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Open Access Article
1 - Nutraceuticals with pleiotropic anti-inflammatory functions for mitigating meta-inflammation
Samila Farokhimanesh Ali Komeili -
Open Access Article
2 - In vitro evaluation of antifungal effect and morphological change due to essential oil of Cuminum cyminum on Fusarium verticillioides on isolated from Iran
علیرضا مختاری علیرضا خسروی تقی زهرایی صالحیFungi like Fusarium species that have generally been referred to as farm fungi, in terms oftoxicity and toxin production are prominent in their group. The most important fumonisin toxinis fumonisin B1. Fusarium toxins are generally produced at lower temperature than opt MoreFungi like Fusarium species that have generally been referred to as farm fungi, in terms oftoxicity and toxin production are prominent in their group. The most important fumonisin toxinis fumonisin B1. Fusarium toxins are generally produced at lower temperature than optimumgrowth temperature. Fumonisin is a toxin produced by Fusarium verticillioides. In recent yearsdue to ecological changes and increased soil nitrogen levels, fusarium contaminations haveincreased. In present study effect of essential oil (EO) of Cuminum cyminum on Fusariumverticillioides isolated in Iran were determined in vitro by micro dillution method.The main EO active ingredient of Cuminum cyminum is aldehydecuminic. This EO is watersoluble. This research was performed inon14 isolated. The drug sensitivity tests were performedaccording to standard methods Broth Micro dillution NLCCLS-M38A2. The tests were repeatedtwice.MIC (Minimum inhibition concentration) frequency of EO was 0.195 μg/mlwith42.84%susceptible isolate and the least frequent was in concentration0.293μg/mlwith7.14% susceptibleisolate. MFC (Minimum fungicidal concentration) frequency distribution was0.39 μg/ml with42.84% susceptible strains and lowest frequency of susceptible isolate were 0.146,0.293and0.586 μg/ml with 7.14%. The results indicate effectiveness of this essential oilinhibited the growth of Fusarium verticillioides. EO effect on transformation the fungus conidiawere proved by microscopic examination. MIC and MFC of cuminum cyminum EO on differentisolate of F. verticillioides were calculated 0.097-0.39μg/ml and 0.146-0.781μg/mlrespectively. Manuscript profile -
Open Access Article
3 - Investigating the effect of Scenedesmus acuminates algae extract on healing wounds infected with Staphylococcus aureus in a rat model
هومن Akasheh, علیرضا Jahandideh امیر اقبال Khajerahimi شاپور Kakoolaki سعید HesarakiThe purpose of this study is to use a seaweed called Scenedesmus acuminates to reduce infection and heal wounds. Sixty rats were divided into four treatment groups, and sampling was done on the third, seventh, and fourteenth days after wound formation. No treatment was MoreThe purpose of this study is to use a seaweed called Scenedesmus acuminates to reduce infection and heal wounds. Sixty rats were divided into four treatment groups, and sampling was done on the third, seventh, and fourteenth days after wound formation. No treatment was done on the first group, the control group. The second group was treated with 25% zinc oxide as the drug of choice. The third and fourth groups were treated with 3% and 7% Scenedesmus acuminates seaweed ointment. The back wounds of mice were infected with 50 microliters of 2x108 CFU/mL Staphylococcus containing suspension. Histopathology and immunohistochemistry (CD68) were performed to compare the number of macrophages on tissue samples. On the third day after wounding, macrophages (CD68) were present in the algae group by 7% more than in the other groups. On the seventh day, fibroplasia and collagen synthesis in the algae group was 7% better than in the other two groups. On the 14th day, the accumulation of new blood vessels in the algae was 7% more than the others. The best result regarding the CD68 (macrophage) molecule expression level was seen in the 7% algae group on the 7th and 14th days. On the third, seventh, and fourteenth days, when macrophages are helpful, algae groups were better than others. The use of algae ointment can reduce the bacterial load of the wound and is better than the administration of zinc oxide. Manuscript profile -
Open Access Article
4 - Evaluation of Microbial Population and Quality Properties of Fresh Veal Meat Packed under Modified Atmosphere and Essential Oils of Rosemary and Cumin
Maryam Azhdar Nazanin ZandIntroduction: In this study, the effect of different concentrations of three types of gasmixtures (carbon dioxide, nitrogen, oxygen), as well as vacuum and also ordinaryconditions as control and essential oils of rosemary and cuminum to increase shelf life ofthe fresh v MoreIntroduction: In this study, the effect of different concentrations of three types of gasmixtures (carbon dioxide, nitrogen, oxygen), as well as vacuum and also ordinaryconditions as control and essential oils of rosemary and cuminum to increase shelf life ofthe fresh veal meat at 40C in a 3-layer pouch(124 μ) were evaluated.Materials and Methods: Ordinary conditions as control packaging, were compared withfour kinds of modified atmosphere packaging 1)80% CO2 + 20% N2 , 2) 20% CO2 + 80%N2 , 3)%48.5 CO2+48.5% N2 + 3%O2 and 4) under vacuum condition along with injectionof rosemary and cuminum essential oils (1.5 % WE/WS), and samples without essentialoils.Microbial test concerned with aerobics and anaerobic count were peformed on thesamples during 20 days of storage , chemical tests concerned with pH and peroxide as wellas sensory evaluation were due conducted.Results: The results indicated that the shelf life of veal meat with rosemary essential oilunder gas compositions , 80% CO2 ; 48.5% CO2 & 20% CO2 ; 20, 18 ,15 days,respectively, in vacuum and ordinary conditions were 12 , 8 days, with cuminum essentialoil in gas compositions, 80% CO2 ,17 days , in conditions 48.5% CO2 & 20% CO2 15 and13 days, in vacuum and control were 10 , 6 days, without essential oil injection, under gascompositions 80% CO2 ; 48.5% CO2 & 20% CO2 ; 13, 11, 10 days in vacuum and ordinaryconditions were 8 , 4 days, respectively.Conclusion: The best condition belonged to the samples containing rosemary essential oilunder the condition 80% CO2 after 20 day, and had desirable effects on microbialpopulation (aerobics bacteria "5.314 logcfu/ml”, anaerobic bacteria "3.77 logcfu/ml”), pH(5.42), PV (3.993) and also sensory properties of the samples. Manuscript profile -
Open Access Article
5 - Development and Evaluation of Color Parameteres of Curcumin Nanocomplex
SH. Shaykhzadeh M. Alizadeh M. Rezazad H. HamishehkarIntroduction: Color is the fundamental qualitative characteristic of food products. Curcumin is a natural polyphenol found in the rizome of the turmeric. Curcumin, possesses multiple biological activities. However, its application is limited due to its poor water solubi MoreIntroduction: Color is the fundamental qualitative characteristic of food products. Curcumin is a natural polyphenol found in the rizome of the turmeric. Curcumin, possesses multiple biological activities. However, its application is limited due to its poor water solubility and instability under adverse conditions. Encapsulation is a way to overcome these challenges. The aim of this study was to develop curcumin-loaded nanocapsules and evaluate the particle size and color parameters of the prepared product. Materials and Methods: Initially, the organic phase (curcumin in ethanol) was introduced to aqueous phase (sodium caseinate, gum arabic and Tween 20). By reduction of the pH from 7 to 4.8, 5 and 5.2 nanoparticles were formed. Measurement of the particle size was carried outbyusing particle size analyzer. Color indices were determined using a Hunter lab. Box-Behnken design was used to explore the effects of 4 independent variables consisting of sodium caseinate (0.1-0.3 %w/w), gum arabic (0.5-1% w/w), Tween 20 (0.1, 0.2 %w/w) and pH (4.8, 5, 5.2) on the responses. Results: Theresults of the analysis showed that the effects of linear, quadratic and interaction of parameters on responses were significant. By increasing the biopolymers concentration, the particles size was increased from 120 nm to 984 nm. By increasing the concentration of sodium caseinate the brightness of samples was reduced.Samples containing Tween 20 had brightness and higher L*. In general, by reducing the particle size the color intensity of the samples was increased. Conclusion: The best sample regarding the smallest particle size and curcumin color index was obtained at the concentration of 0.2 % sodium caseinate, 0.75 % gum arabic, 0.1 %Tween 20 and pH of 5. These nanodispersions might be useful as a hydrophobic nutrient delivery system as well as color factor for utilisation in functional food and beverage products. Manuscript profile -
Open Access Article
6 - Impact of Antioxidative Properties of Cumin and Tarragon Essential Oils on the Quality of Full-Fat White Cheese
S. Rafei M. Azizkhani P. AreaeiIntroduction: Oxidation occurrence in milk and dairy products causes rancidity that leads tochanges in odour and taste, loss of nutritional quality and safety. The aim of this investigationis to assess the antioxidant efficiency of cumin seed and tarragon essential oils MoreIntroduction: Oxidation occurrence in milk and dairy products causes rancidity that leads tochanges in odour and taste, loss of nutritional quality and safety. The aim of this investigationis to assess the antioxidant efficiency of cumin seed and tarragon essential oils (EOs) atdifferent concentrations in full-fat white cheese at 4°C over a 60-day period.Materials and Methods: The components of the extracted essential oils were determined bygas chromatography equipped with mass spectroscopy. In order to evaluate the antioxidantactivity of EOs in cheese, peroxide and tiobarbituric acid values were measured as means toevaluate the extent of oxidation during 60 days of storage.Results: The main compounds present in cumin EO consisted of cumin aldehyde, α-terpinene-7-ol and γ-terpinene and the main compounds present in tarragon EO consisted ofestragol, β-cis-Ocimene and β-trans-ocimene. Two percent concentration of essential oils ofcumin and tarragon exhibited the best antioxidant activity during 60 days of storage. Therewere not significant differences between the peroxide and tiobarbituric acid values of thesamples treated with 1% and 2% of cumin EO on the 60th day of storage. Final peroxide andtiobarbituric acid values of the samples containing 2% cumin and tarragon EOs were 0.19meq O2/kg, 0.07 mg MDA/kg and 0.16 meq O2/kg, 0.03 mg MDA/kg, respectively.Significant differences were observed as compared to the control sample.Conclusion: It was concluded that tarragon EO was more effective than cumin EO in order toprotect the oil against oxidation and cumin EO at the concentration of 1%, obtained thehighest overall score concerning the organoleptic acceptance. Manuscript profile -
Open Access Article
7 - Green Synthesis of Colloidal Gold Nanoparticles by Curcumin Extracted from Turmeric and Evaluation of its Antioxidant activity
N. Khosh Lahjeha K. Larijani E. Pournamdari F. , Zamani Hargalani H. SaeidianIntroduction: Gold nanoparticles can be used as a protective compound in the packaging of nutritionally valuable materials due to their non-toxic effects on humans and high antibacterial and antioxidant properties. Other applications in the food industry, such as the co MoreIntroduction: Gold nanoparticles can be used as a protective compound in the packaging of nutritionally valuable materials due to their non-toxic effects on humans and high antibacterial and antioxidant properties. Other applications in the food industry, such as the construction of sensors to identify the remnants of hazardous materials from agricultural and industrial processes, are conceivable for these materials. One of the methods of synthesis of these nanoparticles is the use of natural compounds due to reducing the side effects of chemicals, a new approach that in recent years has been referred to as "green chemistry".Materials and Methods: gold nanoparticles were synthesized using curcumin purified from turmeric as the main source of this compound. The synthesis process was investigated using UV-VIS, FT-IR spectroscopy methods. The structure and morphology of the nanoparticles were performed using XRD spectroscopy and TEM and SEM imaging. The antioxidant properties of gold-curcumin nanoparticles were evaluated by DPPH free radical scavenging method.Results: Au-nanoparticles were synthesized using the green chemistry method using curcumin purified from turmeric in the form of a cross and cubic crystal structure of filled funds with an average size of 9.80 nm. Antioxidant studies showed that the free radical scavenging ability of gold-curcumin nanoparticles was increased as compared to pure curcumin.Conclusion: Curcumin as a natural compound with antioxidant properties has the ability to reduce gold ions and convert them into nanoparticles, and due to the use of these nanoparticles in the food industry, this method can be used as a green, inexpensive and eco-friendly. Manuscript profile -
Open Access Article
8 - Evaluation of Alginate/Collagen Edible Coatings with Betanin and Cumin to Improve the Shelf Life of Lighvan Cheese
F. Ahmadimaram T. Mostaghim Sh. Shahriari -
Open Access Article
9 - Evaluation of cumin stem powder efficiency in Methylene blue removal from aqueous solutions
Somaye Rahdar Morteza Ahmadabadi Edrise Bazrafshan Mahmoud TaghaviMethylene blue (MB) is a most common paint for dying and it can cause eye burns, breathingproblem, heart rate increasing, nausea, diarrhea, and vomiting, gastritis, shock, cyanosis, jaundice,quadriplegia, and tissue necrosis in humans. In this study, cumin stem powder h MoreMethylene blue (MB) is a most common paint for dying and it can cause eye burns, breathingproblem, heart rate increasing, nausea, diarrhea, and vomiting, gastritis, shock, cyanosis, jaundice,quadriplegia, and tissue necrosis in humans. In this study, cumin stem powder has been used as a lowcost adsorbent for the removal of Methylene blue dye from aqueous solutions.In this experimental study, the efficiency of cumin stem powder in removal of methylene blue and theeffect of effecting operating parameters such as pH (2-12), reaction time (5-210 min), adsorbentdosage (0.1-2 g/l) and initial concentration of dye (10-100 mg/l) on color removal from syntheticwastewater were studied.The results showed that the maximum removal efficiency of methylene blue 93% was achieved atoptimum condition: pH 11, reaction time 90 min, adsorbent dosage 0.5 g/l and initial dyeconcentration 100 mg/l. The results of isotherm study revealed well fitting of the experimental datawith Freundlich (R2=0.9913).According to results of this study, it was found that the cumin stem powder has a high capacity toremove methylene blue dye from aqueous solution and textile industry wastewater. Manuscript profile -
Open Access Article
10 - The effect of hydroalcholic extract of Cuminum cyminum L. on anxiety in Adult male rats
Maryam Khoshsokhan mozaffar zahra alemi heshmat nasrin heidariehBackground and objectives: Anxiety is one of the current psychic disorders among humanistic communities. It is an oppressive feeling that associates an unknown and ambiguous danger. Due to the effect of cuminum cyminum L, this study aims to consider the effect of hydroa MoreBackground and objectives: Anxiety is one of the current psychic disorders among humanistic communities. It is an oppressive feeling that associates an unknown and ambiguous danger. Due to the effect of cuminum cyminum L, this study aims to consider the effect of hydroalcoholic extract of cuminum cyminum L. on anxiety among male Adult wistar rats. Material and Methods: After recognition of the cuminum cyminum L. plant through herbarium of Islamic Azad university of Qom, the hydroalcoholic extract was extracted by laboratory, and the extract powder was produced by using an oven. In this study on 32 male wistar rats (200 230 gr) in healthy groups(intact),the treatment group with DMSO or the solvent extract (0/3 cc), and groups received 50,100 mg/kg hydroalcoholic extract of cuminum cyminum L. (n=8). All injections were peritoneal, and half an hour after injection, with the use of high cross labyrinth, anxiety test was taken, and anxiety evaluation’s standard indicators (staying period and the number of entering to free arm) were considered and registered for 5 minutes. Data were analyzed by the Tukey’s unilateral variance analyze (p<0.001). Results: The received group solvent extract than intact group indicators showed no significant differences in anxiety. the hydroalcoholic extract of cuminum cyminum L.in 100 mg/kg, showed significant increasing in presence period and number commuting time on open arm, than the group who received DMSO (p<0.001). Conclusion: the hydroalcoholic extract of cuminum cyminum L. has anti-anxiety effects. Manuscript profile -
Open Access Article
11 - Protection effect of Curcumin in ovary culture in NMRI mice
Mohsen Husseini farhad mohammadi gheshlagh Zahra khodaparast ali Mohammad einiUsing antioxidants is a known method to increase the number of follicles and ovulation in animals and humans. Curcumin inhibits lipoxygenase, cyclooxygenase. Hence in this study, we examine the effects of different concentrations of curcumin on ovarian tissue culture in MoreUsing antioxidants is a known method to increase the number of follicles and ovulation in animals and humans. Curcumin inhibits lipoxygenase, cyclooxygenase. Hence in this study, we examine the effects of different concentrations of curcumin on ovarian tissue culture in NMRI species mice. In this study, 40 varies of female mouse with five weeks ages are transferred to organ culture containers. Studied groups treated by different concentrations of curcumin (10, 20, 40, 80) ng/ml. The ovaries were cultured for 6 days and studied in the case of number of follicles and single layers size and granulosa and analyzed by SPSS software version 20 and ANOVA test. The number of single layer primary follicles in control group (2/3 ± 7/15) and treat groups with 10, 20, 40, 80 ng/ml concentrations of curcumin were (9/5 ± 3/33, 0/5 ± 0/31, 2/4 ± 5/31, 2/3 ± 7/15) respectively which showed a significant increase in all of the treat groups compared with control group (P <0.05). There is also a significant increase in the number of mature follicles in the number of mature follicles cultured in control group (0/4±40) compared with treat group with 10 ng/ml (2/3 ± 5/48). According to the obtained results on the number and quality of follicles, it seem that this method is effective in production, maintain and development of ovarian follicles in culture medium. Manuscript profile -
Open Access Article
12 - Genotype × environment interaction, rhizome yield stability and selection for region specific stable genotypes in turmeric (Curcuma longa L.)
