curdlan production from Paenibacillus polymyxa using RSM. Materials and Methods: After preparation of the microorganism and the medium, Plackett–Burman design with 12 experimental runs was used to screen the effective factors through 11 variables of batch culture medium for curdlan production. Central composite design with 20 experimental runs was used for optimization of the effective variables. In addition, four characterization methods such as FT-IR, C-NMR, XRD and DSC were employed. Results: The result of the experiments showed that three nutritional factors (glucose, yeast extract and triton x-100) had the predominant effect on curdlan production. The maximum production of curdlan was 4.75 g/l from the optimum condition consisting of glucose (100 g/l), yeast extract (3 g/l) and triton x-100(2.5 g/l). In addition, the average molecular weight of curdlan was determined at 170 kDa by GPC. Conclusion: The results from this study have demonstrated that Paenibacillus polymyxa PTCC 1020 with more specific growth rate (µ) than previous studies is capable to produce curdlan gum and also the production of the synthetic curdlan was confirmed using qualitative methods of identification.   Manuscript profile

Open Access Article

13 - Optimization of Spray Drying Process to Produce Microencapsulated Powders of Functional Extract Obtained from Red-Beet
Sh. Yousefi

Introduction: Spray drying is one of the most important ways to prevent waste of strategic food products and their shelf life extension.Optimization of operating conditions involved in this system can be a suitable background to produce products with ideal physicochemic More

Introduction: Spray drying is one of the most important ways to prevent waste of strategic food products and their shelf life extension.Optimization of operating conditions involved in this system can be a suitable background to produce products with ideal physicochemical quality. Materials and Methods: The effect of three operating parameters including inlet air temperature (IAT, 130-160°C), air flow rate (AFR, 2-4 m3/h) and feed flow rate (FFR, 4-10 mL/min) was investigated to attain the microencapsulated powders of red-beet extract containing functional pigment of betalain using RSM. The yield of produced powders, content of phenolic compounds and antioxidant activity of reconstituted extract were optimized. Results: The quadratic equations with high correlation coefficients (0.960-0.994) can well predict the optimal conditions to achieve the highest physicochemical efficiency. An increase in IAT and AFR had a significant effect on the decrease of the level of phenolic and antioxidant components of the obtained powders, while this trend led to an increase in the yield. The antioxidant and phenolic content of microencapsulated powders with low yield at higher FFRs are well maintained. The analysis of microscopy observations and particle size also confirmed the results clearly. The findings showed that the maximum physical yield (75%), phenolics content (1238.72 µg gallic acid/mL), and free-radical inhibition percentage (78.77%) can be obtained under the optimum conditions of 136.0°C IAT, 3.6 m3/h AFR, and 8.8 mL/min FFR. Conclusion: Production of high-quality powders microencapsulating red-beet extract under the optimal conditions might be a beginning to develop fortification of food products with the obtained powders. Manuscript profile

Open Access Article

14 - Optimization of the Production of Protein Hydrolysates from Cotton Seed by Response Surface Methodology
P. Shabani B. Akbari - Adergani

Introduction: Protein hydrolysates are compounds with low molecular weight that after entering the body are easily absorbed and play important biological roles in cellular levels. The most important functions of bioactive compounds are antioxidant, antimicrobial, antica More

Introduction: Protein hydrolysates are compounds with low molecular weight that after entering the body are easily absorbed and play important biological roles in cellular levels. The most important functions of bioactive compounds are antioxidant, antimicrobial, anticancer activities and enhance the immune system. The main objective of this study was to produce cotton seed protein hydrolysate using pepsin enzyme that was optimized by response surface methodology. Materials and Methods: The factors investigated in this study were temperature (30-40◦C), time (2-5h) and enzyme/substrate ratio (0.5-2%) in order to obtain maximum antioxidant activity. The antioxidant activities were investigated using 1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging capacity, total antioxidant capacity, reducing power and chelating activity. All of the experiments were designed according to the central composite design. Results: Each of the studied variables had a significant effect on the responses (p<0/05). The optimal conditions to achieve maximum antioxidant activity were temperature of 31.1◦C, time of 5h and enzyme/substrate ratio of 1.75%, respectively. Under these conditions, (DPPH) free radical scavenging capacity, reducing power, chelating activity, total antioxidant capacity and degree of hydrolysis were 83%, 0.158 Å, 70%, 1.99 mmol α- tocopherol/mL and 31.75%, respectively. Conclusion: Cotton seed protein hydrolysates have exhibited good antioxidant activity and might be employed as a natural antioxidant in food products and formulations. Manuscript profile

Open Access Article

15 - Optimization of Canola Oil Extraction by Ultrasound Waves and Response Surface Methodology
F. Jalili S. M. Jafari Z. Emamjomeh M. Kashaninejad M. Ganjeh

Introduction: Canola seed is one of the most important oil seed with high ratio of oil andhigh nutritional value and is economically recommended for cultivation and oil extraction.Extraction with ultrasound waves as a nondestructive and novel method might be employed.Th More

Introduction: Canola seed is one of the most important oil seed with high ratio of oil andhigh nutritional value and is economically recommended for cultivation and oil extraction.Extraction with ultrasound waves as a nondestructive and novel method might be employed.Therefore the aim of this research is optimization of extraction of canola oil by ultrasoundwaves and RSM.Materials and Methods: In this project, Response Surface Methodology was employed foroptimization of canola oil extraction by ultrasound waves using hexane andhexane/isopropanol as solvents by the ratio of 3:2 (v/v). The influence of extractiontemperature in the range of 35, 45 and 55℃, ultrasound treatment time for 30, 60 and 90minutes and ratio of solvent to canola in three levels of 5, 10 and 15 ml/g were analyzed byBox-Behnken Design (BBD) based on extracted oil percent. The fatty acid compositions ofthe extracted oils using ultrasound-assisted method and soxhlet method employing gas liquidchromatography were determined and compared.Results: According to the high values of correlation coefficients of selected models optimizedfor hexane solvent extraction methods (R2 =0.93) and hexane-isopropanol solvent mixture(R2 =0.97) and no significant lack of fit tests (P>0.05) selected models might be useful topredict the extraction percentage of canola oil.Conclusion: The results showed that the optimum conditions for canola oil extraction byhexane (22.39 %) and combined hexane/isopropanol (30.66 %) were respectively atultrasound treatment times of 69.5 and 87 minutes, temperatures of 55 and 55 ℃ and ratio ofsolvent to canola of 6.39 and 9.12 (%v/w). Extraction efficiency was significantly improvedby ultrasound as compared to the soxhlet extraction. Fatty acid compositions of the canolaoils were not significantly affected by the application of ultrasound (P> 0.05). Thereforeultrasound might be regarded as a simple and rapid method to improve the extraction of oilwithout affecting the quality of the fatty acids present. Manuscript profile

