Biginelli Synthesis and Theoritical Study of Dihydropyrimidinones
الموضوعات : International Journal of Heterocyclic Chemistry
Mohammad Hosein Farjam
1
(Department of Chemistry , Firoozabad Branch, Islamic Azad University,Firoozabad, Iran.)
Ramin Rezaei
2
(Department of Chemistry , Firoozabad Branch, Islamic Azad University,Firoozabad, Iran.)
الکلمات المفتاحية: Solvent-free, One-pot, Biginelli reaction, Dihydropyrimidinones,
ملخص المقالة :
An effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl2 as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yields, short reaction times for formation of the products and simple work-up are attractive features of this green protocol.
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