Raj Kishori Lal Sougata Sarkar Mohammad Zaim -
Open Access Article
13 - Resistance training with nanocurcumin on IL-4 and STAT-6 gene expression in muscle cells of healthy male rats
Sadra Sheidaei Shahin Riyahi Malayeri Masoumeh Hosseiniزمینه و هدف: محور پیامدهی IL4/STAT-6 یکی از مهم‏ترین مسیرهای مهم درگیر در رشد و توسعه سرطان میباشد. هدف از پژوهش حاضر بررسی تاثیر تمرین مقاومتی همراه با مصرف نانوکورکومین بر IL-4 و STAT-6 در سلول های ضلانی رت های نر سالم بود. مواد و روش ها: در این مطالعه تجربی، 32 Moreزمینه و هدف: محور پیامدهی IL4/STAT-6 یکی از مهم‏ترین مسیرهای مهم درگیر در رشد و توسعه سرطان میباشد. هدف از پژوهش حاضر بررسی تاثیر تمرین مقاومتی همراه با مصرف نانوکورکومین بر IL-4 و STAT-6 در سلول های ضلانی رت های نر سالم بود. مواد و روش ها: در این مطالعه تجربی، 32 سر رت نر نژاد ویستار به طور تصادفی به چهار گروه (کنترل، تمرین مقاومتی، نانوکورکومین، تمرین مقاومتی+ نانوکورکومین) تقسیم شدند. برنامه تمرینی به مدت 4 هفته و 3 جلسه در هر هفته اجرا شد. گروه های دریافت کننده مکمل روزانه 80 میلی گرم نانوکورکومین به ازای هر کیلوگرم وزن بدن به مدت 4 هفته به صورت خوراکی (گاواژ) دریافت کردند. بیان ژنIL-4 و STAT-6 با روش Real-time PCR اندازه گیری شد. داده ها با استفاده از آزمون تحلیل واریانس یک طرفه مورد بررسی قرار گرفتند.یافته ها: نتایج نشان داد تمرین مقاومتی همراه با مصرف نانوکورکومین موجب افزایش معنادار IL-4 نسبت به سایر گروه ها و کاهش STAT-6 نسبت به گروه تمرین سلول عضلانی رت های نر سالم شد(05/0>P ).نتیجه گیری: به نظر می‏ رسد چهار هفته تمرین مقاومتی همراه با مصرف مکمل نانوکورکومین احتمالا با تاثیر بر محور پیام دهی IL-4/STAT-6 می تواند به تنهایی در روند کاهش آن موثرتر باشد. Manuscript profile -
Open Access Article
14 - Study Of Cumin AqueousExtract Effect on Weight Control in High Fat Dietary Obese Male Wistar Rats
Setareh Reyahi Reza Nejatbakhsh Sanaz MahmaziInroduction and Objective:Obesity resulting from general or local fat accumulation in body. High fat diet is one of the risk factors of Obesity. Many herbal supplements compared to synthetic chemical agents can be effective in the treatment of obesity or weight reductio MoreInroduction and Objective:Obesity resulting from general or local fat accumulation in body. High fat diet is one of the risk factors of Obesity. Many herbal supplements compared to synthetic chemical agents can be effective in the treatment of obesity or weight reduction with minimum side effects. The anti-obesity effect of cumin that are Iranian native aromatic and medicinal plants, on the weight loss and stabilize blood parameters associated with metabolic syndrome were measured weekly in Male Wistar rats.Materials and Methods:32 male Wistar rats, (3 months) who were randomly divided into 4 groups that each group contains of 8 rats, the controls were recipient of a normal diet without treatment, obese subjects receiving the high fat diet without extracts and 2 experimental groups received different dose of Cumin aqueous extract (50,100 mgKg -1 ) with High fat diet. Mice were treated with extracts daily by oral gavages after weighed weekly for 20 weeks. After completion of 20 weeks, Heart, liver, kidneys, spleen, pancreas, Omental fat and fats around kidneys isolated and weighed after autopsy. Biochemical tests included measurements of serum levels of glucose, triglycerides, cholesterol, LDL, HDL, and leptin were performed.Results:Cumin aqueous extract resulted in a significant reduction in body mass index, lipid levels, and decreased levels of triglycerides and leptin and Omrntal fat in contrast to obese group (pConclusion:Cumin in a dosage of 50,100 mgKg-1 can be reduce Omntal fat effectively But according to the reduction of liver weight at doses of 100 mgKg-1 it may had side effects on high dose. The herbals have to use in effective and safe dose. Manuscript profile -
Open Access Article
15 - The effect of different levels of black cumin powder on the performance of some blood parameters and intestinal tissue morphology of Japanese quail
Farshid Kheiri Mehrdad AbbaspourIntroduction & Objective: cumin is one of the most ancient medicinal plants in traditional medicine which is used for treatment and prevention of gastrointestinal disorders and disorders .in order to investigate the effect of different levels of cumin (bunium persic MoreIntroduction & Objective: cumin is one of the most ancient medicinal plants in traditional medicine which is used for treatment and prevention of gastrointestinal disorders and disorders .in order to investigate the effect of different levels of cumin (bunium persicum) powder on performance of some blood parameters and morphological characteristics of ileum of Japanese quailMaterials & methods: In this experiment, 400 male Japanese quails were randomly assigned to four treatments, five replicates and 20 quails in each replicate from 14 to 42 days of age. The black cumin powder was applied at four levels (0.5, 1 and 1.5 %) at four levelsResults: There was no significant difference between the levels of black cumin and the control treatment (p< 0.05). Serum albumin was significantly increased under the diet supplemented with 1 and 1.5 % of black cumin powder (p < 0.05 ) .Blood serum calcium and protein levels were significantly increased under the diet containing 1.5 % of black cumin powder (p < 0.05 ).The amount of phosphorus and glucose in the diet containing 0.5 % of the black cumin powder in the diet decreased and significantly (p < 0.05 ) increased in comparison with the control .The triglyceride concentration in the treatment group was significantly lower than the control treatment (p < 0.05).Conclusion: Morphology of ileum in experimental treatments was not significantly different from control treatment. According to the results, adding black cumin powder at 0.5 % level in Japanese quail diet improved the performance and quality of carcass traits compared to other treatments. Manuscript profile -
Open Access Article
16 - Investigation the Effect of Different Crop Rotation Patterns on Weed Community Structure
Laila Alimoradi Aireza Sohani DarbanIn order to investigate the effects of crop and crop rotation on weed community structure, an experiment was carried out in research field of collage of Agriculture, Ferdowsi University, Mashhad, during the years of 2013-14 and 2014-15. In the first year, sugar beet was MoreIn order to investigate the effects of crop and crop rotation on weed community structure, an experiment was carried out in research field of collage of Agriculture, Ferdowsi University, Mashhad, during the years of 2013-14 and 2014-15. In the first year, sugar beet was planted in 17th April and cicer, cumin and onion were sown in 7th and 8th March. All sowing, growing and harvesting managements were conventional and crops were harvested in ripening stage. On November, after the last crop (sugar beet) harvest, barley (beverage) was sown in the filed. In the second year, weed population was sampled with a 1*1 m2 quadrate. Results showed that there was a correlation between crop type and compendium weed population Flore and those species that have similar morphological performance and life cycle with crops was dominant. There was a regression (r2=0.92) between crop growing season and annual broad leaf weed species number and summer weed species. It seems with increasing in summer crop growing season, summer weed species have more opportunity for growth and development. This result was affected on weed population in barley filed, whether; summer weed species was more in those field sections that sugar beet was sown in previous year. Manuscript profile -
Open Access Article
17 - Anti-Shigella Effect of Turmeric Curcumin Composition
Neginsadat Mireshghi Zohreh Jafari Behrooz Shojaei SadiShigella are gram-negative, motionless, spore-causing bacteria that cause a condition called shigellosis, or bacilli. Shigella Due to the low infectious dose (10-100 bacteria) and high side effects, the increase in antibiotic-resistant strains is significant. Shigellosi MoreShigella are gram-negative, motionless, spore-causing bacteria that cause a condition called shigellosis, or bacilli. Shigella Due to the low infectious dose (10-100 bacteria) and high side effects, the increase in antibiotic-resistant strains is significant. Shigellosis is the second leading cause of death in children under 5 years of age. Early diagnosis and antibiotic treatment play a key role in reducing complications and mortality. Curcumin is a phenolic compound extracted from Turmeric, which is due to the pharmacological and antibacterial properties of Turmeric. Recent studies have shown that Curcumin in appropriate doses inhibits Shigella growth. The aim of this study was to evaluate the anti-Shigella effect of Curcumin. The present study is a review research. Research has shown that the inhibitory dilutions of Curcumin on Shigella are 80-256 µg/ml and its minimum lethal concentration is 512 µg/ml. Due to the fact that Curcumin is widely used as a food, it can be used as a drug in clinical Conditions. Manuscript profile -
Open Access Article
18 - Evaluation Of Salicylic Acid Pretreatment On Germination And Seedling Growth Characteristics On Medicinal Plant Of Black Cumin (Nigella Sativa L.) under salt stress
فرشاد سرخیBlack cumin is used medicinally as a decongestant, regularizer, laxative, anti -constipation and sexual enhancer in men. It is also used in the treatment of cancer, diabetes, and ulcers . Salinity stress could decrease seed germination and growth of plants. It has been MoreBlack cumin is used medicinally as a decongestant, regularizer, laxative, anti -constipation and sexual enhancer in men. It is also used in the treatment of cancer, diabetes, and ulcers . Salinity stress could decrease seed germination and growth of plants. It has been found that salicylic acid as endogenous growth regulator of natural phenolic compounds that cause to reduce negative effects of the salt stress on different aspects of plant life. The current research was carried out to evaluate probable positive effects of salicylic acid on the germination and initial growth properties of Nigella Sativa when put with salinity stress. For this purpose, an experiment was conducted of factorial experiment in a randomized complete design in four replications. Treatments consisted of salicylic acid levels of 0, 0.2, 0.6 and 1 mm and salinity stress of 0, 100, 150, and 200 mm. The results indicated that salinity stress decreased germination percentage, rate of germination, radical and plumule length and seedling dry weight. The greatest effect of root/shoot ratio was obtained in concentration of 200mm salt stress. While salicylic acid increased the germination percentage, germination rate, root length, shoot length, seedling dry weight and root/shoot ratio under salt stress and non-stress. Most of these traits were observed at concentration of 1 mm salicylic acid. According to the results of seed priming by salicylic acid in regions with salt stree can increase the resistance of Nigella sativa seeds in the germination stage and initial seedling growth Manuscript profile -
Open Access Article
19 - The study of the efficacy of some herbal essences and chitosan in controlling Rhizoctionia solani, rice sheath blight fungus disease
Saba Souhangar Vahid Zarrinnia Saeed Mohammadzade NaminThe use of natural compounds for disease control and prevention has been considered because of the benefits. Using herbal essences has been developed due to having medicinal properties, antifungal, antibacterial and antioxidant secondary metabolites in the control of pa MoreThe use of natural compounds for disease control and prevention has been considered because of the benefits. Using herbal essences has been developed due to having medicinal properties, antifungal, antibacterial and antioxidant secondary metabolites in the control of pathogens. In this study, the performance of three plant essential oils Cumin (Cuminum cyminum), cinnamon (Cinnamomum zeylanicum) and peppermint (Mentha sp.) and soluble chitosan in the prevention and treatment of rice sheath blight caused by the fungus Rhizoctionia solani in vitro and in Ziveh, were studied. This experiment was done in a completely randomized design with 500 treatments and 3 replications. Treatments consisted of three factors essential oils, each in five different concentrations (100, 200, 400, 600, 800, 1000 ppm) and the Factor chitosan in two concentrations 800 and 1000 milligram per liter and also two control included a positive control (culture medium along with tilt PDA) and negative control (dextrose agar medium potatoes without oil). Each treatment consists of three replicates each also includes three petri dish (for all treatments and positive and negative controls), respectively. Inhibition of different concentrations was determined using the Abbott formula. The full minimum inhibitory concentration of essential oils (MIC) and minimum fungicidal concentration of essential oils (MFC) was also calculated. The factorial experiment was considered in a completely randomized design with three replications in which every essence as a factor and different concentrations of essential oils, different levels of each factor. The results showed that essential oils of cinnamon and cumin inhibited 100% of the growth of R. solani were in effect concentrations ppm 200. The essential oil and chitosan 100% inhibition at concentrations of 600 and 1000 were one of their own. In addition to these three extracts of cinnamon, cumin and mint with a percentage of inhibition, respectively, 67/81, 50/82 and 33/83 showed similar results, with 50% inhibition chitosan least inhibition of pathogenic fungi on plant show. Manuscript profile -
Open Access Article
20 - survey of ceremony and food habit of Mongol
parisa ghorbannejad Maryam TalebiFood has many meanings in human life. The national and indigenous food of different nations and nations presents their biological and cultural life. Preference for taste, tastes, preparation methods and tools used, customs and food rituals show specific complexities in MoreFood has many meanings in human life. The national and indigenous food of different nations and nations presents their biological and cultural life. Preference for taste, tastes, preparation methods and tools used, customs and food rituals show specific complexities in the context of culture, which reflects the way of thinking and cultural and social traditions of these nations. The purpose of this study is to examine the food and how it is prepared among the Mongol people, and to do so, a descriptive-analytical research method has been used. The results show that there is a significant variation in indigenous food components, food sources and nutritional rituals of the Mongol people, and has been an important source for the sustainability and coherence of the Mogul community. Their main feed was in adaptation to the environment, and with the prosperity of livestock, meat and dairy products, and in beverages, milk was especially fermented. The Moguls avoided eating heavy food, hospitable and hungry. After arriving in Iran, they influenced Iran's food habits and came to eating other than meat and dairy products. Manuscript profile -
