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1 - Efficient one-pot synthesis and characterization of 13-Acetyl-9-methyl-11-oxo-8-oxa-10,12-diazatricyclo [7.3.1.0^2,7] trideca-2,4,6-triene
Hojatollah Salehi Mohammad Rabbani Qian-Rong Li Qing-xiang GuoAn efficient and environmentally friendly procedure for one-pot synthesis of 13-acetyl-9-methyl-11-ox-8-oxa-10,12-diazatricyclo [7.3.1. ] trideca-2,4,6-triene from salicylaldehyde, acetylaceton and urea via Biginelli condensation and intramolecular Michael-addition by u أکثرAn efficient and environmentally friendly procedure for one-pot synthesis of 13-acetyl-9-methyl-11-ox-8-oxa-10,12-diazatricyclo [7.3.1. ] trideca-2,4,6-triene from salicylaldehyde, acetylaceton and urea via Biginelli condensation and intramolecular Michael-addition by using magnesium bromide as an expensive and easily available catalyst under solvent-free condition is desired. The structural elucidation of the product is also described by -and -NMR spectra and the detailed fragmentation routs of EI-TOFMS تفاصيل المقالة -
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2 - بررسی واکنشهای چند جزئی مرتبه بالا و کاربردهای بیولوژیکی محصولات آنها
جواد صفایی قمی سیما کلهر زهرا کلهرواکنشهای چندجزئی یکی از موفقترین روشها درزمینهٔ افزایش تنوع ساختاری و پیچیدگی مولکولی با استفاده از یک فرایند ساده است. این روش بهعنوان فرایندی درحالتوسعه برای تهیه ترکیبات دارویی، امکان گسترش بسیاری از ترکیبات شیمیایی را، با تنوع ساختاری بیشتر میدهد؛ بنابراین این أکثرواکنشهای چندجزئی یکی از موفقترین روشها درزمینهٔ افزایش تنوع ساختاری و پیچیدگی مولکولی با استفاده از یک فرایند ساده است. این روش بهعنوان فرایندی درحالتوسعه برای تهیه ترکیبات دارویی، امکان گسترش بسیاری از ترکیبات شیمیایی را، با تنوع ساختاری بیشتر میدهد؛ بنابراین این واکنشها که باعث تغییر و تحول اساسی در سنتز همه محصولات طبیعی شده؛ با سرعت زیادی در طول چند دهه گذشته گسترشیافته است. تا امروز بسیاری از واکنشهای جدید سه و چهارجزئی معرفیشدهاند؛ درصورتیکه نمونههایی از واکنشهای "مرتبه بالاتر" که در آن پنج یا حتی تعداد اجزاء بیشتری در ظرف واکنش باهم ترکیب میشوند، به شکل قابلملاحظهای کمتر بررسی شده است. در پایان قرن بیستم با افزایش مزیتهای "مولکولهای بیولوژیک فعال" ، بررسی کاربرد این واکنشها برای تهیهی "مولکولهای کوچک شبه دارویی" در صنایع و دانشگاهها افزایش یافته است. از مزیتهای این روش نسبت به روشهای دیگر، استفاده از مواد اولیه در دسترس، کمهزینه بودن، روش کار ساده، طیف گسترده کالا، ایجاد تنوع بالا در چند مرحله، سهولت اتوماسیون و... میباشد. هدف از این بررسی، توصیف تحولات ایجادشده در سالهای اخیر، ایدهها، چالشها و ارائه پیشنهادهایی برای پیشرفت در این زمینه میباشد. تفاصيل المقالة -
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3 - Three-component Process for the Synthesis of Some Thiophene Derivatives Using Water as a Green Media
Ali Varasteh MoradiA convenient and efficient three-component reaction to a one-pot synthesis of thiophene derivatives from activated acetylenic compounds and ethyl 2chloroacetoacetate in the presence of tetramethyl thiourea in water lead to the formation of thiophenes in good yields.A convenient and efficient three-component reaction to a one-pot synthesis of thiophene derivatives from activated acetylenic compounds and ethyl 2chloroacetoacetate in the presence of tetramethyl thiourea in water lead to the formation of thiophenes in good yields. تفاصيل المقالة -
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4 - One-pot Synthesis of 2-amino-4H-chromene Derivatives as Potential Antimicrobial Agents using DABCO-CuCl Complex as an Effective Catalyst
Bita Baghernejad Samaneh KooshaA new and efficient synthesis of 2-amino-4H-chromene derivativeswhich have remarkable pharmacological properties is developed by one-pot three-component efficient reaction between aldehydes, malononitrile, andα or β-naphthol in MeOH as solvent using DABCO-CuC أکثرA new and efficient synthesis of 2-amino-4H-chromene derivativeswhich have remarkable pharmacological properties is developed by one-pot three-component efficient reaction between aldehydes, malononitrile, andα or β-naphthol in MeOH as solvent using DABCO-CuCl complex as an effective catalyst at room temperature. The structures of synthesized compounds were characterized by techniques of IR,1H-NMR, Mass and elemental analysis. This method provides an efficient improved pathway for the synthesis of chromenes in the terms of excellent yields, short reaction times and reusability catalyst. تفاصيل المقالة -
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5 - One-pot Synthesis of Amidoalkyl Naphthol Derivatives as Potential Nucleoside Antibiotics and HIV Protease Inhibitors using Nano-SnO2 as an Efficient Catalyst
Bita Baghernejad Elham AshooriAn efficient three-component one-pot synthesis of 1-amidoalkyl-2-naphthols from 2-naphthol, aldehydes, and acetamide using nano-SnO2as catalyst is described. The reactions were carried out at 80oC under water-solvent media. The structures of the compounds were character أکثرAn efficient three-component one-pot synthesis of 1-amidoalkyl-2-naphthols from 2-naphthol, aldehydes, and acetamide using nano-SnO2as catalyst is described. The reactions were carried out at 80oC under water-solvent media. The structures of the compounds were characterized by IR, 1HNMR, 13C-NMR, and Mass spectra and by elemental analysis. The advantages of the effective method were good yields, short reaction times, simple work-up, eco-friendly solvent, and inexpensive and reusable catalyst. The catalyst could be recycled and reused for five times without much loss in its activity. تفاصيل المقالة -
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6 - BF3-SiO2 Nanoparticles: An Efficient Catalyst for the Multi-Component Synthesis of 3-(α-aroylamido) 4-hydroxycoumarin Derivatives in Water
Mona Arfavi-Safari Hossein Anaraki-Ardakani Rashid Badri Elham TahanpesarA green and efficient one-pot three component reaction of 4-hydroxycoumarin or 1,3-dimethylbarbutyric acid, aryl glyoxals and amides (thioacetamide) has been developed in the presence of BF3- SiO2 nanoparticles in water. This method has several advantages such as high t أکثرA green and efficient one-pot three component reaction of 4-hydroxycoumarin or 1,3-dimethylbarbutyric acid, aryl glyoxals and amides (thioacetamide) has been developed in the presence of BF3- SiO2 nanoparticles in water. This method has several advantages such as high to excellent product yields in short reaction time, atom economy, environment friendly, reusable catalyst and no need for chromatographic separations. تفاصيل المقالة -
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7 - 4-Sulfobenzoic Acid as an Efficient Catalyst for the Preparation of 3,4-dihydropyrimidin-2-(1H)-ones Under Solvent-free Conditions
Ali Oudi Nourallah Hazeri Maryam FatahpourIn this research, one-pot three-component synthesis of 3,4-dihydropyrimidin-2-(1H)-ones havebeen developed using Biginelli reaction from the interaction between ethyl/methyl acetoacetate,aromatic aldehydes, and urea/thiourea in the presence of 4-sulfobenzoic acid as a n أکثرIn this research, one-pot three-component synthesis of 3,4-dihydropyrimidin-2-(1H)-ones havebeen developed using Biginelli reaction from the interaction between ethyl/methyl acetoacetate,aromatic aldehydes, and urea/thiourea in the presence of 4-sulfobenzoic acid as a new, effective,inexpensive, and available bronsted acid. Avoidance of toxic and dangerous solvents, easy isolationof products without the need of column chromatography, high yields, and short reaction time aresome important features of the present method. تفاصيل المقالة -
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8 - One-pot Synthesis of Xanthene Derivatives as Potential Antiviral and Anti-inflammatory Agents using Nano-SnO2 as an Efficient Catalyst
Bita Baghernejad Mahsa FiuzatAn efficient three-component one-pot synthesis of 1,8-dioxo-octahydroxanthenes from demedone, aldehydes, in the presence of a catalytic amount of nano-SnO2 is described. The reactions were carried out at 80oC under EtOH-solvent media. The structures of the compounds wer أکثرAn efficient three-component one-pot synthesis of 1,8-dioxo-octahydroxanthenes from demedone, aldehydes, in the presence of a catalytic amount of nano-SnO2 is described. The reactions were carried out at 80oC under EtOH-solvent media. The structures of the compounds were characterized by IR,1 H-NMR,13C-NMR, and Mass spectra and by elemental analysis. The advantages of the effective method were good yields, short reaction times, simple work-up, ecofriendly solvent, and inexpensive and reusable catalyst. The catalyst could be recycled and reused for five times without much loss of its activity. تفاصيل المقالة -
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9 - Sodium Bismuthate: An Efficient Catalyst for the One-pot Synthesis of Biologically Active Spiro[4H-pyran] Derivativesunder Solvent-free Conditions
Farzaneh Mohamadpour Malek Taher Maghsoodlou Reza Heydari Mojtaba LashkariAn efficient sodium bismuthate (NaBiO3) synthesis of biologically active spiro[4H-pyran]derivatives has been accomplished via one-pot three-condensation of isatin/acenaphthequinone, malononitrile and different reagents including 1,3-dicrbonyl compounds, α-naphthol أکثرAn efficient sodium bismuthate (NaBiO3) synthesis of biologically active spiro[4H-pyran]derivatives has been accomplished via one-pot three-condensation of isatin/acenaphthequinone, malononitrile and different reagents including 1,3-dicrbonyl compounds, α-naphthol and 4-hydroxycumarin under solvent-free conditions. The notable advantages of the present procedure are: eco-friendly, environmentally benign nature,low-cost and non-toxic catalyst, simplicity of operation with no necessity of chromatographicpurification steps, short reaction times, good to high yields and solvent-free conditions. تفاصيل المقالة -
