List of Articles
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Open Access Article
1 - The Effects of Cinnamon on Polycystic Ovary Syndrome
مهرداد استادپور مجید غلامی آهنگران سیدحسین حیدریBackground & Aim: Polycystic ovary syndrome (PCOS) is a major endocrine disorder in young age women affecting their health-related quality of life (HRQOL) and their mental well-being as well. In this review, the authors discuss the effect of cinnamon as an herbal me MoreBackground & Aim: Polycystic ovary syndrome (PCOS) is a major endocrine disorder in young age women affecting their health-related quality of life (HRQOL) and their mental well-being as well. In this review, the authors discuss the effect of cinnamon as an herbal medicine on PCOS in humans and introduce the advantages and efficacy of these herbs on the control of this problem.Experimental: In this review, the authors searched the main related keywords e.g. polycystic, and cinnamon in main biological data centers e.g. Science Direct, Pubmed and Google Scholar. Then, the authors classified articles and only discussed the valid full papers in different categories.Results: The study of papers related to the effect of cinnamon on polycystic ovary syndrome revealed that this herb can control this problem via some route e.g., by control of triglyceride and cholesterol to diminish risk factors of fat deposition and by inhibitory effects on oxidative cascade decreasing the cystic formation process.Recommended applications/industries: The review proposed the positive effect of cinnamon on the control of PCOS in humans. Therefore, supplementary cinnamon on feed can diminish PCOS via some metabolic cycle. Manuscript profile -
Open Access Article
2 - Crinum glaucum A. chev bulb: Modulation of endogenous antioxidant enzyme in an animal-induced oxidative stress model
اولوفون میلایو اوگونرینولا اولواسی اوگونرینولا اولواتومیلولا اولاتونجی اولوسگون فاجانا موتیو کاظیم ژمیسولا سایبو حبیب بانکول آدمولا آدیوی باباجید الموBackground & Aim: The mechanism of action of Crinum glaucumbulb (Cgb) A. Chev (Amaryllidaceae) is enigmatic. Therefore, this study aimed at investigating the possible modulating properties of an aqueous extract of Cgb on endogenous antioxidant enzymes during lipopol MoreBackground & Aim: The mechanism of action of Crinum glaucumbulb (Cgb) A. Chev (Amaryllidaceae) is enigmatic. Therefore, this study aimed at investigating the possible modulating properties of an aqueous extract of Cgb on endogenous antioxidant enzymes during lipopolysaccharide (LPS)-induced oxidative stress in a rat model.Experimental: 25 male and 25 female rats were divided into five groups (n=5) each: control group; treatment group, rats were given an aqueous extract of Cgb for 7 days; induced-oxidative stress group, rats were injected with LPS for 4 hours; post-Cgb group, rats were injected with LPS for 4 hours and treated with an aqueous extract of Cgb; and pre-Cgb group, rats were given an aqueous extract of Cgb for 7 days, injected with LPS for 4 hours, and treated with an aqueous extract of Cgb for 7 days. The blood, brain, heart, lungs, liver, and kidneys were harvested for the biochemical analysis. The endogenous antioxidant enzymes (catalase, superoxide dismutase, and glutathione-S-transferase) were analysed spectrophotometrically.Results: The hallmark of LPS is its ability to decrease the activity of oxidative stress marker enzymes, as observed in this study. The pre- and post-administration of an aqueous extract of Cgb significantly (P≤0.05) reversed the damaging effect of LPS by increasing the activities of catalase and superoxide dismutase in the blood and organs of male and female rats, respectively, while plasma glutathione-S-transferase activity was inhibited.Recommended applications/industries: The aqueous extract of Cgb has modulating properties to reduce the action of LPS-induced oxidative stress on endogenous antioxidant enzymes in male and female rats. Manuscript profile -
Open Access Article
3 - Effects of methanol root extract and fractions of Waltheria Indica (linn) on sexual orientation and sexual behavioral parameters in male wistar rats
ساندی سابو ساندی اوتیمنین ساموئل اتوکپاBackground & Aim: Waltheria indica is a shrub whose roots are used in many communities of Northern Nigeria to manage several sexual behavioral disorders; however, there is no scientific study to verify this claim. The aim of the study is to determine the effect of m MoreBackground & Aim: Waltheria indica is a shrub whose roots are used in many communities of Northern Nigeria to manage several sexual behavioral disorders; however, there is no scientific study to verify this claim. The aim of the study is to determine the effect of methanol root extract of Waltheria indica and its fractions (ethyl acetate, n-butanol, and residual ethanol) on sexual orientation and sexual behavioral parameters in male albino rats.Experimental: Male rats were divided into five groups each containing 6 rats. Group 1 rats were treated with normal saline. Rats in Groups 2, 3 and 4 were treated with 50, 100 and 200 mg/kg crude extracts while rats in Group 5 were treated with Sildenafil 5 mg/kg. Treatment was administered once daily for 7 days. Female rats were artificially brought to oestrus by administering oestradiol 25 μg/kg and progesterone 500 μg/kg 48 and 8 h respectively prior to mating The mating was done in a 1:1 ratio and mating behaviour was observed on days 1 and 7. Similar procedure was repeated, normal saline, 12.5 and 25 mg/kg of the ethyl acetate, n-butanol and mother liquor fractions, respectively and sexual behavioral parameters were observed.Results: Crude extract and fractions of Waltheria indica significantly increased sexual behavioral parameters, with the n-butanol and mother liquor fractions being most active.Recommended applications/industries: The study showed that methanol root extract of Waltheria indica and its fractions have aphrodisiac activity with the n-butanol and residual methanol fractions being more active. These revelations further substantiates the traditional use of Waltheria indica for the management of infertility in male, thus such discovery can serve as a lead for the development of drugs for the management of sexual dysfunctions. Manuscript profile