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Open Access Article
1 - Surveying the Effect of Off-Balance Sheet Financing on Profitability Ratios
Gh. , Talebnia F. Rahnamaye roodposhti Ch. TalebpooraslIn this thesis the effect of off-balance sheet financing on profitability ratios (ROA,ROE,ROI) inTehran Stock Exchange has been studied. In fact, this study is an answer to this question that "whateffects can off-balance sheet financing (operating lease) has on profitab MoreIn this thesis the effect of off-balance sheet financing on profitability ratios (ROA,ROE,ROI) inTehran Stock Exchange has been studied. In fact, this study is an answer to this question that "whateffects can off-balance sheet financing (operating lease) has on profitability ratios in Tehran StockExchange?" Off-balance sheet financing means investing or increasing firm´s capital (increaseoperating activities) according to law and accepted accounting concepts that all or part of thatfinancing is not shown on balance sheet and profitability ratios evaluate firm´s efficiency and ability tomake use of resources using sales revenue and investment.In this study causal-comparative method has been used. Which library method (exchange’s archive)were used for gathering needed information in theorical basis and financial information based auditedfinancial statement. In this study, firm´s profitability ratios before and after off-balance sheetfinancing, and firms having and without off-balance sheet financing are compared.Hypothesizes analysis show that, from 1380-1385, off-balance sheet financing hasn’t had considerableeffect on profitability ratios. Manuscript profile -
Open Access Article
2 - Incorporation of essential oils (EOs) and nanoparticles (NPs) into active packaging systems in meat and meat products: A review
Mina Kargozari Hassan Hamedi -
Open Access Article
3 - RRelease from prison policy in the light of the legal changes of the institution of mitigation of punishment in the law of reducing the punishment of taaziri imprisonment and its comparative comparison with the law of England
alireza Emamdadi Mohamad Ali, tahire, alireza, azizi, Sayyed Hassan HashemiRelease from prison policy in the light of the legal changes of the institution of mitigation of punishment in the law of reducing the punishment of taaziri imprisonment and its comparative comparison with the law of England Following the imposition of imprisonment and MoreRelease from prison policy in the light of the legal changes of the institution of mitigation of punishment in the law of reducing the punishment of taaziri imprisonment and its comparative comparison with the law of England Following the imposition of imprisonment and the development of the policy of " Prisonerism " and the emergence of its harms, "" Release from prison "" was gradually included in the criminal policy program of countries and left effects that pay attention to the role of benevolent institutions such as "mitigation of punishment". The title is a tool for detente. It is such While the developments of Iran's criminal policy regarding the institution of mitigation of punishment as a tool to control the criminal population, regardless of the process of " Prisoneris in criminal legislation" with manifestations of extremism in the development or narrowing of the scope of crimes and the powers of the Judicial authority, The UK criminal law defines the dual policy of "reducing the criminal population - criminal prevention" and defining the criteria for determining imprisonment as the most severe punishment in this country, Manuscript profile -
Open Access Article
4 - Juridical and Economic Look to the Ijarah securities, features and benefits
Aziz Neko M. Javad BaqizadehThe nature criticized usury bonds and the need to replace the legitimate means of monetary policy, such as Musharaka securities and Ijarah securities, to fight inflation and recession on the one hand and on the other hand inefficiency of Musharaka securities in practice MoreThe nature criticized usury bonds and the need to replace the legitimate means of monetary policy, such as Musharaka securities and Ijarah securities, to fight inflation and recession on the one hand and on the other hand inefficiency of Musharaka securities in practice, leading some Islamic countries in the Ijarah securities and ability to provide assets and liquidity of the natural and legal persons, in conditions of severe financial restrictions and sanctions of country, by issuing Ijarah securities, are other factors and causes the necessity of applying the attractiveness of Ijarah securities in Iran. This paper seeks to understand the necessity of using financial instruments, as a requirement of undeniable economic and explain the characteristics of Ijarah securities, reviews devoid of the financial instruments from the elements of interest, Gharar and simulation as important criteria of Islamic jurisprudence and concern of the Islamic scholars as an important issue , and with half a glance at the problems and shortcomings Musharaka securities in practice, because of the benefits of Ijarah securities, rather than the Ijarah securities, and the conclusion of it will explain, which has been less attention. Manuscript profile -
Open Access Article
5 - Analysis of the Jurisprudence Nature of Technology Transfer in Petroleum Contracts
Hojjat Shafiei Majid VaziriTechnology transfer in petroleum contracts must have jurisdictional legislation and provide materials to the contracting parties therefore, it is necessary to explain the jurisprudential nature of technology transfer in these contracts. This descriptive-analytic researc MoreTechnology transfer in petroleum contracts must have jurisdictional legislation and provide materials to the contracting parties therefore, it is necessary to explain the jurisprudential nature of technology transfer in these contracts. This descriptive-analytic research answers the questions that what is the jurisprudential nature of technology transfer in petroleum contracts? which of the following is in accordance with Islamic jurisprudence? After examining different types of international legal and indefinite contracts and different formats such as bye back, leasing and reward contract it was found the step four of bye back (IPC) it is very similar to lease and reward contracts. also concluded that technology transfer in Petroleum contracts is similar to leasing. The most important legal effect is that, under the terms of the contract for the lease of individuals, the contractor has no rental right of ownership, and is merely entitled to receive the remuneration provided by the service. Manuscript profile -
Open Access Article
6 - Analysis of Traslative theory of the lease of premises
Marzieh AfzalimehrLease of premises is a contract have a lot of application in society.inaccordance with existance of some practical results on divisionbetween translative and promissory theory of the lease :such aspossibility of possession of interests to others by lease holderanalysis MoreLease of premises is a contract have a lot of application in society.inaccordance with existance of some practical results on divisionbetween translative and promissory theory of the lease :such aspossibility of possession of interests to others by lease holderanalysis of the translative theory-that is an accepted theory byfamous Islamic jurisprudents and civil law- is nessacery. Manuscript profile -
Open Access Article
7 - The Study of the Necesity Acquirerelase of Pationt in Order to Eliminate of Civil Responsibility of a Doctor
Mehdi Khadem sarbakhshThis articles, regarding to religiously opinions and studingIraninand English law, apropratied to study of the necesity acquire relaseof pationt in order to eliminate of civil responsibility of a doctor.This articles is writen in tow parts. First part of this articlesap MoreThis articles, regarding to religiously opinions and studingIraninand English law, apropratied to study of the necesity acquire relaseof pationt in order to eliminate of civil responsibility of a doctor.This articles is writen in tow parts. First part of this articlesaproprated to necesity or non necesity acquire release of pationt inorder to eliminate of civil responsibility of a doctor and secondparts aproprtated to conditions of effectivityrelase or consent ofpationt. In this articles, the resercher is concluded that the consentof pationt is enough in order to eliminate of civil responsibility of adoctor. In the other word, in order to eliminate of civilresponsibility of a doctor about injuries of pationt is not necesery toacquire release of pationt. Manuscript profile -
Open Access Article
8 - Novel Quaternary ammonium modified-tragacanth gum hydrogels for drug delivery applications with antimicrobial activity and release kinetic study
Javid Monjezi Rezvan Jamaledin Mousa Ghaemy Pooyan Majvandi -
Open Access Article
9 - A deductive kinetic study of diclofenac release from chitosan-based magnetic nanocomposite hydrogels
Zargazi M. H. Ghadimi Yari M. Mehran Kurdtabar -
Open Access Article
10 - The Relationship between Heidegger's Thought and Philosophical Mysticism
Bahman PazoukiIn the twentieth century has no philosopher tried as much as Heidegger to go beyond philosophical concepts and reflections. From the period known as the "Kehre", Heidegger's thought has entered into a field of intellectual experience and a borderline realm that goes bey MoreIn the twentieth century has no philosopher tried as much as Heidegger to go beyond philosophical concepts and reflections. From the period known as the "Kehre", Heidegger's thought has entered into a field of intellectual experience and a borderline realm that goes beyond purely rational thought and does not follow its rules. Many commentators have interpreted this way of thinking as similar to the way of Mystik thinking and doubt its ability to answer philosophical questions. By Mystik they mean a kind of thinking that shrugs off the burden of rationality and reason has no access to it. In this article, however, Mystik, that means "philosophical mysticism", is a school of thinking in Christianity that is tied to the name of Meister Eckhart. It covers a wide range of subjects, not all of which necessarily agree with philosophy. In examining the relation of Heidegger's thought to "philosophical mysticism", a report is first given of his own position on this concept. In the next step, in order to find out how close Heidegger's thought is to "philosophical mysticism", we show, in comparing the differences and common aspects of the meanings of both Eckhart's and Heidegger's concept of "releasement (Gelassenheit)". Manuscript profile -
