Chinomso Aaron Articles List

List of Articles Chinomso Aaron

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1 - Cannabis sativa in ethanol (Monkey Tail) and tramadol induced similar degrees of toxicity in adult female Wistar rats
چینومسو آرون امانوئل اکوبوگو سلیمان ایجیوما رابرت اوروکو اوچه آرونسی کینگزلی اوگووانی ویکتور اوگویک
10.30495/medherb.2022.691247

Background & Aim: This study was designed to evaluate the toxic effects of Cannabis sativa local gin formulation (CSLGF) and tramadol in adult female Wistar rats.Experimental: Cannabis sativa local gin formulation (CSLGF) was prepared and was subjected to acute toxi More

Background & Aim: This study was designed to evaluate the toxic effects of Cannabis sativa local gin formulation (CSLGF) and tramadol in adult female Wistar rats.Experimental: Cannabis sativa local gin formulation (CSLGF) was prepared and was subjected to acute toxicity tests together with tramadol. In the main study, 25 rats were assigned into 5 groups (n = 5) in which the group 1 received no treatment, groups 2 and 3 received 25 and 50 mg/kg of tramadol, respectively while groups 4 and 5 received 25 and 50 mg/kg of CSLGF, respectively, for 21 days before the rats were sacrificed.Results: Acute toxicity results indicated narrow margins of safety for CSLGF and tramadol with LD50 values of 123.0 and 133.0 mg/kg body weight, respectively. The rats treated with CSLGF lost weight significantly while that administered tramadol had lower weight gains when compared with the control (P<0.05). The red blood cell counts, packed cell volume and haemoglobin concentrations were significantly lowered by CSLGF (P<0.05). However, a significant increase in the number of platelets and white blood cells were observed in groups treated with both CSLGF and tramadol. Results of biochemical changes showed a significant increase in aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total bilirubin, urea and creatinine with a concurrent decrease in total protein, albumin and globulin values following treatment with both agents (P<0.05), but serum electrolytes concentrations were not significantly altered (P>0.05). Treatment with CSLGF and tramadol also significantly lowered glutathione, superoxide dismutase and catalase activities but increased malondialdehyde concentrations when compared with control.Recommended applications/industries: The findings show that although the toxic effects of CSLGF and tramadol in rats are similar, CSLGF appears to have higher toxicity potentials. Extending the current control on tramadol to CSLGF (monkey tail) is urgently needed in Nigeria to protect human lives. Manuscript profile
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2 - Ameliorative potentials of Aju Mbaise extract (AME) on Dutasteride induced oxidative stress and hepatic injury in rats
رابرت اوروکو الیشا اوگو پل نیوجی-آنیالوو ایکنا اوبیورو چینومسو هارون اوبینا امبا
10.30495/medherb.2023.700160

Background & Aim: Aju Mbaiseis a polyherbal extract with nutraceuticalproperties that helps to replenish the volume of blood lost during childbirth and improves breast milk secretion and the general wellbeing of the mother. This study evaluated the ameliorative pote More

Background & Aim: Aju Mbaiseis a polyherbal extract with nutraceuticalproperties that helps to replenish the volume of blood lost during childbirth and improves breast milk secretion and the general wellbeing of the mother. This study evaluated the ameliorative potentials of Aju Mbaise extract (AME) on Dutasteride-induced oxidative stress and hepatic injury in rats. Twenty-one rats were used to assess the acute toxicity of AME.Experimental: The study for the hepatoprotective effects of AME had five groups of rats, including normal control, Dutasteride only, AME only, Dutasteride + AME (500 mg/kg) and Dutasteride+ AME (1000 mg/kg).Results: The acute toxicity result showed that AME is relatively safe for consumption. Dutasteride caused significant elevation of liver marker enzymes, including aspartate transaminase (AST), alanine transaminase (ALT), transaminase (AST), alkaline phosphatase (ALP), total bilirubin, malondialdehyde (MDA) and significantly reduced catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx), reduced glutathione (GSH), total proteins, albumin, and globulin levels in the rats received only Dutasteride. In contrast, Dutasteride induced rats treated with AME showed a significant decline in the AST, ALT, ALP, MDA, and bilirubin and significantly increased SOD, GSH, GPx, total proteins, albumin, and globulin levels compared to Dutasteride induced untreated rats. The AME-treated rats showed normal liver histo-architecture, unlike the Dutasteride-induced untreated rats that showed mild to moderate vacuolar degeneration of the hepatocytes.Recommended applications/industries: The findings show that AME ameliorates Dutasteride caused rats oxidative stress and hepatic injury. Manuscript profile
Open Access Article
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3 - Evaluation of phytochemicals, antioxidant contents and in vitro antioxidant activities of a combined ethanol extract of Spermacoce radiata and Hypselodelphys poggeana leaves
رابرت اوروکو چیندو آگووامبا چینومسو آرون پوئل نیوجی-آنیالوو مرسیلین اوچه
10.30495/medherb.2022.698466

Background & Aim: Oxidative stress causes lipid peroxidation, damages various macromolecules, tissues and organs, and is involved in the pathogenesis of several diseases. Antioxidant supplementation could help scavenge free radicals and prevent oxidative stress. Thi More

Background & Aim: Oxidative stress causes lipid peroxidation, damages various macromolecules, tissues and organs, and is involved in the pathogenesis of several diseases. Antioxidant supplementation could help scavenge free radicals and prevent oxidative stress. This study evaluated the phytochemicals, antioxidant compositions and in vitro antioxidant activities of a combined extract of Spermacoce radiata and Hypselodelphy spoggeana leaves (CEESH).Experimental: This study determined phytochemicals and antioxidant vitamins contained in CEESH. The in vitro antioxidant activities of CEESH comprising DPPH (1,1-diphenyl-2-picrylhydrazyl), nitric oxide, ferric reducing antioxidant power (FRAP), total antioxidant capacity (TAC) and thiobarbituric acid reactive substances (TBARS) were assayed.Results: The phytochemical results indicated substantial amounts of total phenols, alkaloids, and terpenoids, along with moderate amounts of tannins, flavonoids, and steroids in CEESH with a low glycoside concentration, but saponin was not detected. The plant extract also showed substantial concentrations of vitamins A, C, and E.The DPPH, nitric oxide, FRAP, TAC and TBARS for the CEESH indicated that the extract has substantial free radical scavenging activities. The CEESH demonstrated a dose-dependent significant increase in the nitric oxide, TAC, and TBARS scavenging activities, while the CEESH showed dose-dependent marked increase in FRAP within a concentration range of 40–640 µg/mL. The half-optimal effective concentration (EC50) values of the CEESH for DPPH, nitric oxide, and TBARS were 7.23, 39.40, and 63.41 µg/mL, respectively.Recommended applications/industries: These findings suggest that CEESH contains abundant phytochemicals and antioxidant vitamins and possesses high free radical scavenging potential. Therefore, CEESH could be a viable therapeutic agent for managing oxidative stress. Manuscript profile

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List of Articles Chinomso Aaron