معرفي نشريه
علمی
" مجله گیاهان دارویی" ( داروهای گیاهی سابق) مصوب دانشگاه آزاد اسلامی و دارای مجوز انتشار از سوی وزارت فرهنگ و ارشاد اسلامی است. این مجله توسط دانشگاه آزاد اسلامی واحد شهرکرد به تعداد 4 شماره در سال انتشار می یابد. فصلنامه گیاهان داروئی به منظور گسترش و اعتلای تحقیقات علمی در زمینه گیاهان داروئی و داروهای گیاهی و ایجاد ارتباط و هماهنگی بین محققین، کارشناسان و دانشجویان در دانشگاه ها و موسسات تحقیقاتی از سال 1389 منتشر شده است. این مجله مقالات اصیل تحقیقی در زمینه گیاهان داروئی و موضوعات مرتبط در این زمینه که برای اولین بار ارائه می شوند را با داوری علمی و فنی پذیرفته و منتشر می نماید. مقالات به صورت دو سوکور بررسی خواهند شد، به این معنی که نویسندگان و داوران یکدیگر را نمی شناسند. این فصل نامه نتایج تحقیقات کاربردی و یا بنیادی را به صورت مقالات تحقیقی - مقالات اتنوبوتانی - مقاله کوتاه - مروری - گزارش علمی به زبان انگلیسی و چکیده فارسی به چاپ می رساند. هیات تحریریه مجله گیاهان داروئی از تمامی استادان، پژوهشگران و صاحبنظران دعوت می نماید تا با ارسال مقاله های ارزنده خود، این مجله را درراه رسیدن به اهداف مذکور یاری کنند.
امتیاز و ارجاعات (Citations) در سایت معتبر Google Scholar
Journal of Medicinal Herbs (J. Med Herb) in Google Scholar: H index: 18
آخرین مقالات منتشر شده
-
دسترسی آزاد مقاله
1 - The Effects of Cinnamon on Polycystic Ovary Syndrome
مهرداد استادپور مجید غلامی آهنگران سیدحسین حیدریشماره 3 , دوره 14 , تابستان 2023Background & Aim: Polycystic ovary syndrome (PCOS) is a major endocrine disorder in young age women affecting their health-related quality of life (HRQOL) and their mental well-being as well. In this review, the authors discuss the effect of cinnamon as an herbal me چکیده کاملBackground & Aim: Polycystic ovary syndrome (PCOS) is a major endocrine disorder in young age women affecting their health-related quality of life (HRQOL) and their mental well-being as well. In this review, the authors discuss the effect of cinnamon as an herbal medicine on PCOS in humans and introduce the advantages and efficacy of these herbs on the control of this problem.Experimental: In this review, the authors searched the main related keywords e.g. polycystic, and cinnamon in main biological data centers e.g. Science Direct, Pubmed and Google Scholar. Then, the authors classified articles and only discussed the valid full papers in different categories.Results: The study of papers related to the effect of cinnamon on polycystic ovary syndrome revealed that this herb can control this problem via some route e.g., by control of triglyceride and cholesterol to diminish risk factors of fat deposition and by inhibitory effects on oxidative cascade decreasing the cystic formation process.Recommended applications/industries: The review proposed the positive effect of cinnamon on the control of PCOS in humans. Therefore, supplementary cinnamon on feed can diminish PCOS via some metabolic cycle. پرونده مقاله -
دسترسی آزاد مقاله
2 - Crinum glaucum A. chev bulb: Modulation of endogenous antioxidant enzyme in an animal-induced oxidative stress model
اولوفون میلایو اوگونرینولا اولواسی اوگونرینولا اولواتومیلولا اولاتونجی اولوسگون فاجانا موتیو کاظیم ژمیسولا سایبو حبیب بانکول آدمولا آدیوی باباجید الموشماره 3 , دوره 14 , تابستان 2023Background & Aim: The mechanism of action of Crinum glaucumbulb (Cgb) A. Chev (Amaryllidaceae) is enigmatic. Therefore, this study aimed at investigating the possible modulating properties of an aqueous extract of Cgb on endogenous antioxidant enzymes during lipopol چکیده کاملBackground & Aim: The mechanism of action of Crinum glaucumbulb (Cgb) A. Chev (Amaryllidaceae) is enigmatic. Therefore, this study aimed at investigating the possible modulating properties of an aqueous extract of Cgb on endogenous antioxidant enzymes during lipopolysaccharide (LPS)-induced oxidative stress in a rat model.Experimental: 25 male and 25 female rats were divided into five groups (n=5) each: control group; treatment group, rats were given an aqueous extract of Cgb for 7 days; induced-oxidative stress group, rats were injected with LPS for 4 hours; post-Cgb group, rats were injected with LPS for 4 hours and treated with an aqueous extract of Cgb; and pre-Cgb group, rats were given an aqueous extract of Cgb for 7 days, injected with LPS for 4 hours, and treated with an aqueous extract of Cgb for 7 days. The blood, brain, heart, lungs, liver, and kidneys were harvested for the biochemical