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حرية الوصول المقاله
1 - Synthesis and characterization of bifunctional basic mesoporous organosilica catalyst as an efficient and ecofriendly nanocomposite in Biginelli condensation reaction
Fatemeh Ghalambaz Asadollah Farhadi Ali Reza Kiasat Rashid BadriAn organic–inorganic hybrid nanocomposite was prepared by immobilizing β-cyclodextrin (β-CD) and amino groups onto mesoporous MCM-41 via surfactant-templated sol-gel procedure and post-modification method. The heterogeneous hybrid nanocomposite, MCM-41-& أکثرAn organic–inorganic hybrid nanocomposite was prepared by immobilizing β-cyclodextrin (β-CD) and amino groups onto mesoporous MCM-41 via surfactant-templated sol-gel procedure and post-modification method. The heterogeneous hybrid nanocomposite, MCM-41-β-CD/NH2, was characterized by SEM, TEM, XRD, TGA, BET and FT-IR. The potential application of this covalently linked basic catalyst was also investigated as an efficient, heterogeneous and recyclable stationary micro-vessel and basic heterogeneous catalyst in Biginelli multicomponent condensation reaction. High yield, high efficiency and reusability are among the advantages of this environmentally friendly method. The nano catalyst can be easily separated from the reaction mixture and reused after washing for several runs without less in activity. تفاصيل المقالة -
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2 - New Pt(II) Complexes with Heterocyclic Ligands Derived from Benzimidazole: Synthesis, Characterization, DFT Calculations and Catalytic Activities
Parisa Sadeghzadeh Mehdi Pordel Safar Ali Beyramabadi Abolghasem DavoodniaIn this work, the synthesis, spectral characterization, DFT calculations, and catalytic activity of thenew Pt(II) complexes with the ligand derived from benzimidazole derivatives have been described.The new heterocyclic ligands were obtained from the reaction of o-amino أکثرIn this work, the synthesis, spectral characterization, DFT calculations, and catalytic activity of thenew Pt(II) complexes with the ligand derived from benzimidazole derivatives have been described.The new heterocyclic ligands were obtained from the reaction of o-amino-ketones with hydrazinehydrate in high yieldandPt(II) complexes prepared from the coordination of the new ligands toPt(II) cation. The new compounds have been characterized by spectral and microanalytical data.The DFT calculations at the B3LYP/6-311+G(d,p) level were also applied to gain further insightinto the geometry of Pt(II) complexes. The catalytic activity of Pt(II) complexes in Biginellireactionwas also examined as heterogeneous catalysts. The results showed that the 3,4-dihydropyrimidin-2(1H)-ones have been synthesized, in excellent yields, under solvent-free conditions, by reaction oftert-butyl acetoacetate, alcohol, arylaldehydes, and urea in the presence of Pt(II) complexes as anefficient and heterogeneous and catalyst. تفاصيل المقالة -
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3 - One-Pot Multi-Component Synthesis of Dihydropyrimidinones via Biginelli Condensation
Mohsen Sargordan Arani Behrooz Mirza Mohammad MoghanlouThree-component reactions have emerged as useful methods because the combinationof three components to generate new products in a single step is extremely economical,among the multi-component reactions. A green, simple, efficient, and cost-effective procedure has been c أکثرThree-component reactions have emerged as useful methods because the combinationof three components to generate new products in a single step is extremely economical,among the multi-component reactions. A green, simple, efficient, and cost-effective procedure has been carried out by the synthesis of dihydropyrimidinonesin Biginelli’s condensation of ethyl cyanoacetate, aldehyde and urea or thiourea .H3 BO3 , H2 C2 O4 , Me3 SiCl (TMSCl) using as catalyst and compared product yield.Products were characterized with IR, 1 H NMR, 13C NMR and mass spectroscopy تفاصيل المقالة -
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4 - Tributyl hexadecyl phosphonium bromide as a new and efficient catalyst for the one-pot synthesis of 3,4-dihydropyrimidinones/thiones via a three component condensation reactions