Open Access Article

16 - Investigation on Possibility of Using Hydrated Emulsifier in Soft Biscuits
F. Baei B. Ghiassi Tarzi

10.30495/jftn.2021.19179

Introduction: Biscuits are one of the most important flour products, that are very popular due to its ease of production, storage, and consumption. In biscuits production using an emulsifier has increased the ability to spread fat in the flour and sugar system. The obje More

Introduction: Biscuits are one of the most important flour products, that are very popular due to its ease of production, storage, and consumption. In biscuits production using an emulsifier has increased the ability to spread fat in the flour and sugar system. The objective of this research was to investigate the effect of three emulsifier SSL, DMG, DATEM in the hydrated form in soft biscuits and optimization of the formulation.Materials and Methods: The range of use of each emulsifier is 0.1-0.5 percent based on the weight of flour. The RSM was used to determine treatments and 22 treatments were identified. The experiments performed included measuring the long and short diameter, thickness, hardness, browning index and overall acceptability. The data were then analyzed and optimization performed.Results: The SSL has the most effect on the diameter than the other two emulsifiers and at 0.5% concentration has increased by 2mm in diameter. But, by increasing SSL, the thickness has decreased. The DMG on diameter has a positive effect and its effect is greater on long diameter. DATEM is the most effective factor on the texture and as it increases, the texture becomes softer. The use of hydrated emulsifiers reduces browning index. Increasing DATEM, causes dough adhesion to rotary moulding and the appearance of biscuits is unacceptable.Conclusion: By optimization, the formulation of the combination of emulsifiers was determined that included: 0.37 SSL, 0.45 DMG, 0.5 DATEM. Manuscript profile

Open Access Article

17 - Process Optimization in Vacuum Frying of Green Bean Slices Using Response Surface Methodology
M. Nikkhah Eshghi B. Ghiassi Tarzi A. R. Basiri

Introduction: Vacuum frying is a new technology that might be useful for producing newkind of snacks such as fruit and vegetable chips. The reason for this technology is to reducethe presence of oxygen and lower the processing temperature. The aim of this work is todete More

Introduction: Vacuum frying is a new technology that might be useful for producing newkind of snacks such as fruit and vegetable chips. The reason for this technology is to reducethe presence of oxygen and lower the processing temperature. The aim of this work is todetermine the effect of process parameters namely time, pressure, temperature on the specificcharacteristics of green bean in order to achieve the optimal processing condition.Materials and Methods: In this research, samples were processed in predeterminedtemperatures, pressures and times by using statistical response procedures. The effects offrying time and temperature and pressure on reduction of moisture, oil absorption, shrinkage,texture, and color were studied.Results: The optimum conditions of 119.13oC for the temperature, 285 mbar for the pressureand 14.63 min for the time were obtained. The results showed that the time of the exposure tofrying has a direct and significant relation to vacuum pressure and the samples moisture levelis related to frying time and the moisture of the sample is significantly reduced (p<0.05) byincreasing the frying time. Oil absorption level has a significant relation with temperature andtime (p<0.01).Conclusion :The results indicated that vacuum frying can improve the nutritional quality ofthe food with reduced cost and avoid the loss and wastage of the product. Manuscript profile

Open Access Article

18 - Optimization of Roasting Process of Sesame Seed to Produce High Quality Sesame Oil
ملیکا Borjian Broujeni S. A. Goli مریم Gharachorloo رضا Azizinejad

Introduction: Sesame oil because of having lignans such as sesamin and sesamolinhas greater resistance against oxidative degradation as compared to other edible oils.Roasting process can make a tremendous positive impact on the oxidative resistanceof the oil. The aim of More

Introduction: Sesame oil because of having lignans such as sesamin and sesamolinhas greater resistance against oxidative degradation as compared to other edible oils.Roasting process can make a tremendous positive impact on the oxidative resistanceof the oil. The aim of this work was to evaluate the roasting conditions of sesame interms of temperature and time using response surface methodology regarding thehighest rate of oxidative resistance and best color of roasted sesame oil.Materials and Methods: In order to evaluate the roasting conditions, the twofactors of temperature (200, 215 and 230°C) and time (15, 25 and 35 min) were usedin 3 levels. The total number of tests for each sample was 12 and oxidativeresistance and color (XE and L index) were considered as responses. After dataanalysis by the software, statistical analysis of the models related to the stability andcolor (XE and L index) were evaluated.Results: The results indicated that the temperature was more effective than the timein oil oxidative resistance changes and by increasing the temperature and time, theoxidative resistance and XE index increased while L index decreased.Conclusion: The optimal condition of roasting for brown sesame seeds was at thetemperature of 216.86°C and time of 19.32 minutes while for the white type, the temperatureof 220.47°C and the time of 15 minutes were considered as the optimum condition. Manuscript profile

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19 - Butter Separation from Cream Using Ultrasonication: Optimization of Parameters Using RSM
B. Maheshwari R. Saravanathamizhan N. Balasubramanian

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20 - Modeling Red Monascus Pigment Production on Date Waste Substrate Using Submerged Cultivation
F. Bakhshi M. Jahadi N. Ghasemisepro S. Jahanfar

10.30495/jfbt.2022.19727

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21 - Formulation and Production of New Carbonated Malt and Jujube Drink and Evaluation of its Physicochemical, Microbial and Sensory Properties during Storage
M. Mohseni A. Rahmani F. Soleimany

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22 - Optimization Specific Fuel Consumption of Diesel, Biodiesel and Bioethanol Fuel Blends by Response Surface Methodology
Golmohammad Khoobbakht Mohammad ghahderijani

10.22034/jest.2018.19700.2855

  Background and Objective: Recently much attention has been paid to the development of alternative fuels in order to meet the emission standards and to reduce the dependency on fossil fuel. Especially biodiesel and ethanol have been considered as major alternativ More

  Background and Objective: Recently much attention has been paid to the development of alternative fuels in order to meet the emission standards and to reduce the dependency on fossil fuel. Especially biodiesel and ethanol have been considered as major alternative fuels as they are derived from renewable sources. These fuels are well oxygenated and therefore have a great potential to reduce emissions. Method: This study is aimed at investigating the effect of operating factors of engine load and speed as well as blended levels of biodiesel and ethanol in diesel fuel on the specific fuel consumption of a DI diesel engine OM 314. The experiments were designed using a statistical tool known as response surface methodology (RSM). Findings: The results depicted that specific fuel consumption increased with increasing percentage of bioethanol and biodiesel and the minimum of the specific fuel consumption (156 g/kWh) was accured at full load and engine rotational speed of 2453 rpm for pure diesel (B0E0D100) Discussion and Conclusion: the maximum of specific fuel consumption was obtained with amount of 413 g/kWh at 20% engine load and rotational speed of 2800 rpm and for a fuel blend containing 0.4 l biodiesel, 0.4 l ethanol and 1l diesel (B22E22D56). Manuscript profile