analysis. The endogenous antioxidant enzymes (catalase, superoxide dismutase, and glutathione-S-transferase) were analysed spectrophotometrically.Results: The hallmark of LPS is its ability to decrease the activity of oxidative stress marker enzymes, as observed in this study. The pre- and post-administration of an aqueous extract of Cgb significantly (P≤0.05) reversed the damaging effect of LPS by increasing the activities of catalase and superoxide dismutase in the blood and organs of male and female rats, respectively, while plasma glutathione-S-transferase activity was inhibited.Recommended applications/industries: The aqueous extract of Cgb has modulating properties to reduce the action of LPS-induced oxidative stress on endogenous antioxidant enzymes in male and female rats. پرونده مقاله -
دسترسی آزاد مقاله
3 - Effects of methanol root extract and fractions of Waltheria Indica (linn) on sexual orientation and sexual behavioral parameters in male wistar rats
ساندی سابو ساندی اوتیمنین ساموئل اتوکپاشماره 3 , دوره 14 , تابستان 2023Background & Aim: Waltheria indica is a shrub whose roots are used in many communities of Northern Nigeria to manage several sexual behavioral disorders; however, there is no scientific study to verify this claim. The aim of the study is to determine the effect of m چکیده کاملBackground & Aim: Waltheria indica is a shrub whose roots are used in many communities of Northern Nigeria to manage several sexual behavioral disorders; however, there is no scientific study to verify this claim. The aim of the study is to determine the effect of methanol root extract of Waltheria indica and its fractions (ethyl acetate, n-butanol, and residual ethanol) on sexual orientation and sexual behavioral parameters in male albino rats.Experimental: Male rats were divided into five groups each containing 6 rats. Group 1 rats were treated with normal saline. Rats in Groups 2, 3 and 4 were treated with 50, 100 and 200 mg/kg crude extracts while rats in Group 5 were treated with Sildenafil 5 mg/kg. Treatment was administered once daily for 7 days. Female rats were artificially brought to oestrus by administering oestradiol 25 μg/kg and progesterone 500 μg/kg 48 and 8 h respectively prior to mating The mating was done in a 1:1 ratio and mating behaviour was observed on days 1 and 7. Similar procedure was repeated, normal saline, 12.5 and 25 mg/kg of the ethyl acetate, n-butanol and mother liquor fractions, respectively and sexual behavioral parameters were observed.Results: Crude extract and fractions of Waltheria indica significantly increased sexual behavioral parameters, with the n-butanol and mother liquor fractions being most active.Recommended applications/industries: The study showed that methanol root extract of Waltheria indica and its fractions have aphrodisiac activity with the n-butanol and residual methanol fractions being more active. These revelations further substantiates the traditional use of Waltheria indica for the management of infertility in male, thus such discovery can serve as a lead for the development of drugs for the management of sexual dysfunctions. پرونده مقاله
پربازدیدترین مقالات
-
دسترسی آزاد مقاله
1 - Study the ethnobotany of medicinal plants in Sirjan, Kerman province, Iran
فریبا شریفی فر عابد کوهپایه محمد مهدی متقی آرزو امیرخسروی الهام پور محسنی نسب منصوره خداشناسشماره 3 , دوره 1 , تابستان 2010Background & Aim: Since traditional knowledge is base of producing new herbals and other natural products, and old people of ancient cities know about characteristics of such herbals, therefore, death of such people will gradually causes demolishing of their knowled چکیده کاملBackground & Aim: Since traditional knowledge is base of producing new herbals and other natural products, and old people of ancient cities know about characteristics of such herbals, therefore, death of such people will gradually causes demolishing of their knowledge about herbals. Therefore, it seems it is necessary to register and save such information. The goal of this research is to study and survey about ethnobotany of herbals among people live in Sirjan city in order to learn about way of using these herbals in this area through traditions and customs.Martial & Methods: In this research, at first, the mentioned area divided into different parts by means of geographical maps and then a questionnaire