Rashid Badri Leila Mohammadi Ali Reza kiasat3,4-Dihydropyrimidinones are an important class of heterocycles due to their pharmaceutical and therapeutic properties. The most efficient method for synthesis of these 3,4-dihydropyrimidinones, first reported by Biginelli, involves three component, one-pot condensation أکثر3,4-Dihydropyrimidinones are an important class of heterocycles due to their pharmaceutical and therapeutic properties. The most efficient method for synthesis of these 3,4-dihydropyrimidinones, first reported by Biginelli, involves three component, one-pot condensation of a β-ketoester with an aldehyde and urea under strongly acidic conditions. The major drawbacks associated with this protocol, is poor to moderate yields, when using substituted aromatic and aliphatic aldehydes. Several improved methods for this protocol have been reported, can overcome the drawback of the classical protocol. This project aims investigating tributyl hexadecyl phosphoniuom bromide(TBHDPB) as a novel and efficient catalyst for synthesis of 3,4dihydropyrimidinones/thiones in milder reaction conditions. Optimization of the reaction conditions was attempted. The effect of temperature and solvent was studied. The best results were obtained in ethanol at 80 oC. The best catalytic activity of TBHDPB was optimized to be 10 mol% ( 0.1 mmol , 0.051g). Under optimal conditions, all reactions were completed within 45-80 min. All pure products were obtained in excellent yields (60-90%). The products were characterized by comparison of melting points and 1HNMR with those prepared in accordance with the literature procedures. The remarkable advantages of the present methodology over the literatures method, including the easily and inexpensive available catalyst, simple experimental procedures, shorter reaction times, excellent yields, easy work up and purification of products by non-chromatographic methods. تفاصيل المقالة -
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5 - Synthesis 3 and 4-Dihydropyrimidinone and Thiones using Multi-Walled Carboxylated Carbon Nanotube Catalysts
maryam moghaddasIn the present study, the synthesis of 3 and 4-dihydropyrimidinone and thiones was investigated by Biginelli reaction in the presence of carbon dioxide nanoparticles (MWCNT COOH) as a catalyst. The use of carbon nanotubes has many advantages, including ease of product s أکثرIn the present study, the synthesis of 3 and 4-dihydropyrimidinone and thiones was investigated by Biginelli reaction in the presence of carbon dioxide nanoparticles (MWCNT COOH) as a catalyst. The use of carbon nanotubes has many advantages, including ease of product separation, catalyst recovery capability, and environmental compatibility compared to liquid acidic catalysts. These catalysts are insoluble in most organic solvents and cause little corrosion. In addition, the catalyst is recovered without any reduction in its activity. Therefore, these catalysts can be used as a substitute for catalysts such as sulfuric acid. To investigate the effect of the catalyst on the organic reaction mentioned and to find the optimal conditions, first the synthesis of a derivative is selected as the reaction model and the effect of different reaction conditions such as the amount of catalyst, solvent type and temperature on it is examined. Other derivatives were then prepared under optimal conditions. In most cases, high product efficiency was achieved in a relatively short period of time. Comparing the conditions and results of the reactions performed in this study with other methods reported in the articles shows that the catalyst studied in this study was able to make the conditions of the reaction discussed in terms of time and efficiency, simple separation of products possible. تفاصيل المقالة -
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6 - Fe-Co-V/Zeolite nano composite catalyzed biginelli compounds synthesis and evaluation of their drug cytotoxic activity
shima Zanganeh Yousef Abadi Mohammad Kazem Mohammadi Haman TavakkoliAn effective one-pot synthesis of bis (dihydropyrimidinonoe) benzenes through Biginelli condensation reaction of terephthalic aldehyde, 1,3-dicarbonyl compounds and (thio) urea under solvent free conditions is described. Excellent yields of the products and simple work- أکثرAn effective one-pot synthesis of bis (dihydropyrimidinonoe) benzenes through Biginelli condensation reaction of terephthalic aldehyde, 1,3-dicarbonyl compounds and (thio) urea under solvent free conditions is described. Excellent yields of the products and simple work-up are attractive features of this green protocol. Then, the cytotoxic activities of these compounds were evaluated on 5 different human cancerous cell lines (Raji, HeLa, LS-180, SKOV-3 and MCF7). Their cytotoxic study indicated that they possessed a weak to moderate activity. Furthermore, the higher activity of compound 4b bearing sulfur in C2 position of pyrimidine ring showed the importance of this site for cytotoxic activity of these compounds. تفاصيل المقالة -
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7 - Biginelli Synthesis and Theoritical Study of Dihydropyrimidinone Compounds
Mohammad Hosein Farjam Ramin RezaeiAn effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl2 as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yiel أکثرAn effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl2 as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yields, short reaction times for formation of the products and simple work-up are attractive features of this green protocol. تفاصيل المقالة -
