Abdullahi Nazifi Articles List

List of Articles Abdullahi Nazifi

Open Access Article
- Abstract Page
- Full-Text
1 - Methanol leaf extract of Albizia chevalieri Harms possesses anticonvulsant activity in acute and chronic models of epilepsy
احمد دنبالا بیلکیسو میها نوهو دانجوما عبداله نظیفی

Background & Aim:Albizia chevalieriHarms (Mimosaceae) is widely used in traditional medicine to treat various kinds of diseases such as epilepsy, diabetes mellitus, hemorrhoids, asthma, leprosy and gonorrhoea. The effectiveness of its leaf extract in the management More

Background & Aim:Albizia chevalieriHarms (Mimosaceae) is widely used in traditional medicine to treat various kinds of diseases such as epilepsy, diabetes mellitus, hemorrhoids, asthma, leprosy and gonorrhoea. The effectiveness of its leaf extract in the management of epilepsy is widely acclaimed among communities in northern Nigeria. This study aimed at evaluating the anticonvulsant effects of methanol leaf extract ofA. chevalieriusing acute and chronic models of epilepsy. Experimental:Median lethal dose (LD50) of the extract was determined in chicks, mice and rats via intraperitoneal route. Anticonvulsant screening of the extract was performed using maximal electroshock-induced seizure test in day-old chicks; Pentylenetetrazole (PTZ)-, picrotoxin- and 4-aminopyridine-induced seizure models in mice. Similarly, its effects on pentylenetetrazole-induce kindling in rats was evaluated. Results:Intraperitoneal LD50values of the extract were estimated to be 1200, 1130 and 2150 mg/kg in chicks, mice and rats, respectively. The extract provided a dose dependent protection and significantly (P<0.01) increased in the mean onset of seizures induced by PTZ. At 300 mg/kg, it also offered 66.67 and 50% protection against picrotoxin- and 4-aminopyridine-induced seizures, respectively. The extract reduced the severity of seizure episodes induced by sub-convulsive doses of PTZ. The reduction was significant (P<0.01) at 75 and 300 mg/kg on day 11 when seizure score 5 was reached. These findings suggest thatA.chevalierileaf extract possessesanticonvulsant and antiepileptogenic properties. Recommended applications/industries:The anticonvulsant properties ofA.chevalierican be applied in the treatment of epilepsy Manuscript profile
Open Access Article
- Abstract Page
- Full-Text
2 - Analgesic and anti-inflammatory effects of Chlorophytum alismifolium extract in murine models
عبدالحکیم ابوبکر امینا نازو عبدالهی نظیفی زهاتو محمد ادریس ماج نوحو محمد

Background & Aim:Medical conditions associated with pains and inflammation are prevalent in the global population. The tubers of Chlorophytum alismifolium are widely used traditionally in Nigeria for the management of pain and inflammation. This study aims to establ More

Background & Aim:Medical conditions associated with pains and inflammation are prevalent in the global population. The tubers of Chlorophytum alismifolium are widely used traditionally in Nigeria for the management of pain and inflammation. This study aims to establish the chemical profile and evaluate the anti-inflammatory and analgesic activities of the hexane extract of C. alismifolium (HECA) tubers in experimental animals. Experimental: Gas chromatography-mass spectrometry (GC-MS), phytochemical screening and acute toxicity studies were conducted according to standard protocols. Analgesic activity was investigated with graded doses of HECA (250, 500 and 1000 mg/kg) using acetic acid-induced writhing test in mice and formalin-induced pain in rats; while the anti-inflammatory activity was evaluated using carrageenan-induced paw oedema model in rats. Results: The GC-MS analysis revealed the presence of eighteen compounds covering an area of approximately 100%. Phytochemical screening revealed the presence of flavonoids, alkaloids, steroids and triterpenes while the oral median lethal dose was estimated to be >5000 mg/kg in rats and mice. In the 4th and 5th hour of the carrageenan test, HECA at 500 and 1000 mg/kg significantly (p <0.01) reduced the oedema index, respectively. In the analgesic study, HECA significantly (p <0.001) reduced the mean number of writhes with the highest inhibition (79.67%) obtained at 500 mg/kg. In the formalin test, HECA at 250 mg/kg significantly (p <0.05) reduced the mean pain scores in both phases of the test.Recommended applications/industries: The findings depict that HECA possesses pharmacologically active compounds that can be applied in the management of inflammation and pain. Manuscript profile
Open Access Article
- Abstract Page
- Full-Text
3 - Evaluation of hexane extract of Chlorophytum alismifolium on hyperglycaemia and neuropathic pain in high-fat diet and streptozotocin-induced diabetic Wistar rats
عبدالحکیم ابوبکر ادریس محمد ماج یوسف تانکو جوسف آنوکا عزالدین عبدالرحمن عبدالهی نظیفی

Background & Aim:Diabetes mellitus is an intricate metabolic disorder of the endocrine system associated with complications that result in morbidity and mortality. This study was carried out to establish the antihyperglycaemic profile and the effect of hexane extrac More

Background & Aim:Diabetes mellitus is an intricate metabolic disorder of the endocrine system associated with complications that result in morbidity and mortality. This study was carried out to establish the antihyperglycaemic profile and the effect of hexane extract of Chlorophytum alismifolium (HECA) on diabetic neuropathy in high-fat diet and streptozotocin-induced hyperglycaemic Wistar rats. Experimental: C. alismifolium tubers were extracted with n-hexane using a soxhlet apparatus. The LD50 was determined using the OECD 425 guideline. The animals were served high fat diet for 6 weeks and then administered 40 mg/kg of streptozotocin to induce diabetes. Experimental groups were set up using normal rats in group I and hyperglycaemic rats in 5 groups of 5 rats each. Group I and II were the normal and hyperglycaemic controls given distilled water (1 mL/kg); groups III, IV and V were given categorized doses of HECA (150, 300 and 600 mg/kg) respectively. Group VI received pioglitazone (20 mg/kg). Fasting glycaemic level was evaluated and diabetic neuropathy was investigated using thermal and mechanical methods. Results: Phytochemical screening showed the presence of flavonoids, alkaloids, steroids and triterpenes while the oral median toxic dose was estimated to be >5000 mg/kg. Administration of HECA at all doses evidently (p < 0.05) reduced the glycaemic level relative to the hyperglycaemic group and over time. Treatment with HECA also remarkably (p < 0.05) lowered the withdrawal times in both thermal and mechanical hyperalgesic methods of diabetic neuropathy compared to the hyperglycaemic control. Recommended applications/industries: The findings revealed that the hexane extract of Chlorophytum alismifolium has beneficial effects and can be applied in the management of diabetes and some of its complications. Manuscript profile

Current Issue

Published Issues

Menu

Browse

List of Articles Abdullahi Nazifi