prepared to collect the natives' information about using which parts of herbals in what cases and how to use them. After that, herbals grown in different areas were moved to pharmacy department of Kerman when collected, dried and their herbarium made.Results & Discussion: Finally, 77 species of herbals collected from different areas of Sirjan and registered after identification of each species and their related information (using cases, how and which parts). Due to different cultures of using herbals between natives of Sirjan and other areas of the country and different ways of using various herbals and existence of special herbals in this area, remarkable results about native knowledge of natives using herbals in this area obtained.Conclusion: Considering high potential of herbals in Sirjan, the results of present research and other scientific surveys in this field can provide conditions for better application of herbals in order to prepare products of higher effects and lower harms. پرونده مقاله -
دسترسی آزاد مقاله
2 - Preparation of Echium amoenum herbal tea enriched by Malva and Althaea rosea var. nigra
افشین جعفرپور درسا نبی بخششماره 2 , دوره 9 , بهار 2019Background & Aim: Echium amoenum is most commonly used herb after tea with high nutritional values. The purpose of this research was to produce Echium amoenum herbal tea, enriched by Malva and Althaea rosea var. nigra, in order to enhance the sensory properties and چکیده کاملBackground & Aim: Echium amoenum is most commonly used herb after tea with high nutritional values. The purpose of this research was to produce Echium amoenum herbal tea, enriched by Malva and Althaea rosea var. nigra, in order to enhance the sensory properties and antioxidant activity of herbal tea. Experimental: In this study, antioxidant activity of alcoholic extract was evaluated by DPPH method. The turbidity was determined using spectrophotometer at 800 nm wavelength. Total ash, insoluble ash in acid, moisture content and sensory evaluation were performed according to the national standard methods. The moisture content of the whole samples was higher than the standard range for Echium amoenum. Therefore, for better grinding, the Echium amoenum will be dried again before the packaging process to remove additional moisture absorbed from the environment. Results & Discussion: The results showed that all samples had high antioxidant activity, but the sample containing 0% of the Malva, 30% of Althaea rosea var. nigra and 35% of Echium amoenum showed the most radical inhibition properties (95.04%) (p <0.05). Also, in sensory evaluation, this sample had the highest point with a significant difference (p <0.05) compared to other samples. So, it can be concluded that such a combination of studied herbs is suitable for preparation of herbal tea with high antioxidant and acceptable sensory properties. Industrial/ practical recommendations: The results of this study showed that the use of Echium amoenum and Althaea rosea var. nigra can produce herbal tea as a new product, with high antioxidant and desirable sensory properties. پرونده مقاله -
دسترسی آزاد مقاله
3 - Formulation and characterization of a functional dairy dessert containing Moringa oleifera extract and Inulin
پویا حسن نژاد زهرا بیگ محمدی نفیسه جهانبخشیانشماره 2 , دوره 14 , بهار 2023Background & Aim: Today, due to the importance of nutrition and the role of food on human health, attention has been paid towards the production of foods rich in functional and beneficial compounds, as well as low calorie products to reduce various diseases such as چکیده کاملBackground & Aim: Today, due to the importance of nutrition and the role of food on human health, attention has been paid towards the production of foods rich in functional and beneficial compounds, as well as low calorie products to reduce various diseases such as diabetes, obesity, cardiovascular diseases, etc. The aim of this research was to develop a functional and low-calorie dairy dessert using long-chain inulin and Moringa oleifera extract.Experimental: Moringa oleifera extract (ME) was prepared by the percolation method and used in combination with inulin in the formulation of low-calorie dairy dessert based on maltitol and sucralose as sweeteners. ME was used at 1%, 2% and 3% (w/w) levels and inulin at 5% and 7% levels. The moisture, ash, fat, protein and