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8 - Zno nanoparticles/silica for biginelli solution syntheis
Ali Javid Sabbaghian Parya Nasehi -
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9 - TiO2 nanoparticles/melamine Tri sulfonic acid for biginelli syntheis under solvent-free conditions
Mohammad Kazem MohammadiTiO2 nanoparticles/melamine Tri sulfonic acid (MTSA) supported on silica gel as an efficient catalytic system for simple, one pot, solvent-free and environmentally benign process for synthesis of dihydropyrimidines via Biginelli reaction at 110 °C is described. It w أکثرTiO2 nanoparticles/melamine Tri sulfonic acid (MTSA) supported on silica gel as an efficient catalytic system for simple, one pot, solvent-free and environmentally benign process for synthesis of dihydropyrimidines via Biginelli reaction at 110 °C is described. It was found that the catalyst is reusable and exhibited remarkable activity. The catalyst can be easily separated and reused several times without appreciable loss of activity. The availability and recoverability of the catalytic system with easy operation and work up make this catalytic system attractive for organic synthesis. تفاصيل المقالة -
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10 - TiO2 nanoparticles/melamine Tri sulfonic acid for biginelli syntheis under solvent-free conditions
Mohammad Kazem MohammadiTiO2 nanoparticles/melamine Tri sulfonic acid (MTSA) supported on silica gel as an efficient catalytic system for simple, one pot, solvent-free and environmentally benign process for synthesis of dihydropyrimidines via Biginelli reaction at 110 °C is described. It w أکثرTiO2 nanoparticles/melamine Tri sulfonic acid (MTSA) supported on silica gel as an efficient catalytic system for simple, one pot, solvent-free and environmentally benign process for synthesis of dihydropyrimidines via Biginelli reaction at 110 °C is described. It was found that the catalyst is reusable and exhibited remarkable activity. The catalyst can be easily separated and reused several times without appreciable loss of activity. The availability and recoverability of the catalytic system with easy operation and work up make this catalytic system attractive for organic synthesis. تفاصيل المقالة -
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11 - preparation of 3, 4-dihydropyrimidin-2(1H)-ones using quaternary ammonium- treated clay in water
Soheil Sayyahi Sedigheh Jahanbakhshi Zahra DehghaniIn this study, a variety of 3, 4-dihydropyrimidin-2(1H)-ones derivatives were synthesized via three-component Biginelli reaction. The quaternary ammonium- treated clay -catalyzed process proved to be simple, efficient, and environmentally friendly.In this study, a variety of 3, 4-dihydropyrimidin-2(1H)-ones derivatives were synthesized via three-component Biginelli reaction. The quaternary ammonium- treated clay -catalyzed process proved to be simple, efficient, and environmentally friendly. تفاصيل المقالة -
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12 - TiO2 nanoparticles/melamine Tri sulfonic acid for biginelli syntheis under solvent-free conditions
forough cheldaviTiO2 nanoparticles/melamine Tri sulfonic acid (MTSA) supported on silica gel as an efficient catalytic system for simple, one pot, solvent-free and environmentally benign process for synthesis of dihydropyrimidines via Biginelli reaction at 110 °C is described. It w أکثرTiO2 nanoparticles/melamine Tri sulfonic acid (MTSA) supported on silica gel as an efficient catalytic system for simple, one pot, solvent-free and environmentally benign process for synthesis of dihydropyrimidines via Biginelli reaction at 110 °C is described. It was found that the catalyst is reusable and exhibited remarkable activity. The catalyst can be easily separated and reused several times without appreciable loss of activity. The availability and recoverability of the catalytic system with easy operation and work up make this catalytic system attractive for organic synthesis. تفاصيل المقالة -
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13 - A green and efficient method for the preparation of 3, 4-dihydropyrimidin-2(1H)-ones using quaternary ammonium- treated clay in water
Soheil Sayyahi Sedigheh Jahanbakhshi Zahra DehghaniThe reactive intermediate generated by the addition of tert-butyl and 1,1,3,3-tetramethyl butyl isocyanide and cyclohexyl isocyanide to dialkyl acetylenedicarboxylate was trapped by 3-hydroxy pyridine to produce highly functionalized 4H-chromenes in fairly good yieldsThe reactive intermediate generated by the addition of tert-butyl and 1,1,3,3-tetramethyl butyl isocyanide and cyclohexyl isocyanide to dialkyl acetylenedicarboxylate was trapped by 3-hydroxy pyridine to produce highly functionalized 4H-chromenes in fairly good yields تفاصيل المقالة -
