Synthesis and study of the metal-organic frameworks UiO-66-NH2 and HKUST-1 as drug carriers

Subject Areas :

خلیل طباطبائیان ¹ , عبدالله فلاح شجاعی ² , شیما یوسف امندانی ³ , حسام سلیمانی ⁴

1 - استاد شیمی معدنی، دانشکده علوم پایه، دانشگاه گیلان، رشت، گیلان، ایران
2 - استاد شیمی معدنی، دانشکده علوم پایه، دانشگاه گیلان، رشت، گیلان، ایران
3 - کارشناس ارشد شیمی معدنی، دانشکده علوم پایه، دانشگاه گیلان، رشت، گیلان، ایران
4 - کارشناس ارشد شیمی معدنی، دانشکده علوم پایه، دانشگاه گیلان، رشت، گیلان، ایران

Received: 2019-05-05 Accepted : 2020-01-05 Published : 2020-05-21

Keywords: Drug release, Metal-organic framework, UiO-66-NH2, HKUST-1,

Abstract :

In this study, the synthesis of Metal-organic frameworks UiO-66-NH2 and HKUST-1 were performed using the solvothermal method. Then, Acetaminophen, Amoxicillin, and Ibuprofen were loaded in UiO-66-NH2 and Ergotamine, Acetaminophen were loaded in HKUST-1 as pharmaceutical models. Subsequently, the performances of these two compounds were evaluated as carrier of these four drugs. Also, the crystalline structures of these nanoparticles were characterized by substrate spectroscopy, X-ray diffraction, and. thermogravimetric analysis. Finally, UV-vis spectroscopy was used to measure the release of the drugs. The results showed that ibuprofen, acetaminophen, and amoxicillin were loaded in UiO-66-NH2 at 1.2, 0.7 and 0.5 mg, respectively, and their release rates during two days were 25, 28 and 43 %, respectively. Also, ergotamine and acetaminophen loaded in HKUST-1 were observed to be 1.07 and 0.98 mg, respectively, and their release rates were 35 and 43%, respectively.

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