The effect of aerobic exercise and curcumin on plasma concentrations of C-reactive protein in diabetic rats

Subject Areas : Open Access

Morteza  Ebrahimzadeh ¹ (PhD Student, Department of Physical Education, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran)
Kamal  Azizbeigi ² (Islamic Azad University, Sanandaj Branch)
Khalid  Mohammad Zadeh Salamat ³ (Assistant Professor, Department of Physical Education, Sanandaj Branch, Azad University Eslami, Sanandaj, Iran)
Saman  Pashaie ⁴ (Assistant Professor, Department of Physical Education, Shaqez Branch, Islamic Azad University, Saqez, Iran)

Received: 2022-02-12 Accepted : 2022-03-04 Published : 2021-11-22

Keywords: Curcumin, Diabetes, Aerobic exercise, C-reactive protein,

Abstract :

Background and Aim: Previous studies have shown the positive effect of aerobic exercise and curcumin on various variables in diabetes. Also, the combination of these interventions may have a synergistic effect on research variables. The present study investigates the independent and combined effect of aerobic exercise and curcumin supplementation on plasma C-reactive protein concentration in diabetic rats.Methods: Forty male rats were equally divided into healthy control, diabetic control, diabetic exercise, diabetic curcumin and diabetic curcumin + exercise. Aerobic exercise (five sessions / week, each session 30 minutes at a speed of 22 meters / minute, slope: five percent) and supplementation (30 mg / kg body weight, three days / week) were performed for eight weeks. Rats were sacrificed 48 hours after receiving the last intervention.Results: Diabetes increased the concentration of plasma C-reactive protein (P = 0.001). Exercise decreased plasma C-reactive protein concentration (P = 0.001) in diabetic rats. Curcumin also reduced plasma C-reactive protein (P = 0.001) in diabetic rats. The combination of exercise and supplementation had a greater effect on reducing the plasma C-reactive protein concentration than mono / supplementation alone (P <0.001).Conclusion: Exercise and curcumin separately reduced plasma C-reactive protein concentration in diabetic rats. It also seems that the use of a combination of exercise and curcumin than the use of each alone, has been more effective on the variables of the present study.