Open Access Article
11 - Control Release from Low Acyle Gellan Gum Gels
A. Rahman S. Bakalis -
Open Access Article
12 - Effect of Aerobic and Anaerobic Composting on the Removal of Antibiotics of Enrofloxacin and Ciprofloxacin in Broiler Chicken Manure
mahsa mohammadzadeh forouzan Ghasemian Roudsari Akbar Hassani Abbasali ZamaniBackground and Objective: Many of the antibiotics used in poultry farms are excreted in their feces. This waste is used as organic fertilizer in agriculture and causes the release of animal antibiotics in the environment. These compounds may increase the antibiotic resi MoreBackground and Objective: Many of the antibiotics used in poultry farms are excreted in their feces. This waste is used as organic fertilizer in agriculture and causes the release of animal antibiotics in the environment. These compounds may increase the antibiotic resistance of microbial populations or damage plants grown in these soils. The aim of this study was to determine the effect of aerobic and anaerobic poultry manure composting on the amount of enrofloxacin and ciprofloxacin antibiotics in poultry manure at two levels of high and low concentration and compare them with each other. Method: Two samples of fresh broiler chicken manure were prepared after the end of the chicken treatment with antibiotic enrofloxacin. The two samples contained two levels of high and low concentrations of Enrofloxacin and Ciprofloxacin. The composting of chicken manure was done using a completely randomized design with 4 treatments of 1- aerobic treatments at a low concentration, 2- aerobic treatments at high concentration 3- anaerobic treatments at low concentration 4- anaerobic treatments at a high concentration in five replicates in 75 days. Samples were prepared at specific intervals and the concentration of Enrofloxacin and Ciprofloxacin was measured by HPLC method. The obtained data were fitted with the first-order kinetic equation and the half-life of the antibiotic degradation was calculated. Findings: The results showed that at the end of the period, in treatments 1 to 4, 54.2%, 64.3%, 65.3% and 69.7% of the Enrofloxacin and 41%, 57.8%, 57.8% and 61.8% Ciprofloxacin remained. The correlation coefficient (R2) obtained from the fitting of the first-order kinetic equation in treatments (from 0.71 to 0.92) showed that the data fit well with this equation. The half-life of the Enrofloxacin degradation was obtained between 96.27 and about 150.68 days. The half-life of degradation for Ciprofloxacin was also found to be between 57.28 and 117.48 days. Discussion and Conclusion: Overall, the results showed that the process of composting reduced the concentration of antibiotics and prevented its entry into the environment. The rate and total amount of antibiotic degradation in aerobic conditions was higher than anaerobic. The rate of degradation of both antibiotics at a high initial concentration was lower than its rate of degradation at low concentrations. The rate of ciprofloxacin degradation was also higher than Enrofloxacin. The results of this study can help to create relevant laws and regulations in relevant institutions, in order to reduce the release of veterinary antibiotics into the environment. Manuscript profile -
Open Access Article
13 - Asset Securitization in leasing industry
Fraydoon Rahnamay Roodposhti Mahdiyar Sarshar S. Mohammadjavad MirtaherLeasing companies play an important role in meeting the needs of firms and households. These companies can resolve liquidity problem of their customers by providing their various products. But despite these advantages, leasing industry is relatively young and less devel MoreLeasing companies play an important role in meeting the needs of firms and households. These companies can resolve liquidity problem of their customers by providing their various products. But despite these advantages, leasing industry is relatively young and less developed in Iran. One of the major problems in the path of growth and development of leasing companies is Failure in providing reliable and stable financial resources at different periods of time. From the past, difficulties in financing leasing companies are a key issue in the industry that occupied the minds of managers. The performance of leasing industry in Iran shows that leasing industry at different periods of boom and recession has failed to show the same performance and stability. One of the key causes in the process of stable financing is existing shortcomings. Hence, it is vital to using modern methods, diversified and stable financing in leasing companies in Iran within the interest-free banking system. One of the most effective methods to finance leasing companies in Iran is securitization of assets. It can be said that balance sheet assets of leasing companies which have the ability to transform into securities include assets resulting from installment sale and lease-purchase .This study tries to design and offer asset securitization process in Iran and leasing companies within the interest-free banking and finds proper response to the problems raised in the area of financing leasing companies. Manuscript profile -
Open Access Article
14 - Release of contemporary man from crisis in Khalil Havi's poems
Afshar GhasemabadiKhalil Havi's poems contain an echo from contemporary man and his problems and hardships that speak of the pain, suffering and oppressions on him. Havi considers man in the present age, especially Arabic contemporary man, to be a captive creature that is caught in the c MoreKhalil Havi's poems contain an echo from contemporary man and his problems and hardships that speak of the pain, suffering and oppressions on him. Havi considers man in the present age, especially Arabic contemporary man, to be a captive creature that is caught in the current crisis and is surrounded by oppression. Poet in his poems also deals with the oppressions and crises that caused man to be stagnant in the present age, to the extent that a deep crisis and tragedy is depicted in his poems, and this is the crisis and sorrow that is the basis of human existence. Havi is not unaware of contemporary man's awareness of his oppression and problems and it is to explain contemporary man with the human principle. In his poems, he considers ideas for human release and uses his existential experiences and expresses them. According to Khalil Havi, contemporary man, in order to free himself, has made release as the top priority of his life and with slogans such as hope, waiting for miracles, certainty, struggle and revolution, resurrection and idealism, strives for release and freedom and alleviation of its pains and sufferings in order to be able to do an action with these ideas and efforts and struggles for the release of humanity, in particular, the Arabic man and in all these circumstances, he hoped to achieve the freedom he wanted. Manuscript profile -
Open Access Article
15 - The Time Sharing, Nature and its Effects of the View of Jurisprudent
حمید واحدی محمد مهدی احمدیAbstractA newly developed legal body is timesharing not a long since the emergence of which not a long period has elapsed. It has been prevailing in our country for a few years now. Subject matter of this thesis is the evaluation of this new legal body from the viewpoin MoreAbstractA newly developed legal body is timesharing not a long since the emergence of which not a long period has elapsed. It has been prevailing in our country for a few years now. Subject matter of this thesis is the evaluation of this new legal body from the viewpoints Of law and religious jurisprudence. The present research is an effort for the acquisition Of as precise understanding and knowledge as possible on this new legal body by marking an elaboration into the fundamentals and nature of this new legal body identifying its various kinds, and its conformity to the specified contracts defined by Religious jurisprudence and case law and with unspecified contracts. According to studies, this conclusion is drawn Overall, the studies showed that Different types of time-sharing With some specific contracts or accepted uncertainty in The law is applicable . time-sharing is Shared ownership sale and Peace applicableAlso it can be made under the terms of a contract of non-specified contractsOf course given the long history of mahayat in feghh of iran and more compatible with the legal culture and our regigion.Condominium sales on mahayat condition seemed better Time sharing credit can be awarded in the rorm settled Key words: Temporary ownership(Timesharing), Contract of sale, Lease contract, association contract. Manuscript profile -
Open Access Article
16 - Synthesis and evaluation of magnetic nanoparticles (Fe3O4) to provide the best synthesis method for drug delivery in a controlled manner in the treatment of various types of cancer