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10 - Application of ZnO Nanorods for the Synthesis of Thiazole Derivatives via Multicomponent Reactions in Water
Ali Varasteh MoradiSimple three-component reactions between dialkyl acetylenedicarboxylate, primary amines and isothiocyanates in the presence of catalytic amount of ZnO nanorods are investigated in water at room temperature which produced thiazole derivatives in good yields.Simple three-component reactions between dialkyl acetylenedicarboxylate, primary amines and isothiocyanates in the presence of catalytic amount of ZnO nanorods are investigated in water at room temperature which produced thiazole derivatives in good yields. تفاصيل المقالة -
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11 - Solvent-Free Multicomponent Reactions of Dithiocarbamates, Activated Acetylenes and Isocyanides
F. Rostami-Charati Z. Hossaini R. HajinasiriAn efficient method to synthesis the 2H-pyrans using three component reactions of dithiocarbamats, activated acetylenes and isocyanides in water as the solvent is described. In these reactions, synthesis of 2H-pyrans is possible based on the one-pot reaction and without أکثرAn efficient method to synthesis the 2H-pyrans using three component reactions of dithiocarbamats, activated acetylenes and isocyanides in water as the solvent is described. In these reactions, synthesis of 2H-pyrans is possible based on the one-pot reaction and without using any catalyst. The mild reaction conditions and high yields of the products exhibit synthetic advantage of these methods. تفاصيل المقالة -
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12 - Application of 2-methylpyridinum p-toluenesulfonate ([2-MPy][p-TSA]) as an efficient catalyst for the one-pot synthesis of hexahydroquinolines-3-carboxamides
Matin Asadi Masoud Mokhtary2-Methylpyridinum p-toluenesulfonate ([2-MPy][p-TSA]) as a novel room temperature ionic liquidwas synthesized and evaluated as a recoverable catalyst for the one-pot synthesis ofhexahydroquinoline-3-carboxamide derivatives by four-component reaction of arylaldehydes,dim أکثر2-Methylpyridinum p-toluenesulfonate ([2-MPy][p-TSA]) as a novel room temperature ionic liquidwas synthesized and evaluated as a recoverable catalyst for the one-pot synthesis ofhexahydroquinoline-3-carboxamide derivatives by four-component reaction of arylaldehydes,dimedone, acetoacetanilide and ammonium acetate in high to excellent yield in ethanol at 50 oC.The [2-MPy][p-TSA] catalyst was characterized via FT-IR, 1H NMR and 13C NMR spectroscopy.An environmentally benign procedure, four-component in one pot reaction, high yields and simplepreparation of the catalyst are some advantages of this work. تفاصيل المقالة -
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13 - A simple, solvent-free four-component domino synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives catalyzed by copper (II) oxide
Farzaneh MohamadpourAn eco-safe and facile multi-component domino reaction has been described for the synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives. The products were obtained by a four-component condensation reaction between phthalimide, hydrazine monohydrate, arom أکثرAn eco-safe and facile multi-component domino reaction has been described for the synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives. The products were obtained by a four-component condensation reaction between phthalimide, hydrazine monohydrate, aromatic aldehyde derivatives and malononitrile in the presence of a catalytic amount of copper (II) oxide (CuO) under solvent-free conditions in high yields. The advantages of this one-pot procedure is environmentally friendly, efficient and economic availability of the catalyst, short reaction times, solvent-free conditions and clean reaction profiles. تفاصيل المقالة -
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14 - Water as the Green Media for the Synthesis of Isoquinoline Derivatives
Rokhsar Pahlavan Maedeh Najaf Zinatossadat HossainiAn efficient synthesis of isoquinoline-2,3-dicarboxylates is described via one-pot reactions of isoquinoline and alkyl bromids with dialkyl acetylenedicarboxylates in water at 70oC. Themild reaction conditions and high yields of the products exhibit thegood synthetic a أکثرAn efficient synthesis of isoquinoline-2,3-dicarboxylates is described via one-pot reactions of isoquinoline and alkyl bromids with dialkyl acetylenedicarboxylates in water at 70oC. Themild reaction conditions and high yields of the products exhibit thegood synthetic advantageof these methods. تفاصيل المقالة -
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15 - One-Pot Multi-Component Synthesis of Dihydropyrimidinones via Biginelli Condensation
Mohsen Sargordan Arani Behrooz Mirza Mohammad MoghanlouThree-component reactions have emerged as useful methods because the combinationof three components to generate new products in a single step is extremely economical,among the multi-component reactions. A green, simple, efficient, and cost-effective procedure has been c أکثرThree-component reactions have emerged as useful methods because the combinationof three components to generate new products in a single step is extremely economical,among the multi-component reactions. A green, simple, efficient, and cost-effective procedure has been carried out by the synthesis of dihydropyrimidinonesin Biginelli’s condensation of ethyl cyanoacetate, aldehyde and urea or thiourea .H3 BO3 , H2 C2 O4 , Me3 SiCl (TMSCl) using as catalyst and compared product yield.Products were characterized with IR, 1 H NMR, 13C NMR and mass spectroscopy تفاصيل المقالة -
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16 - One-pot Three-component Functionalization of Carboxylated Shortend Multi-wall Nanotubes with Histidine Derivative
Shahab Zomorodbakhsh Behrooz MirzaIn this project, a three-component functionalization of carboxylated shortend multi-walled carbon nanotubes (MWNT-COOH) by Histidine derivative via amidation method have been investigated. The functionalized MWNTs were characterized by Fourier Transform Infrared spec أکثرIn this project, a three-component functionalization of carboxylated shortend multi-walled carbon nanotubes (MWNT-COOH) by Histidine derivative via amidation method have been investigated. The functionalized MWNTs were characterized by Fourier Transform Infrared spectroscopy (FT-IR), Raman spectroscopy, elemental analysis and scanning electron microscopy (SEM). تفاصيل المقالة -
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17 - Cu(II) complex based on 3-hydroxy-2-naphtoic acid (Cu-HNA) as an efficient catalyst for the one-pot multicomponent synthesis of triazolo[1,2-a]indazole-triones under solvent free conditions
Ali JavidMulticomponent reactions (MCRs) are important for the achievement of high levels of diversity, as they allow more than two building blocks to be combined in practical, time-saving one-pot operations, giving rise to complex structures by simultaneous formation of two or أکثرMulticomponent reactions (MCRs) are important for the achievement of high levels of diversity, as they allow more than two building blocks to be combined in practical, time-saving one-pot operations, giving rise to complex structures by simultaneous formation of two or more bonds, according to the domino principle, higher productivity, simple procedures, facile execution, and play an important role in combinatorial chemistry. Among a large variety of nitrogen-containing heterocyclic compounds, heterocycles containing an urazole moiety are of interest because they constitute an important class of natural and non-natural products, many of which exhibit useful some biological as well as pharmaceutical activity. 1-hydroxy-2-naphtoic acid and 3-hydroxy-2-naphtoic acid as a ligand were applied for complexation with metal ions under different conditions. The lanthanides were used for the indication of oxygen of hydroxyl of the –COOH group in these compounds. In this work, an efficient, environmentally and high yielding procedure for the one-pot, three-component synthesis of triazolo[1,2-a]indazole-1,3,8-trione derivatives by condensation of dimedone, urazole, and aromatic aldehydes catalyzed by Cu (II) complex was equipped with 3-hydroxy-2-naphtoic acid ligand (Cu-HNA), as an ecofriendly catalyst with high catalytic activity and reusability at 100°C under solvent-free conditions is reported. The reaction proceeds to completion within 30–40 min in 82–92% yield. تفاصيل المقالة -
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18 - A Novel, Heterogeneous Catalyst for the One-Pot Synthesis of 1,8-Dioxodecahydroacridine Derivatives Under Solvent-Free Conditions
Tayebeh Sanaeishoar Mitra SaremiAn efficient and environmental-friendly synthetic route to 1,8-dioxodecahydroacridines derivatives have been developed via multi-component one-pot Hantzsch reaction of various aldehydes and ammonium acetate with 2 equivalents dimedone in the presence of Phosphorus pento أکثرAn efficient and environmental-friendly synthetic route to 1,8-dioxodecahydroacridines derivatives have been developed via multi-component one-pot Hantzsch reaction of various aldehydes and ammonium acetate with 2 equivalents dimedone in the presence of Phosphorus pentoxide supported on aluminaas catalyst under solvent-free conditions. The present approach offersseveral advantages such as short reaction times, easy isolation and purification of product, and safe, non-toxic, recyclable and economic use of catalyst. تفاصيل المقالة -