carbohydrate content, as well as calorie, pH, acidity, soluble solids (brix), syneresis, viscosity, color indices, antioxidant capacity and sensory characteristics (color, flavor, texture, mouth feel and overall acceptability) of the dairy dessert treatments were examined after production.Results: The addition of inulin and ME showed a significant effect on the chemical composition of the desserts and reduced the calories of the treatments compared to the control. Increasing the level of ME did not affect the syneresis and viscosity of the desserts, while by increasing the level of inulin from 5% to 7%, viscosity increased and syneresis decreased significantly (P<0.05). Incorporation of ME into the formulation of dairy dessert also reduced the L* and a* and increased the b* values of the samples (P<0.05). By adding ME and increasing its level from 1% to 3% in the formulation, significant improvement in the antioxidant capacity of the desserts was observed, so that the highest antioxidants capacity was evaluated in the samples containing 7% ME (37.53-37.82%). The results of sensory evaluation indicated that all treatments were acceptable, and the desserts containing lower levels of ME obtained higher flavor, color and overall acceptability scores.Recommended applications/industries: The results of this research demonstrated that inulin as a prebiotic and Moringa oleifera extract as a rich source of bioactive and antioxidant compounds can be used to develop a functional low-calorie dairy dessert. پرونده مقاله -
دسترسی آزاد مقاله
4 - Botanical, phytochemical and pharmacological properties of quinoa medicinal plant (Chenopodium quinoa Willd.): A review
نسیم پاکباز حشمت امیدی حسنعلی نقدی بادی امیر بوستانیشماره 4 , دوره 12 , پاییز 2021Background & Aim:Climatic and geographical conditions of Iran and some factors such as climate change, water limitation and the existence of soils with salinity limitation, the cultivation of medicinal plants compatible with such conditions is one of the most import چکیده کاملBackground & Aim:Climatic and geographical conditions of Iran and some factors such as climate change, water limitation and the existence of soils with salinity limitation, the cultivation of medicinal plants compatible with such conditions is one of the most important strategies. Quinoa (Chenopodium quinoa Willd) is a valuable medicinal plant and will also contribute to community health. Quinoa has been cultivated in the Andes for about 5,000 years. The largest area under quinoa cultivation in Bolivia is 100,000 ha. In this review, the botany, traditional uses, phytochemical and pharmacological properties of quinoa are discussed.Experimental:In the current review keywords including quinoa and medicinal properties were searched in scientific websites such as Science Direct, PubMed and Google Scholar to compile the botanical and medicinal properties of quinoa (Chenopodium quinoaWilld.).Results:According to the literature review, quinoa protein is 8-22% with proper quality and balance of essential amino acids (lysine, methionine and thyronine). The amount of essential amino acids in quinoa is higher than the daily requirement set by the World Food Organization and the World Health Organization for each person. Compared to other grains, quinoa is high in alpha tocopherols (vitamin E), riboflavin, thiamine and vitamin C, and has 10 times more folic acid. Quinoa seeds are a safe, gluten-free alternative to cereal grains among celiac patients.Recommended applications/ industries:Quinoawith a high amount of biochemical components and pharmacological effects can be used as a valuable herbal drug. It also provides a gluten-free diet, which is beneficial for celiac patients. Its cultivation for industrial and pharmaceutical purposes can help to improve the production of anti-oxidant, anti-diabetic, anti-inflammatory, anti-celiac and anti-cancer drugs in Iran. پرونده مقاله -
دسترسی آزاد مقاله
5 - Histomorphometric study on the effect of pine tree gum on wound healing of Wistar rats