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23 - Removal of polluting Phenol out of aqueous solutions with the aide of nanocomposites of TiO2/SBA-15 and using Response Surface Methodology
Samira Khodabakhsh Lobat Taghavi Ebrahim Alaie Leila Samiee

10.22034/jest.2020.26389.3537

Background and Objective: Phenolic compounds are one of the most important pollutants that poison water resources. Presence of phenol and its derivatives in water and wastewater is a major concern due to its toxic threat to human, animals and environment. Therefore, ide More

Background and Objective: Phenolic compounds are one of the most important pollutants that poison water resources. Presence of phenol and its derivatives in water and wastewater is a major concern due to its toxic threat to human, animals and environment. Therefore, identifying and tracking these pollutants as well as identifying ways to control and eliminate them is very important in order to protect the environment, treatment of sewage and healthy drinking water supply. In this research, the main goal is to eliminate phenol from aqueous solution,with high initial density by Heterogeneous photocatalysis in the slurry reactor with the quality of Pyrex glass.Method: First,Response Surface Methodology was used for nanocatalystTiO2with hydrogen peroxide and 250 watts UV radiation,to find optimum conditions for the removal of phenol from aqueous solution using heterogeneous photocatalysis.Then,SBA-15, which is highly capable of eliminating phenol due to its porous structure comparing to other absorbents, and then TiO2/SBA-15 were synthesized. Finally, the structure and physical properties of Nano composite were detected by analysis XRD, BET, FESEM, and TEM. Findings: Results of phenol elimination out of aqueous solutions by Heterogeneous photo catalyst and Phenol removal efficiency of 96% at a concentration of 100mg / l at the time of 420 minutes, respectively. Use of Response Surface Methodology to determine optimal conditions is one of the most effective methods to achieve the desired goal in this study.Discussion and Conclusion: According to the results, mesoporous materials containing TiO2 compared with pureTiO2,have high efficiency in photocatalytic degradation of water pollutants. Manuscript profile

Open Access Article

24 - Evaluation of the Efficiency of Catalytic Ozonation Process with magnesium-aluminum double layer hydroxide nanocomposite doped on zeolite in mineralization of cefixime antibiotic in Aqueous Solution
yalda sheikh elham Tazikeh-Lemeski yousef Dadban Shahamat

10.30495/jest.2023.68268.5709

Background and Objective: One of the problems in the health systems of the world today is the prescription or overuse of drugs. Among these, antibiotics are of particular importance. Antibiotics are a group of drugs that are widely used in medicine and veterinary medici More

Background and Objective: One of the problems in the health systems of the world today is the prescription or overuse of drugs. Among these, antibiotics are of particular importance. Antibiotics are a group of drugs that are widely used in medicine and veterinary medicine. Cefixime (CFX) is also one of these antibiotics. The aim of this study was to investigate the removal efficiency of cefixime from synthetic sample using catalytic ozonation with Mg-Al layered double hydroxides Doped with zeolite. Material and Methodology: In this experimental and laboratory study MgAl-LDH/Zeolite nanocomposite was used in laboratory reactor and ozonation to remove cefixime. Effect of pH variables (5,6,7,8,9), amount of nanocomposite (0.5,1,1.5,2,2.5 g/L), initial concentration of cefixime (5,10,15,20,25 mg/L) and reaction time (5,18.75,32.5,46.25,60 min) were examined to find the maximum mineralization efficiency and response surface methodology based on central composite design (CCD) was used to design experiments, analyze data and achieve optimal conditions. Analysis of variance was also used to analyze the date. This research was done in 2021-2022. Findings: The maximum mineralization efficiency of cefixime under optimal conditions (pH=8.70, nanocomposite value=1.76 g/L, initial concentration of cefixime=24.06 mg/L, contact time=40.76 min) is 78%, which increases the target efficiency with increasing pH and contact time. Discussion and Conclusion: Catalytic ozonation process with Mg-Al layered double hydroxides nanocomposite Doped with zeolite can be used effectively and efficiency to remove cefixime in aqueous media.   Manuscript profile

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25 - Set a bi-objective redundancy allocation model to optimize the reliability and cost of the Series-parallel systems using NSGA II ‎problem‎
M. R. Shahriari&lrm;

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26 - Screening and Optimization of Microextraction of Pb(II) by Inductively Coupled Plasma-Atomic Emission Using Response Surface Methodology
Maryam Salahinejad Fereidoon Aflaki

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27 - Production of Ethylene Glycol Diacetate Ester Using a Heterogeneous Titanium (IV) Isopropoxide Catalyst: Response Surface Methodology
Borna Bayat Kambiz Tahvildari Amin Bazyari Alireza Hemmati

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28 - Ultrasonic Assisted Adsorption of Rhodamine B (RhB) Dye by Albizia Stem Bark Lebbeck Modified by Fe2 (MoO4)3 Nanocomposite Synthesis: Experimental Design Methodology
Shiva Enolghozati Nasrin Choobkar Elham Pournamdari Farzaneh Marahel

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29 - Response Surface Methodology Modeling to Determine of Trace Amounts of Phenolic Compounds Using Silver Modified / Zero Valent Iron/ Fe3O4@G Nanocomposite
Mahmoud Reza Sohrabi Mohammad Reza Kashefi Alasl Mehran Davallo

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30 - Ultrasonic-assisted extraction of condensed tannin from acron, gland, leaf and gall of oak using response surface methodology
Reza Tabaraki Alimohammad Safari Ali Yeganeh Faal

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31 - Removal of Benzyl Paraben from Wastewater Using Zeolitic Imidazolate-67 Modified by Fe3O4 Nanoparticles with Response Surface Methodology
Mohammad Pourmohammad Arezoo Ghadi Ali Aghababai Beni

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32 - Investigation and Optimization of EDM Milling and its Comparison with Die Sink EDM
Mahmoud Moradi Reza AbbasiRad Majid Ghoreishi Hadi Abdollahi Majid Rostami

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33 - Experimental Investigation and Modeling of Bubble Departure Frequency for Nucleate Pool Boiling Heat Transfer of Pure Liquids on Flat Heater
Samane Hamzekhani Farhad Shahraki Davood Mohebi- kalhori Mohammad Reza Fardinpour

10.30486/admt.2023.1960198.1354

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34 - Simultaneous optimization of extraction of bioactive compounds and antioxidant activity of aerial parts of Ammi visnaga L. using response surface methodology
Zineb El Jabboury Smail Aazza Driss Ousaaid Oumaima Chater Uros Gasic Peđa Janaćković Zora Dajic Stevanovic Stefan Kola&scaron;inac Meryem Benjelloun Lahsen El Ghadraoui

