List of Articles liver enzymes

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  1 - Effect Of Lead Chloride on Embryonic Stages and Kidney Differentiation in Pterophyllum Scalare
  Sara Shekari mehrengiz sadooghi Homayon Hosseinzadeh
  Introduction and Objective: The amount of heavy metals in the environment has increased with human industrial interference and cause damage to the environment provides.Free of heavy metals are found in combination with other elements in the environment , and mineral wat More

  Introduction and Objective: The amount of heavy metals in the environment has increased with human industrial interference and cause damage to the environment provides.Free of heavy metals are found in combination with other elements in the environment , and mineral waters. Effect of  lead chloride  on fish embryos that named (Pterophyllum   scalar)  is the aim of this studyTherefore, 5 pairs of ornamental fish of a species to determine the toxicity of lead chloride in the process of embryonic development (early life) before the eggs were extractedMaterials and Methods:  In the first study to determine the acute toxicity LC50 concentration of the desired material (lead chloride) 5 concentration of 3 μg/L, 5 μg/L, 10 μg/L and 20 μg/L  and control was performed in three successive iterations .Each test was repeated for 3 days and counting the number of dead embryos (white) Acute toxicity of lead chloride at doses less than μg/L  (5 μg/L  ≤ n) was determinedIn the second phase of research to examine  the changes desired effect of causing toxicity on fetal developmental stages of Angel fish were. Stages of the  test is less than the LC50 concentration of less than 4 were considered g/Lμ5. The concentrations of 5/0, 5/1, 3 and 5/4 g / Lμ and controls for comparisonSome of these samples at the same moment sampling survey was study with photo stereo microscope.Results:The results showed that lead chloride in the initial review abnormally apparent like the tilt, loss of vision or the lack of effect on growth delay. Histological studies of tissues prepared for light microscopy study also showed that lead chloride on growth of embryonic kidney (Prenefroses) did not interfere Manuscript profile
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  2 - Effect Of Injection Of Silver Nanoparticles on Plasma Levels Of Liver Enzymes in Rat
  Hossein Hamzehei Hamed Alizadeh Mohsen Ajalli Farid Dolatshahi
  Background and Purpose:Possible toxic effects of silver nanoparticles on humans are a major concern that encountered the use of this nanoparticles with many challenges. Today, silver nanoparticles, mostly because of their antimicrobial effects have been discussed. But t More

  Background and Purpose:Possible toxic effects of silver nanoparticles on humans are a major concern that encountered the use of this nanoparticles with many challenges. Today, silver nanoparticles, mostly because of their antimicrobial effects have been discussed. But the possibility of their side effects, make its use doubtful. Among the main effects of silver nanoparticles that can have in the body, effects on the liver and its metabolism which has not been mostly considered. The aim of this study was to examine the injected effects of silver nanoparticles on plasma levels of liver enzymes such as AST, ALT and ALP that could open new horizons in relation to current challenges.Methods:In this study, 21 female Wistar rats were used. The rats were randomly divided into 7 groups. The first group was sham group, the second group was control group, the third to seventh groups were tested, were treated with 5, 10, 20, 40 and 80 ppm of silver nanoparticles, respectively. Treatment of mice continued for 10 days. Then the rats were killed with ether anesthesia. Blood samples were taken from the hearts of animals. Plasma levels of liver enzymes (AST, ALT and ALP) were tested by diagnostic kit of Pars Azmoon company using indirect spectrophotometric method.Results:The results showed that there are no significant differences between the control and sham groups. But overall, silver nanoparticles at high concentrations cause significant changes in levels of enzymes.Conclusions:The results of this study showed that silver nanoparticles at high concentrations can have deleterious effects on the liver and should be used with caution in high concentrations Manuscript profile
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  3 - The effect of intraperitoneal injection of hydroalcoholic extract of flaxseed on biochemical, hematological and liver enzymes in rats
  Atefeh Payez
  Background: Medicinal plants have a wide range of applications in various fields, especially in the control of microbial infections, but the discussion of their possible toxicity has caused great concern in the use of these substances in various fields of industry and m More