Open Access Article
21 - Survey of ceremony and food habit of Mongol
پریسا ghFood has many meanings in human life. The national and indigenous food of different nations and nations presents their biological and cultural life. Preference for taste, tastes, preparation methods and tools used, customs and food rituals show specific complexities in MoreFood has many meanings in human life. The national and indigenous food of different nations and nations presents their biological and cultural life. Preference for taste, tastes, preparation methods and tools used, customs and food rituals show specific complexities in the context of culture, which reflects the way of thinking and cultural and social traditions of these nations. The purpose of this study is to examine the food and how it is prepared among the Mongol people, and to do so, a descriptive-analytical research method has been used.The results show that there is a significant variation in indigenous food components, food sources and nutritional rituals of the Mongol people, and has been an important source for the sustainability and coherence of the Mogul community.Their main feed was in adaptation to the environment, and with the prosperity of livestock, meat and dairy products, and in beverages, milk was especially fermented.The Moguls avoided eating heavy food, hospitable and hungry. After arriving in Iran, they influenced Iran's food habits and came to eating other than meat and dairy products. Manuscript profile -
Open Access Article
22 - The Effect Different Irrigation Regimes and Animal Manure on Nutrient, Essential Oil and Chemical Composition on Cumin (Cuminum cyminum L.)
A. Ahmadian A. Ghanbari M. Gholavi B. Siahsar E. ArazmjoTo study the effects of water stress and animal manure on nutrients concentration, essential oil percentage and its chemical components in Cuminum cyminum, an experiment was conducted at the Agricultural Research Station of Zahak, Zabol, during 2003–2004 in a rand MoreTo study the effects of water stress and animal manure on nutrients concentration, essential oil percentage and its chemical components in Cuminum cyminum, an experiment was conducted at the Agricultural Research Station of Zahak, Zabol, during 2003–2004 in a randomized complete block design arranged in factorial with four replicates. Treatments were there irrigation (I1: two times irrigation, I2: three times irrigation and I3: four times irrigation) and two animal manure levels (F1: no manure and F2: 20 ton/ha manure). The chemical composition of the essential oil was examined by gas- chromatography (GC) and GC-MS. The effect of water stress on Na, Ca, Mg, Fe, P and K percentages was significant but its effect on Mn, Zn and Cu was not significant. I1F1 had maximum of Na, Ca, Mg and minimum of micro nutrients. Using of animal manure was not effected on nutrients. The effect of water stress and animal manure were significant on essential oil and its chemical compositions. I2F2 had the highest of cuminaldehyde and ρ-cymene and the lowest of β-pinene, γ-terpinene and α-pinene. Result showed that there is a correlation among the main components of cumin essential oil under water and mineral stress. Manuscript profile -
Open Access Article
23 - Effect of Sowing Date on Qualitative and Quantitative Characteristics of Two Varieties of Black Cumin (Nigella sativa) Populations
A. Vaseghi A. Ghanbari M. Heydari S. DavazdahemamiIn order to investigate the effect of planting date on qualitative and quantitative characteristics of medicinal plant of black cumin was investigated in a split plot experiment based on randomized complete block design with four replications at Khomeini – shahr, MoreIn order to investigate the effect of planting date on qualitative and quantitative characteristics of medicinal plant of black cumin was investigated in a split plot experiment based on randomized complete block design with four replications at Khomeini – shahr, in the province of Isfahan, Iran, during growing season of 2009-2010. In this study India and Isfahan populations were assigned to main plots and four sowing date (16 Nov, 16 Dec, 6 Mar and 4 Apr) to sub plots. The results indicated that planting date, populations and their interactions had significant effect on most of the traits measured. It was also observed that the two populations were significantly different in phenological, morphological and qualitative characteristics. Isfahan population due to its compatibility to the climate of Isfahan produced highest seed yield and oil percent than the Indian population at 6 Mar. planting date. Also, late planting date resulted in reduced values of most of the traits related to yield and yield components. It was also observed that highest dry matter, manganese, sodium, calcium and zinc contents were obtained from the Isfahan and highest content of ash, potassium, phosphorus, magnesium, copper and iron from Indian populations. It may conclude that if it is aimed to have higher seed yield and oil percent it is better to plant Isfahan population at the second and third and Indian population at the third planting dates. Manuscript profile -
Open Access Article
24 - Weed Interference Duration Effect on Yield and Yield Components of Cumin (Cuminum cyminum L.) in Conventional and Organic Conditions
Masoud Zarei Mohammad Armin Mosarreza HokmabadiTo investigate the effect of duration of weed interference on yield and yield components of cumin grown under conventional and organic condition, a field experiment was conducted in a private farm in Sabzevar in 2017-2018. A split plot experiment based on a randomized c MoreTo investigate the effect of duration of weed interference on yield and yield components of cumin grown under conventional and organic condition, a field experiment was conducted in a private farm in Sabzevar in 2017-2018. A split plot experiment based on a randomized complete block design with three replications was conducted. Factors were conventional and organic growing was considered as the main factor and duration of weed interference (0, 2, 4, 6 weeks after emergence and weedy) as subplots. The results showed that conventional farming in terms of weed density, weed dry matter, plant height, lateral branch number, number of seed per umbrella, biologic and seed yield were better than organic farming, while, number of umbrella per plant under organic farming was higher than that of conventional farming. Increasing duration of interference decreased plant height (20.21%), lateral branches (42.85%), the number of umbrella per plant (47.91%), the number of seeds per umbrella (37.5%), biological yield (33.96%) and seed yield (43.90%). Fitted logistic regression function coefficients showed that the onset of yield loss was earlier (11 days after emergence) in conventional condition while in organic condition it was postponed to 17.5 days after emergence. Overall, the results showed that weed interference, under both conventional and organic conditions, reduced seed yield. Weed interference under organic farming delayed 4 weeks and under conventional condition to 2 weeks after cumin emergence and yield reduction was not significant. Thus, control of weeds in conventional conditions should commence from 12 days after emergence and under organic conditions from 18 days after emergence. Manuscript profile -
Open Access Article
25 - Study the effect of nitrite substitution by using black cumin (Nigella sativa) oil on oxidative stability, microbial and sensory properties of cocktail sausage
Mohammadreza Khani Amin Abolhasanzadeh Maryam FahimdaneshOne of the major concerns in modern societies is applying the chemical additives in food products and the risk of catching some types of diseases such as cancer. The aim of this research was investigating the possibility of nitrite substitution in cocktail sausage formu MoreOne of the major concerns in modern societies is applying the chemical additives in food products and the risk of catching some types of diseases such as cancer. The aim of this research was investigating the possibility of nitrite substitution in cocktail sausage formulation by using black cumin oil. For this purpose different levels of nitrate in 0, 30, 60 and 90 ppm was replaced with black cumin oil at concentrations of 2 and 3 percent and its effects were evaluated on oxidative stability (peroxide and thiobarbituric acid indices), microbial properties (total bacterial count and yeasts and molds count), and sensory characteristics during one month of storage at 4 °C at 1, 11, 21, and 31 days. The results showed that replacement of nitrite with black cumin oil in two used concentrations led to a reduction of the peroxide and TBA values in nitrite reduced sausages compared to control (P<0.05). Also, microbial load decreased by increasing the concentration of black cumin oil from 2 to 3 percent in equal concentrations of nitrite. Treatments containing 2 and 3% of black cumin oil with 90 ppm and 60 ppm nitrites had mainly similar total bacterial counts and yeasts and molds counts compared to the control during the storage period (P<0.05). Sensory evaluation results indicated that reduction of nitrite and its substitution with black cumin oil led to significant decrease of color and flavor scores, but had no negative effect on texture and odor properties of sausage samples. Manuscript profile -
Open Access Article
26 - Antioxidant activity of black cumin (Nigella sativa L.) and black caraway (Buniumpersicum Boiss) extracts, individually and in combination on chemical changes and sensory properties of silver carp (Hypophthalmichthysmolitrix) stored in refrigerator
مرضیه Gholamzadeh هدایت Hosseini سهیل Eskandari ابراهیم Hosseini مریم GholamzadehHerbs due to having natural antioxidant compounds are widely used by food, pharmaceutical and cosmetics industries. The purpose of this study was to study the effects of antioxidant activities of black cumin as well as black caraway extracts individually and in the comb MoreHerbs due to having natural antioxidant compounds are widely used by food, pharmaceutical and cosmetics industries. The purpose of this study was to study the effects of antioxidant activities of black cumin as well as black caraway extracts individually and in the combination form on chemical and sensory properties of silver carp during refrigerator storage. To do this, fish was cut into four parts. Three parts were dipped in 1% solution of black cumin and black caraway extracts, and their combination. The forth part was dipped in distilled water as a control sample. All fish cuts were packed up in polyethylene bags and were stored at refrigerator (4±1°C). Chemical indices (i.e., PV, TBA and FFA) and sensory properties were measured over a period of 15 days (0, 3, 6, 9, 12, and 15 days). According to the results, in all three treatments lipid oxidation was delayed significantly (p<0.05) in comparison with the control sample. Moreover, sensory analysis revealed that the sample treated with black cumin extract had the best quality over the period of 15 days. Besides, the rising trend of the chemical indices was hindered significantly in comparison with the other treatments. Based on the results, it was concluded that extracts of black cumin and black caraway and their combination had an antioxidant effect on silver carp fish and could lengthen the shelf-life of the treated samples. Manuscript profile -
Open Access Article
27 - Synergistic effect of Nisin and Cuminum cyminum L. essential oil on the growth of Streptococcus iniae in fillets of rainbow trout (Oncorhynchus mykiss)
منصوره Ghaeni لاله Roomiani Streptococcus iniae is an emerging zoonotic pathogen that represents a threat to the aquaculture industry worldwide and poses a risk to humans’ health. The aim this study, was to evaluate the effect of cumin (Cuminum cyminum) essential oil and nisin o More Streptococcus iniae is an emerging zoonotic pathogen that represents a threat to the aquaculture industry worldwide and poses a risk to humans’ health. The aim this study, was to evaluate the effect of cumin (Cuminum cyminum) essential oil and nisin on the growth of S. iniae. For this purpose, the fillets of rainbow trout (Oncorhynchus mykiss) were inoculated with 103 of S. iniae and afterwards were treated with the different concentrations of cumin essential oil (0, 0.005, 0.135 and 0.405%) as well as nisin (0, 0.25 and 0.75 µg/ml). The samples were stored at 4 and 10 ºC for 15 days. Results revealed that in the samples stored at 4 °C the solo application of each of nisin and cumin essential oil could inhibit the growth of S. iniae until day 9; meanwhile, in combining form the inhibition of bacterial growth was occurred for 3 days. In the samples stored at 10 ºC, nisin and cumin essential oil hindered the bacterial growth for 3 and 6 days, respectively. Moreover, combination of the two materials inhibited the bacterial growth until day 6. The highest synergistic effect was observed in 0.405% of cumin essential oil and 0.75 µg/ml of nisin at 4 ºC. However, at 10 ºC, 0.135 and 0.405% of cumin essential oil together with 0.75 µg/ml of nisin had the highest synergistic effect. As a significant (P<0.05) difference was observed between the treatment and control groups, it could be concluded that cumin essential oil and nisin could efficiently inhibit the growth of S. iniae. Manuscript profile -
Open Access Article
28 - The Effect of Aerobic Exercise Training and Curcumin on Aplin Levels, Insulin Resistance and Glucose in Rats with Type 2 Diabetes