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19 - SOLVENT-FREE SYNTHESIS OF PYRROL DERIVATIVES USING MULTICOMPONENT REACTIONS OF 1,3-DICARBONYLS, ACTIVATED CARBONYL COMPOUNDS, AND PRIMARY ALKYLAMINES
Faramarz Rostami-Charati Mehdi Shahraki Mohammad R Hosseini- Tabatabaei Zinatossadat Hossainione-pot synthesis of pyrrole derivatives via reaction between activated carbonyl compounds, primary amines and 1,3-dicarbonyls under solvent-free conditions is described‎.one-pot synthesis of pyrrole derivatives via reaction between activated carbonyl compounds, primary amines and 1,3-dicarbonyls under solvent-free conditions is described‎. تفاصيل المقالة -
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20 - One-pot synthesis of triazolo[1,2-a]indazole-triones catalyzed by a novel magnetically and reusable green catalyst of Preyssler
Maryam Akbari Ali Javid Farid MoeinpourAn atom-efficient, eco-friendly, solvent-free, high yielding, multicomponent green strategy to synthesize triazolo[1,2-a]indazole-triones derivatives by the one-pot condensation of aldehyde, dimedone, and phenyl urazole under microwave Irradiationis presented. Reactions أکثرAn atom-efficient, eco-friendly, solvent-free, high yielding, multicomponent green strategy to synthesize triazolo[1,2-a]indazole-triones derivatives by the one-pot condensation of aldehyde, dimedone, and phenyl urazole under microwave Irradiationis presented. Reactions catalyzed by A novel nanomagnetic organic-inorganic hybrid catalyst (Fe@Si-Gu-Prs) was prepared by the chemical anchoring of Preyssler heteropolyacid (H14[NaP5W30O110]) onto the surface of modified Fe3O4 magnetic nanoparticles with guanidine-propyl-trimethoxysilane linker. A series of different substituted aromatic aldehydes including either electron-withdrawing or electron-donating groups used in this reaction participated well and gave the corresponding products in good to excellent yield. In this method, catalyst was isolated and reused several times, at least four times without significant loss of activity. تفاصيل المقالة -
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21 - Biginelli Synthesis and Theoritical Study of Dihydropyrimidinone Compounds
Mohammad Hosein Farjam Ramin RezaeiAn effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl2 as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yiel أکثرAn effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl2 as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yields, short reaction times for formation of the products and simple work-up are attractive features of this green protocol. تفاصيل المقالة -
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22 - Synthesis of new phenanthro imidazole derivatives in solvent free condition
Masih Golkariphenanthro Imidazole derivatives were made synthesis the combinations of phenanthroquinone , Benzealdehyde derivatives in the presence of amines compounds. In all reactions, reactions were investigated under Microwave conditions. The structure of all compounds was studi أکثرphenanthro Imidazole derivatives were made synthesis the combinations of phenanthroquinone , Benzealdehyde derivatives in the presence of amines compounds. In all reactions, reactions were investigated under Microwave conditions. The structure of all compounds was studied by an IR Spectrums and 1HNMR Spectrums. Excellent yields, short reaction times, simplicity of operation and easy separation are several advantages of this technique. The results shown that the optimal conditions for the formation of phenanthro derivative of imidazole are at 70 ˚C, the power of 400 W and the time of two minutes. تفاصيل المقالة -
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23 - Heterogeneous Catalyst for the One-Pot Synthesis of 1,8-Dioxodecahydroacridine
Haleh Sanaeishoar Mitra SeramiAn efficient and environmental-friendly synthetic route to 1,8-dioxodecahydroacridines derivatives have been developed via multi-component one-pot Hantzsch reaction of various aldehydes and ammonium acetate with 2 equivalents dimedone in the presence of Phosphorus pento أکثرAn efficient and environmental-friendly synthetic route to 1,8-dioxodecahydroacridines derivatives have been developed via multi-component one-pot Hantzsch reaction of various aldehydes and ammonium acetate with 2 equivalents dimedone in the presence of Phosphorus pentoxide supported on aluminaas catalyst under solvent-free conditions. The present approach offersseveral advantages such as short reaction times, easy isolation and purification of product, and safe, non-toxic, recyclable and economic use of catalyst. تفاصيل المقالة -
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24 - Biginelli Synthesis and Theoritical Study of Dihydropyrimidinones
Mohammad Hosein Farjam Ramin RezaeiAn effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl2 as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yiel أکثرAn effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl2 as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yields, short reaction times for formation of the products and simple work-up are attractive features of this green protocol. تفاصيل المقالة -
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25 - SOLVENT-FREE SYNTHESIS OF PYRROL DERIVATIVES USING MULTICOMPONENT REACTIONS OF 1,3-DICARBONYLS, ACTIVATED CARBONYL COMPOUNDS, AND PRIMARY ALKYLAMINES
Faramarz Rostami-Charati Mehdi Shahraki Mohammad R. Hosseini- Tabatabaei Zinatossadat HossainiA one-pot synthesis of pyrrole derivatives via reaction between activated carbonyl compounds, primary amines and 1,3-dicarbonyls under solvent-free conditions is described‎.A one-pot synthesis of pyrrole derivatives via reaction between activated carbonyl compounds, primary amines and 1,3-dicarbonyls under solvent-free conditions is described‎. تفاصيل المقالة -
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26 - Solvent-free One Pot Biginelli Method for Synthesis of new Dihydropyrimidinone compounds
Masih GolkariAn effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl2 as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yiel أکثرAn effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl2 as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yields, short reaction times for formation of the products and simple work-up are attractive features of this green protocol. تفاصيل المقالة -
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27 - Ultrasonic-assisted Synthesis of New Generation of Coumarins
Lia KarimianA convenient and efficient procedure for synthesis of Bis(4-HydroxyCoumarin) derivatives has been developed by a simple one-pot, one step ultrasonic-assisted reaction to produce Bis(4-HydroxyCoumarins) in room temperature. The present methodology offers several advantag أکثرA convenient and efficient procedure for synthesis of Bis(4-HydroxyCoumarin) derivatives has been developed by a simple one-pot, one step ultrasonic-assisted reaction to produce Bis(4-HydroxyCoumarins) in room temperature. The present methodology offers several advantages, such as a simple procedure with an easy work-up, short reaction times, high yields, and the absence of any volatile and hazardous organic solvents. تفاصيل المقالة -
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28 - An Efficient, One-Pot and new Synthesis of 2-amino-12H-spiro[indolo[1,2-b]quinazoline]pyrano-3-carbonitril
Gholam Hossein Mahdavinia Afsaneh AlamdarAn efficient synthesis of spiroindolopyranoquinazolines has been achieved in good yields by using one-pot, three-component condensation of alkyl malonates, tryptanthrin, and active methylene compounds in the presence of DABCO as organocatalyst in CH3CN at refluxAn efficient synthesis of spiroindolopyranoquinazolines has been achieved in good yields by using one-pot, three-component condensation of alkyl malonates, tryptanthrin, and active methylene compounds in the presence of DABCO as organocatalyst in CH3CN at reflux تفاصيل المقالة -
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29 - A new method for the synthesis of novel derivatives of "1,3- diaryl -2-n-azaphenalene and n-acyl-1,3-diaryl-2-N-azephenylene" By using nano catalyst and analyzing antibacterial activity of structures
asghar eftekhari Naser Forughifar Malak HekmatiIn this research, synthesized well derivatives of 1,3-diaryl-2-N-azaphenalene and N-acyl-1.3-diaryl-2-N- azaphenalene as a macromolecule in the presence of nanoparticles (Fe3O4 coated with L-Arginine) as a magnetic Nano catalyst in a one-pot reaction of compounds 7.2-Na أکثرIn this research, synthesized well derivatives of 1,3-diaryl-2-N-azaphenalene and N-acyl-1.3-diaryl-2-N- azaphenalene as a macromolecule in the presence of nanoparticles (Fe3O4 coated with L-Arginine) as a magnetic Nano catalyst in a one-pot reaction of compounds 7.2-Naphthalene diol, aldehydes, ammonium derivatives (ammonium acetate or ammonium hydro phosphates) and solvent (water and alcohol) with high yield and short reaction times, economical and simple workup.In this study, apart from the innovation in the synthesis of a macromolecule, the antibacterial activity of these compounds was evaluated for the first time The reaction was doe under very moderate conditions at room temperature.The chemical structures of all synthesized compounds were determined using infrared, 1H NMR and 13C NMR spectroscopies.After the production of nanoparticles, the structure of the obtained nanoparticles was characterized via Fourier transform infrared spectroscopy (IR) and field emission scanning electron microscopy (FE-SEM). The results demonstrated that the average size of the synthesized magnetite nanoparticles is about 21 nm.The heterogeneous catalyst used was easily separated magnetically and reused without any significant loss of catalytic activity and magnetism.Eventually, antibacterial activity of the synthesized compounds was investigated by Escherichia coli (ATCC: 25922) and Pseudomonas aeruginosa (ATCC: 27853) as gram negative bacteria, Staphylococcus epidermidis (ATCC: 14990) and Staphylococcus aureus (ATCC: 29213) as gram positive bacteria. Some of these products exhibit significant antibacterial activity. تفاصيل المقالة -
