Study of kinetic and changes in the diffusion coefficient of the release of doxorubicin-Chrysin drugs coated with magnetic nanoparticles and polycaprolactone-polyethylene glycol copolymers

Subject Areas : The Application of Chemistry in Environment

Sahar  Jahangiri ¹ (Ahar Branch, Islamic Azad University)
Leila  Amirkhani ² (عضو هیات علمی گروه مهندسی شیمی دانشگاه آزاد اسلامی واحد اهر)
Abolfazl  Akbarzadeh ³ (Tabriz University of Medical Sciences)
Reza  Hajimohammadi ⁴ (Ahar Branch, Islamic Azad University)

Received: 2022-02-24 Accepted : 2022-03-07 Published : 2020-08-22

Keywords: Magnetic nanoparticles, Drug release, Doxorubicin, Chrysin, Diffusion coefficient,

Abstract :

In recent years, the development of nanoparticles in the field of drug release has received much attention. This research aims to develop new methods for the physical modification of Fe3O4 superparamagnetic nanoparticles with polymers through physical retention. In this study, after synthesizing the biodegradable polycaprolactone-polyethylene glycol magnetic copolymer, the anticancer drugs doxorubicin and Chrysin in these polymers were encapsulated by dual emulsion (w / o / w). The effect of temperature and pH on drug release was investigated. After performing kinetic studies, the diffusion coefficient of drug release was also studied. The drug distribution was considered uniform and the system was assumed to be in Cartesian coordinates. The results showed that the diffusion coefficient of drug release followed Fick's law. At first, due to the high concentration difference of drugs in the early times, the diffusion coefficient was higher, but then with time and with decreasing the concentration difference, the diffusion coefficient decreased and remained constant.