Morteza Ebrahimzadeh Kamal Azizbeigi Khalid Mohammad Zadeh Salamat Saman PashaieIntroduction: Previous studies have shown the positive effect of aerobic exercise and curcumin on diabetes. The aim of this study was to investigate the effect of aerobic exercise with and without curcumin supplementation on apelin levels, insulin resistance, and glucos MoreIntroduction: Previous studies have shown the positive effect of aerobic exercise and curcumin on diabetes. The aim of this study was to investigate the effect of aerobic exercise with and without curcumin supplementation on apelin levels, insulin resistance, and glucose in rats with type 2 diabetes. Materials and methods: Forty male rats were randomly divided into 5 groups of 8 including healthy control, diabetic control, diabetes + curcumin, diabetes + aerobic exercise, diabetes + curcumin + aerobic exercise. After the intervention, the animals were sacrificed based on the name of the group, and the desired variables were measured in the collected plasma samples. Data were analyzed by using one-way analysis of variance and a P value less than 0.05 was considered as a significant difference. Findings: The results showed that moderate-intensity aerobic exercise increased the levels of apelin (P<0.05) and decreased insulin resistance (P<0.05) and glucose (P<0.05) in the plasma of diabetic rats. The use of curcumin also increased the levels of apelin (P<0.05) and decreased insulin resistance (P<0.05) and glucose (P<0.05) in the plasma of diabetic rats. Conclusion: Moderate-intensity aerobic exercise can be a good way to lower blood sugar and to prevent from increasing it in diabetic patients. Also, taking curcumin in the range of health values along with aerobic exercise can affect better on the results. Manuscript profile -
Open Access Article
29 - The effect of aerobic exercise and curcumin on plasma concentrations of C-reactive protein in diabetic rats
Morteza Ebrahimzadeh Kamal Azizbeigi Khalid Mohammad Zadeh Salamat Saman PashaieBackground and Aim: Previous studies have shown the positive effect of aerobic exercise and curcumin on various variables in diabetes. Also, the combination of these interventions may have a synergistic effect on research variables. The present study investigates the in MoreBackground and Aim: Previous studies have shown the positive effect of aerobic exercise and curcumin on various variables in diabetes. Also, the combination of these interventions may have a synergistic effect on research variables. The present study investigates the independent and combined effect of aerobic exercise and curcumin supplementation on plasma C-reactive protein concentration in diabetic rats.Methods: Forty male rats were equally divided into healthy control, diabetic control, diabetic exercise, diabetic curcumin and diabetic curcumin + exercise. Aerobic exercise (five sessions / week, each session 30 minutes at a speed of 22 meters / minute, slope: five percent) and supplementation (30 mg / kg body weight, three days / week) were performed for eight weeks. Rats were sacrificed 48 hours after receiving the last intervention.Results: Diabetes increased the concentration of plasma C-reactive protein (P = 0.001). Exercise decreased plasma C-reactive protein concentration (P = 0.001) in diabetic rats. Curcumin also reduced plasma C-reactive protein (P = 0.001) in diabetic rats. The combination of exercise and supplementation had a greater effect on reducing the plasma C-reactive protein concentration than mono / supplementation alone (P <0.001).Conclusion: Exercise and curcumin separately reduced plasma C-reactive protein concentration in diabetic rats. It also seems that the use of a combination of exercise and curcumin than the use of each alone, has been more effective on the variables of the present study. Manuscript profile -
Open Access Article
30 - بررسی مقایسهای تغییرات سطح برگ و برخی فاکتورهای بیوشیمیایی برگ دو گیاه درختی کنوکارپوس (Conocarpus erectus L.) و جمبو (Syzygium cumini (L.) Skeels.) در اطراف منطقه آلوده صنایع فولاد اهواز
شکوفه انتشاری معصومه ارس خلجی سید منصور سید نژاد جمیل واعظی -
Open Access Article
31 - Phytochemical study and improving the essential oil yield of Cuminum cyminum L. medicinal plant by spraying the metabolic activator of pluramin and the growth regulator of bioxa under rainfed condition
Saeid Hazrati Farhad Habibzadeh Saeed Mollaei Zahra Masoumpour Parina AsgharianCumin (Cumin cyminum L.) the only cumin crop in Iran, which is rich in secondary metabolites has great economic value and is. In order to evaluate the effect of foliar application of growth stimulant of pluramin and bioxa on this plant, a field study was conducted as a MoreCumin (Cumin cyminum L.) the only cumin crop in Iran, which is rich in secondary metabolites has great economic value and is. In order to evaluate the effect of foliar application of growth stimulant of pluramin and bioxa on this plant, a field study was conducted as a factorial experiment in a randomized complete block design with four replications in the research farm of Shahid Madani University of Azerbaijan in 2017- 2018. Experimental factors included foliar application of pluramin at the concentrations of 0, 2.5 and 5 g.l-1 and bioxa at the levels of 0, 5 and 10 ml.l-1. The essential oil was extracted using hydro-distillation method in Clevenger apparatus and analyzed by GC/MS. The effect of foliar application of pluramin on 1000-seed weight, number of seeds per umbel and essential oil yield and the effect of foliar application of bioxa on plant height, number of seeds per umbel and content and yield of essential oil were significant. The interaction of experimental factors on the number of seeds per umbel, content and yield of essential oil was significant. Comparison of means showed that the highest content and yield of essential oil with a significant difference belonged to the foliar application of 10 ml.l-1 bioxa; after that, spraying 2.5 g.l-1 of pluramin produced the highest content of essential oil. The major compounds identified in all treatments included 3-carn-10-al, para-cement, p-comic aldehyde, gamma-terpinene, beta-pinene and 2-carn-10-al. The highest essential oil yield was obtained from foliar application of 10 ml.l-1 bioxa, which was significantly different from the other levels of foliar application. That is, simultaneous foliar application increased this compound. The highest amount of para-cymene, gamma-terpinene and beta-pinene was obtained by spraying 10 ml.l-1 bioxa and the lowest amount of these compounds were obtained by spraying 5 g.l-1 pluramin and 5 ml.l-1 bioxa. Overall, the results showed that foliar application of growth stimulants of pluramin and bioxa can improve the yield and composition of cumin essential oil under the rainfed conditions. Manuscript profile -
Open Access Article
32 - Investigation of the effect of drought stress on yield and yield components ofCuminum cyminum L. ecotypes in climatic conditions of Kerman Province
Elham Moslemi Mohammad Mehdi Akbarian Seid Zabihllah Ravari Mohammad Reza Yavarzadeh Nader Modafeh-BehzadiCumin (Cuminum cyminum L.) is one of the most important medicinal plants, with a short growth period and low water requirement, suitable for cultivation in arid and semi-arid regions of Iran. Drought is one of the most important factors limiting plant growth worldwide a MoreCumin (Cuminum cyminum L.) is one of the most important medicinal plants, with a short growth period and low water requirement, suitable for cultivation in arid and semi-arid regions of Iran. Drought is one of the most important factors limiting plant growth worldwide and the most common environmental stress. In the case of medicinal plants, drought may have a noticeable effect on the yield and amount of active ingredients. In order to investigate the drought tolerance of cumin crop ecotypes, a split-plot experiment was conducted in the form of a randomized complete block design with three replications at the Agriculture and Natural Resources Research and Education Center in the crop year 2019-1400. In this study, the effect of drought stress at three levels (normal irrigation, interruption of irrigation after 50% flowering of the field, and interruption of irrigation after 100% flowering of the field) on five cumin ecotypes (Mahan, Kohbanan, Khosuf, Kashmer, Sabzevar) was investigated. The results of the analysis showed the effect of ecotype and stress separately and together on all investigated traits such as plant height, number of umbels per plant, umbrella number per umbrella, seeds number per plant, harvest index, number of secondary branches, seed yield, biological yield, straw weight and stubble and the percentage of seed essential oil were significant at the five percent level. The highest seed yield and percentage of essential oil in the Khosuf ecotype were obtained under stress-free conditions and irrigation interruption after 50% flowering of the field, respectively. The regression results in all three irrigation conditions showed that the number of umbels, umbrellas and the number of seeds per plant can lead to the highest yield and are the most important factors in determining seed yield. Manuscript profile -
Open Access Article
33 - Preparation and Characterization of Curcumin-Silver Nanoparticle and Evaluation of the Effect of Poly Ethylene Glycol and Temperature
Parisa Adibzadeh Negar Motakef-Kazemi -
Open Access Article
34 - Preclinical Evaluation of Silver-Curcumin Nanogel: A complete Assessment on a New Topical Antimicrobial Formulation for Burn Healing
Sepideh Arbabi Bidgoli -
Open Access Article
35 - Poly Ethylene Glycol-Stearate polymer in the design of nano-drug delivery system for oral administration by curcumin
Marzihe Shahbazi Elham Rostami maryam kolahi alireza kiasat -
Open Access Article
36 - Preclinical Evaluation of Silver-Curcumin Nano- gel : A complete assessment on a new topical antimicrobial product for burn
Monir Aghamoosa Sepideh Arbabi-Bidgoli Solmaz Ghafari Azar Sabokbar Naser Harzandi -
Open Access Article
37 - Adsorption Behaviors of Curcumin on N-doped TiO2 Anatase Nanoparticles: Density Functional Theory Calculations
Amirali Abbasi Jaber Jahanbin Sardroodi -
Open Access Article
38 - Preparation and Characterization of Curcumin-Silver Nanoparticle and Evaluation of the Effect of Poly Ethylene Glycol and Temperature
Parisa Adibzadeh Negar Motakef-Kazemi -
Open Access Article
39 - Predictive mathematical models for evaluation of Cuminum cyminum L. and temperature storage effect on Bacillus cereus in BHI broth
Zohreh MashakBacillus cereus is a food-born pathogen that 20% of total outbreaks of food intoxication in the world are caused by Bacillus cereus. Nowadays there is an increasing interest in the use of plant-derived antimicrobial compounds as natural preservatives for foods. Cuminum MoreBacillus cereus is a food-born pathogen that 20% of total outbreaks of food intoxication in the world are caused by Bacillus cereus. Nowadays there is an increasing interest in the use of plant-derived antimicrobial compounds as natural preservatives for foods. Cuminum cyminum L. is a plant native to Iran that is used in traditional medicine and food products. The aim of this survey is providing of predictive mathematically models for evaluation of antibacterial effect of Cuminum cyminum L. essential oil on Bacillus cereus in a multi-factorial system. The essential oil of Cuminum cyminum L. plant was obtained by steam-distillation and analyzed by GC/MS. Then, effects of different concentrations of Cuminum cyminum L. essential oil (0, 0.005, 0.015, 0.030 and 0.045%) and storage temperature (10, 25 and 35°C) were evaluated on growth of Bacillus cereus in BHI broth during at certain intervals (1, 2, 3, 4, 5, 6, 9, 12, 15, 18, 21 24, 27, 30, 36 and 42 days). The growth of Bacillus cereus was significantly decreased by 0.015% EO concentration incubated at 10°C storage temperature and 0.030% EO concentration incubated at 25 and 35°C storage temperature (p<0.05). The predictive mathematically models produced in this study can be a useful tool for evaluation of changes of this microorganism along of the food chain. Manuscript profile -
Open Access Article
40 - Antimicrobial Effects of Black Cumin (Nigella Sativa) Oil in Nitrite Reduced Sausage
Mohammadreza Khani Amin Abolhasanzadeh Maryam FahimdaneshThis study was aimed to investigate the antimicrobial effects of black cumin oil in sausage and evaluate the possibility of reduction of its nitrite. For this purpose, sausage samples were prepared at concentrations of 2 and 3 percent of black cumin oil containing vario MoreThis study was aimed to investigate the antimicrobial effects of black cumin oil in sausage and evaluate the possibility of reduction of its nitrite. For this purpose, sausage samples were prepared at concentrations of 2 and 3 percent of black cumin oil containing various amounts of nitrite (including 0,30,60,90 ppm) in eight treatments and a control sample without black cumin oil and with 120 ppm nitrite and all stored for a month at 4°C. Then microbial properties of all samples such as total bacterial counts, coliforms, Salmonella, Escherichia coli, Staphylococcus aureus, Clostridium perfringens, yeasts and moulds were examined on 1, 11, 21 and 31 days of storage time and organoleptic properties were evaluated after production of samples. The results showed that treatments containing 2 and 3 percent of black cumin oil with 90 ppm and 60 ppm nitrite, mainly had total bacterial counts, coliforms counts, E.coli, S.aureus, yeasts and moulds counts similar to those had control sample during the storage. But these microbial counts showed significant increase in all the samples at the end of the storage period (P<0.05). Salmonella and Cl. perfringens was not detected in samples. Generally, the results indicated that microbial load decreased by increasing the concentration of black cumin oil from 2 to 3 percent in equal concentrations of nitrite. Also, reduction of nitrite in treatments containing black cumin oil, mainly led to significant decrease of color, flavour, and general acceptance scors comparing with control sample, but had no significant effect on texture and odor properties. Manuscript profile -
Open Access Article
41 - Effect of Cumin (Bunium persicum) essential oil and extract on microbial and chemical properties in traditional lactic cheese
Mahboobeh Rabanifard Javad Tabatabaian Nimavard Reza sharafati chaleshtoriThe aim of this study was to evaluate methanolic extract (ME) and essential oil (EO) of cumin (C) on the chemical, microbial and sensory properties of traditional lactic cheese. In this experimental study, CEO and CME were prepared. The compounds in the CEO were analyze MoreThe aim of this study was to evaluate methanolic extract (ME) and essential oil (EO) of cumin (C) on the chemical, microbial and sensory properties of traditional lactic cheese. In this experimental study, CEO and CME were prepared. The compounds in the CEO were analyzed by gas chromatography/mass spectrometer and the phenolic content of the CME and CEO by the Folin Ciocalteu method. The cheese treatments containing CEO (125 and 250 ppm), CME (1 and 2%) and control group were prepared. Then, during 60 days of storage of samples, microbial tests including coliform counts, Escherichia coli, Staphylococcus coagulase positive, mold and yeast as well as also, chemical tests including fat, moisture, pH, acidity and salt were performed. Most compounds in CEO were cumin aldehyde (30.40 %), phenylglycol (18.99 %) and γ-terpinene (15.52 %). The phenolic content and antioxidant activity in CME was significantly higher than CEO. Adding CEO and CME to the cheese absorbed less water and salt than the control group, but the fat content increased. During storage, the acidity decreased significantly. The pH has increased slightly during storage and was in accordance with the results obtained by the acidity. The results showed no microbial contamination including coliforms, mold and yeast, E. coli and S. aureus in all groups. Sensorial results demonstrated that there was significant difference between the control group and the CEO groups with the CME groups. The results of this study showed that CEO and CME had high antimicrobial and antioxidant activity in traditional lactic cheese. Manuscript profile -