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30 - Co3O4/NiO@GQDs@SO3H nanocomposite as high performance catalyst for the preparation of pyrimidines
Hossein Shahbazi-Alavi Javad Safaei-Ghomi Ali Kareem AbbasCo3O4 / NiO @ GQDs @ SO3H nanocatalyst has been used as an effective catalyst for the preparation of 2,4-diamino-6-arylpyrimidine-5-carbonitrile derivatives through a three-component reaction of malononitrile, aromatic aldehydes and guanidine hydrochloride under reflux أکثرCo3O4 / NiO @ GQDs @ SO3H nanocatalyst has been used as an effective catalyst for the preparation of 2,4-diamino-6-arylpyrimidine-5-carbonitrile derivatives through a three-component reaction of malononitrile, aromatic aldehydes and guanidine hydrochloride under reflux conditions in ethanol. The catalyst has been characterized by FT-IR, XRD, SEM, EDS, BET, TGA, XPS and VSM. Atom economy, reusable catalyst, low catalyst loading, applicability to a wide range of substrates and high yields of products are some of the notable features of this protocol.The best results were gained in EtOH and we found that the reaction gave convincing results in the presence of Co3O4/NiO@GQDs@SO3H nanocomposite (4 mg) under reflux conditions. This green nanocatalyst could be used for other significant organic reactions and transformations. Further explorations of similar protocols are underway in our laboratory. This recoverable catalyst will provide a regular platform for heterogeneous catalysis, green chemistry, and environmentally benign protocols in the near future. تفاصيل المقالة -
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31 - Sulfuric Acid Functionalized Magnetic Nanocatalyst as a Green Catalyst for One-pot Synthesis of 2,3-dihydroquinazolin-4(1H)-ones
Amanollah Zarei Ahmady Seyyed Jafar Saghanezhad Neda MohtashamSulfuric acid functionalized Magnetic Nanocatalyst (SAMNC) has been prepared as an efficient acidic catalyst and has been applied in the one-pot preparation of 2,3-dihydroquinazolin-4(1H)-one derivatives. This catalyst has been characterized by FT-IR, SEM, VSM, TEM and أکثرSulfuric acid functionalized Magnetic Nanocatalyst (SAMNC) has been prepared as an efficient acidic catalyst and has been applied in the one-pot preparation of 2,3-dihydroquinazolin-4(1H)-one derivatives. This catalyst has been characterized by FT-IR, SEM, VSM, TEM and TGA. According to the obtained results including time, yield and recyclability, SAMNC could be considered as an efficient catalyst for organic transformations.Sulfuric acid functionalized Magnetic Nanocatalyst (SAMNC) has been prepared as an efficient acidic catalyst and has been applied in the one-pot preparation of 2,3-dihydroquinazolin-4(1H)-one derivatives. This catalyst has been characterized by FT-IR, SEM, VSM, TEM and TGA. According to the obtained results including time, yield and recyclability, SAMNC could be considered as an efficient catalyst for organic transformations.Sulfuric acid functionalized Magnetic Nanocatalyst (SAMNC) has been prepared as an efficient acidic catalyst and has been applied in the one-pot preparation of 2,3-dihydroquinazolin-4(1H)-one derivatives. This catalyst has been characterized by FT-IR, SEM, VSM, TEM and TGA. According to the obtained results including time, yield and recyclability, SAMNC could be considered as an efficient catalyst for organic transformations. تفاصيل المقالة -
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32 - A New Method for the Synthesis of New Derivatives of “1,3- diaryl-2-n-azaphenalene and n-acyl-1,3-diaryl-2-N-azephenylene” by Using Nano catalyst and Analyzing Antibacterial Activity of Structures
Asghar Eftekhari Naser Forughifar Malak HekmatiIn this research, synthesized well derivatives of 1,3-diaryl-2-N-azaphenalene and N-acyl-1.3-diaryl-2-N- azaphenalene as a macromolecule in the presence of nanoparticles (Fe3O4 coated with L-Arginine)as a magnetic Nano catalyst in a one-pot reaction of compounds 7.2-Nap أکثرIn this research, synthesized well derivatives of 1,3-diaryl-2-N-azaphenalene and N-acyl-1.3-diaryl-2-N- azaphenalene as a macromolecule in the presence of nanoparticles (Fe3O4 coated with L-Arginine)as a magnetic Nano catalyst in a one-pot reaction of compounds 7.2-Naphthalene diol, aldehydes,ammonium derivatives (ammonium acetate or ammonium hydro phosphates) and solvent (waterand alcohol) with high yield and short reaction times, economical and simple workup. In this study,apart from the innovation in the synthesis of a macromolecule, the antibacterial activity of thesecompounds was evaluated for the first time. The reaction was doe under very moderate conditionsat room temperature. The chemical structures of all synthesized compounds were determined usinginfrared, 1H NMR and 13C NMR spectroscopies. After the production of nanoparticles, the structure ofthe obtained nanoparticles was characterized via Fourier transform infrared spectroscopy (IR) and fieldemission scanning electron microscopy (FE-SEM). The results demonstrated that the average size ofthe synthesized magnetite nanoparticles is about 21 nm. The heterogeneous catalyst used was easilyseparated magnetically and reused without any significant loss of catalytic activity and magnetism.Eventually, antibacterial activity of the synthesized compounds was investigated by Escherichia coli(ATCC: 25922) and Pseudomonas aeruginosa (ATCC: 27853) as gram negative bacteria, Staphylococcusepidermidis (ATCC: 14990) and Staphylococcus aureus (ATCC: 29213) as gram positive bacteria. Someof these products exhibit significant antibacterial activity. تفاصيل المقالة -
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33 - Sulfuric Acid Functionalized Magnetic Nanocatalyst for One-pot Green Synthesis of 2,3-Dihydroquinazolin-4 (1H) -ones
Amanollah Zarei Ahmady Seyyed Jafar Saghanezhad Neda MohtashamSulfuric acid functionalized magnetic nanocatalyst (SAMNC) has been prepared as an efficientacidic and applied in the one-pot preparation of 2,3-dihydroquinazolin-4 (1H) -one derivatives.This catalyst has been characterized by FT-IR, SEM, and VSM. According to the obtai أکثرSulfuric acid functionalized magnetic nanocatalyst (SAMNC) has been prepared as an efficientacidic and applied in the one-pot preparation of 2,3-dihydroquinazolin-4 (1H) -one derivatives.This catalyst has been characterized by FT-IR, SEM, and VSM. According to the obtainedresults, including time, yield and recyclability, SAMNC could be considered as an efficient catalystfor organic transformations. تفاصيل المقالة -
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34 - A Simple and one-pot synthesis of imintriazole derivatives under Solvent-free conditions
Narges Ghasemi Parvaneh Firoozi Khanghah Mahboubeh Ghasemian DazmiriAn efficient synthesis of iminetriazole derivatives is described via an one-pot reaction between acid chlorides, 3-amino-2-butanone, primary amines and hydrazonoyl chloride under solvent-free conditions at room temperature in good yields. Also, the antimicrobial activit أکثرAn efficient synthesis of iminetriazole derivatives is described via an one-pot reaction between acid chlorides, 3-amino-2-butanone, primary amines and hydrazonoyl chloride under solvent-free conditions at room temperature in good yields. Also, the antimicrobial activity of some synthesized compounds proved by employing the disk diffusion test on Gram-positive and Gram-negative bacteria. This procedure has some benefits such as short reaction time, product with excellent yields, simple catalyst and products separation. تفاصيل المقالة -
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35 - Cellulose nanocrystal functionalized palladium nanoparticles as an efficient heterogeneous catalyst for the synthesis of α-amino nitriles via Strecker reaction
Atieh Mirosanloo Daryoush Zareyee Mohammad KhalilzadehAn efficient route reported to the application of palladium nanoparticles dispersed on 2-aminopyrimidine functionalized cellulose nanocrystal (CNC-AMPD-Pd) as a novel, suitable and reusable catalyst in the one-pot, three component synthesis of different α-aminonit أکثرAn efficient route reported to the application of palladium nanoparticles dispersed on 2-aminopyrimidine functionalized cellulose nanocrystal (CNC-AMPD-Pd) as a novel, suitable and reusable catalyst in the one-pot, three component synthesis of different α-aminonitriles at ambient temperature under solvent free reaction conditions. The heterogeneous catalyst could be easily separated from the reaction mixture and reused at least 6 times with no significant loss of catalytic activity. تفاصيل المقالة -
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36 - A favourable ultrasound-assisted method for the combinatorial synthesis of 2,3-dihydroquinazolin-4(1H)-ones via CoAl2O4 spinel nanocrystal as an efficient catalyst
