Background & Aim:Nigella sativa L. (Black seeds) which is a member of the Ranunculaceae family, grows in Southwestern Asia, Europe, and Northern Africa. The use ofN. Sativaseeds and oil in traditional remedies goes back more than 2000 years, and the herb is describe
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Background & Aim:Nigella sativa L. (Black seeds) which is a member of the Ranunculaceae family, grows in Southwestern Asia, Europe, and Northern Africa. The use ofN. Sativaseeds and oil in traditional remedies goes back more than 2000 years, and the herb is described as ‘the Melanthion’ by hippocrates and dioscorides.Experimental: In the current literature review, key words including N. Sativa, thymoquinone, black seeds, toxicity, protection of hepatocellular were searched in scientific websites such as Science Direct, PubMed, Google Scholar etc. to compile the protective effects of N. Sativaagainst hepatocellular damage.Results: Many active components of N. Sativahave been identified, including thymoquinone, dithymoquinone, thymohydroquinone, nigellone, melanthin, nigilline, nigelamine, damascenone, p -cymene and pinene. N. Sativais a medicinal plant with antifungal, anti-viral, anti-bacterial, anti-parasite, anti-oxidant, analgesic, antipyretic, anti-tussive, and anti-inflammatory properties. Thymoquinone could prevent many disorders such as neurobehavioral kidney and liver disorders. N. Sativawas also found to be able to relieve the symptoms of patients with several diseases, such as hypertension, dyslipidemia, metabolic syndrome, diabetes and natural and chemical toxicities.Recommended applications/industries: According to literature,N. Sativatreatment will decrease the elevated lipid peroxidation, liver enzyme levels and increase antioxidant enzyme levels. N. Sativaadministration can also protect hepatic tissue from deleterious effects of toxic metals.
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