Sayed Esmaeil Mohammadi mehr Mehdi Faramarzi Sayed Abotaleb MousaviparsaIntroduction: In this research, nanoparticles were synthesized by two methods of hemolipation and precipitation-reduction under optimal conditions. Using X-Ray Diffraction and Fourier Infrared Spectroscopy (FTIR) tests, the optimal conditions for nanoparticle synthesis MoreIntroduction: In this research, nanoparticles were synthesized by two methods of hemolipation and precipitation-reduction under optimal conditions. Using X-Ray Diffraction and Fourier Infrared Spectroscopy (FTIR) tests, the optimal conditions for nanoparticle synthesis were determined by sediment-reduction method. Finally, by analyzing the images taken by electron microscopy from two samples, the average size of magnetite nanoparticles synthesized by co-precipitation method was measured at 39nm and by sediment-reduction method at 4/5nm. By plotting the particle size distribution, in the co-precipitation method, the particle size distribution of nanoparticles was relatively wide and in the sediment-reduction method, the relatively narrow particle size distribution was obtained. Finally, by comparing the average size, distribution, particle size and morphology of nanoparticles synthesized by the two methods mentioned, magnetite nanoparticles synthesized by sediment-reduction method are proposed for drug delivery applications. Material and methods: This is a research study involving experiments and reviewing library studies on controlled drug delivery systems. After conducting library studies and obtaining sufficient information, laboratory tests of this study were performed. Results: With the creation of particle systems, new properties were introduced into drugs that did not exist before. The use of nanoparticles has led to its optimization and has created features such as therapeutic target, improved cell permeability, longer life, etc. that were not previously available in conventional drugs. Nanoparticles synthesized by the deposition-reduction method, which are more synthetic than the co-precipitation method, have a higher purity, a much smaller particle size, and a narrower particle size distribution. Due to the fact that magnetite nanoparticles in sizes below 15 nm show the properties of paramagnetic cloud and also nanoparticles suitable for pharmaceutical applications should have a uniform distribution of particle size, nanoparticles synthesized by sediment-reduction method are recommended for drug delivery applications. Conclusion: Due to the fact that magnetite nanoparticles in sizes below 15 nm show superparamagnetic properties and also nanoparticles suitable for pharmaceutical applications should have a uniform distribution of particle size, nanoparticles synthesized by sedimentary-reduction method for drug delivery applications are recommended. Manuscript profile -
Open Access Article
17 - Investigating levothyroxine drug release on synthesized nanocomposite containing magnetic cores covered with alginate polymer and metal-organic framework
Zaynab Madadi Fadaeian Manochehr Mohammad Ali GhasemzadeObjectives: Levothyroxine drug is used to treat thyroid diseases, which is one of the most common chronic diseases in the world, and considering that levothyroxine is a hydrophobic drug with low solubility and low stability, it requires an advanced drug delivery system. MoreObjectives: Levothyroxine drug is used to treat thyroid diseases, which is one of the most common chronic diseases in the world, and considering that levothyroxine is a hydrophobic drug with low solubility and low stability, it requires an advanced drug delivery system. Among the targeted drug delivery systems, magnetically modified porous carriers have a high capacity to store drugs due to the presence of side groups, the adaptability of its porosity, and release it over a long period of time and instead of spreading throughout the body, it affects only the desired cell. he does.Materials and methods: The present research deals with preparing and identifying the metal-organic framework and investigating its performance in levothyroxine drug loading and release. First, MnCuFe2O4 nanoparticles were synthesized and covered by alginate polysaccharide. After that, the metal-organic framework 66-UiO was placed on it and the three-layer composite MnCuFe2O4@Alginate@UiO-66 was made.Findings: loading and release of levothyroxine drug on the synthesized nanocarrier was investigated at pH 7.4. The fabricated nanocomposite was examined by various methods such as SEM, EDX, FT-IR, BET. Nanocomposite was made with cheap and biodegradable raw materials such as alginate using an easy method with targeted drug delivery and magnetic strength.Conclusions: This nanocomposite with 87% loading capacity and 73% levothyroxine release can be used as a new and targeted drug delivery system. Manuscript profile -
Open Access Article
18 - In Vitro Release Studies of Enoxaparin in Nanoparticle form and Enterically Coated Tablets Containing Surfactants
Orkide Ghorban Dadras Morvarid Goharzadeh Mohammad Reza Avadi Zahra Ghassemi Asal Mirmohammad Sadeghi -
Open Access Article
19 - Preparation and Characterization of Magnetic Gelatin-Polyvinyl Alcohol Hydrogel for using in the Release of Furosemide Drug
Benyamin Masoumi Masoud Mokhtary -
Open Access Article
20 - An Investigation of the Charge Effects on the Uptake and Release Capacity of Mesoporous Silica Nanoparticles as Vehicles for Short Oligonucleotides
Rafatosadat Badihi Ali Mahmoudi Mohammad Reza Sazegar Khodadad Nazari -
Open Access Article
21 - Preparation, Characterization and in vitro Release Studies of Enoxaparin in Nanoparticle form and Enterically Coated Tablets Containing Different Enhancers
Orkide Ghorban Dadras Morvarid Goharzadeh Mohammad Reza Avadi Assal Mir Mohammad Sadeghi -
Open Access Article
22 - Investigation of the Potential of Adsorption and Drug Delivery Application of the Duloxetine Antipsychotic by using its Molecular Imprinted Polymer
Seyyedeh Fatemeh Hoseini chehreghani Parviz Aberoomand Azar Maryam Shekarchi Bahram Daraei -
Open Access Article
23 - Preparation, Characterization and in vitro Studies of Chitosan Nanoparticles Containing Androctonus Crassicauda scorpion venom
Orkideh Ghorban Dadras Asal Mir Mohammad Sadeghi Nastaran Farhangi Nazanin Forouhar Naser Mohammadpour Mohammad Reza Avadi -
Open Access Article
24 - Preparation of Novel Thermo-sensitive Polymer/βCD/WS2 Nano-carriers for invitro Drug Release of Tamoxifen in the Presence and Absence of Near-Infrared (NIR) Laser
Abbas Bohloli Maryam Daghighi Asli Elham Moniri Azar Bagheri -
Open Access Article
25 - Antimicrobial Modified-Tragacanth Gum/Acrylic Acid Hydrogels for the Controlled Release of Quercetin
Javid Monjezi Rezvan Jamaledin -
Open Access Article
26 - Improving the efficiency of trifluralin herbicide by microcapsule formulation in weed control of tobacco (Nicotiana tobacum)
Ahmad Rahbari Ebrahim Izadi Darbandi Mohammad Hassan Rashed Mohassel Gholam hossein Zohuri Eskandar ZandReduce pesticides usage and improve efficiency of them can be achieved by the technology of controlled release formulations. This experiment conducted to investigate the efficiency of synthesized microcapsule formulation of trifluralin in Tirtash Research and Education MoreReduce pesticides usage and improve efficiency of them can be achieved by the technology of controlled release formulations. This experiment conducted to investigate the efficiency of synthesized microcapsule formulation of trifluralin in Tirtash Research and Education Center (located in Mazandaran province, the north of Iran) during the 2014 growing season. The experiment design was three-way factorial arrangement on a CRD with three replications. The treatments consisted of the microcapsule and emulsifiable concentrate (Treflan® 48%) formulation in different doses, 50, 75 and 100 percent of recommended dose (0.6, 0.9 and 1.2 kg a.i./ha) and application methods, soil-incorporated pre-planting and pre-planting. Weeding and weed infest were prepared as control plots. Density and dry weight of weed at 40 and 60 days after tobacco transplanting and tobacco yield were measured during the growth season. Based on the relative abundance of weeds, Setaria viridis L. and Amaranthus retroflexus L. were dominant species. The experimental results show there were significant difference between formulation type, dose and method of application on density and dry weight of weed and tobacco yield. The effectiveness of MC formulation in each applied dose were higher than EC formulation. The 50% recommended dose of MC formulation had the same weed control effectiveness as 75% recommended dose of the EC formulation. The green foxtail and redroot pigweed control were about 72 and 69% in 50% recommended dose of MC formulation and about 79 and 65% in 75% recommended dose of EC formulation, respectively. Also 50% of MC formulation could increase yield as same as the 100% of EC formulation, 4.26 and 4.30 ton.ha-1, respectively. Soil incorporation of trifluralin was very necessary to achieve best efficiency. Manuscript profile -
Open Access Article
27 - Obayd's humors and their funniness based on Freud release theory
Sadiq Karim YahyaWe can classify all different topics of Obayd humors in two types: topics on prohibited matters and topics on defected ones. The former are topics we are not allowed to talk of and to approach them. They are sextual taboos, religious taboos or legal and political prohib MoreWe can classify all different topics of Obayd humors in two types: topics on prohibited matters and topics on defected ones. The former are topics we are not allowed to talk of and to approach them. They are sextual taboos, religious taboos or legal and political prohibitions including sextual, religious and political humors. The second type are topics on defects including external and physical defects, or internal, moral and behavioral as well as topics on personality, or mental defects. Humors of bodily defects, cultural and moral humors, and humors of stupidity and ignorance are within this classification. This research by presenting types of Obayd humors, seeks to find why they are funny. The first type of Obay humors maches to the first Freudian category, i.e., humors that are funny because they release repressed emotions. The second type matches to the second Freudian category, i.e., awkward imitation of natural and conventional movements and laws that lead to smile because they release thinking energy. The third Freudian category has no specific topic and relates to one of the Obayd's humor techniques, i.e., surprise technique. Every humor, no matter what is its topic, can make smile, if it uses surprise technique, because it puts the mind on the threshold of release contrast between two different senses. Manuscript profile -
Open Access Article
28 - A Comparison of Selective Processing of Data on the Threat in Patients With Released AnixietyDisorder and Post-Traumatic Stress Disorder
حسن توزندهجانیThis research is of causal-comparative research type done with the aim of comparing selective information processing and the role of cognitive attention in the process of anxiety disorders (GAD and PTSD). In this research three groups of subjects including a normal gr MoreThis research is of causal-comparative research type done with the aim of comparing selective information processing and the role of cognitive attention in the process of anxiety disorders (GAD and PTSD). In this research three groups of subjects including a normal group, the group with generalized anxiety disorder and the group of cases with post-traumatic stress disorders (selected of psychological clinics and private psychiatrics clinics in Neyshabour) were selected randomly and then tested in a stroop test and a recognition test. The results of the study indicated that patients with generalized anixiety disorder was compared with other groups, their attention bias was toward signs of physical and social threat. Although patients with PTSD showed attention bias just toward threatening signs of PTSD, processing these stimuli selectively. One other findings of the study indicates that in contrast with more processing of signs of social and physical threat in the generalized anxiety disorder group and threat signs related to PTSD group, three groups were related to remembering the sings after the test. Manuscript profile -