Javad Safaei-Ghomi Rahele TeymuriMesoporous CoAl2O4 spinel nanocrystals ( nano-CoAl2O4 ) were synthesized and fully characterized by X- ray diffraction patterns (XRD), energy-dispersive X-ray spectroscopy (EDS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), DLS (dynamic li أکثرMesoporous CoAl2O4 spinel nanocrystals ( nano-CoAl2O4 ) were synthesized and fully characterized by X- ray diffraction patterns (XRD), energy-dispersive X-ray spectroscopy (EDS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), DLS (dynamic light scattering) and FT-IR. The nanocrystals promoted the preparation of quinazolinones via the one-pot, three component condensation reaction of benzaldehydes, isatoic anhydride, primary aromatic amine or ammonium acetate at 45°C under ultrasound irradiation. Experimental simplicity, great yields in concise times, the retrievability of the nanocrystals and performing the sonochemical methodology as an effective way in synthetic chemistry for the preparation of medicinally privileged heterocyclic molecules are some of the substantial features of this method. The present catalytic process is applicable to an extensive diversity of substrates for the preparation of a variety-oriented library of dihydroquinazolinones. The feasibility of doing one-pot synthesis under ultrasonic irradiation with a heterogeneous nanocrystal could improve the reaction rates and shorten the reaction times. تفاصيل المقالة -
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37 - Preparation and characterization of ionic liquid functionalized SBA-15 and its application in the synthesis of 2,3-dihydroquinazolinones
Ghodsi Mohammadi Ziarani Leila Seiedakbari Parisa Gholamzadeh Alireza BadieiN-Methyl-N</em>ʹ-propyltrimethoxysillylimidazolium chloride was prepared as ionic liquid (IL) containing silylating agent and then used for modification of the internal surface of SBA-15 to gain a heterogeneous ionic liquid catalyst. Subsequently, the obtained SBA-IL wa أکثرN-Methyl-N</em>ʹ-propyltrimethoxysillylimidazolium chloride was prepared as ionic liquid (IL) containing silylating agent and then used for modification of the internal surface of SBA-15 to gain a heterogeneous ionic liquid catalyst. Subsequently, the obtained SBA-IL was characterized using various techniques, including SEM and TEM images, FT-IR, X-ray diffraction, TGA/DTA and BET analyses. It was found that the uniform SBA-15 particles, with a dimension of 400-800 nm, showed the decreasing in the pore volume, surface area, and pore diameter after modification process which is as a results of incorporating imidazole groups onto the pores of SBA-15. Afterward, catalytic activity of SBA-IL was investigated in the synthesis of 2,3-dihydroquinazolinones under solvent free condition. تفاصيل المقالة -
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38 - Rapid, convenient and solventless green approach for the synthesis of aryloximes using ZnO nanoparticles as an efficient catalyst
Leila Dinparast Hassan ValizadehFreshly prepared ZnO nanoparticles were used as an effective heterogeneous base catalyst for the synthesis of aryloximes. The conversion of arylaldehydes and arylketones into the corresponding oximes (up to quantitative yields) was achieved by simply mixing the liquid r أکثرFreshly prepared ZnO nanoparticles were used as an effective heterogeneous base catalyst for the synthesis of aryloximes. The conversion of arylaldehydes and arylketones into the corresponding oximes (up to quantitative yields) was achieved by simply mixing the liquid reactants and hydroxylamine hydrochloride with ZnO nanoparticles under solvent-free condition. The procedure was carried out under wet conditions for solid reactants. The advantages of this method include mild reaction conditions, one-pot procedure, operational simplicity and use of inexpensive and non-toxic catalyst. تفاصيل المقالة -
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39 - One-pot synthesis of tri- and tetrasubstituted imidazoles using nano-LaMnO3 perovskite-type oxide as reusable heterogeneous catalyst in solvent-free condition
Haleh Sanaeishoar Haman Tavakkoli Mahsa Asareh Fouad MohaveA convenient synthetic method for the synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetra substituted imidazole derivatives, has been developed via one-pot condensation reaction in solvent-free condition when aldehyde, ammonium acetate/amine, and 1,2-diketone are reacte أکثرA convenient synthetic method for the synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetra substituted imidazole derivatives, has been developed via one-pot condensation reaction in solvent-free condition when aldehyde, ammonium acetate/amine, and 1,2-diketone are reacted using 0.8 mol% of NP-LaMnO3 at 80 °C under solvent free conditions. Catalyst could be recovered and reused in five reaction cycles without any loss of its activities, giving a total turnover number (TON) = 594 and turn over frequency (TOF) = 71 h−1. High yield, little catalyst loading, elimination of solvent, simple workup, recovery and reusability of the catalyst are some of the impressive features of the present method. تفاصيل المقالة -
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40 - 1-(1-Propylsulfonic)-3-methylimidazolium chloride Brønsted acidic ionic liquid catalyzed one-pot synthesis of 14-aryl-14H-dibenzo[a,j]xanthene derivatives under solvent-free conditions
Sima Abbaspour Mogharab Torabi Jafroudi Shima Haghi Sohan RezayatiA rapid, green and efficient method for the synthesis of 14-aryl-14H-dibenzo[a,j]xanthene derivatives through a one-pot condensation of 2-naphthol with various aromatic aldehydes in the presences of several acidic ionic liquids including [PSMIM]Cl, [BMIM]HSO4, [BMIM]Cl, أکثرA rapid, green and efficient method for the synthesis of 14-aryl-14H-dibenzo[a,j]xanthene derivatives through a one-pot condensation of 2-naphthol with various aromatic aldehydes in the presences of several acidic ionic liquids including [PSMIM]Cl, [BMIM]HSO4, [BMIM]Cl, [BMIM]Br, and [BMIM]BF4 as organocatalysts and task-specific acidic ionic liquids (AILs) under solvent-free conditions is described. Compared with other synthetic methods, this new method has the advantages such as milder reaction conditions, good to excellent yields, short reaction times, and environmentally benign procedure. Also, 1-(1-Propylsulfonic)-3-methylimidazolium chloride [PSMIM]Cl acts as a catalyst under solvent-free conditions and can be recovered and reused six times without apparent loss of its catalytic activity. تفاصيل المقالة -
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41 - One-pot pseudo-five-component synthesis of dihydropyrano[2,3-g] chromenes using sodium phthalimide/[BMIM]BF4 as high efficient catalytic system
Leila Moradi Maryam Aghamohammad SadeghAn efficient route for the synthesis of dihydropyrano[2,3-g] chromenes via one-pot pseudo-five component cyclization reaction of an aldehyde, malononitrile and 2,5-dihydroxy-1,4-benzoquinone in the presence of an effective and mild catalytic system containing sodium pht أکثرAn efficient route for the synthesis of dihydropyrano[2,3-g] chromenes via one-pot pseudo-five component cyclization reaction of an aldehyde, malononitrile and 2,5-dihydroxy-1,4-benzoquinone in the presence of an effective and mild catalytic system containing sodium phthalimide and 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM]BF4) ionic liquid (SPI/IL) was studied. The reaction products were characterized using 1H NMR, 13C NMR, FTIR, Mass spectroscopy and elemental analysis. Environmentally eco-friendly catalyst, clean reaction with easy work-up (through simple filtration) and high yield products with no more purification are the main merits of this protocol. Presented method can be used for the synthesis of mentioned products (with pharmacology and Biologic properties) in large scales. تفاصيل المقالة -
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42 - Synthesis of dihydrofurans using biosynthesized CuO nanoparticles
Javad Safaei-Ghomi Hossein Shahbazi-AlaviThe preparation of trans-dihydrofurans has been achieved by a one-pot condensation reaction of 4-bromophenacyl bromide, aromatic aldehydes and 5,5-dimethyl-1,3-cyclohexanedione using biosynthesized CuO nanoparticles under reflux conditions in ethanol. CuO nanoparticles أکثرThe preparation of trans-dihydrofurans has been achieved by a one-pot condensation reaction of 4-bromophenacyl bromide, aromatic aldehydes and 5,5-dimethyl-1,3-cyclohexanedione using biosynthesized CuO nanoparticles under reflux conditions in ethanol. CuO nanoparticles (CuO NPs) were prepared using extractof leaves of Ajuga chamaecistus Subsp. Scoparia. The key advantages of this process are the diastereoselective synthesis, reusability of the catalyst, low catalyst loading, excellent yields, short reaction times, simple workup and environmentally benign. Fully optimized structures of trans and cis dihydrofurans were obtained by B3LYP/6-31G(d,p) method. The structures of the prepared trans-2,3-dihydrofurans were fully characterized by 1H and 13C NMR spectra, IR spectra, and elemental analysis. تفاصيل المقالة -
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43 - Employing a hydrophobic-bentonite as a highly efficient and versatile catalyst for a green one-pot and rapid synthesis of 4H-benzo-[b]-pyran derivatives
Mohammad Ebrahim Sedaghat Faranak Farhadi Mohammad Reza Nazarifar Rezvan Sheikhi KamarejiA hydrophobic-bentonite catalyst (cetyltrimethyl ammonium bromide-bentonite) has been used as a very mild, neutral, eco-friendly, reusable, non-toxic, low-cost and easily available catalyst. It was prepared by replacing the exchangeable Na+ cations of a homoionic Na&nda أکثرA hydrophobic-bentonite catalyst (cetyltrimethyl ammonium bromide-bentonite) has been used as a very mild, neutral, eco-friendly, reusable, non-toxic, low-cost and easily available catalyst. It was prepared by replacing the exchangeable Na+ cations of a homoionic Na–bentonite with cetyltrimethyl ammonium bromide (CTMAB) cations. The catalyst was characterized by XRD, BET and SEM. The BET data and XRD patterns showed that the surfactant ions enter the interlayer space of catalyst. In order to study the catalytic properties, we carried out a one-pot practical, efficient and green multicomponent synthesis of 4H-benzo-[b]-pyran derivatives in terms of high yield, simple experimental procedure, low reaction time and simple work-up. تفاصيل المقالة -