Open Access Article
42 - Evaluation of the effect of Cuminum ciminum and Satureja hortensis nano essences on isolated Aspergillus species from fish meal produced by factories in Mazandaran Province, Iran
Mahsa Enayati Alireza Mokhtari Mansour Bayat Afshin Mohsenifar Reza KhansariAbstract The fungi producing mycotoxins reduce production of agricultural crops and cause irreparable loses to public health. Aspergillus is one of the most important fungi in the environment being capable to grow in nearly all compounds and organic materials and their MoreAbstract The fungi producing mycotoxins reduce production of agricultural crops and cause irreparable loses to public health. Aspergillus is one of the most important fungi in the environment being capable to grow in nearly all compounds and organic materials and their conidia are substantially scattered in the water, soil and air. Cuminum ciminum and Satureja hortensis are Iranian herbal medicines having many therapeutic effects. The aim of this study was to evaluate the inhibitory effect of Cuminum and Satureja nano essences on Aspergillus species isolated from fish meal produced by factories in Mazandaran Province. Twelve Aspergillus species isolated from 89 fish meal samples and inhibitory effect of Cuminum and Satureja nano essences were evaluated by micro dilution. The highest and least numbers were related to Aspergillus fumigatus and Aspergillus nidulance, respectively. The MIC and MFC foe different species was in the range of 1.56-6.25 and 3.12-25 μg ml-1. The results revealed the high effectiveness of the nano essence on Aspergillus species. Manuscript profile -
Open Access Article
43 - مکملسازی جیره جوجههای گوشتی با زیره سیاه (Nigella sativa)، و تأثیر آن بر وزن کبد و آنزیمهای آن
K. Shirzadegan P. Fallahpour I. Nickkhah H.R. Taheriآزمایشی به منظور ارزیابی اثرات افزودن دانه زیره سیاه (Nigella sativa) در جیره روی عملکرد، وزن و آنزیمهای کبد جوجههای گوشتی صورت گرفت. آزمایش در قالب یک طرح بلوک کامل تصادفی انجام شد. 240 جوجه گوشتی تعیین جنسیت نشده (کاب 500) به چهار گروه تقسیم و به چهار تیمار تغذیهای Moreآزمایشی به منظور ارزیابی اثرات افزودن دانه زیره سیاه (Nigella sativa) در جیره روی عملکرد، وزن و آنزیمهای کبد جوجههای گوشتی صورت گرفت. آزمایش در قالب یک طرح بلوک کامل تصادفی انجام شد. 240 جوجه گوشتی تعیین جنسیت نشده (کاب 500) به چهار گروه تقسیم و به چهار تیمار تغذیهای با چهار تکرار (15 جوجه در هر تکرار) تخصیص داده شدند. گروه 1 به عنوان گروه شاهد در نظر گرفته شده که به آنها جیرههای پایه بدون افزودنی داده شد. به گروههای 2، 3 و 4 به ترتیب جیرههای مکملسازی شده با 5، 10 و 15 گرم در کیلوگرم دانه زیره سیاه داده شد. هیچ اثر معنیداری (05/0P>) روی وزن زنده، مصرف خوراک و وزن اندامها به جز برای کبد، در پرندگان تغذیه شده با جیرههای مکملسازی شده در مقایسه با تیمار 0 گرم در کیلوگرم مشاهده نشد (05/0P<). همچنین، در مقایسه با گروه شاهد، غلظت AST و LDL پلاسمای حاصل از جوجههای گوشتی تغذیه شده با جیرههای حاوی 5، 10 و 15 گرم دانه زیره سیاه کمتر بود (05/0P<). بیشترین و کمترین درصد وزن کبد نیز به ترتیب مربوط به گروههای 15 گرم در کیلوگرم دانه زیره سیاه و شاهد بود. به طور کلی، این مطالعه نشان داد که مکملسازی دانه زیره سیاه در سطوح متفاوت با وجود تحت تأثیر قرار دادن برخی از پارامترهای خونی، هیچ اثر منفی یا مثبتی روی عملکرد رشد جوجههای گوشتی نداشت. Manuscript profile -
Open Access Article
44 - تأثیر کورکومین و سمیت حاصل از استامینوفن در عملکرد و فراسنجههای خونی بلدرچین ژاپنی از 0 تا 37 روزگی
M. Emadi A. Hadavi J. Ameri H. Kermanshahiبه منظور بررسی اثر کورکومین "استخراج شده از گیاه زردچوبه" بر شاخصهای عملکرد و فراسنجههای خونی بلدرچین ژاپنی که متأثر از آسیب کبدی ناشی از استامینوفن بودند آزمایشی صورت گرفت. اعمال چهار تیمار با چهار تکرار با استفاده از 240 قطعه بلدرچین از روز اول شروع و برای یک دوره 3 Moreبه منظور بررسی اثر کورکومین "استخراج شده از گیاه زردچوبه" بر شاخصهای عملکرد و فراسنجههای خونی بلدرچین ژاپنی که متأثر از آسیب کبدی ناشی از استامینوفن بودند آزمایشی صورت گرفت. اعمال چهار تیمار با چهار تکرار با استفاده از 240 قطعه بلدرچین از روز اول شروع و برای یک دوره 37 روزه در 16 پن صورت گرفت. تیمارهای استفاده شده شامل: کنترل (بدون کورکومین)، جیره تجاری همراه با 20 گرم کورکومین در تن، جیره تجاری همراه با 40 گرم کورکومین در تن و جیره تجاری همراه با 60 گرم کورکومین در تن بودند. تمام تیمارها میزان 750 میلیگرم در کیلوگرم وزن بدن استامینوفن در 12 روزگی دریافت کردند. مصرف خوراک و اضافه وزن بدن در طول مدت آزمایش به صورت هفتگی اندازهگیری شده و مورد تجزیه و تحلیل آماری قرار گرفتند. برای اندازهگیری فراسنجههای خونی (آلبومین، گلوکز، پروتئین کل، تری گلیسیرید، آسپارتات آمینوترانسفراز، آلانین آمینوترانسفراز، بیلی روبین، اسید اوریک و کراتینین) خونگیری در روزهای 28 و 35 روزگی انجام شد. افزودن کورکومین به جیره مقدار آسپارتات آمینوترانسفراز سرم را در 28 روزگی افزایش داد و همچنین مقدار تری گلیسیرید و بیلی روبین را در 37 روزگی کاهش داد (05/0P<). این دادهها میتوانند نشان دهند که کورکومین آنتی اکسیدانی طبیعی برای محافظت از کبد است هنگامی که آسیب کبدی ناشی از استامینوفن روی دهد. بنابراین به نظر میرسد کورکومین در درمان آسیبهای ناشی از استامینوفن ارزش برابری با داروهای محافظتکننده از کبد داشته باشد. Manuscript profile -
Open Access Article
45 - Effects of Adding Ethanol Extract of Propolis and Cumin Essential Oil to Diet on the Performance, Blood Parameters, Immune Response and Carcass Traits of Broiler Chicks
م. ترکی ژ. سلطانی ح. محمدی -
Open Access Article
46 - Effects of non-thermal atmospheric plasma on physiological characteristics of black cumin plant
Farzaneh Yasamani Masouleh Giti Barzin Malihe Entezari Tania Davari Mahabadi Leila Pishkar -
Open Access Article
47 - Physiological responses of Nigella Sativa ecotypes to drought stress condition
Atena Alaghemand Shahab Khaghani Mohammad Reza Bihamta Masoud Gomarian Mansour Ghorbanpour -
Open Access Article
48 - Plasma seed priming in green cumin, physiological and developmental aspect
Zahra Rasooli Giti Barzin Tania Davari Mahabadi Malihe Entezari Daniel Piriaei -
Open Access Article
49 - The Role of signaling of hydrogen peroxide and 24-epibrassinosteroid on physiological traits of cumin (Cuminum cyminum L.) under drought stress
Nasim Roudbari Hosein Abbaspour Khosrow Kalantari Ahmad Aien -
Open Access Article
50 - The alteration of germination percentage and leaf stomatal features of black cumin (Nigella sativa L.) subjected to drought and salinity stresses.
Shiva Aghajanzadeh Gheshlaghi Maryam Peyvandi Ahmad Majd Hosein AbbaspourBlack cumin (Nigella sativa L.) as an herbal plant with high medicinal and economical usage, belongs to Rannunculaceae family. Due to the economic and medicinal importance of this plant and the seriousness of salinity and drought problems in Iran, in this study, the eff MoreBlack cumin (Nigella sativa L.) as an herbal plant with high medicinal and economical usage, belongs to Rannunculaceae family. Due to the economic and medicinal importance of this plant and the seriousness of salinity and drought problems in Iran, in this study, the effect of salinity and drought stress on germination percentage and stomatal changes was investigated. The experiment was performed based on completely randomized design with three replications in the pot condition. To create different levels of drought and salinity, two days/ three days of drought and 30, 60 mM NaCl were used respectively. Germination percentage was recorded daily by placing 10 seeds in Petri-dish. Leaf stomata traits were studied using a light microscope two months after treatment. Variance analysis results showed that increasing drought and salinity stress reduced germination percentage. Drought stress also had a greater effect on reducing the size of the pore so that the diameter and the length of the pore showed a significant decrease and the pores were elongated, which shows the effect of dry stress on the closing stomata. Also, high salinity stress (60 mM NaCl) caused a significant increase in pore width and had no significant effect on other stomatal characteristics. The applied drought and salinity stresses did not show a significant increase in the number of stomata. According to the stomatal reaction in different levels of draught stress rather than salinity, it could be indicated the higher sensitivity of this plant to drought treatments. Manuscript profile -
Open Access Article
51 - Application of solid phase microextraction method using polypyrrole/curcumin coated fiber for measurement of agricultural toxins by gas chromatography
Atefeh Noora hamid ahmar mostafa jafari Mohammad Hossein BanitabaIn this study, the possibility of using solid phase microextraction method directly with a new fiber for preconcentration and measurement of butachlor pesticide by gas chromatography was investigated. Polypyrrole/ curcumin coated fiber was used as an adsorbent to prepar MoreIn this study, the possibility of using solid phase microextraction method directly with a new fiber for preconcentration and measurement of butachlor pesticide by gas chromatography was investigated. Polypyrrole/ curcumin coated fiber was used as an adsorbent to prepare the solid phase microextraction fiber from aqueous samples and electrochemical polymerization was employed using cyclic voltammetry method. The properties of the new fiber including adhesion, mechanical strength, and thermal stability were evaluated. Morphology of the prepared sample was studied using scanning electron microscope (SEM). Then the effective parameters on the extraction efficiency of butachlor from aqueous samples including extraction time, extraction temperature, and pH were evaluated. Under optimized conditions, the performance characteristics of the proposed method including detection limit, linear range, and intera day and inter days repeatability were evaluated. The detection limit of the method was found to be 1 ng/l, linear range was 0.067-40 g/l, repeatability intra day was 2.9% and repeatability inter days was 5.0 %. The developed method was used for analysis of water samples from rice fields in northern Iran region as a real sample. Manuscript profile -
Open Access Article
52 - Study of growth indices, survival and resistance to Salinity stress of Caspian roach (Rutilus rutilus caspicusJakowlew,1870) fed by diet comprising of black Cumin seed
F. Zohieri H. Sahraei M. R. Imanpour A. R. Pirali ZefreiIn recent years, use of herbs as dietary growth stimulant factor and replacing it with artificial materials in aquaculture is widely discussed. The impact of black cumin seed (Nigella sativa)powder at four levels of 0, 0.5, 1 and 2 percent, per kilogram of diet, on grow MoreIn recent years, use of herbs as dietary growth stimulant factor and replacing it with artificial materials in aquaculture is widely discussed. The impact of black cumin seed (Nigella sativa)powder at four levels of 0, 0.5, 1 and 2 percent, per kilogram of diet, on growth, survival and resistance to salinity stress in the Caspian roach (Rutilus rutilus caspicus) was investigated for 60 days. At the end of the study, growth factor and feed conversion factorwere calculated. In addition,the effect of black cumin seed powder on resistance to salinity stress was investigated, in intervals of 24, 48 and 72 hours.The results showed that using black cumin seed, up to the 0.5 percent, cause highest body weight gain (7.09±0.38), specific growth rate (1.59±0.04), condition factor (0.11±0.006) and lowest feed conversion factor (1.29±0.08) in fingerlingroach. Statistical analysis showed significant differences (p< 0.05) in growth indices and feed conversion factor, between treatments and the control group. This study showed that black cumin seed powder in the diet, despite increased growth performance in roach, lacked positive effect on the resistance to salinity stress in the fish. Manuscript profile -
Open Access Article
53 - The effects of drought stress and foliar application micronutrients on growth yield and nutritional elements of black cumin ( Nigella sativa L. )
علی اکبر عاملیIn order to survey the effects of irrigation and foliar application of micronutrients on vegetative growth, yield and yield components black cumin ( Nigella sativa L. ), an experimental design was conducted in the research farm of North Khorasan agricultural and natural MoreIn order to survey the effects of irrigation and foliar application of micronutrients on vegetative growth, yield and yield components black cumin ( Nigella sativa L. ), an experimental design was conducted in the research farm of North Khorasan agricultural and natural resources research center in Bojnourd in 2009. Experimental design was split plot based on randomized complete block design with three replications. The main factors were irrigation intervals in three levels ( I1=7, I2= 14, I3=21 days ) and subfactors were foliar application micronutrients included M1 = control ( no foliar application ), M2= foliar application with the zinc ( concentration of three parts per thousand ), M3 = foliar application with the Boron ( concentration of two parts per thousand ), M4 = foliar application with the iron ( concentration of four parts per thousand ), and M5 foliar application with the mixture of above elements. Experiment results showed that the impact of irrigation intervals on plant height, branch number, number of capsules per plant, biological yield and seed number per plant , seeds per capsule, seed weight, harvest index percentage, and seed yield, was significant and decreased with increasing irrigation intervals. The effects of foliar application of micronutrients on plant height, branch number, number of capsules per plant, biological yield, and Fe, Zn, and Br concentration in plant organs was significant. Foliar application of micronutrients caused plant height, branch number, number of capsules per plant, biological yield and Fe, Zn, and Br concentration in plant to be increased. Foliar application of micronutrient and irrigation interaction on plant height and biological yield were noticeable. Seven days irrigation intervals and foliar application, the mixture of micronutrient treatment caused the highest plant height, biological yield and Fe, Zn, and Br concentration in plant organs. Manuscript profile -