Open Access Article
29 - The Effect of Investment on the Financing of Listed Companies in Tehran Stock Exchange
Mahdieh Mardani Ahmad Sarlak -
Open Access Article
30 - A Review of Slow-release Fertilizers from the Perspective of the Environment and Economy, and its Future in Iran and the World
Hassan Seddighi Keivan Shayesteh Mahsa ArjmandSlow-release fertilizers prevent the rapid release of nutrients by creating a barrier. These fertilizers are produced in two ways: coated and matrix. Slow-release fertilizers can reduce nutrient loss and cause more use of plant needs. This will increase the efficiency a MoreSlow-release fertilizers prevent the rapid release of nutrients by creating a barrier. These fertilizers are produced in two ways: coated and matrix. Slow-release fertilizers can reduce nutrient loss and cause more use of plant needs. This will increase the efficiency and effectiveness of fertilizer. The process of producing fertilizers, including nitrogen fertilizers, is growing yearly in Iran and the world. This trend can also be predicted to continue in the coming years. Research on slow-release fertilizers shows that their production and consumption are increasing globally. Many sulfur is produced in refineries in Iran due to significant oil and gas sources. As a result, slow-release fertilizers can be made cheaper in Iran by creating sulfur coating compared to other countries. This article aims to examine the use of slow-release fertilizers, their advantages and disadvantages, and to present their production method. Also, this study investigates the rate of production of slow-release fertilizers in the world. This article can provide helpful information to investors, producers, farmers, and consumers interested in slow-release fertilizers and their role in agriculture. Manuscript profile -
Open Access Article
31 - Application of chitosan polymeric carriers as controlled drug delivery systems
Milad Ghezelsofloo Abdulhamid Dehghani Soheila GhasemiIn recent decades, natural polymers, especially polysaccharides, have been used as carrier to deliver a wide range of therapeutic agents. Chitosan, the second most abundant natural polysaccharide after cellulose, is a biocompatible, biodegradable, hydrophilic, non-toxic MoreIn recent decades, natural polymers, especially polysaccharides, have been used as carrier to deliver a wide range of therapeutic agents. Chitosan, the second most abundant natural polysaccharide after cellulose, is a biocompatible, biodegradable, hydrophilic, non-toxic, high bioavailability polymer with the ability to form films, gels, nanoparticles, microparticles, and granules. Chitosan is a linear polysaccharide obtained by deacetylation of chitin. Also, biodegradable chitosan in the human body is broken down into safe compounds (amino sugars) that are easily absorbed. Chitosan has hydroxyl and amine chemical functional groups that can be modified to achieve specific goals and turn it into a polymer with a wide range of potential applications. The aim of this paper is to provide insight into the potential applications of chitosan as a drug carrier. In the following, the use of chitosan to build deliverable sustainable delivery systems in other ways (oral, nasal, ocular, mucosal adhesion, buccal, and vaginal) is discussed. This report shows that research on chitosan-based systems containing different drugs for various therapeutic applications such as cancer treatment, gastrointestinal diseases, lung diseases, drug delivery to the brain and eye infections has increased in recent years. Manuscript profile -
Open Access Article
32 - Study of kinetic and changes in the diffusion coefficient of the release of doxorubicin-Chrysin drugs coated with magnetic nanoparticles and polycaprolactone-polyethylene glycol copolymers
Sahar Jahangiri Leila Amirkhani Abolfazl Akbarzadeh Reza HajimohammadiIn recent years, the development of nanoparticles in the field of drug release has received much attention. This research aims to develop new methods for the physical modification of Fe3O4 superparamagnetic nanoparticles with polymers through physical retention. In this MoreIn recent years, the development of nanoparticles in the field of drug release has received much attention. This research aims to develop new methods for the physical modification of Fe3O4 superparamagnetic nanoparticles with polymers through physical retention. In this study, after synthesizing the biodegradable polycaprolactone-polyethylene glycol magnetic copolymer, the anticancer drugs doxorubicin and Chrysin in these polymers were encapsulated by dual emulsion (w / o / w). The effect of temperature and pH on drug release was investigated. After performing kinetic studies, the diffusion coefficient of drug release was also studied. The drug distribution was considered uniform and the system was assumed to be in Cartesian coordinates. The results showed that the diffusion coefficient of drug release followed Fick's law. At first, due to the high concentration difference of drugs in the early times, the diffusion coefficient was higher, but then with time and with decreasing the concentration difference, the diffusion coefficient decreased and remained constant. Manuscript profile -
Open Access Article
33 - An Efficient Bi-objective Genetic Algorithm for the Single Batch-Processing Machine Scheduling Problem with Sequence Dependent Family Setup Time and Non-identical Job Sizes
Javad Rezaeian Yaser Zarook -
Open Access Article
34 - Adaption of Time-Sharing Contracts with the Universitas Facti Lease Contract in Iranian Law
Alireza Fasihizadeh Maryam Jalali On the basis of the Time-Sharing contract, a person, in a certain course of time, becomes the owner of the substance or its usufruct, or holds the right to benefit from the subject of the contract upon which the agreement is concluded. Under the inf More On the basis of the Time-Sharing contract, a person, in a certain course of time, becomes the owner of the substance or its usufruct, or holds the right to benefit from the subject of the contract upon which the agreement is concluded. Under the influence of the Time-Sharing contract, the person holding the above-stated rights, will be able to directly or representatively fulfill his or her rights periodically for a limited or perennial course of time. These contracts are being concluded in a diverse set of forms almost in all of the countries around the world. The main purpose of this research is not to render a clear definition of the nature of the Time-Sharing contracts; but rather is to put emphasis on whether it is conceivable, based on Iranian legal system, to achieve contractual outcomes particular to the Time-Sharing contracts through a special type of Lease contract. In the very meaning of timeshare there is no substantive detachment between the substance of a contract and its usufruct and ownership is considered as a right. However, in the light of the tenets of the Civil Code of Iran and Islamic jurisprudential decrees in this regard, it is conceivable to attain the outcomes particular to the Time-Sharing contracts through a specific kind of the Lease contract or through the assignment of the “Substitutive Generality” to the subject and duration of the Lease contract. Manuscript profile -
Open Access Article
35 - Comparative Study of the Statute of Non-determinant Leasehold in Rent Contract from the Perspective of Imamieh Jurisprudence and Laws of Iran
hamid abhari Benyamin BabaeiRent is a bilateral contract and as such the other contracts, the considerations on both parts must be determined at the time that the contract is concluded. According to the general principles of contracts, if a consideration is indeterminate, the contract will be void MoreRent is a bilateral contract and as such the other contracts, the considerations on both parts must be determined at the time that the contract is concluded. According to the general principles of contracts, if a consideration is indeterminate, the contract will be void. However, under article 3 of the landlord and tenant acts, 1977 and 1983, non-determination of leasehold in a verbal lease contract will not render the contract void and if there is difference between the parties, the court will determine the leasehold. This rule is an exception to the general principles and determination of leasehold by the court ignores the autonomy of the parties in tenant contract. In this article, the authors first examine the matter of non-determination of leasehold in the Jurisprudence and then they will describe the subject under Iranian laws. Manuscript profile -
Open Access Article
36 - Execution of Options in Sukuk Al-Ijara Bonds
Alireza Hamisi Majid Ghorbanali Dolabi Majid Vaziri Mahmoud VeysiFinancing is one of the most important issues in the resistive economy. There are a variety of financing options available in Iran, including the capital market, but given the risk aversion of investors to enter this market, Islamic financial instruments such as securit MoreFinancing is one of the most important issues in the resistive economy. There are a variety of financing options available in Iran, including the capital market, but given the risk aversion of investors to enter this market, Islamic financial instruments such as securities emerged and were highly sought after. Islamic financial instruments known as Sukuk bonds have been widely accepted. Sukuk Al Ijara are the most applicable Sukuk in our country. One of the unprecedented topics in this field is the study of executable options as a means of terminating the securities. In this study, at first the basic legal and jurisprudential foundations of options such as rule of prohibition of detriment, interpretative law, the rule of will power, intention and consent of contract's parties, expediency, protective theory were described. Then, Enforceable options in Sukuk Al Ijara bonds as predictive and offsetting measures of contracts by mentioning examples of each option was examined. The results of this study indicates that it is possible to execute following options such as defect, deceit, lesion, conditions, unfulfilled conditions, inspection, sales unfulfilled in part, impossibility of delivery and insolvency in relations of the contract's parties. Manuscript profile -