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44 - Co3O4 nanoparticles as a robust and recoverable catalyst for one-pot synthesis of polyhydroquinolines and tetrahydrobenzopyrans
Mohammad Ali Ghasemzadeh Zahra ElyasiThis study introduces a green and efficient method for preparation of biologically-active substituted 4H-pyrans using the one-pot three-component reaction of aromatic aldehydes, dimedone and malononitrile in the presence of cobalt oxide nanoparticles. Co3O4 nanoparticle أکثرThis study introduces a green and efficient method for preparation of biologically-active substituted 4H-pyrans using the one-pot three-component reaction of aromatic aldehydes, dimedone and malononitrile in the presence of cobalt oxide nanoparticles. Co3O4 nanoparticles were used as an efficient catalyst for the synthesis of polyhydroquinoline derivatives by the reaction of aromatic aldehydes, ethyl acetoacetate, dimedone and ammonium acetate. The preparation and use of Co3O4 as a powerful and reusable nanocatalyst under solvent-free conditions is described. The catalyst was characterized by spectral techniques including XRD, FE-SEM, FT-IR, VSM, EDX and TEM analysis. This method offers the advantages of high yield, short reaction time, comfortable work-up and reusability of the catalyst. تفاصيل المقالة -
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45 - Highly efficient one-pot four-component synthesis of polyhydroquinoline derivatives catalyzed by stannous chloride under solvent-free conditions
Surekha Deshmukh Jitendra Gujar Ramrao Mane Murlidhar ShingareA rapid and efficient one-pot, four-component protocol towards the synthesis of polyhydroquinoline derivatives has been developed. The condensation of aldehyde, dimedone, ethyl acetoacetate and ammonium acetate in presence of stannous chloride was carried out under solv أکثرA rapid and efficient one-pot, four-component protocol towards the synthesis of polyhydroquinoline derivatives has been developed. The condensation of aldehyde, dimedone, ethyl acetoacetate and ammonium acetate in presence of stannous chloride was carried out under solvent free condition to synthesize a variety of polyhydroquinoline derivatives in good to excellent yields. Stannous chloride was proved to be an efficient heterogeneous Lewis acid catalyst, which could be relatively non-toxic, inexpensive, possess good thermal stability and easy to handle. The present method provides several advantages such as mild reaction conditions, green methodology, inexpensive catalyst, simple work-up procedure, short reaction time and high yields. تفاصيل المقالة -
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46 - Kaolin-SO3H as an efficient catalyst for one-pot synthesis of 1,2,4,5-tetrasubstituted imidazoles
Bi Bi Fatemeh Mirjalili Hamidreza AkramiKaolin-SO3H as a new solid acid is prepared via reaction of kaolin and chlorosulfonic acid. This natural based catalyst is very inexpensive and easy available. Imidazoles are an important class of heterocycles being the core fragment of different natural products and bi أکثرKaolin-SO3H as a new solid acid is prepared via reaction of kaolin and chlorosulfonic acid. This natural based catalyst is very inexpensive and easy available. Imidazoles are an important class of heterocycles being the core fragment of different natural products and biological systems such as anti-allergic, anti-inflammatory, analgesic, antifungal, antimycotic, antibiotic, antiulcerative, antibacterial, antitumor and inhibitors of the p38 MAP kinase. A simple, highly versatile and efficient synthesis of 1,2,4,5-tetrasubstituted imidazoles is achieved using Kaolin-SO3H as a catalyst at moderate temperature under solvent free condition. The key advantages of this process are high yields with simple work-up using easy available inexpensive natural based catalyst. تفاصيل المقالة -
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47 - Nano TiO2@SiO2 as an efficient and reusable catalyst for the synthesis of multi-substituted imidazoles
Maryam Haghighi Kobra NikoofarNano TiO2 supported on SiO2 (Nano TiO2@SiO2) as a solid Lewis acid, was described to be an effective and reusable catalyst for one-pot three-component reaction of benzil, aryl aldehydes and ammonium acetate for the synthesis 2-aryl-4,5-diphenyl-1H-imdazoles synthesis. T أکثرNano TiO2 supported on SiO2 (Nano TiO2@SiO2) as a solid Lewis acid, was described to be an effective and reusable catalyst for one-pot three-component reaction of benzil, aryl aldehydes and ammonium acetate for the synthesis 2-aryl-4,5-diphenyl-1H-imdazoles synthesis. To explore the high efficacy of the catalytic system the four-component cyclization of benzil, aryl aldehydes, ammonium acetate and anilines has also been accomplished successfully to obtain their 1,2-diaryl-4,5-diphenyl-1H-imidazole adducts. A plausible mechanism has also been expressed. The catalyst has been recovered and its reusability confirmed in 4 runs. High yields, simple operation, easy-work procedure, mild reaction conditions in addition with reusability are some advantages of this protocol. تفاصيل المقالة -
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48 - One-pot three component synthesis of 2-amino-4H-chromenes under green and high efficient conditions
Leila Moradi Mina ZareA simple, mild and high efficient procedure for one pot three component synthesis of 2-amino 4-H chromene derivatives was studied. The reaction was performed in water using aryl aldehydes, malononitrile and resorcinol, phloroglucinol or naphthole in the presence of N-me أکثرA simple, mild and high efficient procedure for one pot three component synthesis of 2-amino 4-H chromene derivatives was studied. The reaction was performed in water using aryl aldehydes, malononitrile and resorcinol, phloroglucinol or naphthole in the presence of N-methyl D-glucamine (Meglumine) as a green high efficient catalyst. The reaction was studied in thermal, microwave (MW) and ultrasonic (US) conditions. Obtained results show that meglumine, as a green catalyst, has high efficiency in all reaction conditions and the yield of products (in all cases) is high to excellent. Environment friendly solvent and catalyst, short reaction times and high yield products are the advantageous of presented research. تفاصيل المقالة -
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49 - An efficient synthesis of 4-aryl-7-benzylidene-hexahydro-2H-cyclopenta[d] pyrimidin-2-ones/thiones catalyzed by p-dodecylbenzenesulfonic acid
Krishnamoorthy Aswin Majid Ghashang Sheik MansoorA new and efficient method has been developed for the synthesis of 4-aryl-7-benzylidene-1,3,4,5,6,7-hexahydro-2H-cyclopenta[d]pyrimidin-2-ones through Biginelli-like reaction of cyclopentanone, with urea/thiourea and aromatic aldehyde employing p-dodecylbenzenesulfonic أکثرA new and efficient method has been developed for the synthesis of 4-aryl-7-benzylidene-1,3,4,5,6,7-hexahydro-2H-cyclopenta[d]pyrimidin-2-ones through Biginelli-like reaction of cyclopentanone, with urea/thiourea and aromatic aldehyde employing p-dodecylbenzenesulfonic acid (DBSA) as a recyclable catalyst under solvent-free condition. The recovered catalyst was recycled for further runs. The product formation takes place via a cross-aldol condensation of benzaldehyde with cyclopentanone in the presence of DBSA to produce benzylidene intermediate and subsequent Michael addition. The present approach offers the advantages of short reaction time, mild reaction conditions, high yields and convenient operation. All the products were obtained in good to excellent yields and the structures of the synthesized compounds were established by advanced spectroscopic data. تفاصيل المقالة -
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50 - One-pot and efficient synthesis of triazolo[1,2-a]indazole-triones catalyzed by poly(ethylene glycol) based magnetic dicationic ionic liquid
Bijan Mombeni Goodajdar Soghra SoleimaniAn atom-efficient, eco-friendly, solvent-free, high yielding, multicomponent green strategy to synthesize triazolo[1,2-a]indazole-triones derivatives by the one-pot condensation of aldehyde, dimedone, and phenyl urazole is presented. A series of different substituted ar أکثرAn atom-efficient, eco-friendly, solvent-free, high yielding, multicomponent green strategy to synthesize triazolo[1,2-a]indazole-triones derivatives by the one-pot condensation of aldehyde, dimedone, and phenyl urazole is presented. A series of different substituted aromatic aldehydes including either electron-withdrawing or electron-donating groups used in this reaction participated well and gave the corresponding products in good to excellent yield. Poly (ethylene glycol) based magnetic room temperature dicationic ionic liquid, PEG-MRTDIL, was prepared by mixing PEG-DIL with anhydrous FeBr3 under neat conditions. The catalyst was studied by UV and IR spectroscopy. This method provides several advantages such as environment benign, high yield, simple work up procedure and reusable catalyst. تفاصيل المقالة -