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14 - Biginelli Synthesis and Theoritical Study of Dihydropyrimidinones
Mohammad Hosein Farjam Ramin RezaeiAn effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl2 as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yiel أکثرAn effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl2 as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yields, short reaction times for formation of the products and simple work-up are attractive features of this green protocol. تفاصيل المقالة -
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15 - A green and efficient method for the preparation of 3, 4-dihydropyrimidin-2(1H)-ones using quaternary ammonium- treated clay in water
Soheil Sayyahi Sedigheh Jahanbakhshi Zahra DehghaniIn this study, a variety of 3, 4-dihydropyrimidin-2(1H)-ones derivatives were synthesized via three-component Biginelli reaction. The quaternary ammonium- treated clay -catalyzed process proved to be simple, efficient, and environmentally friendly.In this study, a variety of 3, 4-dihydropyrimidin-2(1H)-ones derivatives were synthesized via three-component Biginelli reaction. The quaternary ammonium- treated clay -catalyzed process proved to be simple, efficient, and environmentally friendly. تفاصيل المقالة -
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16 - Solvent-free One Pot Biginelli Method for Synthesis of new Dihydropyrimidinone compounds
Masih GolkariAn effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl2 as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yiel أکثرAn effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl2 as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yields, short reaction times for formation of the products and simple work-up are attractive features of this green protocol. تفاصيل المقالة -
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17 - New method for preparation of MWCNT-SO3H as an efficient and reusable catalyst for the solvent-free synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones
Leila Moradi Gholam Reza Najafi Hakimeh SaeidiroshanMultiwalled carbon nanotubes (MWCNTs) have been functionalized with -SO3H groups using new three steps chemical routes. Firstly, OH groups have been attached to CNT surfaces through a radical reaction. The second step involves converting the hydroxyl groups into the oxi أکثرMultiwalled carbon nanotubes (MWCNTs) have been functionalized with -SO3H groups using new three steps chemical routes. Firstly, OH groups have been attached to CNT surfaces through a radical reaction. The second step involves converting the hydroxyl groups into the oxide one and last step included the attachment of –SO3H groups on the MWCNTs surfaces in the presence of 1-butyl-3-methyl imidazolium tetrafluoroborate [bmim]BF4 ionic liquid as catalyst. Functionalized MWCNTs were characterized by Fourier transform infrared (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM) and Raman Spectroscopy. Obtained product have be used as acidic nano catalyst in the Biginelli reaction for the synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives. The reaction was performed under solvent-free conditions with excellent yields and short reaction times in the presence of a reusable efficient catalyst. تفاصيل المقالة -
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18 - Highly efficient multicomponent Biginelli’s synthesis of 3,4-dihydropyrimidin-2(1H)-ones catalyzed by Al-MCM-41 under solvent-free conditions
Soheil Sayyahi Mehdi Behvandi BehvandiIn this study, an efficient and green process for the synthesis of dihydropyrimidin-2(1H)-ones from aromatic benzaldehydes, ethyl acetoacetate and urea using Al-MCM-41 as heterogeneous catalyst and microreactor under solvent-free conditions has been developed. The advanta أکثرIn this study, an efficient and green process for the synthesis of dihydropyrimidin-2(1H)-ones from aromatic benzaldehydes, ethyl acetoacetate and urea using Al-MCM-41 as heterogeneous catalyst and microreactor under solvent-free conditions has been developed. The advantages of this method are easy work-up procedure, regeneration of the catalyst, clean and neutral reaction conditions. تفاصيل المقالة -
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19 - An efficient synthesis of 4-aryl-7-benzylidene-hexahydro-2H-cyclopenta[d] pyrimidin-2-ones/thiones catalyzed by p-dodecylbenzenesulfonic acid