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35 - Novel TiO2 NPs Loaded on Activated Carbon as a Green and High Efficient Absorbent: Synthesis, Characterization, Kinetic and Equilibrium Studies of the Adsorption of Bismarck Brown and Thymol Blue from Aaqueous Solutions
Saideh Bagheri Hossein Aghaei Mehrorang Ghaedi

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36 - A Study on the Role of Nanosilica Seeds on the Synthesis of Silica Colloids
Fatemeh Kholghi Seyed Mojtaba Zebarjad Elham Katoueizadeh Habib Daneshmanesh

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37 - RSM in Analysis of Energy Absorption of thin-walled conical groove tubes filled with polyurethane foam
بتول سرکبیری علی جهان محمد جواد رضوانی

AbstractEnergy absorbers are used in various – especially in the automotive – industries as a solution to reduce the damages stroke on the passengers, and to enhance automobile safety. Nowadays, thin-walled tubes as one of the most efficient energy absorptio More

AbstractEnergy absorbers are used in various – especially in the automotive – industries as a solution to reduce the damages stroke on the passengers, and to enhance automobile safety. Nowadays, thin-walled tubes as one of the most efficient energy absorption systems have found increasing applications. In this study, energy absorption parameters is performed to investigate the impacts of designing variables related to thin-walled conical groove tubes using finite element analysis. However, since the output of these studies depends to methods of designing computational experiments, the design of experiments technique (DOE) is used in this study along with the finite element analysis. For this purpose a conical aluminium tube filled with polyurethane foam is simulated that the grooves are designed with a given distance on the inside and outside surfaces under quasi-static load. Objectives of the design include the specific energy absorption e (SEA), and designing variables including conical angle, grooves distance, foam density, groove depth, and tube thickness. response surface methodology (RSM) showed that the tube thickness foam density, groove depth and grooves distance, respectively and linearly relate to the amount of specific energy absorption These results can be helpful in the design of thin-walled tubes with different conical geometries. Manuscript profile

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38 - Investigation of energy absorption in shock absorbers of grooved circular using response surface
شیما شهروی محمد جواد رضوانی علی جهان

The main objective of this research is improving the design and performance of the polyurethane foam-filled thin-walled aluminum grooved circular tubes. The tubes are shaped with the inner and the outer circular grooves at different positions along the axis. In this stu More

The main objective of this research is improving the design and performance of the polyurethane foam-filled thin-walled aluminum grooved circular tubes. The tubes are shaped with the inner and the outer circular grooves at different positions along the axis. In this study, the effects of the grooves distance, tube diameter, grooves depth, foam density, and tube thickness are investigated on the Specific Energy Absorption (SEA) of grooved circular tubes. finite-element analysis (FEA) and response surface methodology (RSM) is carried out for crush force efficiency. Finite-element analysis is performed with design of experiments technique (DOE) at the different combinations of the design parameters. The results of RSM indicate that SEA is related to the grooves distance, tube diameter, tube thickness of the groove and groove depth, by a quadratic model. Moreover, the effects of the interaction between the grooves distance - the foam density and the grooves distance - the tube diameter on the SEA was significant. Manuscript profile

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39 - Design And Numerical Analysis of Propeller for Khazar Dredger
احد عابدینی سهیل اسدی

In this article, using a central composite design response surface methodology is that design of the optimal propeller geometry for khazar dredger will be discussed. B_Wageningen standard series is designed propeller-type licenses. To verify the performance and Check no More

In this article, using a central composite design response surface methodology is that design of the optimal propeller geometry for khazar dredger will be discussed. B_Wageningen standard series is designed propeller-type licenses. To verify the performance and Check non-occurrence of cavitation ,the propeller designed using Computational Fluid Dynamics, numerical modeling and compare with B_Wageningen series. The results show the ability of response surface methodology in finding the optimal geometry propeller. Numerical solution of fluid flow, to prove non-occurrence of cavitation in the propeller designed for kazar dredger. Manuscript profile

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40 - Bioethanol production from starch by glucose cerevisiae assessed with Response Surface Methodology (RSM)
Ali Kazemi mohamad sadegh davari mahsa shokri foad naeem abadi mosareza mohamadi

Saccaromyces cerevisiae has many different uses such as baker's yeast and bioethanol production. Response surface methodology (RSM) is a complex of statistical techniques for experimental model creation. In this study was done to determination of optimal condition of bi More

Saccaromyces cerevisiae has many different uses such as baker's yeast and bioethanol production. Response surface methodology (RSM) is a complex of statistical techniques for experimental model creation. In this study was done to determination of optimal condition of bioethanol production from starch by yeast using RSM. Initially saccaromyces cerevisiae was proliferated on agar then by α-amylase, dextranase and amyloglucosidase respectively, then starch 5% was hydrolyzed to glucose. 250 cc glucose was put at 30 C° and velocity of 150 rpm for 36 h. Bioethanol quantity was evaluated by dichromate oxidation and ethanol measurement methods and temperature, time and pH variables were considered at 25-98 C°, 1 to 6 weeks and 3 to7, respectively. The highest bioethanol production was 12.5 ml at 30 C°, pH 4 also at 80 C°, pH 7 for 5 weeks. The lowest bioethanol production was 3 ml at 98 C°, pH 7 for 1 week which was practically compatible. Regarding the results, RSM method has many benefits such as increase in efficiency of chemical reactions, prevention of wasting raw material, time, money and energy which could use in different biological reactions. Manuscript profile

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41 - Modeling and Solution Procedure for a Preemptive Multi-Objective Multi-Mode Project Scheduling Model in Resource Investment Problems
Mostafa Salimi Amir Abbas Najafi

10.22094/joie.2017.592.1381

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42 - An Efficient Economic-Statistical Design of Simple Linear Profiles Using a Hybrid Approach of Data Envelopment Analysis, Taguchi Loss Function, and MOPSO
Maryam Fazelimoghadam Mohammad Javad Ershadi Seyed Taghi Akhavan Niaki

10.22094/joie.2019.580054.1607

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43 - Reliability Modelling of the Redundancy Allocation Problem in the Series-parallel Systems and Determining the System Optimal Parameters
Mani Sharifi Mohsen Yaghoubizadeh

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44 - Thermal stability optimization of the Soybean oil affected by thymus daenensis Celak essential oil by use of response surface methodology
M. Eghbalian Rad A. A. Sari A. Daraei Garmakhany

Oxidative stability of oils and fats was affected by various factors such as oxygen, light, heat, metal ions and enzymes. The use of synthetic antioxidant for preventing oxidative deterioration, despite having high performance, due to the possibility of toxicity and car More