احمد روزبهانی الهام مقتدایی مصطفی نوربخششماره 2 , دوره 9 , بهار 2019Background & Aim: The most therapeutic properties of different species of Pinus class are antimicrobial and anti-inflammatory characteristics, soothing effect, resolver of skin itches, wound, acne and rash healer and improvement of ulcers and chronic lesions. In anc چکیده کاملBackground & Aim: The most therapeutic properties of different species of Pinus class are antimicrobial and anti-inflammatory characteristics, soothing effect, resolver of skin itches, wound, acne and rash healer and improvement of ulcers and chronic lesions. In ancient medical literature of Iran, different parts of Pinus classes, particularly its resin, had been used for treating the chronic lesions. This research was conducted to evaluate the effects of resin extract of Pinus eldarica on skin wound healing process in rats. Experimental: In this research, ointment was prepared with 40% of Pinus eldarica resin. Then, 24 Wistar rats divided into 4 groups of 6 rats including resin recipient group (experimental group), positive control group (topical phenytoin), negative control group (Eucerin group) and the control group which received no treatment. After anesthesia, a 2 × 2 cm lesion was created on the lumbar area of the rats. After wounding, ointments plastering was conducted until 21 days after incision. Results & Discussion: On day 3, 7, 21 after incision, morphological and histological characteristics of the wounds were examined. Statistical analysis of results showed that on different days, wound surface was meaningfully decreased (p<0.05) and the effect of phenytoin and pine tree resin on wound healing was equal without significant differences (p<0.05). On the other hand, reducing the wound surface in all three experimented group were greater than the control group. Histopathologically, in resin recipient group, the collagen fiber arrangements were in the best condition and the inflammatory cells were in their lowest numbers maybe because of the effect on fibroblasts. Therefore, preparation and plastering of pine tree resin are recommended for flesh wounds. Industrial/ Practical recommendations: Considering the positive effects of pine resin on wound healing, it can be used in the preparation of burning ointments. پرونده مقاله -
دسترسی آزاد مقاله
6 - Cannabis sativa in ethanol (Monkey Tail) and tramadol induced similar degrees of toxicity in adult female Wistar rats
چینومسو آرون امانوئل اکوبوگو سلیمان ایجیوما رابرت اوروکو اوچه آرونسی کینگزلی اوگووانی ویکتور اوگویکشماره 1 , دوره 13 , زمستان 2022Background & Aim: This study was designed to evaluate the toxic effects of Cannabis sativa local gin formulation (CSLGF) and tramadol in adult female Wistar rats.Experimental: Cannabis sativa local gin formulation (CSLGF) was prepared and was subjected to acute toxi چکیده کاملBackground & Aim: This study was designed to evaluate the toxic effects of Cannabis sativa local gin formulation (CSLGF) and tramadol in adult female Wistar rats.Experimental: Cannabis sativa local gin formulation (CSLGF) was prepared and was subjected to acute toxicity tests together with tramadol. In the main study, 25 rats were assigned into 5 groups (n = 5) in which the group 1 received no treatment, groups 2 and 3 received 25 and 50 mg/kg of tramadol, respectively while groups 4 and 5 received 25 and 50 mg/kg of CSLGF, respectively, for 21 days before the rats were sacrificed.Results: Acute toxicity results indicated narrow margins of safety for CSLGF and tramadol with LD50 values of 123.0 and 133.0 mg/kg body weight, respectively. The rats treated with CSLGF lost weight significantly while that administered tramadol had lower weight gains when compared with the control (P<0.05). The red blood cell counts, packed cell volume and haemoglobin concentrations were significantly lowered by CSLGF (P<0.05). However, a significant increase in the number of platelets and white blood cells were observed in groups treated with both CSLGF and tramadol. Results of biochemical changes showed a significant increase in aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total bilirubin, urea and creatinine with a concurrent decrease in total protein, albumin and globulin values following treatment with both agents (P<0.05), but serum electrolytes concentrations were not significantly altered (P>0.05). Treatment with CSLGF and tramadol also significantly lowered glutathione, superoxide dismutase and catalase activities but increased malondialdehyde concentrations when compared with control.Recommended applications/industries: The findings show that although the toxic effects of CSLGF and tramadol in rats are similar, CSLGF appears to have higher toxicity potentials. Extending the current control on tramadol to CSLGF (monkey tail) is urgently needed in Nigeria to protect human lives. پرونده مقاله -