  Background: Medicinal plants have a wide range of applications in various fields, especially in the control of microbial infections, but the discussion of their possible toxicity has caused great concern in the use of these substances in various fields of industry and medicine. This study was performed to clarify some of these ambiguities and to investigate the effect of intraperitoneal injection of flaxseed extract on biochemical, hematological, and hepatic factors in rats.Materials and Methods: In this experimental study, 15 female spiral rats were randomly divided into 5 groups. The first group was the sham group, the second group was the control group, and the third to fifth groups as experimental groups with concentrations of 200, 400, and 600 mg/ml of flaxseed extract were treated, respectively. The mice were treated for 10 days, then on the eleventh day the mice were anesthetized with ether and blood samples were taken from their hearts. Then biochemical parameters, blood, and lactate dehydrogenase, and plasma levels of liver enzymes were evaluated.Results: The results of this study did not show much change in biochemical factors except cholesterol and triglycerides which showed a significant decrease in the extract-treated groups. Blood factors did not show significant changes but increased in high concentrations of liver enzymes.Conclusion: Intraperitoneal injection of flaxseed extract has no effect on blood factors and many biochemical factors in mice, but high concentrations of the extract can affect liver enzymes. Manuscript profile
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  4 - Green synthesis of zinc nanoparticles and investigation of changes in some biochemical parameters of blood and its effect on wound healing caused by burns in laboratory Wistar male rats
  Zahra Sinaee pour Fard Nooshin Naghsh Nasrin Yazdanpanahi Gholam Reza Amiri
  Introduction & Objective: Currently, zinc and its compounds are used as a suitable material for the treatment of infection in burns, open wounds and chronic wounds. This investigation, was designed and carried out with the aim the local effect of green zinc nanopart More

  Introduction & Objective: Currently, zinc and its compounds are used as a suitable material for the treatment of infection in burns, open wounds and chronic wounds. This investigation, was designed and carried out with the aim the local effect of green zinc nanoparticles on blood biochemical parameters and skin tissue repair during wound healing in laboratory rat. Materials and methods: In this experimental study, 42 male Wistar rats were divided into 7 groups of 6. Then, by creating a 2 cm burn on the back of the rats, treatment was immediately performed with zinc nanoparticles ointment (1%, 4%, 16%) and zinc oxide ointment and pure Vaseline for 21 days. After sampling from the percentage of wound repair in the skin of rats was calculated. Similarly, blood sampling was done from the hearts of rats and serum was used to check biochemical parameters. Results: The percentage of wound healing in the 4% ointment group and zinc oxide ointment was significantly higher than the control group. In addition, all the concentrations of ointment were safe in terms of their effect on liver enzymes. Conclution: The results of investigation showed that the ointment of 4% zinc nanoparticles was the best treatment group, which accelerated the repair of skin wounds. Based on the results of the present experimental study, probably the ointment produced by the identified green nanoparticles could be suggested as a strong repair agent in skin lesions naturally. Manuscript profile
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  5 - Comparison the effect of melatonin and the selective inhibitor of serotonin reuptake citalopram drug on the ultrastructure of liver tissue and hepatic enzymes in Adult Female three-spotted gourami Fish (Trichogaster trichopterus)
  Mohammadreza Pouravaz طاهره ناجی Homayon Hosseinzadeh sahafi
  Background & Aims: Most of the various drugs that are used to treat various diseases are metabolized in the liver. The purpose of this study is to investigate the effect of melatonin and selective serotonin reuptake inhibitor drug citalopram on liver tissue ultrastr More