Krishnamoorthy Aswin Majid Ghashang Sheik MansoorA new and efficient method has been developed for the synthesis of 4-aryl-7-benzylidene-1,3,4,5,6,7-hexahydro-2H-cyclopenta[d]pyrimidin-2-ones through Biginelli-like reaction of cyclopentanone, with urea/thiourea and aromatic aldehyde employing p-dodecylbenzenesulfonic أکثرA new and efficient method has been developed for the synthesis of 4-aryl-7-benzylidene-1,3,4,5,6,7-hexahydro-2H-cyclopenta[d]pyrimidin-2-ones through Biginelli-like reaction of cyclopentanone, with urea/thiourea and aromatic aldehyde employing p-dodecylbenzenesulfonic acid (DBSA) as a recyclable catalyst under solvent-free condition. The recovered catalyst was recycled for further runs. The product formation takes place via a cross-aldol condensation of benzaldehyde with cyclopentanone in the presence of DBSA to produce benzylidene intermediate and subsequent Michael addition. The present approach offers the advantages of short reaction time, mild reaction conditions, high yields and convenient operation. All the products were obtained in good to excellent yields and the structures of the synthesized compounds were established by advanced spectroscopic data. تفاصيل المقالة -
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20 - Application of SBA-Pr-SO3H as a solid acid nanoreactor in the Biginelli reaction
Ghodsi Mohammadi Ziarani Shima Ghorbi Parisa Gholamzadeh Alireza BadieiSulfonic acid functionalized nanoporous silica (SBA-Pr-SO3H) with a pore size of 6 nm catalyzed three component coupling of aromatic aldehydes, urea and ethyl acetoacetate to afford the corresponding dihydropyrimidinones under solvent free condition. This new protocol f أکثرSulfonic acid functionalized nanoporous silica (SBA-Pr-SO3H) with a pore size of 6 nm catalyzed three component coupling of aromatic aldehydes, urea and ethyl acetoacetate to afford the corresponding dihydropyrimidinones under solvent free condition. This new protocol for Biginelli reaction has important advantages such as green synthesis, short reaction time, easy isolation and high yields of products and reusability of the catalyst. SBA-Pr-SO3H was proved to be an efficient heterogeneous nanoporous solid acid catalyst which could be easily handled and removed from the reaction mixture by simple filtration and can be recovered and reused for several times without any loss of activity. تفاصيل المقالة -
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21 - Oxalic acid dihydrate catalyzed synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives under thermal and solvent-free conditions
Farzaneh Mohamad Pour Malek Taher Maghsoodlou Reza Heydari Mojtaba LashkariOxalic acid dihydrate as a green, mild and efficient catalyst for the one-pot three-component Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives from the reaction between β-keto esters (methyl or ethyl acetoacetate), aromatic aldehyde (benzaldehye d أکثرOxalic acid dihydrate as a green, mild and efficient catalyst for the one-pot three-component Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives from the reaction between β-keto esters (methyl or ethyl acetoacetate), aromatic aldehyde (benzaldehye derivatives) and urea or thiourea under thermal and solvent-free conditions with excellent yields and short reaction time is studied. The most remarkable benefits of this synthetic method include the green methodology, an eco-friendly, inexpensive and non-toxic catalyst, solvent-free conditions, the availability of materials, and a simple operational procedure with no column chromatographic separation. The products were characterized by melting points, IR and 1H NMR spectroscopy. تفاصيل المقالة -
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22 - Novel acidic ChCl/TFA DES as reaction medium and catalyst for Biginelli and Hantzsch reactions
Adeleh Moshtaghi Zonouz Abdolreza Abri Nasrin babajani Hemayat ShekaariNovel deep eutectic solvent (DES) using Choline Chloride (ChCl) as the hydrogen bond acceptor and triflouroacetic acid (TFA) as hydrogen bond donor (1.0:1.5 molar ratio) was prepared at room temperature and characterized by FT- IR and 1H NMR spectroscopy. Also, this nov أکثرNovel deep eutectic solvent (DES) using Choline Chloride (ChCl) as the hydrogen bond acceptor and triflouroacetic acid (TFA) as hydrogen bond donor (1.0:1.5 molar ratio) was prepared at room temperature and characterized by FT- IR and 1H NMR spectroscopy. Also, this novel acidic RTDES (room temperature deep eutectic solvent) was successfully used both as a reaction medium and catalyst in Biginelli, Biginelli-like, and Hantzsch reactions. The procedures have the advantages of high yields, short reaction times and easy work-up as well as relatively mild conditions and they do not require additional catalysts and organic solvents. The DES could be easily recycled without considerable loss of activity even after more than three cycles. تفاصيل المقالة -
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23 - Nano-Silica phosphoric acid: an efficient catalyst for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones (thiones) under solvent-free or sonication conditions