دسترسی آزاد مقاله
7 - Chemical composition and biological activities of Nepeta hindostana (Roth) Haines, Nepeta graciliflora Benth. and Nepeta cataria L. from India
مونیکا جوشی راوندرا کومار ام پراکاش آنیل پانت D. راواتشماره 2 , دوره 12 , بهار 2021Background & Aim:Intraditional medicine system, Nepeta species are widely used to reduce chicken pox, tuberculosis, malaria, pneumonia, influenza, measles, stomach disorders, eye complaints, respiratory disorders, asthma, colds, coughs etc. The aim of the present st چکیده کاملBackground & Aim:Intraditional medicine system, Nepeta species are widely used to reduce chicken pox, tuberculosis, malaria, pneumonia, influenza, measles, stomach disorders, eye complaints, respiratory disorders, asthma, colds, coughs etc. The aim of the present study was to evaluate the chemical composition and biological activities of the essential oils from three species of genus Nepeta viz: Nepeta hindostana (Roth) Haines (NHO), Nepeta graciliflora Benth (NGO) and Nepeta cataria L (NCO).Experimental: The essential oils were analysed by the combination of GC and GC-MS. Antioxidant activity was tested by using reducing power assay, metal chelating of Fe2 +assay, and DPPH radical scavenging assay. In-vitro antinflammatory activity was evaluated using albumin denaturation assay and anti-diabetic activity was determined by using α-amylase assay.Results: The major components present in NCO, NHO and NGO were cis-nepetalactone (69.78%), β-farnesene (43.41%) and sesquisabinene (28.75%), respectively. NCO showed the highest percentage inhibition of DPPH radical (IC50=5.89 µl/ml) followed by NHO (IC50=8.63 µl/ml) and then NGO (IC50=13.81 µl/ml). In terms of reducing power assay and metal chelating of Fe2+ assay, the highest antioxidant activity was also shown by NCO. Among the tested essential oil, NCO showed highest in-vitro anti-inflammatory potential (IC50 18.463±0.14 µg/ml) followed by NGO and NHO with IC50 22.035±0.11 µg/ml and 26.17±0.14 µg/ml, respectively. NHO showed maximum antidiabetic activity with IC50 8.92±0.10 µg/ml of α-amylase.Recommended applications/industries: On the basis of present research work it is marked that the essential oil of Nepeta hindostana (Roth) Haines, Nepeta graciliflora Benth. and Nepeta cataria L. is a potent antioxidant, anti-inflammatory and anti-diabetic agent indicating their potentiality in the field of food, pharmaceutical and cosmetic industry پرونده مقاله -
دسترسی آزاد مقاله
8 - The Effects of Cinnamon on Polycystic Ovary Syndrome
مهرداد استادپور مجید غلامی آهنگران سیدحسین حیدریشماره 3 , دوره 14 , تابستان 2023Background & Aim: Polycystic ovary syndrome (PCOS) is a major endocrine disorder in young age women affecting their health-related quality of life (HRQOL) and their mental well-being as well. In this review, the authors discuss the effect of cinnamon as an herbal me چکیده کاملBackground & Aim: Polycystic ovary syndrome (PCOS) is a major endocrine disorder in young age women affecting their health-related quality of life (HRQOL) and their mental well-being as well. In this review, the authors discuss the effect of cinnamon as an herbal medicine on PCOS in humans and introduce the advantages and efficacy of these herbs on the control of this problem.Experimental: In this review, the authors searched the main related keywords e.g. polycystic, and cinnamon in main biological data centers e.g. Science Direct, Pubmed and Google Scholar. Then, the authors classified articles and only discussed the valid full papers in different categories.Results: The study of papers related to the effect of cinnamon on polycystic ovary syndrome revealed that this herb can control this problem via some route e.g., by control of triglyceride and cholesterol to diminish risk factors of fat deposition and by inhibitory effects on oxidative cascade decreasing the cystic formation process.Recommended applications/industries: The review proposed the positive effect of cinnamon on the control of PCOS in humans. Therefore, supplementary cinnamon on feed can diminish PCOS via some metabolic cycle. پرونده مقاله -
دسترسی آزاد مقاله