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51 - ZrP2O7 NPs: A recyclable, efficient heterogeneous catalyst for the synthesis of 1,6-diamino-2-oxo-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitrile derivatives via a multi-component reaction
Javad Safaei-Ghomi Hossein Shahbazi-Alavi Mohammad Reza Saberi-Moghadam Abolfazl ZiaratiZrP2O7 nanoparticles (NPs) as an efficient catalyst have been used for the preparation of 1,6-diamino-2- oxo-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitrile derivatives via one-pot coupling of hyrazine hydrate, ethyl cyanoacetate, malononitrile and aromatic aldehydes un أکثرZrP2O7 nanoparticles (NPs) as an efficient catalyst have been used for the preparation of 1,6-diamino-2- oxo-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitrile derivatives via one-pot coupling of hyrazine hydrate, ethyl cyanoacetate, malononitrile and aromatic aldehydes under reflux conditions in ethanol. Using this method we obtained low reaction times, easy isolation of the targeted molecules, excellent yields. تفاصيل المقالة -
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52 - Synthesis of methyl 6-amino-5-cyano-4-aryl-2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylates using nanocrystalline ZnZr4(PO4)6 ceramics as an efficient catalyst
Javad Safaei-Ghomi Mehrnoosh Asgari-Kheirabadi Hossein Shahbazi-Alvi Abolfazl ZiaratiNanocrystalline ZnZr4(PO4)6 ceramics as an efficient catalyst have been used for the preparation of methyl 6-amino-5-cyano-4-aryl-2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylates by the four component reaction of dimethylacetylenedicarboxylate, hydrazinehydrate, malononi أکثرNanocrystalline ZnZr4(PO4)6 ceramics as an efficient catalyst have been used for the preparation of methyl 6-amino-5-cyano-4-aryl-2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylates by the four component reaction of dimethylacetylenedicarboxylate, hydrazinehydrate, malononitrile and aromatic aldehydes in water at room temperature. In this research Nano-ZnZr4(PO4)6 coordinate with the active groups(particular C=O, C≡N and active H) thus increasing the activity of the groups. Also this nanoscale heterogeneous catalysts present higher surface areas which are mainly responsible for their catalytic activity. These surface atoms behave as the centers where the chemical reactions could be catalytically activated. The key advantages of this process are high yields, shorter reaction times, reusability of catalyst, easy work-up, milder reaction conditions and environmentally benign. تفاصيل المقالة -
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53 - One-pot, Three Component, and Green Synthesis of 2-(Aryl)-3-((2-oxo-2-(2-oxo-2H-chromen-3-yl)ethyl)amino)imidazolidin-4-one Derivatives using Graphene Oxide Nanosheets under Microwave Irradiation: A Comparison Study Between One-pot and Step by Step Synthesis
Sajid Maksad Radhi Ban Hasan Taresh Nesser Kadham Shareef Luma Majeed AhmedIn this study, two different methods were described for the synthesis of 2-(aryl)-3-((2-oxo-2-(2-oxo-2H-chromen-3-yl)ethyl)amino)imidazolidin-4-one derivatives under microwave irradiation. The first method was step by step method. In step by step method, 3-(2-hydrazinyl أکثرIn this study, two different methods were described for the synthesis of 2-(aryl)-3-((2-oxo-2-(2-oxo-2H-chromen-3-yl)ethyl)amino)imidazolidin-4-one derivatives under microwave irradiation. The first method was step by step method. In step by step method, 3-(2-hydrazinylacetyl)-2H-chromen-2-one and aromatic aldehydes in 1 mL of absolute ethanol were irradiated with appropriate power within 3-10 min to obtain imine products. Then, the imine products were isolated and reacted with glycine to produce the 2-(aryl)-3-((2-oxo-2-(2-oxo-2H-chromen-3-yl)ethyl)amino)imidazolidin-4-one under microwave irradiation. In the one-pot method, the graphene oxide nanosheets were applied as heterogeneous catalysts. Hence, the graphene oxide nanosheets were synthesized based on Hummer’s method. The catalyst was characterized by field emission scanning electron microscopy (FE-SEM), Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, and X-ray diffraction (XRD) techniques. Then, 3-(2-hydrazinylacetyl)-2H-chromen-2-one, glycine, and aromatic aldehydes were irradiated using microwave irradiation in the presence of 0.5 mol% of graphene oxide nanosheets in ethanol. The prepared catalyst showed superior reusability for seven catalytic cycles. Our results showed that the one-pot method was better than the step by step method. تفاصيل المقالة -
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54 - A Novel Cobalt Organic-Inorganic Hybrid Magnetic Nanocatalyst for Convenient Four-Component Synthesis of 3,4-Dihydropyridones
Maryam Barazandehdoust Manouchehr Mamaghani Hassan KefayatiDensely functionalized 3,4-dihydropyridones were synthesized by a four-component reaction of Meldrumʼs acid, ethyl acetoacetate, ammonium acetate, and proper aromatic aldehydes in the presence of novel organic-inorganic cobalt incorporated magnetic nanocatalyst (γ أکثرDensely functionalized 3,4-dihydropyridones were synthesized by a four-component reaction of Meldrumʼs acid, ethyl acetoacetate, ammonium acetate, and proper aromatic aldehydes in the presence of novel organic-inorganic cobalt incorporated magnetic nanocatalyst (γ-Fe2O3@HAp/Co(II)) using ethanol as a green solvent at reflux condition. This new synthetic method provided the target compounds in a high yield (70-95%) and lower reaction time (20-75 min). The protocol benefits from the high purity of the products, environmentally friendly, milder reaction conditions, recyclability of the catalyst, and facile workup procedure. The structure of the synthesized novel nanocatalyst was confirmed by FT-IR, XRD, FSEM, TEM, EDS, and TGA analyses. The catalyst was used in eight cycles without any notable variation in catalytic activities. تفاصيل المقالة -
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55 - La2O3 as a very effective double-functional catalyst for the production of 2-amino-4-aryl-4H-pyrans and Pyrazolopyranopyrimidines
Alireza Kohzadian Rohollah Fathollahi Mostafa Karami Esmail Korani Abdolkarim ZareLanthanum (III) oxide (La2O3) was applied as an efficient bifunctional catalyst to develop a new methodology in the production of 2-amino-4-aryl-4H-pyrans and pyrazolopyranopyrimidines in the absence of solvent. In both synthetic protocol, due to the dual functionality أکثرLanthanum (III) oxide (La2O3) was applied as an efficient bifunctional catalyst to develop a new methodology in the production of 2-amino-4-aryl-4H-pyrans and pyrazolopyranopyrimidines in the absence of solvent. In both synthetic protocol, due to the dual functionality of lanthanum (III) oxide (i.e. having basic and acidic Lewis sites), it was very useful and general, and plausible mechanisms were presented in support of this generality and high capability. The current protocol featured environmentally friendly conditions, the ability to recycle and reuse the heterogeneous catalyst up to 6 times, providing products in short times with high yields, easy work-up and no need for difficult steps of catalyst synthesis by using a commercially available catalyst, which makes it an appealing route for the preparation of these derivatives. تفاصيل المقالة -
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56 - Nano silica supported ferric chloride as a green and efficient catalyst for one pot synthesis of 1,2-dihydro-1-arylnaphtho[1,2-e][1,3]oxazine-3-ones
Javad Safaei-Ghomi Safura Zahedi Mohammad Ali GhasemzadehAn efficient green route for the preparation of naphthoxazinones, applying a three-component one-pot condensation reaction of 2-naphthol, aromatic aldehyde and urea in the presence of nano silica supported ferric chloride under solvent-free conditions has been developed أکثرAn efficient green route for the preparation of naphthoxazinones, applying a three-component one-pot condensation reaction of 2-naphthol, aromatic aldehyde and urea in the presence of nano silica supported ferric chloride under solvent-free conditions has been developed. The present procedure offers several advantages such as short reaction time, simple workup, recovery and reusability of the catalyst. تفاصيل المقالة -
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57 - Nanocrystalline TiO2 as an efficient and reusable catalyst for the one-pot synthesis of polyhydroquinolien derivatives via Hantzsch reaction
Farhad Shirini Seyyed Vahid Atghia Meysam Alipour KhoshdelAn efficient synthesis of polyhydroquinoline derivatives was reported via four-component coupling reactions of aldehydes, 1,3-dicarbonyl ketones (dimedone or 1,3-cyclohexanedione), ethyl acetoacetate or methyl acetoacetate and ammonium acetate in the presence of a catal أکثرAn efficient synthesis of polyhydroquinoline derivatives was reported via four-component coupling reactions of aldehydes, 1,3-dicarbonyl ketones (dimedone or 1,3-cyclohexanedione), ethyl acetoacetate or methyl acetoacetate and ammonium acetate in the presence of a catalytic amount of nanocrystalline TiO2 under solvent free conditions. The reported method is mild, rapid and has the advantages such as heterogeneous catalysis, simple work-up procedure, recyclability of the catalyst and purification of products without chromatographic methods. تفاصيل المقالة -
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58 - Bi(NO3)3.5H2O: An efficient acidic reagent for synthesis of azo dyes at room temperature