  Background & Aims: Most of the various drugs that are used to treat various diseases are metabolized in the liver. The purpose of this study is to investigate the effect of melatonin and selective serotonin reuptake inhibitor drug citalopram on liver tissue ultrastructure and liver enzymes in adult female Trichogaster. Materials & Methods: For this purpose, 120 pieces of Trichogaster with an average weight of 4.23 ± 0.70 g divided into eight groups of 15, which included the control groups, solvent intact, three groups which received citalopram with a dose of 5, 10 and 20 mg/kg and three treatment groups receiving melatonin with doses of 10, 50, and 100 mg/kg. A dose of 0.02 ml of the drug was injected intramuscularly between the dorsal fin and the lateral line every other day for 10 times, over a period of 20 days. Then, the fish were euthanized and dissected. Results: The results showed that melatonin and citalopram had a significant effect on the level of all liver enzymes compared to the control groups (P<0.05). The highest levels of ALT, AST and ALP were measured after the injection of 20 mg/kg citalopram (P<0.05). In fish treated with the highest concentration of melatonin and all concentrations of citalopram, dissociation between hepatocytes and expansion of sinusoids occurred. Fat vacuoles were formed in high concentrations of melatonin and citalopram. Conclusion: Therefore, melatonin at a concentration of 100 mg/kg and citalopram at a concentration higher than 5 mg/kg have a negative effect on the ultrastructure of liver tissue and liver enzymes. Manuscript profile
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  6 - The effect of eight weeks of aerobic training and Anethum herbal supplementation on lipid risk factors for cardiovascular disease in inactive obese men
  Ardeshir Zafari Taher Jalili
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  7 - The effect of yoga exercise with dumbbells along with spirulina supplement on liver enzymes of elderly Bushehr women
  Mohadeseh Bandarrigi Saeid Shakerian Roohollah ranjbar Sadegh Abdollahi
  10.30495/pah.2023.1992928.1054
  A B S T R A C TObjectives: The purpose of this study is to investigate the effect of yoga with dumbbells at the same time as taking spirulina supplements on liver enzymes in obese elderly women.Methods & Materials: This study, which is applied and semi-experimental, More

  A B S T R A C TObjectives: The purpose of this study is to investigate the effect of yoga with dumbbells at the same time as taking spirulina supplements on liver enzymes in obese elderly women.Methods & Materials: This study, which is applied and semi-experimental, was conducted on 40 elderly women who were randomly divided into four equal groups. Then, after performing the initial tests as a pre-test, they were divided into supplement and exercise + supplement groups for daily consumption of 500 mg spirulina capsules in three servings. Therefore, the exercises were performed for 8 weeks (three sessions per week) and an average of 60 minutes. Therefore, after the completion of 8 weeks, the experiments were repeated, and for their statistical analysis, correlation and covariance t-tests were used with a significance level of P < 0.05.Results: The current research on elderly women with an average age of 60-65 showed that doing yoga with dumbbells along with spirulina supplementation led to a significant decrease in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) enzymes in the exercise group) AST)=P ،(003/0>ALT=)p(003/0>) and exercise/supplement group (ALT= (P>0.0001), AST= (P>0.001); but Significant difference in the control group (AST=(P=0.82), ALT=(P=0.82)) and supplement group without training (AST=(P=0.21), ALT=(P=0.21)) was not observed.Conclusion: According to the results of the present study, it seems that taking spirulina supplements at the same time as yoga exercises with dumbbells can have positive effects on liver enzymes; Therefore, it is suggested to sports trainers to improve health status and prevent liver diseases in elderly people. Manuscript profile
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  8 - The effect of zinc-methionine supplementation on antioxidant status and expression of interleukin-4 and interleukin-6 genes in female rats under heat stress
  Matin Jamei Ali Asghar Sadeghi Mohammad Chamani
  10.30495/zisti.2023.1973380.1144
  Introduction:During heat stress, the animal body requires more antioxidant compounds and activity of antioxidant enzymes. Zinc plays a role in the structure and activity of antioxidant enzymes. One of the ways to supply the zinc requirement, is to use organic zinc suppl More