Oxidative stability of oils and fats was affected by various factors such as oxygen, light, heat, metal ions and enzymes. The use of synthetic antioxidant for preventing oxidative deterioration, despite having high performance, due to the possibility of toxicity and carcinogenicity, has been under question. The aim of this study was to optimize the thermal stability of soybean oil by the addition ofThymus daenensis Celakessential oil. In this study soybean oil was treated under various conditions of frying temperature (150, 170 and 190 °C), frying time (0, 6 and 12 h) and Thymus daenensis Celak essential oil concentrations (0, 400 and 800 ppm) and different quality attributes of samples such as the acid value, peroxide value, thiobarbituric acid, polar compounds, and conjugated diene value were studied. Results showed that Thymus essential oil due to containing different phenolic compounds increased the thermal stability of soybean oil significantly (p<0.05). The results of the acidic value, peroxide value, thiobarbituric acid, and polar compounds in fried oil samples for 12 hours at 190 °C showed that the addition of essential oil of thyme oil keeps the quality of fried oil after 12 hours frying at 190 °C. This study shows that essential oils can be a good alternative for synthetic antioxidants. Manuscript profile

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45 - Thermal processing optimization of honey using physicochemical properties and hydroxymethylfurfural content
S. Seyyedi Mansoor L. Roufegari-Nejad

Hydroxymethylfurfural (HMF) is one of the compounds formed due to the heat treatment and storage of honey and the maximum level of HMF in honey have been set in 40 ppm under codex standards. In this study, the effects of heating temperature (55, 65 and 75 °C), heati More

Hydroxymethylfurfural (HMF) is one of the compounds formed due to the heat treatment and storage of honey and the maximum level of HMF in honey have been set in 40 ppm under codex standards. In this study, the effects of heating temperature (55, 65 and 75 °C), heating duration (10, 20 and 30 min) as well as storage temperature (25 and 40 °C) were assayed during the three months of storage, based on response surface methodology. The effect of the above-mentioned variables on physicochemical properties (Lab color factors, pH, and moisture) and HMF content (based on spectrophotometric technique) of the samples was studied. Prediction model of each treatment was calculated. The outcomes during the 45 and 90 days of storage were analyzed. Results showed that temperature, time of heat treatment and storage duration had no effect on pH, moisture content, and color; while storage temperature had a significant effect on L* and a*. HMF content was affected by of all the variables so that its rate was increased significantly with increasing thermal process and storage time. Among the studied samples, HMF content was exceeded the standard limit in the sample heated at 75 °C for 20 min and kept at 40 °C for 90 days. The optimal level of HMF resulted by heating at 55 °C for 10 min and under the storage temperature of 25 °C for 45 days. Manuscript profile

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46 - Statistical Analysis and Optimization of Factors Affecting the Surface Roughness in UVaSPIF Process Using Response Surface Methodology
Mehdi Vahdati Ramezanali Mahdavinejad Saeid Amini Mahmoud Moradi

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47 - Dissimilar resistance spot welding of AISI 1075 eutectoid steel to AISI 201 stainless steel
Mehdi Safari Hossein Mostaan

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48 - Synthesis of nano-structured sphene and mechanical properties optimization of its scaffold via response surface methodology
Amirmostafa Amirjani Masoud Hafezi Ali Zamanian Mana Yasaee Noor Azuan Abu Osman

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49 - Optimization of inulin extraction from Cynara scolymus L. root using response surface methodology (RSM)
Mohammad Mohsenzadeh Jalal Ehsani Morteza Khomeiri azem Ghasem Nejad

Inulin is a low digestable or indigestible fiber which is found in various plants. Inulin amount ranging from 1% in Banana to more than 15% in Chicory roots changing. It has a positive impact on the composition of the intestinal flora, mineral absorption, blood lipid co More

Inulin is a low digestable or indigestible fiber which is found in various plants. Inulin amount ranging from 1% in Banana to more than 15% in Chicory roots changing. It has a positive impact on the composition of the intestinal flora, mineral absorption, blood lipid composition and prevents colon cancer. Artichoke (Cynara scolymus L.) is one of the most important sources of inulin. The aim of the present study was extraction of inulin from artichoke root and optimization of extraction conditions to achieve the highest extraction efficiency. For this purpose, the artichoke roots were collected from the research stead of Gorgan University of Agricultural Sciences and Natural Resources in september 2015 and inulin extraction with using of warm water solvent and response surface methodology (RSM)and central composite design (CCD) was performed. Response surface methodology in comparison to voluminous methods such as full factorial is preferred. In this technique for optimization of inulin extraction process, three variables extraction time (35-65 min), extraction temperature (55-95 °C) and the ratio of water to the roots (3:1 to 9:1)as independent variables were considered and their effect on the extraction efficiency of inulin were examined. After performing experiments, linear, 2FI and quadratic models on the inulin extraction yield were evaluated, also lack of fit test, coefficient of determination (R2)and Adjusted coefficient of determination (R2adjusted) for investigation the adequacy of the model were calculated. Study of the lack of fit test as well as R2 and  R2adjusted values were showed the suitability of quadratic model. This model was used to find the best condition of extraction process with maximum efficiency. Results showed that the optimum condition for extraction of inulin with highest extraction yield (8.01%) related to temperature (95 °C), time (35.67 min) and ratio of water to root (9:1) with desirability of (92%).   Manuscript profile

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50 - Optimization of Effective Parameters in Essential Oil Extraction of Heracleum persicum Desf. Ex Fischer Seed Using Response Surface Methodology
محمد فتاحی maryam rezapoor

Abstract In the recent years use of plant essential oils (EOs) in the food and medicine industry is increasing. So, the aim of this study was to optimize effective factors for maximizing essential oil yield and evaluation of its composition under the optimal conditions. More

Abstract In the recent years use of plant essential oils (EOs) in the food and medicine industry is increasing. So, the aim of this study was to optimize effective factors for maximizing essential oil yield and evaluation of its composition under the optimal conditions. The effect of different parameters including different amounts of plant (X1), extraction time of essential oils (X2) and particle size of seeds obtained with mesh (X3) on three levels (1, 0, 1-) as independent variable to optimize essential oil percentage as dependent variables were evaluated using response surface methodology. The seeds of Heracleum persicum Desf. Ex Fischer were collected from Ayalono area (East Azerbaijan) in August 2015. The essential oil was extracted by Clevenger apparatus and were identified by GC/MS. ANOVA analysis results and experimental error for the RSM model were showed that the predicted model for the essential oil percentage was significantly accurate (P Manuscript profile

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51 - Response surface methodology analysis of the photocatalytic removal of Methylene Blue using a new Cu(II)-MOF
Zahra Mohseni nik Majid Ramezani Saeed Jamehbozorgi Tahere Momeni Esfahani