9 - Formulation design and evaluation of the physicotechnical and hypoglycaemic properties of tablets containing Dioscorea dumetorum fraction in alloxanized diabetic rats
آزوبیکه اوکولی چوکووبوکا اومیور کالیستوس نواکیله ابره اوکویی توچوکو او ککه امانوئل اوروناچیشماره 3 , دوره 12 , تابستان 2021Background & Aim: There is increasing interest in the quest for safe and relatively inexpensive medicines from natural products for the treatment of diabetes mellitus (DM). Thus, the main thrust of this study was to formulate and evaluate the anti-diabetic activity چکیده کاملBackground & Aim: There is increasing interest in the quest for safe and relatively inexpensive medicines from natural products for the treatment of diabetes mellitus (DM). Thus, the main thrust of this study was to formulate and evaluate the anti-diabetic activity of tablets containing aqueous fraction of Dioscorea dumetorum (bitter yam).Experimental: D. dumetorum was extracted using ethanol followed by aqueous fractionation. A rational amount (200 mg) of the fraction (drug) was blended used to produce seven batches of granules by wet granulation and their micromeritic profiles were determined. The granules were compressed into seven batches of tablets and quality control tests including weight uniformity, crushing strength, friability, drug content, disintegration, and dissolution profiles were undertaken. Anti-diabetic activity of the tablets was assayed using alloxan-induced diabetic rats.Results: Results showed that the granules had good flow properties and compressibility. Tablets produced had good uniformity of weight (0.64 ± 0.01 to 0.66 ± 0.01 g), hardness (4.33 to 8.67 kgf), were less friable (0.05 ± 0.03 to 0.31 ± 0.04 %) with high drug content (98.91 ± 0.55 to 101.39 ± 0.92 %), had acceptable disintegration time (6.44 ± 0.46 to 14.05 ± 0.42 min) for normal release tablets, and recorded 70 – 100 % drug release in 60 min. The result of the anti-diabetic activity study showed that the tablets had blood glucose lowering ability similar to metformin tablet, and therefore could be used as an important alternative in the treatment of diabetes.Recommended applications/industries: Aqueous fractions of D. dumetorum should be further purified and used in the preparation of tablets for the treatment of diabetes mellitus. Extraction and fractionation methods for the plant should be made reproducible for easier industrial application. پرونده مقاله -
دسترسی آزاد مقاله
10 - Approaches and therapeutic effects of Saffron (Crocus sativus L.) and Barberry (Berberis vulgaris) in the treatment and prevention of diseases: A review
محمد سعیدیشماره 3 , دوره 12 , تابستان 2021Background & Aim: Natural compounds as drugs have fewer and more cost-effective side effects that can be utilized as pharmacological and therapeutic approaches. Traditional medicine can be an efficacious resource in the development of research to treat diseases.Expe چکیده کاملBackground & Aim: Natural compounds as drugs have fewer and more cost-effective side effects that can be utilized as pharmacological and therapeutic approaches. Traditional medicine can be an efficacious resource in the development of research to treat diseases.Experimental: In this review article, keywords including Saffron (Crocus sativus L.), Barberry (Berberis vulgaris), and their medicinal attributes were searched in prominent databases (such as Scopus, and Web of Science, etc.) and professional websites to collect the medicinal properties of Saffron, and Barberry.Results: Saffron is one of the most important natural compounds that has a wide range of utilizations in traditional medicine and has effects such as anti-cancer, anti-depressant, antispasmodic, nerve sedative, appetizer and also barberry is another natural substance that has considerable influences such as anti-arrhythmia, sedative, reducing blood pressure (BP) and anti-cancer. Saffron and its bioactive components have been revealed to have anti-neurodegenerative influences.Recommended applications/industries: In the present review article, we have made an endeavor to explore approach and therapeutic effects of Saffron and Barberry in the treatment of diseases in clinical trials and animal model studies. Research in clinical trials promising findings that support the role of barberry and saffron in ameliorating disease and safety, although more research is needed to prove their role in treating the disease پرونده مقاله