  Introduction:During heat stress, the animal body requires more antioxidant compounds and activity of antioxidant enzymes. Zinc plays a role in the structure and activity of antioxidant enzymes. One of the ways to supply the zinc requirement, is to use organic zinc supplements, which zinc combined with methionine, and have more intestinal absorption Aim: This study was done to evaluate the effects of different doses of zinc-methionine supplementation on the blood antioxidant status and the expression of interleukin 4 and 6 genes in rats exposed to heat stress.Materials and methods: In a completely random design, 20 female rats were divided into four treatment groups with five replicates. Rats were kept at a temperature of 31±2 °C for 20 hours and at a temperature of 38±2 °C for 4 hours per day (to create heat stress). The rats in the control group were fed standard pellets without additives, and the three experimental groups were fed standard pellets plus 15, 30 and 45 mg zinc-methionine supplement per kilogram of dry matter for 30 days. At the end of the experiment, a blood sample was collected from the inferior vena cava. Total antioxidant capacity, malondialdehyde concentration, antioxidant enzymes, liver enzymes in the serum and the expression of interleukin-4 and interleukin-6 genes were measured.Results: Serum zinc concentration increased linearly with increasing zinc dose in the diet (P<0.05). The serum activity of two enzymes, alanine aminotransferase and aspartate aminotransferase decreased linearly with increasing zinc-methionine dose in the diet (P<0.01). The highest activity of glutathione reductase and glutathione peroxidase was observed in the group receiving 30 mg/kg, and the lowest activity of these enzymes was observed in the control group. In general, the relative expression of the interleukin-4 gene was increased, and the relative expression of the interleukin-6 gene was decreased (P<0.05). The highest expression of interleukin-4 gene belonged to the group receiving 30 mg, and the highest relative expression of interleukin-6 gene belonged to the control group and the group receiving 15 mg/kg.Conclusion: The results of this study showed that the dose of up to 30 mg of zinc-methionine per kg of diet used in this study increases the activity of superoxide dismutase enzyme and glutathione peroxidase enzyme activity, decreases the activity of liver enzymes in the serum, increases the expression of the anti-inflammatory gene (Interleukin-4) and decreases the expression of inflammatory gene (Interleukin-6), which indicates the reduction of oxidative stress and the reduction of the effects of heat stress in the body of the rat. Manuscript profile
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  9 - Biochemical effects of olive leaf extract in ovariectomized rats
  M.R. Nasirzadeh jafar rahmani kahnamoei
  Estrogen depletion in postmenopausal women and ovariectomized animals causes abnormalities in lipid metabolism, weight gain and fat accumulation in non-adipose tissues such as liver. On the other hand, estrogen replacement therapy may cause side effects including breast More

  Estrogen depletion in postmenopausal women and ovariectomized animals causes abnormalities in lipid metabolism, weight gain and fat accumulation in non-adipose tissues such as liver. On the other hand, estrogen replacement therapy may cause side effects including breast cancer. Olive leaf is a significant source of bioactive phenolic compounds with antioxidant, anti-inflammatory and radical scavenging capacity. The purpose of this study was to evaluate the effects of Olive Leaf Extract (OLE) on liver enzymes, serum lipid profileand atherogenic index. For this purpose, 21 female Wistar rats were randomly allocated into 3 groups: 1- control (intact animals), 2- ovariectomized: OVX ( ovaries removed by surgery) and 3- treatment group (OVX+received OLE) Which &nbsp;received 100 mg/kg OLE in 0.5 ml drinking water using gavage for 8 weeks. At the end of the treatment, levels of liver enzymes and serum lipid profiles were measured. Body weight was increased significantly in OVX group in comparison to control group (pp</em>˂0.05).This study showed that oral administration of 100 mg/kg/day of OLE for 8 weeks can prevent increase of lipid profile, liver enzymes and atherogenic index in serum of ovariectomized rats. Manuscript profile
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  10 - The effect of resistance training with different intensities on liver enzymes levels in patients with fatty liver: The case for Ahvaz disciplinary force staff
  Abbas Khalili Masoud Nikbakht Mohsen Ghanbarzadeh Sedigheh Karampour
  10.30495/varzesh.2022.1961184.1037
  Introduction: Fatty liver disease is the most common cause of liver enzyme disorders. The aim of this study was to evaluate the effect of resistance training with different intensities on liver enzymes levels in patients with fatty liver who were working as disciplinary More