10.22034/jna.2020.1877138.1156

A novel metal–organic framework (MOF), with the formula [Cu(II)L]n (L= 4, 4′-diamino diphenyl sulfone), has been synthesized conventionally and hydrothermally methods and characterized by FT-IR, PXRD, EDX, and SEM techniques. The results MOFs were applied for photodegra More

A novel metal–organic framework (MOF), with the formula [Cu(II)L]n (L= 4, 4′-diamino diphenyl sulfone), has been synthesized conventionally and hydrothermally methods and characterized by FT-IR, PXRD, EDX, and SEM techniques. The results MOFs were applied for photodegradation of Methylene Blue (MB). The influence of affecting variables, such as initial MB dye concentration (2–8mg L−1), Cu(II)-MOF mass (0.01–0.03 mg), pH (3.0–9.0), and time of irradiation (30–90 min). The photocatalytic degradation efficiency was investigated by the central composite design (CCD) methodology. The results of CCD analysis for optimum values of variables revealed that Cu(II)-MOF mass was 0.025g, the initial concentration of MB was 3.51 mg L−1, pH was 4.50 and irradiation time was 75 min.Under the optimum conditions, the photocatalytic MB degradation percentage at the desirability function value of 1.0 was found to be 70%. In addition, the obtained R2 value of 0.97 in the regression analysis showed a high photocatalytic efficiency of the proposed method for MB degradation. Manuscript profile

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52 - Application of response surface methodology for optimization of fluoride adsorption from aqueous solution using MgO-based nanocomposites
Abbas Rahdar Somayeh Rahdar laili Mohammadi Saiedeh Sistani Shabnam Ahmadi Md. Abu Bin Hasan Susan

10.22034/jna.2020.1874451.1149

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53 - Preparation of Ag Loaded WO3 Nano Rod and Its Highly Efficient Degradation of Flumequine under Sunlight Irradiation
Somayeh Saleh Fekr Mehdi Ardjmand Reza Fazaeli Mehdi Rafizadeh

10.22034/jna.2021.1926352.1250

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54 - Application of response surface methodology for optimization of fluoride adsorption from aqueous solution using MgO-based nanocomposites
Somayeh Rahdar Leili Mohammadi Abbas Rahdar Shahin Ahmadi Saeideh Sistani Md. Abu Bin Hasan Susan

10.22034/jna.2020.677399

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55 - Photo Degradation of methylene blue in aqueous solution by a new Cu(II)-MOF based on diaminodiphenyl sulfone ligand through response surface methodology (RSM)
Zahra Moseni nik Saeed Jamehbozorgi Majid Ramezani Tahere Momeni Esfahani

10.22034/jna.2020.677395

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56 - Optimization of Fused Deposition Modeling Process Parameters to Achieve Maximum Mechanical Properties Using Response Surface Methodology
Ali Hasanabadi Hossein Afshari Seyyed Mohammad Bagher Mirafzali

In this study, the researchers investigated the impact of various parameters, including layer raster angle, infill extrusion width, and layer height, on mechanical properties such as tensile strength, elongation, and Young's modulus of polylactic acid printed samples. T More

In this study, the researchers investigated the impact of various parameters, including layer raster angle, infill extrusion width, and layer height, on mechanical properties such as tensile strength, elongation, and Young's modulus of polylactic acid printed samples. To reduce experimental costs, the Box-Behnken method was employed along with response surface methodology using Minitab software to establish the relationship between input and output variables. The results of the tension test indicated that the raster angle had a significant impact on all three properties. Furthermore, the regression equations showed that changes in infill extrusion width and layer height had a strong effect on tensile strength but had a less significant impact on elongation and Young's modulus. The optimal output parameters were determined to be 38.67 MPa tensile strength, 3.42% elongation, and 1117.47 MPa Young's modulus using input parameters of 10 degree raster angle, 170% infill extrusion width, and 0.2 mm layer height. The study validated the results obtained through experimental testing and concluded that the response surface methodology could predict part properties with high accuracy (less than 6% error) based on input parameters. Manuscript profile

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57 - Antioxidant Effect optimization of ethanol extract of Cirsium vulgare on oxidative stability of soybean oil and comparison with synthetic antioxidant (BHT)
الهام Azadfar Maryam Sabetghadam زهره Bahrami بیتا Beyzaei

10.30495/jfm.2021.683625

Various factors such as oxygen, light, heat, metal ions and enzymes can affect the oxidative stability of oils and lipids and finally, oxidative rancidity can occur. The application of synthetic antioxidants has been questioned to delay oxidative rancidity due to their More

Various factors such as oxygen, light, heat, metal ions and enzymes can affect the oxidative stability of oils and lipids and finally, oxidative rancidity can occur. The application of synthetic antioxidants has been questioned to delay oxidative rancidity due to their toxicity and carcinogenic probability. This study aims to optimize the oxidant performance of an ethanolic extract of Cirsium vulgare on oxidative stability of soybean oil and compare it with synthetic antioxidants (BHT). In this study, Cirsium vulgare extract was extracted under the influence of concentration (100-300 ppm), duration hours and temperatures . After performing different experiments on the extraction of the best extraction conditions, the best extraction conditions were determined using response surface methodology and extraction in optimum conditions. Data analysis was carried out. The results of the optimization process showed that the oxidative stability of oil showed that; time 24.0 min and concentration 100/01temperature 44/745 were determined. Results showed that the optimum sample of Cirsium vulgare in the stability of soybean oil during storage time was more effective than synthetic antioxidant (BHT), due to higher levels of phenolic compounds and antioxidant present in the optimized sample of Cirsium vulgare. Manuscript profile

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58 - The effect of rice flour on survival of Lactobacillus paracasei in fruit yoghurt and its qualitative properties with response surface methodology
Farnaz Nabizadeh Paniz Zinsaz

In this study the effect of rice flour on survival of lactobacillus paracasei and qualitative properties of fruit yogurt was investigated during storage, using response surface method (RSM). For this, rice flour in three ranges of (0, 1.5 and 3%) was added to the milk. More

In this study the effect of rice flour on survival of lactobacillus paracasei and qualitative properties of fruit yogurt was investigated during storage, using response surface method (RSM). For this, rice flour in three ranges of (0, 1.5 and 3%) was added to the milk. Then the milk and was pasteurized in 85ºC for 15 minutes. After cooling, yoghurt starter culture and probiotic bacterium inoculated in 43 ºC and added into sterile containers containing 15% peach puree. The samples were incubated in 42 ºC until reaching pH 4.6 ±0.1. Then the samples were cooled down to 4 ºC and refrigerated in the same temperature until experiment day. Survival of lactobacillus paracasei, pH, amount of moisture, acidity, syneresis and apparent viscosity and sensory properties were investigated in three periods of (1, 11 and 21 days). The statistical analysis of the results showed that with increasing of rice flour, lactobacillus paracasei count increased and decreased during storage (p Manuscript profile