Abdolhamid Bamoniri Bi Bi Fatemeh Mirjalili Sedigheh NazemianTwo simple protocols for the synthesis of three-component condensation reaction of an aldehyde, β-ketoester and urea or thiourea to obtain the 3, 4-dihydropyrimidin-2(1H)-ones (thiones) using nano silica phosphoric acid are reported. Short reaction times, high yiel أکثرTwo simple protocols for the synthesis of three-component condensation reaction of an aldehyde, β-ketoester and urea or thiourea to obtain the 3, 4-dihydropyrimidin-2(1H)-ones (thiones) using nano silica phosphoric acid are reported. Short reaction times, high yields, reusability of catalyst and easy workup are some advantages of these protocols. تفاصيل المقالة -
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24 - CuO-CeO2 nanocomposite: A green recyclable catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones
Jalal Albadi Azam MansournezhadCuO-CeO2 nanocomposite is reported as a green and highly efficient recyclable catalyst for the multicomponent synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones under solvent-free conditions. The catalyst was synthesized by co-precipitation method and characterized by أکثرCuO-CeO2 nanocomposite is reported as a green and highly efficient recyclable catalyst for the multicomponent synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones under solvent-free conditions. The catalyst was synthesized by co-precipitation method and characterized by XRD, BET specific surface area, FESEM and EDS analysis. تفاصيل المقالة -
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25 - Decatungstodivanadogermanic heteropoly acid (H6GeW10V2O40.22H2O): A green and reusable heterogeneous catalyst for the synthesis of Biginelli-type 3,4-dihydropyrimidin-2-(1H)-ones/thiones
Srinivasa Rao Jetti Divya Verma Shubha JainDecatungstodivanadogermanic acid (H6GeW10V2O40.22H2O) was used as a green heterogeneous catalyst for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones from one-pot three-component cyclocondensation reaction of a β-ketoester, an aldehyde and urea/thiourea under solv أکثرDecatungstodivanadogermanic acid (H6GeW10V2O40.22H2O) was used as a green heterogeneous catalyst for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones from one-pot three-component cyclocondensation reaction of a β-ketoester, an aldehyde and urea/thiourea under solvent-free conditions is reported. This method provides an efficient and much improved modification of the original Biginelli reaction reported in 1893, in terms of high yields, and short reaction times. It has the ability to allow a wide variety of substitutions in all three components. تفاصيل المقالة -
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26 - Green procedure for synthesis of 3, 4 dihydropyrimidinones using 12-molybdophosphoric acid, as a catalyst and solvent free condition under microwave irradiation
Hojjatollah SalehiSimple and improved conditions have been found to carry out the Biginelli reaction for the synthesis of 3, 4-dihydropyrimidin-2(1H) - one derivatives. This synthesis was performed in the presence of 12-molybdophosphoric acid (H3PMo12O40) as catalyst. These reactions wer أکثرSimple and improved conditions have been found to carry out the Biginelli reaction for the synthesis of 3, 4-dihydropyrimidin-2(1H) - one derivatives. This synthesis was performed in the presence of 12-molybdophosphoric acid (H3PMo12O40) as catalyst. These reactions were performed under solvent free conditions with microwave irradiation as the energy source. Compared with the classical Biginelli reaction conditions, this new method has the advantage of excellent yields (76–96%). The advantages of this novel protocol include the excellent yield, operational simplicity, short time, and the avoidance of the use of organic solvents and friendly preparation. Products were identified using physical and spectroscopic data. تفاصيل المقالة -
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27 - SbCl5.SiO2: an reusable lewis acid for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones (thiones)
Bi Bi Fatemeh Mirjalili Esmat Mohammadnejad Abdolhamid BamoniriNano-SbCl5.SiO2 and SbCl5.SiO2 are bench-top catalysts which are reusable, readily available, versatile andefficient for promotion of many acid catalyzed organic reactions. These catalysts do not need specialprecautions for preparation, handling or storage, and they can أکثرNano-SbCl5.SiO2 and SbCl5.SiO2 are bench-top catalysts which are reusable, readily available, versatile andefficient for promotion of many acid catalyzed organic reactions. These catalysts do not need specialprecautions for preparation, handling or storage, and they can be stored at an ambient temperature for monthswithout losing their catalytic activity. 4-dihydropyrimidin-2(1H)-ones(thiones) were synthesized in thepresence of Nano-SbCl5.SiO2 or SbCl5.SiO2 as a reusable and efficient catalyst. تفاصيل المقالة