  Introduction: Fatty liver disease is the most common cause of liver enzyme disorders. The aim of this study was to evaluate the effect of resistance training with different intensities on liver enzymes levels in patients with fatty liver who were working as disciplinary force staff in Ahvaz, Iran.Materials and methods: Participants in this study were patients with fatty liver in age range of 30-50 years who were working as disciplinary force staff in Ahvaz, Iran. Out of 200 patients diagnosed with fatty liver, 30 volunteers were selected and studied in this study. The participants were randomly divided into 3 groups of 10 subjects, including: 1. High-intensity resistance training 2. Moderate-intensity resistance training, and 3. Control group. Using blood sampling, the levels of AST, ALT and ALKp enzymes were measured in the laboratory at the beginning and end of 8 weeks of resistance training. Data normalization was performed using the Kolmogorov-Smirnov and Shapiro-Wilk tests. Also, analysis of variance (ANOVA) and LSD post hoc test were used to examine the differences between the three groups. All statistical analyses were performed using SPSS software version 18 at a significance level of 0.05 (&alpha; = 0.05).Findings: The results showed that high intensity resistance training had a significant effect on AST, ALT and ALKp enzymes (P &le; 0.001). On the other hand, moderate intensity training had a significant effect on AST and ALT enzymes (P &le; 0.001), while this type of training had no significant effect on ALKp levels (P &le; 0.099). Conclusion: Both moderate and high intensity resistance training can improve AST, ALT and ALKp enzyme levels; however, high-intensity resistance training seems to play a more prominent part. Manuscript profile
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  11 - عملکرد و پاسخ های متابولیکی گاوهای تازه زا به استفاده از منبع پیش ساز قندی به صورت روزانه و یا به صورت یک روز در میان
  م. کاظمی بن چناری م. جهانی مقدم ع.ر. علیزاده پ. قدرتی ح. شهابی ا. محجوبی م. گرجی دوز
  تأثیر نحوه ارائه منبع قندی (ترکیب آن شامل؛ 500 گرم گلیسرین، 250 گرم منوپروپیلن گلیکول، 150 گرم کلسیم پروپیونات، 1 گرم نیاسین و 350 میلی&shy;گرم سولفات کبالت در هر کیلوگرم) در گاوهای شیری (به صورت پیوسته یا یک روز در میان) بر عملکرد، متابولیت&shy; های خونی و آنزیم&shy; ه More

  تأثیر نحوه ارائه منبع قندی (ترکیب آن شامل؛ 500 گرم گلیسرین، 250 گرم منوپروپیلن گلیکول، 150 گرم کلسیم پروپیونات، 1 گرم نیاسین و 350 میلی&shy;گرم سولفات کبالت در هر کیلوگرم) در گاوهای شیری (به صورت پیوسته یا یک روز در میان) بر عملکرد، متابولیت&shy; های خونی و آنزیم&shy; های کبدی مورد مطالعه قرار گرفت. تعداد 24 رأس گاو شیری چند بار زایش&shy; کرده در قالب طرح کاملاً تصادفی (8 رأس در هر تیمار) برای مدت 14 روز بعد از زایش به صورت انفرادی تغذیه شدند. تیمارهای آزمایشی شامل؛ 1) عدم استفاده از منبع قندی، 2) استفاده پیوسته از منبع قندی و 3) استفاده یک روز در میان از منبع قندی. استفاده روزانه از منبع قندی در روزهای 3، 4، 5، 6 و 7 بعد زایش و استفاده یک روز در میان در روزهای 3، 5، 7، 9 و 11 بعد زایش بود. مقدار مصرف منبع قندی به صورت مشابه و 1 کیلو در روز برای هر رأس بود. نمونه&shy; های خون در روزهای 5 و 14 از دام &shy;ها گرفته شد. نتایج نشان داد ماده خشک مصرفی در روش استفاده یک روز در میان بهبود یافت (0.05=P). مقدار شیر تصحیح شده برای چربی برای گروه شاهد بیشترین مقدار بود (0.01=P). پروتئین و چربی شیر در تیمارهایی که منبع قندی استفاده کرده بودند نسبت به گروه شاهد بیشتر بود. تعداد سلول&shy; های بدنی در تیماری که منبع پیش&shy;ساز قندی استفاده شده بود نسبت به گروه شاهد کمتر بود (64.5 در برابر 103&times;365 در هر میلی&shy;لیتر بود) (0.02=P). غلظت پروتئین کل در تیماری که منبع قندی به صورت روزانه استفاده شده بود بالاتر بود. غلظت انسولین نیز در تیماری که منبع قندی را به صورت پیوسته مصرف نمودند در روز 5 بالاتر بود (0.05&gt;P). غلظت اسیدهای چرب غیر استریفیه و همچنین بتاهیدروکسی بوتیرات در بین تیمارها تفاوتی نداشت و آنزیم &shy;های کبدی تحت تأثیر تیمارهای آزمایشی قرار نگرفتند. اما شاخص حساسیت به انسولین در تیماری که مکمل پیش&shy;ساز قندی استفاده شده بود نسبت به شاهد پایین&shy;تر بود (0.05&gt;P). به طور خلاصه، بر پایه میزان مصرف ماده خشک در گاوهای تازه&shy; زا، ارائه منبع قندی به صورت یک روز در میان (ناپیوسته) قابل توصیه می&shy;باشد اما با این وجود نیاز به مطالعه &shy;های بیشتر در این زمینه می&shy;باشد. Manuscript profile
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  12 - مکمل‌سازی جیره جوجه‌های گوشتی با زیره سیاه (Nigella sativa)، و تأثیر آن بر وزن کبد و آنزیم‌های آن
  K. Shirzadegan P. Fallahpour I. Nickkhah H.R. Taheri
  آزمایشی به منظور ارزیابی اثرات افزودن دانه زیره سیاه (Nigella sativa) در جیره روی عملکرد، وزن و آنزیم‌های کبد جوجه‌های گوشتی صورت گرفت. آزمایش در قالب یک طرح بلوک کامل تصادفی انجام شد. 240 جوجه گوشتی تعیین جنسیت نشده (کاب 500) به چهار گروه تقسیم و به چهار تیمار تغذیه‌ای More