Open Access Article
54 - Investigation of antifungal effect of nanoparticle-encapsulated curcumin on CDR1 gene expression in fluconazole-resistant isolates of Candida albicans
Hadiseh Golpour Najmeh Ranji Seyedeh Hajar SharamiBackground & Objectives: Curcumin as a natural phenolic compound derived from Curcuma longa plant has shown an antifungal property. Candida albicans is the most common opportunistic fungal pathogen. Continuous deployment of antifungals against this pathogen has led MoreBackground & Objectives: Curcumin as a natural phenolic compound derived from Curcuma longa plant has shown an antifungal property. Candida albicans is the most common opportunistic fungal pathogen. Continuous deployment of antifungals against this pathogen has led to the emergence and increasing of the multi-drug resistance. In this study, the effect of nanoparticle-encapsulated curcumin on CDR1 gene expression was evaluated in fluconazole-resistant isolates of C. albicans. Materials & Methods: In this study, 6 fluconazole-resistant isolates of C. albicans were treated just by fluconazole (1/2MIC) as the control sample and in the combination with nanoparticle-encapsulated curcumin as the test sample. After 24h, two cell groups were cultured in Sabouraud Dextrose Agar to estimate cell death percentage. Following RNA extraction and cDNA synthesis, CDR1 gene expression was investigated quantitatively by real-time PCR method in both curcumin-treated and untreated cells. Results: Our findings showed that the combination of fluconazole (1/2MIC) and nanoparticle-encapsulated curcumin treatment reduces the fungal growth by 50% after 24 h. Moreover, quantitative real-time PCR analysis revealed that nanoparticle-encapsulated curcumin decreases the expression level of CDR1. Conclusion: Our findings suggested that curcumin can inhibit fungal growth through different mechanisms such as decreasing the number of ABC efflux pumps at the cell surface and synergically increases the antifungal effect of fluconazole in resistant isolates of C. albicans. Manuscript profile -
Open Access Article
55 - A study to investigate antibacterial effect of Nanocurcumin against pre-clinical methicillin resistant staphylococcus aureus infection
Elham Ansari Khosro Issazadeh Alireza Shoae HassaniBackground and Objectives: Bacteremia and endocarditis are the most commonly infection in Staphylococcus aureus. Due to curative effects of curcumin, including as an antibiotic, it can be used as a medicine albeit after reducing its side effects. This study aimed to inv MoreBackground and Objectives: Bacteremia and endocarditis are the most commonly infection in Staphylococcus aureus. Due to curative effects of curcumin, including as an antibiotic, it can be used as a medicine albeit after reducing its side effects. This study aimed to investigate antimicrobial effects of curcumin on methicillin-resistant Staphylococcus aureus in vitro and in an animal model (Balb/C mice). Materials and Methods: This pre-clinical study was performed in the department of scientific research and clinical technology of Khomeini Hospital, Tehran. Following synthesis of curcumin-PLGA nanoparticles, their size were measured using scanning electron microscopy and their toxicity were determined by a colorimetric method (MTT). In vitro studies to analyze the effects of this compound on MRSA were performed firstly based on MIC and MBC tests and broth dilution. Next, a same procedure was conducted on blood cultures obtained from infected mice. Results: A concentration of 6 micrograms of urcumin-PLGA nanoparticles per millimeter showed Antibacterial activity on MRSA strains. A same effect was observed in vivo in mice after treatment by 10 μg/ml urcumin. Furthermore, based on this results, there were no side effects on the normal cells and 75% of the cells treated with the highest concentration of this particle were survived. Conclusion: these results show that curcumin-PLGA nanoparticles can be used safely for the treatment of bacteremia and endocarditis prophylaxis of infections caused by MRSA. Manuscript profile -
Open Access Article
56 - Application of Soil‐borne Streptomycetes for Biological Control against Fusarium Wilt of Cumin (Cuminum cyminum L) caused by Fusarium oxysporum fsp cumini
Mozhgan Golmoradi Gholamhosein Shahidi Bonjar Sonia Aghighi Meysam Soltani NejadCumin )C uminum cyminum L.) is an annual plant belonging to Apiaceae family. One of the major diseases of cumin is Fusarium wilt caused by a soil-borne, vascular wilt pathogen Fusarium oxysporum f.sp. cumini which is a devastating disease that occurs in major cumin grow MoreCumin )C uminum cyminum L.) is an annual plant belonging to Apiaceae family. One of the major diseases of cumin is Fusarium wilt caused by a soil-borne, vascular wilt pathogen Fusarium oxysporum f.sp. cumini which is a devastating disease that occurs in major cumin growing areas of the world; while plants reach to 0.5- 2.5 cm in height, they die as the result of the disease. In the current research, 80 isolates of Streptomyces spp. isolated from the rhizosphere soil of Astragalus sp. and screened against Fusarium under laboratory condition. Three out of 80 isolates including M15, M26 and M80 revealed having the highest antagonistic activity, hence, selected for further evaluation under greenhouse conditions. After emergence of cumin seedlings, mortality and growth indices were compared between different treatments weekly and results were recorded. Plants were harvested after teen weeks and growth indices such as plant height and weight were recorded. The Streptomyces sp. Isolate No. M15 was showed the strongest effects on plant growth and suppression of the wilt disease as compared to the controls. The present research is an attempt to control cumin Fusarium wilt disease using Streptomyces spp. The final goal of this research is to introduce an effective biological agent for controlling managing Fusarium wilt disease under field condition. this pathogen. Manuscript profile -
Open Access Article
57 - Evaluation of the effect of different levels of plant density and N fertilizer on yield and yield components of cumin (Cuminum cyminum L.)
یدالله قادری محمد مقدمThis experiment was conducted to assay the effect of plant density and nitrogen fertilization on growth and yield of cumin during growing season 2012 at field experimental of Nasra conservatory in Golge Rokh Torbat Heydarei. The experiment was done as factorial based on MoreThis experiment was conducted to assay the effect of plant density and nitrogen fertilization on growth and yield of cumin during growing season 2012 at field experimental of Nasra conservatory in Golge Rokh Torbat Heydarei. The experiment was done as factorial based on randomized complete block design with three replications; which factors included four levels of nitrogen fertilization (0, 50, 100 and 150 kg/ha) and three levels of plant density (50, 67 and 100 plant/m2). The results variance analysis showed that the effect of nitrogen fertilization and planting density had significant effect on yield and yield components of cumin. The highest plant height and seed per plant were obtained from 67 plant/m2 with 50 kg/ha N treatment. While the highest number of primary shoot, number of umbel and 1000 seed weight were obtained from 50 plant/m2 with 50 kg/ha N treatment and the highest seed yield was obtained from 50 plant/m2 with 0 kg/ha N fertilizer. In conclusion, plant density of 50 plant/m2 and application of lower amount (50 kg/ha) or without N fertilizer is sutiable for the maximum of growth and seed yield of cumin. Manuscript profile -
Open Access Article
58 - Agroecological zoning for cultivation of Cumin (Cuminum cyminum) in East-Azerbaijan province, using analytic hierarchy process approach
Behzad Shokati Mohammadreza Asgharipour Bakhtiar FeyzizadehThis study aims to assess Agro-climatic suitability for Cumin producing in East-Azerbaijan province based on GIS spatial analysis technique. For this goal, several criteria including soil conditions, climatologically indicators, topography situation and agro-climatology MoreThis study aims to assess Agro-climatic suitability for Cumin producing in East-Azerbaijan province based on GIS spatial analysis technique. For this goal, several criteria including soil conditions, climatologically indicators, topography situation and agro-climatology criteria were taken into account of modeling process. The methodology was performed based on GIS spatial analysis. For this to happen, standardization process was performed on criteria and weighting process was done using Analytic Hierarchy Process (AHP) approach. GIS based multicriteria decision analysis was employed for weighted overlapping of indicators and results were achieved based on GIS- Multi-Criteria Decision Analysis (MCDA) method. Initial results indicated that East-Azerbaijan province has potential for cultivating of Cumin. Based on results, Cumin plant can be cultivated in Mianeh, Shabestar, Maragheh, Marand, Sahand, Sarab, Varzrghan, Kaleybar and Bostan Abad regions which are classified in suitable category. Also, the rest regions indicated moderate potential for this purpose. Finally, about 2561151 ha of this province has high suitability, 2017916 ha has moderate suitability. Lacks of enough attention to the feasibility assessment of Cumin plant in this province, results of this research are great of importance for the purpose of regional planning in East-Azerbaijan province. Manuscript profile -
Open Access Article
59 - The Effect of Azotobacter On Growth Indices, Yield and Essence Content Of Two Cultivars of Cumin (Cuminum cyminum L.) Under Salinity
HENGHAMEH VOSOUGHI TABAR HAMID DEHGHANZADEH SEID ALI HOSSEINI TAFRESHI -
Open Access Article
60 - Protective effect of nanocurcumin on renal histological damage in salinomycin-induced toxicity of broiler chickens
Seyed Mohammad Hosseini Reza Sayrafi Saber Yousefi-Robati Abolfazl Akbari Alireza SalehiSalinomycin (SLM) is an ionophore antibiotic used extensively in the poultry industry for the control and prevention of coccidiosis. The toxicity of the ionophore is thought to be due to oxidative damage caused by the production of free radicals. Curcumin is a major com MoreSalinomycin (SLM) is an ionophore antibiotic used extensively in the poultry industry for the control and prevention of coccidiosis. The toxicity of the ionophore is thought to be due to oxidative damage caused by the production of free radicals. Curcumin is a major component of turmeric, which has a wide range of antioxidant, anti-inflammatory and anticancer activities. The aim of this study was to evaluate the effect of nanocurcumin (NC) as a natural antioxidant on broiler chickens poisoned with a toxic dose of SLM. In this study, 60 broilers were randomly divided into 5 groups. The first group was considered as control. The second group received SLM at a dose of 300 mg/kg bw per day for 14 days. Groups 3, 4 and 5 received oral doses of NC at 50, 100 and 200 mg/kg bw per day for 14 days in addition to SLM. After 14 days, blood and kidney tissue samples were collected for biochemical and histopathological evaluation. It was observed that NC reduced the incidence and severity of renal histopathological lesions. The highest levels of inflammatory cells were observed in the cortex and medulla of the SLM group and it appeared that treatment with NC improved the condition and reduced the presence of inflammatory cells. It also significantly improved renal histomorphometric parameters (P<0.05). It seemed that SLM-induced adverse conditions can be reversed by oral administration of NC. Manuscript profile -
Open Access Article
61 - Effects of Osmotic Potential on Germination and some Characters in cimin (Cuminum Cyminum ) Genotypes
M. kakaei D. Kahrizi M. MansouriTo control water potential in seed germination studies osmotic solution of polyethylene glycol (PEG) are commonly used environmental stress, such as drought and (Osmotic) stress can play an important role in disturbing different stage of medical plant growth, developmen MoreTo control water potential in seed germination studies osmotic solution of polyethylene glycol (PEG) are commonly used environmental stress, such as drought and (Osmotic) stress can play an important role in disturbing different stage of medical plant growth, development, and especially seed germination in arid and regions high percent of medicines are used for people have plant origin. With attention to the development of drought area and the shortage of agricultural area, it comes in to great importance to make use of drought tolerant plant an experiment was carried out in order to study the effect of different drought (Osmotic) levels on Cuminum Cyminum in germination in a completely randomized design with three replications. Drought (Osmotic) levels applied were zero (Control), 5%, 10% and 15% (0, -0.03, -0.19 and -0.41 Mpa). The purpose of this study was to determine genotype in PEG solution had a detrimental effect on germination percentage and germination rate. Manuscript profile -
Open Access Article
62 - Study of agronomical properties of local population of cuminum cyminum L. in different nitrogen fertilizing levels
M. A. Afshari M. Valadabadi J. Daneshian A. AkbariniaIn order to study the effect of nitrogen levels on yield, Physiological characteristicsand essential oil content of cumin seeds, an experiment was conducted in research farm of Qazvin agriculture instruction center in 2006. The experiment was laid out by adopting split MoreIn order to study the effect of nitrogen levels on yield, Physiological characteristicsand essential oil content of cumin seeds, an experiment was conducted in research farm of Qazvin agriculture instruction center in 2006. The experiment was laid out by adopting split plot design with four replications. Main plots were nitrogen (30, 60, 90 and 120 kg/ha) and subplots were local seed populations gathered from Sabsevar, Bojnord and Esfarayen. Results showed in using 120 kg Nitrogen/ha the highest seed yield (801kg/ha) essential oil yield (16.99 kg/ha), (19.59cm) and seed number /m2 (19400) were obtained. The highest harvest index as 45.08% belongs to 30 kg Nitrogen/ha. Esfarayen with 765.6 kg/ha, harvest index 45.25 and 2.52% essential oil content was the best treatment. Sabsevar had the highest plant high and Bojnord had the highest biologic. Seed yield and essential oil yield of Esfraen with using of 90 kg Nitrogen/ha was 828 and 20.3 kg/ha respectively. Manuscript profile -
Open Access Article
63 - Effects of Biological and Chemical Fertilizers Nitrogen on Yield Quality and Quantity in Cumin (Cuminum Cyminum L.)
