One-Pot Multi-Component Synthesis of Dihydropyrimidinones via Biginelli Condensation

الموضوعات :

Mohsen Sargordan Arani ¹ ()
Behrooz Mirza ² ()
Mohammad Moghanlou ³ ()

تاريخ الإرسال : 18 الإثنين , ربيع الثاني, 1438 تاريخ التأكيد : 18 الإثنين , ربيع الثاني, 1438 تاريخ الإصدار : 03 الأحد , ربيع الثاني, 1438

الکلمات المفتاحية:

ملخص المقالة :

Three-component reactions have emerged as useful methods because the combinationof three components to generate new products in a single step is extremely economical,among the multi-component reactions. A green, simple, efficient, and cost-effective procedure has been carried out by the synthesis of dihydropyrimidinonesin Biginelli’s condensation of ethyl cyanoacetate, aldehyde and urea or thiourea .H3 BO3 , H2 C2 O4 , Me3 SiCl (TMSCl) using as catalyst and compared product yield.Products were characterized with IR, 1 H NMR, 13C NMR and mass spectroscopy