  آزمایشی به منظور ارزیابی اثرات افزودن دانه زیره سیاه (Nigella sativa) در جیره روی عملکرد، وزن و آنزیم‌های کبد جوجه‌های گوشتی صورت گرفت. آزمایش در قالب یک طرح بلوک کامل تصادفی انجام شد. 240 جوجه گوشتی تعیین جنسیت نشده (کاب 500) به چهار گروه تقسیم و به چهار تیمار تغذیه‌ای با چهار تکرار (15 جوجه در هر تکرار) تخصیص داده شدند. گروه 1 به عنوان گروه شاهد در نظر گرفته شده که به آنها جیره‌های پایه بدون افزودنی داده شد. به گروه‌های 2، 3 و 4 به ترتیب جیره‌های مکمل‌سازی شده با 5، 10 و 15 گرم در کیلو‌گرم دانه زیره سیاه داده شد. هیچ اثر معنی‌داری (05/0P&gt;) روی وزن زنده، مصرف خوراک و وزن اندام‌ها به جز برای کبد، در پرندگان تغذیه شده با جیره‌های مکمل‌سازی شده در مقایسه با تیمار 0 گرم در کیلوگرم مشاهده نشد (05/0P&lt;). همچنین، در مقایسه با گروه شاهد، غلظت AST و LDL پلاسمای حاصل از جوجه‌های گوشتی تغذیه شده با جیره‌های حاوی 5، 10 و 15 گرم دانه زیره سیاه کمتر بود (05/0P&lt;). بیشترین و کمترین درصد وزن کبد نیز به ترتیب مربوط به گروه‌های 15 گرم در کیلوگرم دانه زیره سیاه و شاهد بود. به طور کلی، این مطالعه نشان داد که مکمل‌سازی دانه زیره سیاه در سطوح متفاوت با وجود تحت تأثیر قرار دادن برخی از پارامترهای خونی، هیچ اثر منفی یا مثبتی روی عملکرد رشد جوجه‌های گوشتی نداشت. Manuscript profile
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  13 - The Effect of Dusts on Liver Enzymes and Kidney Parameters of Serum in Male Rats in Khuzestan, Iran
  Najmeh Soleimani Hassan Faridnouri Mohammadreza Dayer
  10.22034/jchr.2020.1902789.1148
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  14 - Biochemical and Histopathological Study of the Toxicity of Zinc Oxide Nanoparticles on Liver in Rat
  S.M Hosseini A.H Moshrefi رضا Amani S.V Razavimehr M.H Aghajanikhah
  Zinc oxide (ZnO) is one of the most widely used materials in diverse industrial fields, for this reason most widely produced and Have many technological applications. The human body may be intentionally or unintentionally exposed to these nanoparticles. In this study, a More