Open Access Article
37 - Molecular diversity of Pasteurella multocida isolated from cattle and buffaloes in East Azerbaijan province based on restriction endonuclease analysis
jalal shayegh alireza monadi jalil Dolgari Sharaf In order to increase information about the molecular diversity of Pasteurella multocida isolated from cattle and buffalo, 2 buffalo and 8 cattle isolates were investigated by Restriction Endonuclease Analysis (REA). REA was performed with Hha-I Endonuclease More In order to increase information about the molecular diversity of Pasteurella multocida isolated from cattle and buffalo, 2 buffalo and 8 cattle isolates were investigated by Restriction Endonuclease Analysis (REA). REA was performed with Hha-I Endonuclease which established 2 distinct profiles: I and II. Cattle and buffalo isolates fell into both REA profiles. Contrary to previous studies, the genetic diversity of the isolates was negligible. Considering the similarity of cattle and buffalo isolates is the present study, further studies witch larger samples should be carried out to investigate the possibility of inter-species transmission. Manuscript profile -
Open Access Article
38 - Application of near-infrared responsive nano-carrier for controlled drug delivery: synthesis, isotherm and kinetic studies
Mohammadreza Mahdavijalal Homayon Ahmad Panahi Ali Niazi Atefeh Tamaddon Elham Moniri -
Open Access Article
39 - The evaluation of carbohydrate, phenol compounds changes and anti-oxidant enzymes activity during the release of dormancy in Persian walnut lateral buds by different chilling treatments
ژیلا Gholizadeh حمیدرضا صادقی پور احمد عبدل زاده خدایار همتیThe purpose of this study was assessing the impacts of different chilling periods on the release of dormancy in walnut lateral buds, carbohydrates metabolism, phenol compounds content, and activities of soluble and cell wall peroxidase and polyphenol oxidase. In this li MoreThe purpose of this study was assessing the impacts of different chilling periods on the release of dormancy in walnut lateral buds, carbohydrates metabolism, phenol compounds content, and activities of soluble and cell wall peroxidase and polyphenol oxidase. In this line, one-year-old shoots were collected randomly from ten-year-old trees of Ziyarat village (Gorgan) in defoliation which were then cut into 9 cm pieces each with a single lateral bud and were subjected to different chilling treatments (0, 700, 1400 hour) at 4±1 °C and then forcing condition (25 ± 2 ◦C, 12 h light:12 h dark photoperiod, 20 µmol m−2 s−1). Results showed that 700 and 1400 chilling hours significantly increased percentage and rate of walnut lateral bud dormancy release and decreased time of initiation bud break in comparison with control. Chilling caused starch and non-reducing sugar degradation and resulted in the increase of reducing sugars. This had a positive significant relationship with the percentage of bud dormancy release. Phenols content, soluble and cell wall peroxidase activities increased up to 700 hour chilling while polyphenol oxidase activity increased up to 1400 hour as compared with control. It seems that the buildup of reducing sugars provides the required energy for dormancy release, and the increase of phenols and soluble and cell wall peroxidase activities result in decrease of oxidative stress and development of cold tolerance in buds. Moreover, rising polyphenol oxidase activity caused removing phenolic inhibitors and/or synthesis of antioxidant phenols. These processes in parallel promoted dormancy release of Persian walnut lateral buds. Manuscript profile -
Open Access Article
40 - Study of growth, ammonium release and nitrate reductase activity of green algae Dunaliella salina in salinity stress, low light and CO2 conditions
زهرا Hosseini k آرین Sateei Sh . Shokravi فریبا Amirlatifi مریم Safaei عماد Hosseini KThe ability of green microalgae, Dunaliella salina for existence, growth, nitrat reductase activity and ammonium release in low light, ambient CO2 and saline condition was studied for a better understanding of it is biotechnological importance. Samples were cultivated i MoreThe ability of green microalgae, Dunaliella salina for existence, growth, nitrat reductase activity and ammonium release in low light, ambient CO2 and saline condition was studied for a better understanding of it is biotechnological importance. Samples were cultivated in Johnson medium whit NaCl, 7.5, 15, 30 and 50% or without NaCl(control), 30◦C±1◦C, continious white light, 1500 lux, provided by fluorescent lamps and were aerated continiously using aquarium pumps. Based on the results of the present research, the best growth obtained in NaCl 7.5% for along term period, although in short term, a very high growth rate was obtained in NaCl 50% (Saturated salinity). Ammonium release was maximum in NaCl 50% and the nitrate reductase activity was minimum in the same salinity but there was no statistically significant correlation between ammonium release and nitrate reductase activity. The ability of Dunaliella salina in releasing high amount of ammonium and growth in low and high salinity makes it an important candidate as a new biofertilizer. Manuscript profile -
Open Access Article
41 - Biological application of Layered double hydroxides in drug delivery systems
nahid shahabadi Mahtab Razlansari -
Open Access Article
42 - Preparation and Characterization of Silica Coated Magnetic Cu Based MOF as a Nanocarrier for Gradual Release of the Capecitabine Anticancer Drug
Azar Asgari Pari Susan Samadi Mohammad Reza__Allahgholi__Ghasri Mohammad Reza__Allahgholi__Ghasri Maryam Torbati Mohammad YousefiThis study developed a novel silica-coated magnetic nanoparticle (Fe3O4@SiO2@Cu BTC) based on a metal-organic framework (MOF) for targeted anticancer medication delivery. Using a co-precipitation method, the Fe3O4@SiO2 core was coated with Cu(OH)2 shell, which was then MoreThis study developed a novel silica-coated magnetic nanoparticle (Fe3O4@SiO2@Cu BTC) based on a metal-organic framework (MOF) for targeted anticancer medication delivery. Using a co-precipitation method, the Fe3O4@SiO2 core was coated with Cu(OH)2 shell, which was then converted to CuBTC in a hydroethanolic mixture. Finally, a post-synthetic approach was used to manufacture a 3-(mercaptopropyl) trimethoxysilane functionalized Fe3O4@SiO2@Cu BTC nanocomposite. The resulting material is characterized using SEM-EDX, TEM, VSM, XRD, TGA, BET, UV–Vis, and FTIR techniques. TEM and SEM micrographs confirmed the core-shell structure. The resulting nanocomposite has high thermal stability, according to TGA findings. Because of their great biocompatibility and drug loading capability, coated Fe3O4@SiO2@Cu BTC nanoparticles might be perfect for drug delivery. Capecitabine (CAP), an anticancer medication, was successfully dispersed through MOF pores. The acquired data revealed that 91 percent of the CAP was adsorbed on the constructed framework, and that the release of capecitabine in PBS buffer solution (pH 5.7) at 37 °C took up to 60 hours to complete. The findings show that nano-sized MOFs-based magnetic NPs with high drug loading and acceptable biocompatibility are viable options for targeted drug delivery. Manuscript profile -
Open Access Article
43 - Poly Ethylene Glycol-Stearate polymer in the design of nano-drug delivery system for oral administration by curcumin
Marzihe Shahbazi Elham Rostami maryam kolahi alireza kiasat -
Open Access Article
44 - Hollow Mesoporous Silica Nanoparticles (HMSNs) Synthesis and in vitro Evaluation of Cisplatin Delivery
Zohreh Jomeh Farsangi Seyed Mehdi Rezayat Ali Beitollahi Saeed Sarkar Mahmoudreza Jaafari Amir Amani -
Open Access Article
45 - Biological Application of Layered Double Hydroxides in Drug Delivery Systems
Nahid Shahabadi Mahtab Razlansari -
Open Access Article
46 - Simulation of Drug Release in a Polymer Screw
Amirhossein Badami Sayed Hasan Mirtalaie -
Open Access Article
47 - تجزیه و تحلیل مقایسه ای برچسب های توالی بیان شده از Picea abies برای شناسایی ژن های مرتبط با تنظیم خواب در مریستم رأس ساقه
شادی حیدری پیوند حیدریاساس مولکولی رهاسازی خواب مریستم گیاه یک فرآیند پیچیده است و به خوبی درک نشده است. برای یافتن ژنهای مربوط به رهاسازی خواب مریستم آپیکال P. abies، از تجزیه و تحلیل برچسب توالی بیان شده استفاده شد. داده های اولیه برای دو کتابخانه cDNA با استفاده از پایگاه داده دانشگاه ها Moreاساس مولکولی رهاسازی خواب مریستم گیاه یک فرآیند پیچیده است و به خوبی درک نشده است. برای یافتن ژنهای مربوط به رهاسازی خواب مریستم آپیکال P. abies، از تجزیه و تحلیل برچسب توالی بیان شده استفاده شد. داده های اولیه برای دو کتابخانه cDNA با استفاده از پایگاه داده دانشگاه هاروارد (کتابخانه های خواب و رهاسازی خواب به ترتیب با 6987 و 6981 EST) جمع آوری شد. نرم افزار EGassembler برای جمع آوری تمام توالی های EST به منظور یافتن شباهت بین دو کتابخانه استفاده شد. پس از آن، همه کانتبگ ها با استفاده از نرم افزار CLC bio X-blast در برابر یک پایگاه داده پروتئین غیر تکراری پردازش شدند. برای شناسایی ژنهای دارای بیان افتراقی در دو کتابخانه، از نرمافزار IDEG6 و آزمون Audic-Claverie استفاده شد. ابزار طبقه بندی مقایسه ای GoMapMan برای دسته بندی کاتالوگ های کاربردی استفاده شد. همه یونیژن ها در 35 کاتالوگ عملکردی گروه بندی شدند که 10 کاتالوگ عملکردی متفاوت از جمله متابولیسم اصلی CHO، متابولیسم هورمون، استرس، انتقال، متابولیسم ثانویه، کوفاکتورها و ویتامین ها، متابولیسم نوکلئوتید، تنظیم ردوکس، انتقال الکترون میتوکندری/ATP و تخمیر شناسایی شدند. تاکنون گزارشی مبنی بر نقش متابولیت های ثانویه در تنظیم خواب مریستم گیاهی گزارش نشده است. این مطالعه بینشی در مورد عملکرد احتمالی متابولیت های ثانویه به عنوان تنظیم کننده اصلی خواب مریستم آپیکال در P. abies ارائه می دهد. علاوه بر این، تغییرات ردوکس و اپی ژنتیک در پایین دست هورمون ها نیز به نظر می رسد که در تنظیم خواب دخیل هستند. پتانسیل اختصاصیت ROS از نظر ویژگی های مکانی-زمانی که بیان آنزیم های آنتی اکسیدانی را مشخص می کند به آنها اجازه می دهد تا به عنوان نشانگرهای زیستی در مراحل رشد استفاده شوند. این تحقیق همچنین اطلاعاتی در مورد مکانیسمهای مولکولی فرآیند مورفوژنز در صنوبر نروژ ارائه میکند. Manuscript profile -
Open Access Article
