4-Sulfobenzoic Acid as an Efficient Catalyst for the Preparation of 3,4-dihydropyrimidin-2-(1H)-ones Under Solvent-free Conditions

الموضوعات :

Ali Oudi ¹ (Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran)
Nourallah Hazeri ² (Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran)
Maryam Fatahpour ³ (Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran)

تاريخ الإرسال : 15 السبت , ربيع الثاني, 1440 تاريخ التأكيد : 15 السبت , ربيع الثاني, 1440 تاريخ الإصدار : 25 الثلاثاء , ربيع الثاني, 1440

الکلمات المفتاحية:

ملخص المقالة :

In this research, one-pot three-component synthesis of 3,4-dihydropyrimidin-2-(1H)-ones havebeen developed using Biginelli reaction from the interaction between ethyl/methyl acetoacetate,aromatic aldehydes, and urea/thiourea in the presence of 4-sulfobenzoic acid as a new, effective,inexpensive, and available bronsted acid. Avoidance of toxic and dangerous solvents, easy isolationof products without the need of column chromatography, high yields, and short reaction time aresome important features of the present method.