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59 - کاهش نیتریت در سوسیس با استفاده از روش سطح پاسخ و بکارگیری اسانس مرزه ی بختیاری و پودر گوجه
بنفشه محمدی نفیسه جهانبخشیان مریم جعفری

10.30495/medherb.2022.698517

Background & Aim: The use of synthetic additives is one of the main approaches for preventing microbial growth and oxidative reactions in meat products. These preservatives were recently marked as unhealthy to humans; therefore, the consumers demand for fresh, natur More

Background & Aim: The use of synthetic additives is one of the main approaches for preventing microbial growth and oxidative reactions in meat products. These preservatives were recently marked as unhealthy to humans; therefore, the consumers demand for fresh, natural, and negligibly processed products with lower content of artificial additives is increasing.Experimental:  The effect of Satureja bachtiarica Bunge essential oil (EO) and tomato powder (TP) to optimize sausage formulation with reduced nitrite content was investigated. Response surface methodology (RSM) was used to investigate the effects of different levels of EO (200-400 ppm), TP (5-15%) as Hurdles, and sodium nitrite (SN) (0-300 ppm) in sausage formulation during storage (0- 24 days). Dependent variables including residual nitrite, pH, color indices, microbial load, and hardness were investigated and finally model optimization and validation were conducted.Results: The results showed that residual nitrite was strongly depending on initial added nitrite and storage time (p<0.001), so the use of nitrite substituent was undeniable to have an improved sausage formulation without microbial defect. RSM represented a quadratic model for all responses except in texture which was linear and the pH and microbial load showed interaction. The optimized predicted values for SN, EO and TP were 56 ppm, 378 ppm and 5%, respectively. The model validation revealed that the results of the experiments were in good agreement with the predicted values.Recommended applications/industries: The results of the present study can be useful for consideration in meat products industry to reduce the nitrite level in sausage formulation. Manuscript profile

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60 - استخراج روغن کنجد با کمک امواج فراصوت
حسن غزالی وردنجانی سمیه تقیان مهدی عمو حیدری

مقدمه و هدف: کنجد یکی از قدیمی‌ترین گیاهان کشت شده در جهان و یکی از قدیمی‌ترین محصولات روغنی مورد استفاده بشر است. روغن کنجد به عنوان یک روغن صنعتی،خوراکی و دارویی دارای اهمیت ویژه‌ای است. امروزه استفاده از امواج فراصوت با توجه به اثرات مؤثر آن در نگهداری و فرآیند مواد More

مقدمه و هدف: کنجد یکی از قدیمی‌ترین گیاهان کشت شده در جهان و یکی از قدیمی‌ترین محصولات روغنی مورد استفاده بشر است. روغن کنجد به عنوان یک روغن صنعتی،خوراکی و دارویی دارای اهمیت ویژه‌ای است. امروزه استفاده از امواج فراصوت با توجه به اثرات مؤثر آن در نگهداری و فرآیند مواد غذایی گسترش قابل توجه‌ای یافته است. روش تحقیق: در این تحقیق از مدل آماری سطح پاسخ به منظور بررسی اثرات دو متغیر نسبت دانه به حلال و زمان استخراج باامواج فراصوت بر متغیرهای وابسته شامل راندمان استخراج، عدد پراکسید، عدد 2-تیوباربیتوریک اسید، فاکتورهای رنگ سنجی و نوع و میزان اسیدهای چرب موجود در روغن استحصالی استفاده شد. نتایج و بحث: نتایج تجزیه واریانس نشان داد افزایش نسبت حلال به دانه و زمان استخراج با امواج فراصوت دارای اثر آماری معنی‌داری (01/0 P ≤)بر افزایش راندمان استخراج بودند. شرایط عملیاتی بهینه برای فرآیند استخراج جهت حصول بیشینه راندمان شامل زمان استخراج 55 دقیقه و نسبت دانه به حلال 25/0 تعیین شد. توصیه کاربردی/ صنعتی: نتایج این مقاله نشان داد که فرایند استخراج اولتراسونیک نسبت به زمان مشابه استخراج با روش سوکسله، بازده بیشتری حاصل نمود. همچنین نتایج حاکی از آن بود که امواج فراصوت تأثیر نامطلوبی روی رنگ روغن استخراج شده نداشت و در شرایطی حتی باعث بهبود رنگ روغن استحصالی نیز شد. Manuscript profile

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61 - Photocatalytic degradation of rhodamine B by nano bismuth oxide: Process modeling by response surface methodology (RSM)
Seyed Ali Hosseini Ramin Saeedi

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62 - Optimization of main parameters affecting activity and octane number produced from catalytic isomerization of n-heptane using response surface methodology
Nastaran Parsafard

10.30495/ijc.2023.1980650.1994

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63 - IMPORTANT ISSUES IN MULTIPLE RESPONSE OPTIMIZATION
محمد طالقانی

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64 - The Effects of Sugar Beet Pulp with Tallow and Soybean Oil on Broiler Chicken Performance and Jejunum Morphology
F. Aziz-Aliabadi A. Hassanabadi A. Golian S. Zerehdaran H. Noruzi

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65 - Optimisation of wire-cut EDM process parameter by Grey-based response surface methodology
Amit Kumar Tarun Soota Jitendra Kumar

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66 - An experimental analysis and optimization of machining rate and surface characteristics in WEDM of Monel-400 using RSM and desirability approach
Vinod Kumar Vikas Kumar Kamal Kumar Jangra

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67 - A weighted metric method to optimize multi-response robust problems
R Noorossana M Kamali Ardakani

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68 - Investigation of simultaneous removal of Basic Orange 2 dye and Ni(II) from aqueous solutions by modified nanoclay in continuous washing system using response surface methodology (RSM)
Armin Geroeeyan Ali Niazi Elaheh Konoz

10.30495/jacr.2022.698061

In the present study, the removal of Basic Orange 2 (BO2) dye and Ni(II) from aqueous solutions was studied using modified montmorillonite nanoclay (MMT). To characterize the adsorbent, FESEM and EDX-MAP analyses were performed. The process of the removal of pollutants More