  Zinc oxide (ZnO) is one of the most widely used materials in diverse industrial fields, for this reason most widely produced and Have many technological applications. The human body may be intentionally or unintentionally exposed to these nanoparticles. In this study, acute toxicity of zinc oxide nanoparticles on the liver enzymes and liver histopathology was evaluated. Fifty female rats with 180-220 grams of weight were divided into five groups, including control, Sham and Three groups with different doses of ZnO nanoparticle (25, 50 and 100 mg/kg twice a week for four weeks). The rats were then sacrificed and cholesterol, triglycerides, totalprotein, albumin and liver enzymes (ALT, AST and ALP) were determined and livers were fixed in formalin processed, sectioned and stained with Hematoxylin- Eosin. After removal of the tissue, samples digestion and zinc concentrations were measured by atomic absorption; Finally Data were analyzed using one way ANOVA. Also the most of the Zno nanoparticles absorption on the dose of 100 mg/kg was observed. Histopathological analysis of liver sections showed tissue damage, such as necrosis, congestion and vacuolar degeneration at a dose of 25 mg/ kg andin addition inflammatorycell infiltrationin doses 50 and 100 mg/kg was observed. In Serological studyalso increased serum ALT, AST and ALP Liver enzymes levels. Results of the present study showed the dose-dependent toxicity of ZnO nanoparticles on the liver; therefore exposure to nanoparticles can make serious risks in humans. Manuscript profile
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  15 - The Effects of Hydroalcohlic Walnut Extract of Juglans regia Male Flower on Blood Sugar Level and Liver Enzymes Activity in Intact and Diabetic Adult Male Rat
  سید ابراهیم حسینی کاظم کریم زاده
  Diabetes is a metabolic disorder with hyperglycemia due to defects in secretion, insulin function or both are specified. Walnut nutritional purposes in addition to traditional medicine in Iran is also used to treat diabetes, so this study examines the effect of male flo More

  Diabetes is a metabolic disorder with hyperglycemia due to defects in secretion, insulin function or both are specified. Walnut nutritional purposes in addition to traditional medicine in Iran is also used to treat diabetes, so this study examines the effect of male flowers on some walnut diabetes on diabetic male rats by measuring the amount of blood sugar and liver enzymes. The study on 80 male rats with 200 to 225 grams weight, which accidentally in three groups were performed. The first group: Control, Second: Diabetic 32 and next Group: Non-diabetic 32 over each of the groups to four are divided into eight categories: (A) The control group received normal saline, (B) treated with experimental group received the extract 2g/kg,) C) Received the extract 4g/kg, (D) Extract the downloaded 6g/kg. Eight rats were used for determination of lethal doses of LD50. For diabetes as IP 60mg/kg of streptozotocin were used. Rat daily for 15 days as a single dose extracts were treated at the end of the fifteenth day from the ventricular blood sampling were performed.Results showed a significant reduction blood sugar and ASAT,ALP in diabetics than non-diabetic group receiving thehydroalcoholic extractof male flowers walnut. However this effect is not dependent dose. In this study hydroalcoholic extract useful effect of male flowers Walnut liver damage due to inhibition and reduced blood sugar and liver enzymes levels, non-dose dependent, was observed. Manuscript profile
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  16 - The Effect of Urtica dioica Hydro-Alcoholic Extract on the Plasma Level of Pituitary Thyroid Axis Hormones and Some of the Liver Enzymes in Adult Male Wistar Rat
  حیدر آقابابا سیده نیره حسینی سید ابراهیم حسینی
  Urtica dioicais a herbaceous, perennial and enumerate medicinal plant.Urtica dioica is an indigene plant in Iran and in last years many pharmaceutics effect are reported about it plant. In this research, the effect of Urtica dioicahydro-alcoholic extract of the plasma l More