Ghasem Hosein Talaei Hosein Talaei Shocofeh Gholami Zeynab Kobra Pishva Majid Amini Dehaghi -
Open Access Article
64 - Anti-proliferative and Cytotoxic Effects of Curcumin in MCF-7 Human Breast Cancer Cells
Hossein Abbaspour Akbar Safipour Afshar -
Open Access Article
65 - Ethanol Consumption Promotes TNF-α Signaling Pathway in Rat Kidney: Rescue Effect of Curcumin
Amin Abdollahzade Fard Mahrokh Samadi Alireza Shirpoor Yousef Rasmi -
Open Access Article
66 - Short-term Effect of Aerobic Exercise, High-fat Diet and Curcumin Extract on Interleukin-six Gene Expression in Muscle Tissue of Rats
Sara Aghayan Tahereh Bagherpour Nematollah Nemati -
Open Access Article
67 - Protective Effect of Curcumin on Hormones of Spermatogenesis and DNA Breaks in Rats Exposed to Gamma-radiation
زهرا حمزوی جهرمی سمانه ذوالقدری جهرمی وحید حمایت خواه جهرمیRadiation therapy is a stage of therapeutic in the management of tumors that causes normal cells damage. So compounds with name Radio protective drugs injected before of radiotherapy that reduce cell damages and death against ionizing radiation. Curcumin is an antioxida MoreRadiation therapy is a stage of therapeutic in the management of tumors that causes normal cells damage. So compounds with name Radio protective drugs injected before of radiotherapy that reduce cell damages and death against ionizing radiation. Curcumin is an antioxidant compound. The aim of this study is to investigate the possible protective effect of curcumin on Hormones of spermatogenesis and DNA strand break against Gamma-Radiation in rats. 70 adult male Wister rats randomly divided in to 10 groups including: control, sham, Experimental 1(treatment with maximum of cur cumin in amount of 100 mg/ml), Experimental 2 (treatment with medium of cur cumin in amount of 50 mg/ml), Experimental3(treatment with minimum of curcumin in amount of 25 mg/ml), Experimental 4 (treatment with curcumin + radiation in amount of maximum), Experimental 5 (treatment with curcumin+radiation in amount of medium), Experimental 6 (treatment with curcumin+radiation in amount of minimum), Experimental 7 (treatment with solvent+ radiation), Experimental 8 (exposure to irradiation). All of animals received for 15 days respectively as Intraperitonealinjection. Then the animals were euthanized and blood collection for FSH, LH and tesostrone hormones and extraction of DNA from bone marrow slides for molecular biology studies. ELISA hormone assay for measuring of hormones levels and agarose gel electrophesis with Ethidium Bromide-stained for separating of DNA breaks was used. Data were analyzed by SPSS 15 software and statistical tests including two-way ANOVA and Duncan test. This study showed that Gamma-radiation with dose of 2 Gy caused significantly decreased of plasma testosterone level and significantly increased of plasma LH, FSH hormones levels (pandlt; 0.05) and many breaks in DNA molecule in irradiation and solvent + radiation groups with control. So treatment with curcumin balances these adverse effects of Gamma-radiation on testis hormones of spermatogenesis and DNA molecule and leads toward normal position.These results suggest curcumin have an ameliorative effect on concentration of plasma hormones of spermatogenesis and DNA molecule breaks against Gamma-radiation Manuscript profile -
Open Access Article
68 - The Effect of Treadmill Exercise and Curcumin on Catalepsy Reserpine-induced Parkinsonian Male Rat Models
R. Mohammadi رامش احمدی AhmadiParkinson’s disease (PD) is the most common neurologically based movement disorder, clinically diagnosed by the presence of bradykinesia, postural instability, resting tremor and rigidity. Curcumin is a natural polyphenol derived from turmeric that has a neuroprotective MoreParkinson’s disease (PD) is the most common neurologically based movement disorder, clinically diagnosed by the presence of bradykinesia, postural instability, resting tremor and rigidity. Curcumin is a natural polyphenol derived from turmeric that has a neuroprotective role in many neuronal degenerative disorders. Studies indicate that exercise may have beneficial effects on neurodegenerative disorders. Therefore, in the present study, we evaluated the effects of curcumin together with treadmill running on animal model of PD. In this study, 48 Wistar rats were divided in 8 groups (control, curcumin, exercise, Parkinson's disease, Parkinson's disease+ curcumin, Parkinson's disease+ curcumin + exercise, Parkinson's disease+ exercise and curcumin + exercise).Parkinson's disease was induced by injection of reserpine (1mg/kg, i.p) for 2days. The bar-test was used to measure cataleptic symptoms. Each of animals in the curcumin groups was given injection of curcumin (50 mg/kg, i.p) for 21 days. All animals in the exercise group were forced to run on a motorized treadmill (24 m/min for 20 min, 5 day/week), for 3 week. SPSS software was used for analyzing data by using of analysis of variance that it was performed at a significance level of p≤0.05. Catalepsy had no significant difference between the group of curcumin + Parkinson's disease+ exercise and Parkinson's disease+ curcumin and Parkinson's disease+ exercise. curcumin can reduce catalepsy induced by reserpine in male rat's model of Parkinson's disease. But its reducing effect isn't as effect of exercise. Manuscript profile -
Open Access Article
69 - Biosynthesis of Zinc Oxide Nanoparticles Using Curcumin and Evaluation of its Antioxidant Activity and Cytotoxicity
Elaheh Dianati Vida Hojati Jina Khayatzadeh Saeideh ZafarbalanejadBiocompatibility and stability of zinc oxide nanoparticles (ZnO NPs) synthesized using plants due to their wide applications in biomedical, industrial, cell imaging and biosensors is an interesting research field in the arena of nanotechnology. The present study involve MoreBiocompatibility and stability of zinc oxide nanoparticles (ZnO NPs) synthesized using plants due to their wide applications in biomedical, industrial, cell imaging and biosensors is an interesting research field in the arena of nanotechnology. The present study involved the synthesis of green stable zinc oxide nanoparticles using zinc acetate and aqueous extract of turmeric as a reducing agent. In this characterization study, the antioxidant and cytotoxic activities of the synthesized nanoparticles were investigated by different methods. First, nanoparticles were synthesized by green method and the properties of synthesized nanoparticles were investigated using various spectroscopic and microscopic techniques. Assessment of antioxidant activity was performed using DPPH free radical scavenging and cytotoxicity activity in fibroblasts by MTT method. The involvement of the bioactive compounds of curcumin in the stabilization of zinc oxide nanoparticles was confirmed by FTIR. FESEM electron microscopy showed irregular spherical, rod, and plate-like morphology with uneven surface. Antioxidant activities performed using the free radical scavenging method DPPH showed IC50 values higher than 500 μg/ ml. In addition, biosynthesized zinc oxide nanoparticles showed significant toxic effects on fibroblasts in a concentration and time dependent manner. In general, zinc oxide nanoparticles were synthesized through a sustainable, simple, and environmentally friendly green pathway using curcumin. Biosynthesized zinc oxide nanoparticles showed antioxidant activity and cytotoxicity. Manuscript profile -
Open Access Article
70 - Examining the Effect of Curcumin on the Nervous Protection and Movement Disorders in Cell Model of Parkinson's Disease induced by 6-HDOP
Mahdieh Azarshab Ramin Hajikhani Mehdi Rahnama Mohammadreza Bigdeli Jalal SolatiParkinson's disease is one of the most common types of the neurodegenerative disease, which is characterized by the movement disorders such as slowness, lack of movement, muscle stiffness, and resting tremor, and hypophonic. The main reason of disease is the destruction MoreParkinson's disease is one of the most common types of the neurodegenerative disease, which is characterized by the movement disorders such as slowness, lack of movement, muscle stiffness, and resting tremor, and hypophonic. The main reason of disease is the destruction of dopaminergic neurons in the Substantia Nigra in the midbrain and a decrease in dopamine concentration in the striatum terminals. In this study, used culture medium was DMEM with FBS, and the cells under study were catecholaminergic cells.6-Hydroxy dopamine toxin was used on cells to create a Parkinson cell model. Curcumin was used as a drug, and MTT, and BT methods were used to count the living cells. This research was designed to study the curcumin effect on Parkinson's disease with cellular model induced by 6-Hydroxy dopamine toxin with reduced inflammation. This study's results showed that using curcumin can increase the antioxidant power and protect the cell from damage caused by reactive oxygen species. Due to the results of MTT, and curcumin treatment due to its anti-inflammatory properties BT test also showed that cellular protection had increased, the death of aminergic catechol cells by 6-hydroxy dopamine toxin was significantly reduced. It shows the antioxidant and anti-inflammatory effects of curcumin on the damage caused by Parkinson's disease and reducing the progression of symptoms. Treatment withcurcumin to be anti-inflammatory can reduce the death of catecholaminergic cells by 6-hydroxy dopamine toxin. Manuscript profile -
Open Access Article
71 - Protective Effect of Curcumin on Hepatic Enzyme Transaminases and Alkaline Phosphatase in Male Rats After Receiving Nickel Nanoparticles
Rahimeh Khezri Motlagh Akbar Vahdati Seyed Ebrahim Hosseini Mohammad Amin EdalatmaneshNickel nanoparticles are widely distributed in the environment, resulting in damage to various tissues of body, including the lung, liver, testis, and kidney which is the major effect on the liver tissue. Therefore, this study aims to investigate Curcumin protective eff MoreNickel nanoparticles are widely distributed in the environment, resulting in damage to various tissues of body, including the lung, liver, testis, and kidney which is the major effect on the liver tissue. Therefore, this study aims to investigate Curcumin protective effect on the number of enzymes (ALT, AST, and ALP) to obtain nickel nanoparticles in rats. In this experimental study, 50 Wistar adult male rats were randomly selected and divided in to five groups (control, witness, receiver group (nickel 50 mg/kg), receiver group (nickel 50 mg/kg + Curcumin 150 mg/kg), and receiver group (nickel 50 mg/kg + Curcumin 300 mg/kg). The treatment of rats continued for 28 days. In the end, after bloodletting of rats, (ALT, AST and ALP) enzymes were investigated. Nickel nanoparticles caused a significant difference in Serum level of Aspartate Aminotransferase, Alanine aminotransferase, and Alkaline Phosphatase enzymes in the class of p < /em> ˂ 0.0001 than the control group. While, Curcumin in different dosages caused a significant reduction in the serum level of enzymes expressed at the class of p < /em> ˂ 0.0001 ratio to the control group. The treatment by Curcumin results in reducing the liver damage induced by nickel nanoparticles. Also, we can say that the concurrent consumption of Curcumin with nickel nanoparticle due to the antioxidant properties of Curcumin reduces this activity Manuscript profile -
Open Access Article
72 - The Effect of Turmeric Powder on the Histology and Antioxidant Status of Japanese Quail liver Exposed to Oral Cadmium
Omid KarimiPoultry diet contamination with cadmium (Cd) is both important in terms of economic losses due to reduced production and public health. This study aimed to evaluate the effect of turmeric powder (TP) containing a certain amount of curcuminoids (2.96%) on Japanese quail MorePoultry diet contamination with cadmium (Cd) is both important in terms of economic losses due to reduced production and public health. This study aimed to evaluate the effect of turmeric powder (TP) containing a certain amount of curcuminoids (2.96%) on Japanese quail exposed to dietary cadmium. 180 male Japanese quail from 22 to 55 days of age were divided into 6 groups and received, basal diet(BD), BD + 3 g/kg TP, BD + 5 g/kg TP, BD + 100mg/kg Cd, BD + 100 mg/kg Cd and 3 g/kg TP, and BD + 100mg/kg Cd and 5 g/kg TP. Cadmium contaminated diet significantly decreases SOD, CAT, and total antioxidant capacity and increasing MDA concentration in liver tissue. Cadmium induced hepatic histological lesions, including fatty change, hyperaemia, single hepatocyte necrosis, and leukocyte infiltration. Turmeric powder substantially increased antioxidant status and decreased the severity of liver histological lesions in a cadmium-contaminated diet (P <0.5). When 5 g/kg of turmeric powder was added to the cadmium-contaminated food, the deleterious effects of dietary cadmium in Japanese quail were reduced more effectively. Manuscript profile -
Open Access Article
73 - The Effect of Curcumin on Testosterone and Liver Enzyme Levels in Varicocele-induced Rats
Mohamad Reza Sadraie Marzieh Tavalaee Mohammad Hosein Nasr-Esfahani Mohsen ForouzanfarVaricocele is one of the most important causes of infertility in men, which in addition to negatively affecting spermatogenesis, can also affect the endocrine system. The link between varicocele and testosterone production is unclear. The liver is one of the most effect MoreVaricocele is one of the most important causes of infertility in men, which in addition to negatively affecting spermatogenesis, can also affect the endocrine system. The link between varicocele and testosterone production is unclear. The liver is one of the most effective organs in the metabolism of substances and hormones. This study aimed to evaluate serum testosterone levels and their association with liver enzymatic changes. Fifty male Wistar rats were divided into 5 groups, including sham control, varicocele induction, varicocele induction (50 mg/kg curcumin), and varicocele induction (100 mg / kg curcumin). After the treatment period, iron (Fe2 +), testosterone, direct bilirubin, total bilirubin and serum concentrations of ALT, and AST were assessed and liver tissue was isolated and examined. Varicocele caused a significant increase in iron levels (p ≤ 0.05) and a non-significant decrease in testosterone levels (p = 0.242) and total bilirubin (T) (p = 0.639). The treatment resulted in a significant decrease in the levels of iron (p = 0.056) and total bilirubin (p = 0.639), as well as a significant increase in testosterone levels (p < 0.05) compared to the varicocele. While the level of direct bilirubin (p ≥ 0.05) in the varicocele showed a significant increase compared to the sham and control. Using curcumin significantly reduced it compared to the varicocele (p = 0.03). Evaluation of ALT (p = 0.762) and AST (p = 0.367) levels did not show a significant difference among the groups. The levels of iron, testosterone, bilirubin, and liver enzymes are negatively affected by varicocele. Curcumin may lessen the harmful effects of varicocele on biochemical components linked with liver tissue in addition to preventing varicocele damage to testicular tissue. In varicocele rats, greater dosages of curcumin may lower the liver enzyme AST. Manuscript profile -