In the present study, the removal of Basic Orange 2 (BO2) dye and Ni(II) from aqueous solutions was studied using modified montmorillonite nanoclay (MMT). To characterize the adsorbent, FESEM and EDX-MAP analyses were performed. The process of the removal of pollutants was investigated through the designing and fabrication of the continuous washing system and the effect of important variables influencing the process such as concentration of dye and Ni(II), pH, length of column and the number of washing cycles was evaluated. Response surface methodology (RSM) using central composite design (CCD) has been applied to study the influence of experimental factors on the simultaneous removal of BO2 dye and Ni(II) in continuous system and the interaction of the variables were scrutinized through response surface curves. According to RSM results and optimization of simultaneous removal of BO2 dye and Ni(II) using desirability function, the optimal values for the five variables of dye concentration, Ni(II) concentration, pH, length of column, and number of washing cycles were found 12.07 mg L-1, of 12.97 mg L-1, 8.18, 12.97 cm and 2, respectively. The results of the removal of BO2 dye and Ni(II) in continuous washing system using modified montmorillonite nanoclay showed that this method can be efficient for the adsorption of pollutants from aqueous solutions. Manuscript profile

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69 - Application of Response Surface Methodology for Xanthan Gum and Biomass Production Using Xan-thomonas campestris
Hadi Hashemi Gahruie Marzieh Moosavi-Nasab Esmaeil Ziaee

10.22034/jchr.2015.544105

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70 - Using Response Surface Methodology for Assessment of Heating Effect on Reduction of Aflatoxin
Moslem Lari Najafi

10.22034/jchr.2020.1891864.1095

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71 - Preparation of polystyrene – multi walled carbon nanotube nanocomposite with improved mechanical properties using response surface methodology
مریم فربودی مهیا ترابی

In this research, with the aim of improving mechanical properties of polystyrene (PS), multi walled carbon nanotube (MWCNT) was selected as reinforcement agent. PS-MWCNT nanocomposite was prepared by mixing of MWCNT nanostructurs with a solution of PS. The effects of th More

In this research, with the aim of improving mechanical properties of polystyrene (PS), multi walled carbon nanotube (MWCNT) was selected as reinforcement agent. PS-MWCNT nanocomposite was prepared by mixing of MWCNT nanostructurs with a solution of PS. The effects of three factors containing MWCNT percentage, film drying temperature and stirring time were investigated in different levels by Box Behnken design of response surface methodology (RSM). According this method, 15 experiments were performed. The tensile strength values of nanocomposite films were used as response for data analyzing by variance analysis. The linearity of normal probability plot of the residuals established the correctness of the proposed model. The contour and surface plots of RSM were studied and the optimal conditions of nanocomposit preparation were determined. The results showed that increasing of MWCNT percentage and stirring time cause to increase of tensile strength, while the increasing of film drying temperature causes to decrease of tensile strength. Also, some physicochemical properties of the nanocomposite film were examined using FT-IR spectroscopy and TGA techniques. Manuscript profile

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72 - On the use of Response Surface Methodology for Optimization of Scaffold Composite of the Hydroxyapatite and Diopside
Nasrin Rafiee Saeid Karbasi amirabas nourbakhsh kamran amini

10.30495/apme.2021.1889820.1973

The response surface methodology is a statistical approach to design the experiments, modeling and analysis of the effective factors as well as to help optimizing the process. In this study, we use the central composite design technique to select the optimum scaffold co More

The response surface methodology is a statistical approach to design the experiments, modeling and analysis of the effective factors as well as to help optimizing the process. In this study, we use the central composite design technique to select the optimum scaffold composite of the Hydroxyapatite and Diopside. This method suggested twenty different scaffold specimens by optimizing the suitable percentage of porosity via determining the percentage weight concentrations of the three effective parameters. After making the scaffold and determining their porosity, the optimum case for composite scaffolds was 77.57 wt% nHA (22.43wt% Di), 0.64wt% lubricant (STPP) and heat treatment temperature 1200. Also, the results of SEM, FTIR, and XRD confirm that the scaffold specimen made with the response method is an ideal specimen for use in bone tissue engineering. In general, according to the results of this research, the response surface methodology can be a useful tool for optimizing composite scaffolds in tissue engineering. Manuscript profile

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73 - Simultaneous optimization of extraction of bioactive compounds and antioxidant activity of Ammi visnaga (L.) Lam aerial parts using response surface methodology
Zineb El Jabboury Smail Aazza Driss Ousaaid Oumaima Chater Uroš Gašić Peđa Janaćković Zora Dajic Stevanovic Stefan Kolašinac Meryem Benjelloun Lahsen El Ghadraoui

In this report, different extracts from the aerial parts of Ammi visnaga (L.), e.g., flowers, leaves, and stems were prepared using water, methanol, and ethanol. To optimize the extraction process, the design of mixtures was carried out using different extracting solven More

In this report, different extracts from the aerial parts of Ammi visnaga (L.), e.g., flowers, leaves, and stems were prepared using water, methanol, and ethanol. To optimize the extraction process, the design of mixtures was carried out using different extracting solvents and their combinations. The special cubic model explained the variance of the TPC and the antioxidant activity of the extracts at a level of R2 > 95%. In general, the analysis of the model-derived response surfaces revealed that in binary mixtures (50% ethanol + 50% methanol), the yielded values of phenolic compounds and the antioxidant activity increase with the water proportion of different prepared mixtures. The ability of the quaternary mixture to extract the phenolic compounds was also positively and significantly influenced by the water content, creating a mild polar medium for the extraction of phenolic compounds. The phenolic profile of different extracts under study revealed the presence of a cocktail of active ingredients, including chlorogenic acid, caffeic acid, rutin, p-coumaric acid, etc. especially the flower extract of A. visnaga (L.). Manuscript profile

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74 - An Investigation on the Metal Injection through the Producing of MIM-ed Low-Alloy Steel
S. Rezaei A. Askari

In this study, we demonstrate the injection stage of Metal Injection Molding (MIM) process to fabricate a small bend-type component. This non-standard but critical engine part is made of a feedstock from the low alloy steel 4605. To optimize various injection parameters More

In this study, we demonstrate the injection stage of Metal Injection Molding (MIM) process to fabricate a small bend-type component. This non-standard but critical engine part is made of a feedstock from the low alloy steel 4605. To optimize various injection parameters, the five-variable Box-Behnken Design (BBD) is used with the assumption of a quadratic model, together with the statistical method of Response Surface Methodology (RSM). Samples are then fabricated, and their densities are measured. Hence, the significance of these factors as well as the mutual coupling between each two parameters are investigated using the analysis of variance (ANOVA). Finally, this paper reveals that injection temperature of 155 ◦C, the injection speed of 80 mm/s, holding pressure of 83 bar, holding time of 9 s and the injection pressure of 132 bar led to an optimum density of the green part, which becomes 4.892 g/cm3. Then, a new sample is produced using these optimized settings, and the green component density is measured, which is extremely near to the predicted value. After sintering, the optimized sample’s density and hardness are compared to the MIM-4605 standard criteria. Manuscript profile

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