The effect of hydroalcholic extract of Cuminum cyminum L. on anxiety in Adult male rats
Subject Areas : zoologyMaryam Khoshsokhan mozaffar 1 , zahra alemi heshmat 2 , nasrin heidarieh 3
1 - assistant Professor/ Islamic Azad University, Qom Branch
2 - Department of Biology, Faculty of Science, Qom Branch, Islamic Azad University, Qom, Iran
3 - depatment of biology, faculty of basic science, islamic azad University, Qom branch, Qom, iran.
Keywords: Adult male rat, Anxiety, elevated plus maze, The hydroalcoholic extract of cuminum cyminum L,
Abstract :
Background and objectives: Anxiety is one of the current psychic disorders among humanistic communities. It is an oppressive feeling that associates an unknown and ambiguous danger. Due to the effect of cuminum cyminum L, this study aims to consider the effect of hydroalcoholic extract of cuminum cyminum L. on anxiety among male Adult wistar rats. Material and Methods: After recognition of the cuminum cyminum L. plant through herbarium of Islamic Azad university of Qom, the hydroalcoholic extract was extracted by laboratory, and the extract powder was produced by using an oven. In this study on 32 male wistar rats (200 230 gr) in healthy groups(intact),the treatment group with DMSO or the solvent extract (0/3 cc), and groups received 50,100 mg/kg hydroalcoholic extract of cuminum cyminum L. (n=8). All injections were peritoneal, and half an hour after injection, with the use of high cross labyrinth, anxiety test was taken, and anxiety evaluation’s standard indicators (staying period and the number of entering to free arm) were considered and registered for 5 minutes. Data were analyzed by the Tukey’s unilateral variance analyze (p<0.001). Results: The received group solvent extract than intact group indicators showed no significant differences in anxiety. the hydroalcoholic extract of cuminum cyminum L.in 100 mg/kg, showed significant increasing in presence period and number commuting time on open arm, than the group who received DMSO (p<0.001). Conclusion: the hydroalcoholic extract of cuminum cyminum L. has anti-anxiety effects.
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