Open Access Article
74 - Anti-glioblastoma Effects of Nano-micelle Curcumin Plus Erlotinib
Ali Bagherian Hamed Mirzaei Nahid Masoudian Bostan RoudiGlioblastoma is one of the most dangerous types of brain cancer, with a high rate of therapy resistance. Apoptosis, angiogenesis, autophagy, NF-κB, and Wnt pathways are just a few of the molecular and cellular processes that play a role in Glioblastoma development MoreGlioblastoma is one of the most dangerous types of brain cancer, with a high rate of therapy resistance. Apoptosis, angiogenesis, autophagy, NF-κB, and Wnt pathways are just a few of the molecular and cellular processes that play a role in Glioblastoma development. The effectiveness of curcumin and Nano-micell curcumin with Erlotinib to suppress Glioblastoma in vitro was investigated in this study.The suppression is carried out by affecting NF-κB and Wnt signaling pathways, angiogenesis inhibition, and autophagy and apoptosis induction. Curcumin and Nano-micelle Curcumin (50 μM) was investigated alone and with Erlotinib (50 μM) in the U87 glioblastoma cells. The expression of Wnt and NF-κB signaling pathways, apoptosis, angiogenesis, and autophagy-related genes and proteins were assessed by qRT-PCR and Western blot. Compared with the control group, all treatments declined the U87 glioblastoma cells viability. Furthermore, Angiogenesis-associated proteins, i.e., Cox-2, VEGF, HIF-1α & bFGF, were remarkably decreased. Each treatment regulated autophagy and apoptosis-associated proteins, i.e., Bax, Beclin 1, caspase 8, Bcl-2, LC3-II, and LC3-I. Total NF κB (p65) and phospho NF. κB (p65) declined by each treatment at protein levels. Expressions of VEGF, cyclin D1, Twist, ZEB, and Wnt pathway-associated genes were also decreased. In general, our findings demonstrated that curcumin and Nano-micelle Curcumin, either alone or in conjunction with Erlotinib, had anti-Glioblastoma effects via modulating a number of processes including apoptosis, autophagy, angiogenesis, Wnt, and NF. κB signaling pathways. Manuscript profile -
Open Access Article
75 - The Short-term Effects of Aerobic Exercise and High-Fat Diet and Curcumin Extract on the Expression of Adiponectin and Interleukin Genes in Six Muscle Tissues in Male Wistar Rats
Sedighe Aghayan Tahereh Bagherpoor Nematollah NematiAdiponectin is a peptide hormone that is secreted from adipose tissue in humans and is effective on fat and glucose metabolism. Interleukin-6 also has the main role in various types of host defense mechanisms, including immune reactions and acute phase reactions. Theref MoreAdiponectin is a peptide hormone that is secreted from adipose tissue in humans and is effective on fat and glucose metabolism. Interleukin-6 also has the main role in various types of host defense mechanisms, including immune reactions and acute phase reactions. Therefore, the aim of the present study was to compare the short-term effects of aerobic exercise and high-fat diet and curcumin extract on the expression of adiponectin and interleukin genes in six muscle tissues of male Wistar rats. For this purpose, 50 two-month-old male rats were prepared and divided into five control groups, high-fat diet, curcumin and high-fat diet, exercise and high-fat diet, curcumin + exercise + high-fat diet. Data analysis was compared using one-way analysis of variance. The mean of intra-group differences was also compared using the one-way statistical test. The results showed that the average expression of the adiponectin gene of the subjects showed a significant difference among the 5 groups. The results of Bonferroni's post hoc test also showed a significant difference between the control group and other groups. Also, the expression of interleukin 6 gene increased in two groups - high-fat diet and high-fat + curcumin diet group compared to the control group. But in two groups of high-fat diet + exercise and high-fat diet + exercise + curcumin group, there was a significant decrease. Manuscript profile -
Open Access Article
76 - The Effect of Six Weeks of Intense Intermittent Exercise and Curcumin on Glucose Levels and BMP-2 Gene Expression in Vascular Smooth Muscle of Diabetic Male Rats
Reza Sheikh Mohammad GalehdariThe present study was conducted with the aim of investigating the effect of six weeks of intermittent exercise and curcumin consumption on BMP2 gene expression in the vascular smooth muscle of male Wistar rats. In an experimental trial, 30 male Wistar rats were randomly MoreThe present study was conducted with the aim of investigating the effect of six weeks of intermittent exercise and curcumin consumption on BMP2 gene expression in the vascular smooth muscle of male Wistar rats. In an experimental trial, 30 male Wistar rats were randomly divided into six groups (5 rats in each group): control, diabetic, healthy intermittent exercise, intermittent exercise diabetes, curcumin diabetes and curcumin exercise diabetes. Diabetes was induced by intraperitoneal injection of streptozotocin poison (50 mg/kg). Intermittent training consisted of 5-12 bouts of intense work (75 to 100% of maximum speed) of 60 seconds with active rest intervals of 75 seconds, six days a week for six weeks. Curcumin was fed to animals by gavage at a dose of 50 mg per kilogram of body weight. After six weeks, unconscious animals and blood samples were collected from their hearts. The data were analyzed using ANOVA statistical test and Benferroni post hoc test. Induction of diabetes increased BMP2 gene expression in vascular smooth muscle of male rats. Intermittent training decreased BMP2 gene expression in vascular smooth muscle of diabetic rats. Six weeks of curcumin consumption reduced the expression of BMP2 gene in vascular smooth muscle of diabetic rats. In general, the results of the present study showed that intermittent exercise and curcumin improve diabetes disorders caused by BMP2 gene expression and calcification and its complications. Manuscript profile -
Open Access Article
77 - Effect of Nano-curcumin on the Treatment of Non-alcoholic Fatty Liver Disease (NAFLD) in Hypercholesterolemia Mice
Sahar Farzaneh Sepideh FarahiniaAccording to the widespread use of nanoparticles in medicine, the pathological study seems to be necessary. Important properties of nanoparticles are their small size. Accumulation of fat and inflammation of the liver are the beginning stage of liver cirrhosis. We aimed MoreAccording to the widespread use of nanoparticles in medicine, the pathological study seems to be necessary. Important properties of nanoparticles are their small size. Accumulation of fat and inflammation of the liver are the beginning stage of liver cirrhosis. We aimed to determine the effect of nano-curcumin on fatty liver disease. Sixty male mice were divided into 6 groups (n=10): control, gavaged with normal food. The second group were fed cholesterol, third group were fed cholesterol and curcumin. Other groups were fed different dose of nano-curcumin. Then, lipid profile and liver enzymes were measured and liver tissues were fixed in formalin buffer, staining with hematoxylin-eosin. Data were analyzed using SPSS. Evaluation of serum cholesterol showed that treatment with curcumin significantly decreased cholesterol, TG, and LDL of plasma level. Histopathological changes of the liver in the group received cholesterol showed vacuoles of fat, in groups which were fed low doses of the nano-curcumin did not show fat vacuoles of fat. Nano-curcumin may be used in the safe doses for treatment of nonalcoholic fatty liver disease. Manuscript profile -
Open Access Article
78 - Antibacterial effect of Curcumin encapsulated in polymersome nanoparticles on the expression of efflux pump MDR1 gene in fluconazole resistant isolates of Candida albicans
ُSahar Pourasgar Aida Bejari Mahkameh Hedayatsafa Mahdi Shahriarinour Najmeh RanjiCurcumin, a natural product of turmeric, is known for its antibacterial and antifungal properties. Candida albicans is a major fungal pathogen with high mortality rate, particularly in immunocompromised patients. This study aimed to evaluate the effect of curcumin encap MoreCurcumin, a natural product of turmeric, is known for its antibacterial and antifungal properties. Candida albicans is a major fungal pathogen with high mortality rate, particularly in immunocompromised patients. This study aimed to evaluate the effect of curcumin encapsulated in nanoparticles (polymersomes) in combination with fluconazole on the expression of the MDRI gene in drug-resistant isolates of C. albicans. This descriptive cross-sectional study involved obtaining 50 clinical samples, from women with vulvovaginal infections at Al-Zahra hospital (Rasht, Iran). After identifying the strains, resistance to fluconazole was assessed using disc diffusion and broth dilution methods. Six fluconazole-resistant isolates of C. albicans were treated with ½ MIC fluconazole (control) alone and in combination with curcumin encapsulated in nanoparticles. After 24 hours, the two cell groups were cultured on Sabouraud dextrose agar (SDA) to estimate the cell death rate. The expression of the MDR1 gene was quantitatively investigated using the qRT-PCR method in treated and untreated isolates. Our finding indicated that combined therapy with ½ MIC fluconazole and curcumin encapsulated in nanoparticles (at a concentration of 400µg/ml) reduced fungal growth by up to 50% within during 24 hours. In treated cells, qRT-PCR analysis revealed a decrease in MDR1 gene expression compared to untreated cells. Curcumin appears to enhance the effectiveness of fluconazole in fluconazole-resistant isolates by reducing MDR1 gene expression. Manuscript profile -
Open Access Article
79 - Investigation on the trend and effective factors on export of sweet root and cumin medicinal plants in Iran
Ehteram Deilami Hamid Mohammadi Amir Borjian The main objective of this study was to analysis the export trend of sweet root and cumin and to determine factors affecting their export over 1981-2003. Exported amount of cumin revealed a growth, accompanied with fluctuations. In the case of sweet root, however, More The main objective of this study was to analysis the export trend of sweet root and cumin and to determine factors affecting their export over 1981-2003. Exported amount of cumin revealed a growth, accompanied with fluctuations. In the case of sweet root, however, export growth was less important with more fluctuations than that of cumin. Based on estimated results, it was revealed that exchange rate and domestic - world price ratio of cumin had a positive significant effect on it’s export and one percent increase in the value of the above variables will resulted in 1.8 and 1.1 percent growth in cumin export, respectively. Findings also showed that domestic – world price ratio of sweet root, GDP and exchange rate had a positive significant effect on sweet root export. Like the cumin, it was expected that one percent increase in the mentioned variables will raise the sweet root export 1.05, 3.2 and 0.84 percent, respectively. Manuscript profile -
Open Access Article
80 - Effects of vermincompost and nitrogen fertilizer levels ongrowth and essential oil of cumin (Cuminum cyminum L.)
Shahram Mohammadi Bahram Mirshekari Varharam Rashidi Rahim AliMohammadiA greenhouse study was conducted based on a complete randomized block design with twelve treatments and four replications in Islamic Azad University , Miyaneh Branch during 2010 in order to evaluate the effects of vermicompost and nitrogen fertilizer levels on growth an MoreA greenhouse study was conducted based on a complete randomized block design with twelve treatments and four replications in Islamic Azad University , Miyaneh Branch during 2010 in order to evaluate the effects of vermicompost and nitrogen fertilizer levels on growth and essential oil of cumin (Cuminum cyminum L.). Treatments consisted of three amounts of vermicompost (10, 20 and 30 pot volume) and four levels of nitrogen fertilizer (0, 50, 100, 150 kg/ha). ANOVA revealed a significant difference for all characteristics except for plant height, harvest index, and essential oil. The comparison of the mean characteristics showed that the treatment with 20% vermicompost increased the number of seed per plant, 1000 grain weight and eventually seed yield. The comparison of the mean traits showed an increase in measured traits in treatment with 100 kg/ha. The application of 100 kg/ha nitrogen fertilizer and 20% of vermicompost had an effective role in increasing the seed yield in cumin. Because of highly desirable effects of vermicompost and improvement of soil fertility level it is recommended to apply high ratio of this fertilizer and if possible, in lands using manures for soil fertility it is advisable to modify these fertilizers which are infected by weed seeds with the help of earthworms. Manuscript profile -
Open Access Article
81 - The effect of Cuminum cyminum, acidity, temperature and inoculums’ level on the growth of Xanthomonas campestris
Nazanin Miri Roya Rezaeian-Doloei Reza Sadrabadi HaghighThe Xanthomonas genus is one of the most important groups of plant pathogenic bacteria that cause post-harvest spoilage. Substantial crop losses may result from the rapid spread of the bacteria under favorable conditions, lack of seed germination, seedling death and vas MoreThe Xanthomonas genus is one of the most important groups of plant pathogenic bacteria that cause post-harvest spoilage. Substantial crop losses may result from the rapid spread of the bacteria under favorable conditions, lack of seed germination, seedling death and vascular obstruction of plant. The aim of this study was to investigate the combined effects of different concentrations of Cuminum cyminum essential oil (EO; including 0, 0.2, 0.4 and 0.8%), three levels of acidity (5, 6 and 7), two inoculums’ level (103 and 105 CFU/ml) and two incubation temperatures (26 and 28˚C) on the growth of X. campestris in the nutrient broth medium in a completely randomized design with three replications. Growth was monitored by visible turbidity during a 30-day period. The minimum inhibitory concentration and minimum bactericidal concentration of EO against X. campestris was 1 and 2% respectively. According to the results, P-cuminaldehyde was the main component, with a content of 30.5%. The statistical analysis of data showed that the maximum time to detection of bacteria (19 days) in the concentrations of 0.8% EO, pH of 5, the inoculum level of 103 CFU/ml and incubation temperature of 26˚C and the minimum time to detection (16 hours) in the inoculums level of 105 CFU/ml, pH of 7, 28 ˚C and no EO was observed. In addition to the concentration of Cuminum cyminum EO as an antimicrobial agent, acidity of medium is also considered the factors influencing the growth of X. campestris. By decreasing the pH, the time-to-detection of bacteria was increased. In conclusion, using a combination of different factors can inhibit the growth of bacteria, significantly. Manuscript profile
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