48 - A fuzzy mixed-integer goal programming model for a parallel machine scheduling problem with sequence-dependent setup times and release dates
A.H Gharehgozli -
Open Access Article
49 - PEGylation of polyamidoamine-G3 dendrimer bonded with silica-coated magnetic nanoparticles as a pH-sensitive targeted drug delivery system
seyed esmaeil mhamadi mehr Mehdi Faramarzi seyed abotaleb mosavi parsaThis research, reports the fabrication of a new pH-responsive nanocarrier based on iron oxide nanoparticle with dendrimer coating and PEG conjugated for targeted and controlled delivery of chemotherapy drugs to cancer cells. The structure of the nanocarrier was confirme MoreThis research, reports the fabrication of a new pH-responsive nanocarrier based on iron oxide nanoparticle with dendrimer coating and PEG conjugated for targeted and controlled delivery of chemotherapy drugs to cancer cells. The structure of the nanocarrier was confirmed by Fourier transform infrared (FT-IR) spectra analysis. transmission electron microscope (TEM), Field Emission Scanning Electron Microscopy (FE-SEM) and vibrating sample magnetometer (VSM) analysis showed that the nanocarrier has a spherical structure with super paramagnetic properties. The efficiency of nanocarrier was evaluated with cyclophosphamide chemotherapy drug. The in vitro drug release studies at different pH proved the pH-sensitivity of the nanocarrier. Due to the open state of dendritic structure in acidic pH, the maximum release observed at pH 4.5 (lysosomal pH). Mass transfer studies showed that drug release from nanocarrier is rapid in short contact time and slow in long contact time. These results indicate that cyclophosphamide-loaded magnetic nanocarrier is promising for targeted delivery and controlled drug release. Manuscript profile -
Open Access Article
50 - Application of Nano Hydrogels In Improving The Performance Of Wound Dressings and Drug Delivery: A Review Study
MohammadHossein Karami Majid Abdouss MohammadReza Kalaee Omid MoradiOne of the most common clinical diseases is skin scarring, which is defined as damage to the structure or integrity of skin tissue. Nanohydrogel can help in sustained release of drug by entrapping drug or loading drugs and thus promote wound healing. A hydrogel is a thr MoreOne of the most common clinical diseases is skin scarring, which is defined as damage to the structure or integrity of skin tissue. Nanohydrogel can help in sustained release of drug by entrapping drug or loading drugs and thus promote wound healing. A hydrogel is a three-dimensional hydrophilic network that is insoluble in water or aqueous solutions and is able to absorb water or other biological fluids that can promote wound healing. Various nano hydrogels have been designed to improve the design of wound dressings, and nano hydrogels are also used in drug release. The advantage of hydrogels over traditional wound dressings is their ability to improve the wound and the wound healing process. Hydrogels meet most criteria for modern wound dressings due to their unique properties. Among the unique properties of nano-hydrogels, we can mention the ability to absorb wound secretions, maintain a moist environment, gas exchange, remove the dressing from the wound surface without pain and replace the dressing for the patient, ease of movement for surgery. In this research, an overview of the use of nano-hydrogels in improving the performance of wound dressings and drug delivery, along with the investigation of antibacterial properties, introduction of commercial wound dressings and wound healing mechanisms, has been discussed. Manuscript profile -
Open Access Article
51 - Targeted delivery of Elesclomol to colorectal cancer using a drug delivery system based on magnetic mesoporous silica nanoparticles
Mojtaba Tarin Maryam Babaei Hossein Eshghi Maryam Matin Amir Shokooh SaljooghiIn this research, the targeted delivery of elesclomol to colorectal cancer cells was explored through the development of magnetic mesoporous silica nanoparticles (MMSNs) loaded with elesclomol and surface modification with gold gatekeepers, bifunctional polyethylene gly MoreIn this research, the targeted delivery of elesclomol to colorectal cancer cells was explored through the development of magnetic mesoporous silica nanoparticles (MMSNs) loaded with elesclomol and surface modification with gold gatekeepers, bifunctional polyethylene glycol (PEG) polymer, and epithelial cell adhesion molecule (EpCAM) aptamers to improve drug delivery performance. The physicochemical properties of nanocarriers were characterized and the cellular toxicity of elesclomol, and nano-delivery system with and without EpCAM aptamer modification has been investigated in vitro. High resolution transmission electron microscopy (HRTEM) and field emission scanning electron microscopy (FESEM) showed that MMSNs had a uniform spherical morphology with a diameter of 19 nm and a negative surface charge. Elesclomol was successfully encapsulated in the open porous structure of the nanocarrier. The encapsulation efficiency (EE) and drug loading capacity (LC) were about 88% and 39%, respectively. Moreover, the prepared Au-ELC-MMSN-NH2 displayed pH responsive and sustained drug release within 96 h. Targeted nano-delivery systems were prepared with a final diameter of 89 nm and a negative surface charge. The MTT assay revealed that the targeted nano-delivery system induced highly effective cytotoxicity on colorectal cancer cells-expressing EpCAM aptamer (HT-29) compared to the CHO cells. This engineered nano-platform is a promising elesclomol replacement therapy for colorectal cancer. However, further experiments are required before it can be practiced in the clinic. Manuscript profile -
Open Access Article
52 - Synthesis and study of the metal-organic frameworks UiO-66-NH2 and HKUST-1 as drug carriers
خلیل طباطبائیان عبدالله فلاح شجاعی شیما یوسف امندانی حسام سلیمانیIn this study, the synthesis of Metal-organic frameworks UiO-66-NH2 and HKUST-1 were performed using the solvothermal method. Then, Acetaminophen, Amoxicillin, and Ibuprofen were loaded in UiO-66-NH2 and Ergotamine, Acetaminophen were loaded in HKUST-1 as pharmaceutical MoreIn this study, the synthesis of Metal-organic frameworks UiO-66-NH2 and HKUST-1 were performed using the solvothermal method. Then, Acetaminophen, Amoxicillin, and Ibuprofen were loaded in UiO-66-NH2 and Ergotamine, Acetaminophen were loaded in HKUST-1 as pharmaceutical models. Subsequently, the performances of these two compounds were evaluated as carrier of these four drugs. Also, the crystalline structures of these nanoparticles were characterized by substrate spectroscopy, X-ray diffraction, and. thermogravimetric analysis. Finally, UV-vis spectroscopy was used to measure the release of the drugs. The results showed that ibuprofen, acetaminophen, and amoxicillin were loaded in UiO-66-NH2 at 1.2, 0.7 and 0.5 mg, respectively, and their release rates during two days were 25, 28 and 43 %, respectively. Also, ergotamine and acetaminophen loaded in HKUST-1 were observed to be 1.07 and 0.98 mg, respectively, and their release rates were 35 and 43%, respectively. Manuscript profile -
Open Access Article
53 - Synthesis and characterization of conductive hydrogel nanocomposite for controlled drug delivery of cis-platin
حسن فتحی نژاد جیرندهی مروارید نباتی احمدی معصومه مسکین فامThe present work is including synthesis and characterization of conductivity of a super-absorbent conductive hydrogelnanocomposte and its controlled drug release. For this purpose, superabsorbent conductive hydrogel by Guar gum was synthesized based on grafting copolyme MoreThe present work is including synthesis and characterization of conductivity of a super-absorbent conductive hydrogelnanocomposte and its controlled drug release. For this purpose, superabsorbent conductive hydrogel by Guar gum was synthesized based on grafting copolymerization of acrylic acid monomer and proximity of some carbon nanotubes; in addition, polymerization reaction was done in aqueous phase )distilled water( and in the presence of ammonium persulfate as initiator and Methylene bisacrylamide as cross-linked. The results were assessed by FT-IR, cyclic Voltammetry and Scanning Electron microscope. However, the effect of carbonnanotube’s amount on nanocomposite was characterized by increasing this amount, the gel content, equilibrium swelling in distilled water, pH sensitivity, and conductivity increases. In the second stage, cisplatin drug was loaded in hydrogelnao composite and the percentage of drug release in phosphate buffer solution )PBS( was measured by appropriate electrical stimulation. The results show that the synthesized hydrogel is reasonable option for controlled drug release Manuscript profile -
Open Access Article
54 - Investigation of the release kinetics of strong optical photosensor Hypericin from Poly (e-caprolacton) nanofibrous mat
محمودرضا سهرابی فائقه پورحجت شهاب شریعتیTransdermal drug delivery systems with controlled release are a useful device for local transfer of pharmaceutical components to the damaged site and healthy layers of the skin. These devices are particularly suitable for wound healing in cases where long-term treatment MoreTransdermal drug delivery systems with controlled release are a useful device for local transfer of pharmaceutical components to the damaged site and healthy layers of the skin. These devices are particularly suitable for wound healing in cases where long-term treatment and frequent wound dressing exchange are needed. In this research, due to the superior feature of nanofibers, high surface to volume ratio, electrospinning technique was used to make dressings, for antimicrobial photodynamic therapy (aPDT), using biocompatible and biodegradable polymers such as poly (Ɛ-caprolactone) (PCL). Optimized conditions (voltage, flow rate nozzle to collector distance rotation) for obtaining nanofibers PCL/Extract (10, 30, 50%V/V) are as follows: Voltage of 12kV for nanofibers PCL and PCL-E50, and 20kV for PCL-E10 and PCL-E30, flow rate of 0.1ml/h for PCL and PCL-E50, and 0.5 ml/h for PCL-E10 and PCL-E30, and distance of 100 mm for all the nanofibers. Manuscript profile -
Open Access Article
55 - Lease contract and its relationship with the right of goodwill in the laws of Iran and Egypt
