Examining the Effect of Curcumin on the Nervous Protection and Movement Disorders in Cell Model of Parkinson's Disease induced by 6-HDOP

Subject Areas : Journal of Animal Biology

Mahdieh Azarshab ¹ ( Department of Biology, North Tehran Branch, Islamic Azad University, Tehran, Iran )
Ramin Hajikhani ² ( Department of Biology, North Tehran Branch, Islamic Azad University, Tehran, Iran )
Mehdi Rahnama ³ ( Department of Biology, Zanjan Branch, Islamic Azad University, Zanjan, Iran )
Mohammadreza Bigdeli ⁴ ( Department of Biology, Faculty of Biological Sciences, Shahid Beheshti University, Tehran, Iran )
Jalal Solati ⁵ ( Department of Biology, Karaj Branch, Islamic Azad University, Karaj, Iran )

Received: 2020-12-05 Accepted : 2021-02-23 Published : 2021-05-22

Keywords: Curcumin, Parkinson, Catecholaminergic cell, 6-Hydroxy dopamine,

Abstract :

Parkinson's disease is one of the most common types of the neurodegenerative disease, which is characterized by the movement disorders such as slowness, lack of movement, muscle stiffness, and resting tremor, and hypophonic. The main reason of disease is the destruction of dopaminergic neurons in the Substantia Nigra in the midbrain and a decrease in dopamine concentration in the striatum terminals. In this study, used culture medium was DMEM with FBS, and the cells under study were catecholaminergic cells.6-Hydroxy dopamine toxin was used on cells to create a Parkinson cell model. Curcumin was used as a drug, and MTT, and BT methods were used to count the living cells. This research was designed to study the curcumin effect on Parkinson's disease with cellular model induced by 6-Hydroxy dopamine toxin with reduced inflammation. This study's results showed that using curcumin can increase the antioxidant power and protect the cell from damage caused by reactive oxygen species. Due to the results of MTT, and curcumin treatment due to its anti-inflammatory properties BT test also showed that cellular protection had increased, the death of aminergic catechol cells by 6-hydroxy dopamine toxin was significantly reduced. It shows the antioxidant and anti-inflammatory effects of curcumin on the damage caused by Parkinson's disease and reducing the progression of symptoms. Treatment withcurcumin to be anti-inflammatory can reduce the death of catecholaminergic cells by 6-hydroxy dopamine toxin.

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