Bi Bi Fatemeh Mirjalili Abdolhamid Bamoniri Naimeh SalehiAn one-pot method has been developed for the synthesis of azo dyes via sequential diazotization–diazo coupling of aromatic amines with coupling agents at room temperature in the presence of Bi(NO3)3. 5H2O. Short reaction times, high yields, a clean process, simple أکثرAn one-pot method has been developed for the synthesis of azo dyes via sequential diazotization–diazo coupling of aromatic amines with coupling agents at room temperature in the presence of Bi(NO3)3. 5H2O. Short reaction times, high yields, a clean process, simple methodology, easy work-up and green ‎conditions are advantages of this protocol.‎ تفاصيل المقالة -
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59 - Boric acid as a highly efficient and reusable catalyst for the one-pot synthesis of 1,8-dioxo-octahydroxanthenes under solvent-free conditions
Sobhan Rezayati Rahimeh Hajinasiri Zahra Erfani Saman Rezayati Saeid Afshari-sharifabadAn efficient and simple procedure for the synthesis of 1,8-dioxo-octahydroxanthenes from the aromatic aldehydes and 5,5-dimethylcyclohexane-1,3-dione (dimedone) in the presence of boric acid [BO3H3 or B(OH)3] as an inexpensive and reusable catalyst is described. The sal أکثرAn efficient and simple procedure for the synthesis of 1,8-dioxo-octahydroxanthenes from the aromatic aldehydes and 5,5-dimethylcyclohexane-1,3-dione (dimedone) in the presence of boric acid [BO3H3 or B(OH)3] as an inexpensive and reusable catalyst is described. The salient features of this methodology are: the elimination of corrosive liquid acids, high yields, simple methodology, short reaction times, easy work-up and green heterogeneous catalyst. تفاصيل المقالة -
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60 - One-pot synthesis of 2,4,5-trisubstituted imidazoles catalyzed by dicationic magnetic room temperature ionic liquid
Bijan Mombani Godajdar Ali Reza KiasatRegarding the green chemistry's goals, dicationic magnetic room temperature ionic liquid open up new avenue to introduce an amazing and efficient system for facilitating catalyst recovery in different organic reactions. Ability of this dicationic magnetic room temperatu أکثرRegarding the green chemistry's goals, dicationic magnetic room temperature ionic liquid open up new avenue to introduce an amazing and efficient system for facilitating catalyst recovery in different organic reactions. Ability of this dicationic magnetic room temperature ionic liquid catalyst in the one-pot three-components condensation reaction of benzil, aromatic aldehyde, and ammonium acetatate are also described. Utilization of easy reaction conditions, catalyst with high catalytic activity and good reusability, and simple magnetically work-up, makes this methodology as an interesting option for the synthesis of 2,4,5-trisubstituted imidazoles. تفاصيل المقالة -
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61 - Green procedure for synthesis of 3, 4 dihydropyrimidinones using 12-molybdophosphoric acid, as a catalyst and solvent free condition under microwave irradiation
Hojjatollah SalehiSimple and improved conditions have been found to carry out the Biginelli reaction for the synthesis of 3, 4-dihydropyrimidin-2(1H) - one derivatives. This synthesis was performed in the presence of 12-molybdophosphoric acid (H3PMo12O40) as catalyst. These reactions wer أکثرSimple and improved conditions have been found to carry out the Biginelli reaction for the synthesis of 3, 4-dihydropyrimidin-2(1H) - one derivatives. This synthesis was performed in the presence of 12-molybdophosphoric acid (H3PMo12O40) as catalyst. These reactions were performed under solvent free conditions with microwave irradiation as the energy source. Compared with the classical Biginelli reaction conditions, this new method has the advantage of excellent yields (76–96%). The advantages of this novel protocol include the excellent yield, operational simplicity, short time, and the avoidance of the use of organic solvents and friendly preparation. Products were identified using physical and spectroscopic data. تفاصيل المقالة -
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62 - تهیه و شناسایی یک نانوکاتالیست مؤثر و جدید اسیدی جامد و بررسی رفتار کاتالیستی آن در تهیه ′1-آریل-′2-(2-اکسوایندولین-3-ایل) اسپیرو[ایندولین-5،′3-پیرولین]-3،′2-دیاونها
کبری نیکوفر زهرا خادمی شیوا خانیدر این پژوهش، در مرحله اول پاراتولوئن سولفونیک اسید نشانده شده روی نانوسیلیکا بهعنوان یک نانوکاتالیست جدید به روش آسان و ساده تهیه شد. سپس، با روشهای اندازهگیری نقطه ذوب، طیفسنجی فروسرخ تبدیل فوریه (FT-IR)، میکروسکوپی الکترونی روبشی (SEM) و تجزیه عنصری با روش طیفسن أکثردر این پژوهش، در مرحله اول پاراتولوئن سولفونیک اسید نشانده شده روی نانوسیلیکا بهعنوان یک نانوکاتالیست جدید به روش آسان و ساده تهیه شد. سپس، با روشهای اندازهگیری نقطه ذوب، طیفسنجی فروسرخ تبدیل فوریه (FT-IR)، میکروسکوپی الکترونی روبشی (SEM) و تجزیه عنصری با روش طیفسنجی تفکیک انرژی (EDX)، شناسایی شد. در مرحله بعدی، بهمنظور تهیه مشتقهای ′1-آریل-′2-(2-اکسوایندولین-3-ایل) اسپیرو[ایندولین-5،′3-پیرولین]-3،′2-دیاونها، کارایی این نانوکاتالیست اسیدی جامد طی واکنش شبهتراکمی چهارجزیی، تکمرحلهای و تکظرف آنیلینها، ایساتینها و استون در حضور آب تحت شرایط بازروانی مورد بررسی قرار گرفت. استفاده از آب بهعنوان حلال سبز و در دسترس، بازدههای عالی فراوردهها، زمانهای کوتاه واکنش، عدم تولید فراوردههای جانبی که ممکن است از طریق تراکم آلدولی استون بهوجود آیند، قابلیت حمل آسان، ارزان قیمت بودن، غیرسمی بودن و توانایی بازیافت و استفاده دوباره کاتالیست حداقل در چهارچرخه بدون کاهش محسوس قدرت کاتالیستی، برخی از ویژگیهای بسیار مهم نانوکاتالیست تهیه شده در این پژوهش است. تفاصيل المقالة -
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63 - Clean synthesis of 1,8-dioxo-octahydroxanthene derivatives using NBS as an efficient and almost neutral catalyst in aqueous media
Gholam Hossein MahdaviniaAn efficient one-pot condensation for the synthesis of 1,8-dioxo-octahydroxanthene is achieved through a condensation of aryl aldehydes and 5,5-dimethyl-1,3-cyclohexandione in the presence of NBS. This method enjoys several advantages such as low cost, simple work up pr أکثرAn efficient one-pot condensation for the synthesis of 1,8-dioxo-octahydroxanthene is achieved through a condensation of aryl aldehydes and 5,5-dimethyl-1,3-cyclohexandione in the presence of NBS. This method enjoys several advantages such as low cost, simple work up procedure and safe reaction condition. In addition, water was chosen as a green solvent. تفاصيل المقالة -
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64 - MCM-41 functionalized sulfonic acid catalyzed one-pot synthesis of 1,8- dioxo-octahydroxanthenes
Gholam Hossein Mahdavinia Mohammad Mehdi Ghanbari Hamid Sepehrian Fatemeh KootiMCM-41-R-SO3H catalyzed one-pot synthesis of 1,8-dioxo-octahydroxanthenes is reportedunder reflux conditions. The catalyst is easily prepared, highly stable, very simple to handle andrecycled for five times without loss of significant activityMCM-41-R-SO3H catalyzed one-pot synthesis of 1,8-dioxo-octahydroxanthenes is reportedunder reflux conditions. The catalyst is easily prepared, highly stable, very simple to handle andrecycled for five times without loss of significant activity تفاصيل المقالة -
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65 - Biological Activity and Efficient Synthesis of 3, 4-Dihydropyrimidin-2-(1H)-one/thione Derivatives
Farhad HatamjafariThe present study aimed to use a method for the synthesis of some 3, 4-dihydropyrimidin-2-(1H) - ones/thiones. The study tried to answer the question whether this reaction can be performed without solvent and with new catalyst or not. To find answer to the question, we أکثرThe present study aimed to use a method for the synthesis of some 3, 4-dihydropyrimidin-2-(1H) - ones/thiones. The study tried to answer the question whether this reaction can be performed without solvent and with new catalyst or not. To find answer to the question, we described a novel protocol for the efficient synthesis of 3, 4-dihydropyrimidin-2-(1H)-one derivatives using aromatic aldehyde, ethylacetoacetate, and urea/thiourea under solvent-free conditions by using SiO2-CaCl2as acatalyst. Using this catalyst has some advantages; it's high yields, usable in mild conditions, available, reusable, ecofriendly, cost effective and environmentally friendly. The structural features of the synthesized compounds were characterized by IR, 1H NMR and 13C NMR. The compounds were screened for antimicrobial activity. The results showed these compounds react against all the tested bacteria. We have demonstrated a novel method for the synthesis of substituted dihydropyrimidinones catalyzed by SiO2-CaCl2 under solvent-free conditions. تفاصيل المقالة -
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66 - Glutamic Acid as an Environmentally Friendly Catalyst for One-Pot Synthesis of 4H-Chromene Derivatives and Biological Activity
Farhad HatamjafariIn this study, the synthesis of 4H-chromenes of biological activity via a multicomponent reaction of dimedone, aromatic aldehydes and malononitrile catalyzed by glutamic acid as a catalyst was investigated. The structural features of the synthesized compounds were chara أکثرIn this study, the synthesis of 4H-chromenes of biological activity via a multicomponent reaction of dimedone, aromatic aldehydes and malononitrile catalyzed by glutamic acid as a catalyst was investigated. The structural features of the synthesized compounds were characterized by melting point, IR and 1H NMR analysis. The catalyst being reported here is cheap, safe to handle and the whole procedure is eco-friendly, Milder conditions, one-pot, excellent yields, operational simplicity and ecofriendly preparation are some advantages of this protocol. The compounds were screened for antimicrobial activity. The results showed that these compounds reacted against all the tested bacteria and fungi. تفاصيل المقالة