zakiye soltan alireza lotfi dodran davood andatrzField and Aims: The current research has been carried out with the subject and purpose of the lease contract and its relationship with the right to goodwill in Iranian and Egyptian laws. In fact, this research aims to show that: goodwill is a type of lease contract and MoreField and Aims: The current research has been carried out with the subject and purpose of the lease contract and its relationship with the right to goodwill in Iranian and Egyptian laws. In fact, this research aims to show that: goodwill is a type of lease contract and has common characteristics in the laws of Iran and Egypt. As a type of lease contract between lessor and lessee, goodwill has always had dark and ambiguous points in it.Method: The research method is descriptive and analytical.Findings and Conclusion: In Iranian law, goodwill is associated with the lease contract, so if goodwill is transferred to the lessee, the owner does not have the option of renting it to a non-lessee. Also, in the leases subject to the Law of Landlord and Tenant Relations 1376, goodwill does not exist independently of the lease relationship and is a matter that is realized only by the existence of the lease contract; Therefore, if there is no reason for the occurrence of the lease contract; The claim is not required to prepare an official peace document. The characteristics and common characteristics of the lease contract in Iranian and Egyptian law are: exchangeability of the lease contract, consensuality of the lease contract, necessity, temporaryness, gradualness, etc. Manuscript profile -
Open Access Article
56 - Investigating the Impact of Excuses of Impossibility and Difficulty of Contract performance completion on the Lease Contract (with an emphasis on the Corona pandemic)
Pari khaledi Leila hakkak Mehri Afshari KavehAbstract: Undoubtedly, one of the basic necessities of society is committing to obligations and fulfilling them completely. For this reason, the first principle in contracts is the principle of necessity. However, it sometimes happens that the fulfillment of the obligat MoreAbstract: Undoubtedly, one of the basic necessities of society is committing to obligations and fulfilling them completely. For this reason, the first principle in contracts is the principle of necessity. However, it sometimes happens that the fulfillment of the obligations arising from the contract becomes impossible due to the events that are beyond the obligator’ control. One example of the impossibility or difficulty of performance is the spread of contagious diseases, a special type of which known as Coronavirus is prevalent across the world. This raises the question as whether this disease can be considered as an excuse for the frustration of the contract (excuse) or the difficulty of its fulfillment (difficulty). If it is the case, what will happen to the contract and what will be the contractors’ duties? In response, it should be said that due to the similarity of the components, this disease can be a true example of the difficulty of contract fulfillment, and regarding its role and impact on the scope of contracts, no general rule can be provided for all cases. Therefore, the study of the impact of the Coronavirus on the contract depends entirely upon the type of contract and the conditions governing it. One of the most important contracts affected by this disease was the lease contracts, especially the lease of commercial places in which with the government's order to temporarily close these places, the status of the existing contracts turned into a serious legal issue. In addition, different issues such as dissolution, modification, and suspension of contract were proposed as the possible solutions for the existing situation.Keywords: frustration of contract, difficulty of performance, contract, lease, Coronavirus Manuscript profile -
Open Access Article
57 - A comparative study of assignment of contract in Iranian legal system and common law with emphasis on lease contract
amir abbas kavoosi Hassan Badini Nejad ali AlmasiThe assignment of the contract and the assignment of the position related to the contract by the assignor of the contract to the receiver causes the party to the original contract to withdraw from the primary legal relationship and another person or persons are placed i MoreThe assignment of the contract and the assignment of the position related to the contract by the assignor of the contract to the receiver causes the party to the original contract to withdraw from the primary legal relationship and another person or persons are placed in the contractual position of the assignor as a substitute. The most vital effect of the secondary transfer of the lease contract is the same as the voluntary transfer of the contract of the third party, for the method of subrogation of the buyer in the secondary transfer of the lease, it is clear that it is the buyer's representative in the same tenant in relation to the transfer of the right to receive rent and the right Termination and discharge to him is disputed and disputed in the courts. The findings of the research indicate that in the English legal system, with the secondary transfer of the lease contract to the buyer, he is obliged to conclude and accept the terms of the lease contract, and despite the contractual legal transfer to the buyer, the seller also becomes responsible. The research method is descriptive and analytical. Manuscript profile -
Open Access Article
58 - Preparation of acrylic-type derivative of ibuprofen and in vitro evaluation studies of its polymeric prodrugs
Mirzaagha Babazadeh Ladan Edjlali Zeynab Hajizeynalabedini -
Open Access Article
59 - Effect of Some Physical Treatments to Overcome Zarin-giyah (Dracocephalum kotschyi Boiss.) Seed Dormancy
MAEDEH BOHLOULI HOSSEIN ALI ASADI - GHARNEH ELHAM CHAVOSHI NAFISEH ZAMINDAR -
Open Access Article
60 - The study of biological manure effect on decreasing demand chemical fertilizer in Hyssopus officinalis L
N. Nemati A. Pazoki GH. Naderi S. TaherabadiThere is noticeable insoluble phosphorus in the soil and some of bacterium have not capability of release insoluble phosphorus. Today, the lack of this element have compensate with use of chemical Fertilizer, chemical fertilizer have harmful effect on the bioenvironment MoreThere is noticeable insoluble phosphorus in the soil and some of bacterium have not capability of release insoluble phosphorus. Today, the lack of this element have compensate with use of chemical Fertilizer, chemical fertilizer have harmful effect on the bioenvironmental and decrease quality of agriculture production. Literally in nowadays for developing sustainable agriculture execute system with sufficient form inputs with integrated usage of chemical fertilizer and bio fertilizer specially bio fertilizer as a effective solution for replacing Agriculture for produce crop and keeping yield crop in a acceptable level. This study had performed in order to; study the effect of the release Phosphate-solubilizing bacteria on Hyssopus officinalis L. This experiment performed in the randomized complete blocks base design as a factorial with three frequencies. Two level Phosphate-solubilizing bacteria (PS1: use Phosphate-solubilizing bacteria), (PS0: no use Phosphate-solubilizing bacteria) and five level (P0: 0kg/h pure P2O5), (P90: 90 kg/h pure P2O5) (p115: 115 kg/h pure P2O5), (P140:140 kg/h pure P2O5), (P165:165 kg/h pure P2O5). In this research used Triple phosphate super as phosphate fertilizer and Baver2 as Phosphate-solubilizing bacteria.This research had performed in Arak in year 1388. The results of this experiment showed that, the mixture of biologic phosphorus and Triple phosphate super, Characteristic. plant height, flower branch height, the number of flower branch,percent of essential oil, yield of essential oil per hectare, noticeable increase with application phosphorus fertilizer treatment as compared with non-phosphorus fertilizer treatment.Almost use of 90 Kg/h with Phosphate-solubilizing bacteria was best in total Characteristic. Interaction between phosphorus and Phosphate-solubilizing bacteria all of characteristic was signification. it can be concluded that, we can reduce phosphorus fertilizer to 50% in the seeds yield, by using release bacteria, without any significant reduction. Manuscript profile -
Open Access Article
61 - Comparison the effect of biologic fertilizer with chemical on oil sunflower (helianthus annus) in Arak condition
M. Moradi H. Madani M. A. Malboubi R. Pilehvari KhomamiThis is noticeable that insoluble phosphorus in the soil and some of bacterium has not capability of release insoluble phosphorus. This study was performed in order to study the effect of the release bacteria sunflower (helianthus annus). This experiment performed in RC MoreThis is noticeable that insoluble phosphorus in the soil and some of bacterium has not capability of release insoluble phosphorus. This study was performed in order to study the effect of the release bacteria sunflower (helianthus annus). This experiment performed in RCBD based on a factorial design with 4 replications. This research was performed in the research farm of Arak Islamic Azad University during 2008. Factors were considered as two level Bacteria (B1: use Biologic phosphorus), (B2: no use Biologic phosphorus) and four level (P1; 150 kg/ha Ammonium phosphate), (P2; 300 kg/ha Ammonium phosphate), (P3; 150 kg/ha Triple phosphate super) and (P4: 300 kg/ha triple phosphate super). The results showed that using mixture of biologic phosphorus and Ammonium phosphate caused to improve planted sunflower. Characteristic such as weight of 1000 seeds, the number of seeds per head, yield of seed per hectare, head diameter, harvest index and biomass yield noticeable increase. Interaction of phosphorus and bacteria except in the empty percent and oil percent in the other characteristic was signification on the whole. Totally, results showed that by using released bacteria we can reduce phosphorus fertilizer by 50% without any significant reduction of yield. Manuscript profile -
Open Access Article
62 - Investigating of boron and zinc compound application on corn seed set in Mazandaran environment, Iran
