Nuhu Danjuma Articles List

List of Articles Nuhu Danjuma

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1 - Methanol leaf extract of Albizia chevalieri Harms possesses anticonvulsant activity in acute and chronic models of epilepsy
احمد دنبالا بیلکیسو میها نوهو دانجوما عبداله نظیفی

Background & Aim:Albizia chevalieriHarms (Mimosaceae) is widely used in traditional medicine to treat various kinds of diseases such as epilepsy, diabetes mellitus, hemorrhoids, asthma, leprosy and gonorrhoea. The effectiveness of its leaf extract in the management More

Background & Aim:Albizia chevalieriHarms (Mimosaceae) is widely used in traditional medicine to treat various kinds of diseases such as epilepsy, diabetes mellitus, hemorrhoids, asthma, leprosy and gonorrhoea. The effectiveness of its leaf extract in the management of epilepsy is widely acclaimed among communities in northern Nigeria. This study aimed at evaluating the anticonvulsant effects of methanol leaf extract ofA. chevalieriusing acute and chronic models of epilepsy. Experimental:Median lethal dose (LD50) of the extract was determined in chicks, mice and rats via intraperitoneal route. Anticonvulsant screening of the extract was performed using maximal electroshock-induced seizure test in day-old chicks; Pentylenetetrazole (PTZ)-, picrotoxin- and 4-aminopyridine-induced seizure models in mice. Similarly, its effects on pentylenetetrazole-induce kindling in rats was evaluated. Results:Intraperitoneal LD50values of the extract were estimated to be 1200, 1130 and 2150 mg/kg in chicks, mice and rats, respectively. The extract provided a dose dependent protection and significantly (P<0.01) increased in the mean onset of seizures induced by PTZ. At 300 mg/kg, it also offered 66.67 and 50% protection against picrotoxin- and 4-aminopyridine-induced seizures, respectively. The extract reduced the severity of seizure episodes induced by sub-convulsive doses of PTZ. The reduction was significant (P<0.01) at 75 and 300 mg/kg on day 11 when seizure score 5 was reached. These findings suggest thatA.chevalierileaf extract possessesanticonvulsant and antiepileptogenic properties. Recommended applications/industries:The anticonvulsant properties ofA.chevalierican be applied in the treatment of epilepsy Manuscript profile
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2 - Memory-enhancing potentials of hydroalcoholic extract of Eragrostis tremula Hochst. exSteud. (Poaceae) in mice
عبداله نظیفی محمد گربا موسی علیو نوحو محمد دانجوما

Background & Aim:Cognitive impairment is one of the age-related mental problems and a typical indicator of neurodegeneration. Eragrostis tremula Hochst. ex Steud. is a commonly used medicinal plant in Nigeria for memory enhancement. This study, therefore, aimed at e More

Background & Aim:Cognitive impairment is one of the age-related mental problems and a typical indicator of neurodegeneration. Eragrostis tremula Hochst. ex Steud. is a commonly used medicinal plant in Nigeria for memory enhancement. This study, therefore, aimed at evaluating the memory-enhancing potential of aqueous ethanolic extract of E. tremula in mice. Experimental: Classes of phytochemicals present in the extract were determined using standard protocol while its oral median lethal dose (LD50) in mice was estimated. The effect of E. tremula extract (125, 250 and 500 mg/kg) on learning and memory was evaluated in mice using behavioural paradigms: elevated plus maze (EPM), novel object recognition and Barnes maze. Open field and hole-board tests were also carried out to evaluate locomotion. Results: The phytochemical constituents of E. tremula were alkaloids, cardiac glycosides, flavonoids, tannins, saponins, steroids and triterpenes. Oral LD50 was estimated to be >5000 mg/kg. E. tremula extract significantly (P<0.05) decreased the transfer latency of mice during the retention phase of EPM test. In the novel object recognition test, it significantly (P<0.05) increased the discrimination index. In Barnes maze test, the extract significantly (P<0.05) decreased the mean primary errors during the acquisition trials. It also significantly (P<0.05) decreased the primary latency, primary error and increased the time spent in the target quadrant during the probe trial. E. tremula extract significantly (P<0.05) decreased the immobility time of mice in an open field at 250 mg/kg, while in the hole-board test, it significantly (P<0.05) increased the mean head-dip of mice at 125 mg/kg when compared to the negative control. Recommended applications/industries: The ethanol extract of E. tremula possesses memory enhancing properties which can be utilized in the management of amnesia and cognitive deficit. Manuscript profile
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3 - Analgesic and anti-inflammatory effects of Chlorophytum alismifolium extract in murine models
عبدالحکیم ابوبکر امینا نازو عبدالهی نظیفی زهاتو محمد ادریس ماج نوحو محمد

Background & Aim:Medical conditions associated with pains and inflammation are prevalent in the global population. The tubers of Chlorophytum alismifolium are widely used traditionally in Nigeria for the management of pain and inflammation. This study aims to establ More

Background & Aim:Medical conditions associated with pains and inflammation are prevalent in the global population. The tubers of Chlorophytum alismifolium are widely used traditionally in Nigeria for the management of pain and inflammation. This study aims to establish the chemical profile and evaluate the anti-inflammatory and analgesic activities of the hexane extract of C. alismifolium (HECA) tubers in experimental animals. Experimental: Gas chromatography-mass spectrometry (GC-MS), phytochemical screening and acute toxicity studies were conducted according to standard protocols. Analgesic activity was investigated with graded doses of HECA (250, 500 and 1000 mg/kg) using acetic acid-induced writhing test in mice and formalin-induced pain in rats; while the anti-inflammatory activity was evaluated using carrageenan-induced paw oedema model in rats. Results: The GC-MS analysis revealed the presence of eighteen compounds covering an area of approximately 100%. Phytochemical screening revealed the presence of flavonoids, alkaloids, steroids and triterpenes while the oral median lethal dose was estimated to be >5000 mg/kg in rats and mice. In the 4th and 5th hour of the carrageenan test, HECA at 500 and 1000 mg/kg significantly (p <0.01) reduced the oedema index, respectively. In the analgesic study, HECA significantly (p <0.001) reduced the mean number of writhes with the highest inhibition (79.67%) obtained at 500 mg/kg. In the formalin test, HECA at 250 mg/kg significantly (p <0.05) reduced the mean pain scores in both phases of the test.Recommended applications/industries: The findings depict that HECA possesses pharmacologically active compounds that can be applied in the management of inflammation and pain. Manuscript profile

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List of Articles Nuhu Danjuma