M. Ghadamgahi H. Madani Sh. KhaghaniThe experiments to evaluate the possibility of enriching sunflower seeds nuts on the farm by bacteria release phosphorus sulfat, In a randomized complete block design with three replications in a split plot, Arak Islamic Azad University Research Farm in 1390 was carried MoreThe experiments to evaluate the possibility of enriching sunflower seeds nuts on the farm by bacteria release phosphorus sulfat, In a randomized complete block design with three replications in a split plot, Arak Islamic Azad University Research Farm in 1390 was carried out. Factors include four levels of P (P1, P2, P3 and P4, respectively, 350 kg ammonium phosphate ha175 kg ammonium phosphate, ammonium phosphate and 175 kg P -2 reproductive biology, biological phosphorus fertilization -2) and four levels of zinc(Z1, Z2, Z3 and Z4, respectively, of zinc sulfate, zinc sulfate 25 kg ha sprayed on with a concentration of 10%, 25 kg ha sprayed zinc and zinc) were considered. Foliar application of zinc and phosphorus-releasing bacteria in the field, In the pre-flowering and 10 days after return again. The grain yield per hectare, biological yield, head diameter, harvest index, The grain yield per hectare, biological yield, head diameter, harvest index, The results showed that the highest yield of 50% ammonium phosphate ha treated with biological phosphorus fertilization -2 And application of zinc dust consumption of 78/5632kg ha treatments applied at 50% -2 Biological phosphorus fertilized with ammonium phosphate with zinc sulfate soil and foliar application of zinc Rate of 52/5493kg per hectare, respectively. Manuscript profile -
Open Access Article
63 - Consequence Modeling of a Rupture of Methyl Diethanolamine (MDEA) Storage Spherical Tank (Catastrophic Rupture Scenario)
Mojtaba Khorani Mohsen Mansouri Seyyed Hossein Hosseini Naimeh Setarehshenas -
Open Access Article
64 - Simulation of Drug Release in Expanding Hydrogels Containing Chitosan and Gelatin
Thair Aljawahiry Mohaned Adil Mohammed Abdulkadhim Sayah Abed J. Kadhim Mazin Abdullateef Alzubaidi Ahmed S. Abed Naseer Mehdi Mohammed -
Open Access Article
65 - Controlled Release of Amoxicillin from Bis(2-hydroxyethyl)amine Functionalized SBA-15 as a Mesoporous Sieve Carrier
Nafiseh Yaghobi Leila Hajiaghababaei Alireza Badiei Mohammad Reza Ganjali Ghodsi Mohammadi Ziarani -
Open Access Article
66 - The Study of the Structure and Activity of the Bovine Pancreatic Ribonuclease A in the Presence of Allopurinol
محمود نجفیان فرشید کفیل زاده سحر جانفشانBovine pancreatic ribonuclease A is an endoribonuclease. This enzyme cut chemical phosphodiesteric bond in a single stranded RNA with two steps reaction. The first step of this enzymatic reaction is transphosphorylation and the second step is hydrolysis. Allopurinol is MoreBovine pancreatic ribonuclease A is an endoribonuclease. This enzyme cut chemical phosphodiesteric bond in a single stranded RNA with two steps reaction. The first step of this enzymatic reaction is transphosphorylation and the second step is hydrolysis. Allopurinol is one the structural isomer of hypoxanthine (one of the natural purine) that inhibits xanthine oxidase so reduce production of uric acid and is one of the current drugs ingout treatment. This drug has a nucleotidic structure so may has an effect on the structure and activity of ribonuclease A. In attention to key role of RNase A in degredation of RAN for maintanace of cellular system equilibrium, it is necessarytoinvestigate the effect of different biological molecules and drugs on the activity of RNase A. So in this project we investigated the effect of different concentration of allopurinol on the activity and structure of bovine pancreatic ribonuclease A .At first saturation curve of enzyme in the presence of cCMP is drawn. Then effect of allopurinol in the range of 0-1, 0-5 mM on the maximum rate of enzyme is investigated and saturation curve of enzyme in the presence of allopurinol is drawn. The results show that drug reduces activity of this enzyme in tested concentrations. Structural studies with ligand binding and CD prove the considerable change in enzyme. In general, we can say that allopurinol may inhibit activity of RNase A. Manuscript profile -
Open Access Article
67 - A review on evaluation of natural polymers with the approach of drug delivery system using herbal plant microcapsules
Amirreza Esmaeili Romina Hemami Yashar Ghaffari Somayeh Abdollahi -
Open Access Article
68 - بررسی عددی شروع رشد تورق در تیر کامپوزیتی یک سرگیردار با دو لبۀ متقارن
محمود مهرداد شکریه محمد حیدری رارانی سجاد رحیمیهدف اصلی این تحقیق بررسی شروع رشد مُد I تورق در کامپوزیتهای لایهای چند جهتی با ترک بین دو لایه صفر درجه است. به عبارت دیگر تاثیر لایههای دوردست محل تورق، بر توزیع نرخ رهایی انرژی کرنشی در پیشانی ترک و مقدار بار بحرانی نمونه تیر یکسرگیردار دولبه بررسی شده است. همچنین Moreهدف اصلی این تحقیق بررسی شروع رشد مُد I تورق در کامپوزیتهای لایهای چند جهتی با ترک بین دو لایه صفر درجه است. به عبارت دیگر تاثیر لایههای دوردست محل تورق، بر توزیع نرخ رهایی انرژی کرنشی در پیشانی ترک و مقدار بار بحرانی نمونه تیر یکسرگیردار دولبه بررسی شده است. همچنین شرایط لازم برای تعیین چقرمگی شکست بین لایهای تیر یک سر گیردار دولبه با چیدمان دلخواه، بر اساس معادلسازی آن با چیدمان تکجهته مشخص شده است. ابتدا تیر یک سر گیردار دولبه کامپوزیتی در نرمافزار اجزا محدود ANSYS به صورت سهبعدی مدلسازی شده و مقدار چقرمگی شکست بین لایهای آن با روش بسته شدن مجازی ترک محاسبه شده است. سپس با مطالعه دقیق توزیع نرخ رهایی انرژی کرنشی برای چیدمانهای مختلف، پارامتر غیر یکنواختی توزیع نرخ رهایی انرژی کرنشی به نام β، که مقدار آن وابسته به چیدمان لایهها و ابعاد هندسی قطعه است، ارائه شده است. مقایسه نتایج اجزا محدود با نتایج تجربی موجود در منابع دیگر نشان میدهد که اگر < 20% β باشد مقدار چقرمگی شکست تیر یک سر گیردار دولبه چند جهتی با خطایی کمتر از 6/3 درصد با چقرمگی شکست کامپوزیت تکجهتی برابر است. بنابراین میتوان مقدار بار بحرانی شروع رشد تورق در چندلایههای کامپوزیتی را با دقت خوبی از روابط تحلیلی موجود با داشتن چقرمگی شکست کامپوزیت تکجهته بدون انجام آزمایش پیشبینی کرد. Manuscript profile -
Open Access Article
69 - پیشبینی مود II نرخ رهایی انرژی کرنشی در کامپوزیتهای چند لایهای چند جهته
افشین زینالدینی منصور علیزادهجهتگیری الیاف یکی از مهمترین پارامترهای مؤثر بر مود دوم نرخ رهایی انرژی کرنشی در شروع جدایش بینلایهای است. از تیری با شکاف انتهایی برای اندازهگیری نرخ رهایی انرژی کرنشی در شروع جدایش بینلایهای کامپوزیتهای لایهای استفاده شده است. در واقع هدف از این تحقیق، پیشبی Moreجهتگیری الیاف یکی از مهمترین پارامترهای مؤثر بر مود دوم نرخ رهایی انرژی کرنشی در شروع جدایش بینلایهای است. از تیری با شکاف انتهایی برای اندازهگیری نرخ رهایی انرژی کرنشی در شروع جدایش بینلایهای کامپوزیتهای لایهای استفاده شده است. در واقع هدف از این تحقیق، پیشبینی مقدار نرخ رهایی انرژی کرنشی نمونه­ی چندجهته از روی نتایج تجربی مربوط به قطعه­ی تکجهته میباشد، بدون اینکه مستقیماً به آزمایشهای تجربی و مدلسازی اجزاء محدود قطعه­ی کامپوزیتی لایهای چندجهته نیاز شود. در این زمینه، روشی پیشنهاد شده که ترکیبی از روشهای پیشبینی و تحلیلی است. ضمناً نتایج بدست آمده از این روش با نتایج مدلسازی عددی و نتایج تحلیلی مقایسه شده ­است. این روش، حجم محاسبات عددی و تحلیلی و نیز هزینه­ی مطالعات آزمایشگاهی را به مقدار چشمگیری کاهش می­دهد Manuscript profile -
Open Access Article
70 - The Effect of Green Synthesis of Chitosan with Oat Extract on the Germination of Pigweed (Amaranthus retroflexus)
Ali ebadi Fatemeh AhmadniaOats (Avena sativa L.) possess allelopathic properties and can serve as effective cover crops to inhibit weed growth. This study aimed to investigate the effect of the aqueous extract and formulated extract of oats with chitosan nanoparticles on the germination of red r MoreOats (Avena sativa L.) possess allelopathic properties and can serve as effective cover crops to inhibit weed growth. This study aimed to investigate the effect of the aqueous extract and formulated extract of oats with chitosan nanoparticles on the germination of red root pigweed (Amaranthus retroflexus) in the year 2021. The experiment was designed using a factorial based on a completely randomized design, with three repetitions. The experimental treatments included the type of extract (aqueous extract of oats and formulated extract of oats with chitosan nanoparticles) and six control concentrations (distilled water and chitosan without plant extract), 10, 50, 100, 150, and 200 g/L. The results of the study demonstrated that the interaction between the type of extract and different concentrations significantly affected the evaluated traits at the probability level of 1%. The percentage of germination in the aqueous extract of oats and its formulated extract with chitosan nanoparticles in concentrations of 100, 150, and 200 were zero, 16.66, 15.33, and 5.33%, respectively. Also, increasing the concentration of the extract formulated with chitosan caused a decrease in germination rate (85.46, 87.95, and 96.10%), mean daily germination percentage (82.75, 84.20, and 94.49%), seedling vigor index (85.53, 87.60 and 97.71%) and synchronization index (45.76, 47.90 and 14.75%) of the red root pigweed compared to chitosan without plant extract. These findings suggest that of the aqueous extract of oats had a greater inhibition on the germination the red root pigweed weed. Manuscript profile -
Open Access Article
71 - Construction and Characterization of polyvinyl alcohol-sodium alginate magnetic hydrogel for use in release of famotidine
Mahdiyeh Poorgholam Masoud Mokhtary mohammad alikaramiAbstract Polyvinyl alcohol-sodium alginate magnetic hydrogel was prepared using K2S2O8 in aqueous media in the presence of N,N′-methylenebisacrylamide and Fe3O4 nanoparticles. The magnetic polyvinyl alcohol-sodium alginate (nano-Fe3O4/PVA-SA) hydrogel was characteriz MoreAbstract Polyvinyl alcohol-sodium alginate magnetic hydrogel was prepared using K2S2O8 in aqueous media in the presence of N,N′-methylenebisacrylamide and Fe3O4 nanoparticles. The magnetic polyvinyl alcohol-sodium alginate (nano-Fe3O4/PVA-SA) hydrogel was characterized by FTIR, SEM, and EDX methods. Also, magnetic characterization of the synthesized nanoFe3O4/PVA-SA hydrogel was identified by vibrating sample magnetometer (VSM) method. Then, loading and release of famotidine drug was studied by nano-Fe3O4/PVA-SA hydrogel. The FT-IR results confirmed the formation of nano-Fe3O4/PVA-SA hydrogel. The effects of temperature and pH on the loading and release of famotidine drug in gelatin-polyvinylalcohol magnetic hydrogel were studied. The polyvinyl alcohol-sodium alginate magnetic hydrogel is sensitive to pH and temperature and provides the controlled release of famotidine. The results showed that the highest drug loading was achieved at 37 °C after 6 hours. Farther more, the highest drug release rate was obtained after 6 hours at 37 °C at pH = 2 with 57.95 ppm. Manuscript profile
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