  Urtica dioicais a herbaceous, perennial and enumerate medicinal plant.Urtica dioica is an indigene plant in Iran and in last years many pharmaceutics effect are reported about it plant. In this research, the effect of Urtica dioicahydro-alcoholic extract of the plasma levels of thyroid hormones (T4, T3), TSH and liver enzymes,alanin amino transfrase(ALT), aspartate amino transfrase(AST), alkaline phosphatase(ALP) were studied. In this experimental study, the experiments were performed on 40 adult male wistar rats with weight about 210andplusmn;10 gr, which were divided into 5 groups. The experimental groups received 25, 50 and 100 mg/kg of the Urtica dioica extract with injected intraperitoneally (IP) for 28 days respectively. Sham group received only solvent (distilled water) and control group did not receive any thing. At the end of experiment by collecting the blood samples from heart animals, plasma level of T3,T4 and TSH were measured by using ELISA Technique and enzymes liver AST, ALT, ALP by photometric method. Detected data were analyzed by T-test and ANOVA (pandle; 0/05). The results showed significant increase in the level of TSH hormone in the each three experimental groups compared with the control group. The level of T4 hormone significantly decreased in the each three experimental groups compared with the control group. Also the level of T3 showed significant decrease in experimental group receiving 50,100 mg/kg extract compared with the control group. The Level of AST, ALT enzymes in experimental groups showed no significant difference compared with the control group, While ALP enzyme in experimental and sham groups showed significant increase compared with control group. The results of this research have been shown that extract of this plant could affect on HPT axis and have no effect on some of the liver enzymes respectively. Manuscript profile
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  17 - Effects ofMelissa officinalisExtractonLiver Enzymes and Histologyin Mice ر
  مهرداد مدرسی صفیه گلخنی مهران مجلسی
  Balm (Melissa officinalis) has many medical properties including relaxing, anti oxidant, and anti bacterial. This study was conducted to investigate the effect of hydro alcoholic extract of balm on activity of liver enzymes including AST, ALT, and ALP and also liver tis More

  Balm (Melissa officinalis) has many medical properties including relaxing, anti oxidant, and anti bacterial. This study was conducted to investigate the effect of hydro alcoholic extract of balm on activity of liver enzymes including AST, ALT, and ALP and also liver tissues variation in Balb/C mice. In this experimental study, samples were randomly divided into fivegroups (three treatment groups, placebo and control group) with eight members in each group. Groups were kept under similar conditions. Hydro alcholic extract was prepared in three doses (50,100, and 200 mg/kg) and were IP for twenty days. Normal saline was used for placebo group. After the last injection blood samples were taken and liver tissues were separated. Changes of AST, ALT, and ALP enzymes was evaluated using one way variance analysis and SPSS program (P ر Manuscript profile
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  18 - The Effects of Hydroalcoholic Leaf Extract of Passiflora Caerulea on Activity of Liver Enzymes in Male Rats
  طیبه Sadeghi مهرداد Shariati مختار Mokhtari
  Passiflora caerulea is one of medicinal plants and use in medicinal industry. Passiflora caerulea contain high anti oxidant combinations this combinations pain properties and are useful in curing have anti cancer and anti  inflammatory and antiepilepsy, diarrhea, burn, More

  Passiflora caerulea is one of medicinal plants and use in medicinal industry. Passiflora caerulea contain high anti oxidant combinations this combinations pain properties and are useful in curing have anti cancer and anti  inflammatory and antiepilepsy, diarrhea, burn, hemorrhoid and in regulating liver enzymes. In this experiential study, 40  wistar   male rats, use weighting about 195-200 g each were used in five groups eight including :control without received nothing, sham group received distilled water and 3 experimental groups receiving  150,300,600, mg/kg leaves of passiflora  caerulea  Hydro-alcohol extract respectively. According to obtained results, ALT, AST and Albumin in experimental group receiving the highest dose of the extract 600 mg/kg, pation in control group, meaningful in level. The Level of ALP, Total Protein, Creatinin and total body weight to comparison by control group not show significant changes and hydro alcoholic extract Passiflora cearulea Author decrease level BUN to experimental groups extraction of receiving. Hydro-alcohol extract of Passiflora caerulea leaves probably has a significant effect on hepatic activity. This effect by anti oxidant property active, mechanisms via like free radical control and peroxides neutralization and prevention of revive glutathione, evacuate and cell  membrane  stabilization and by stimulating DNA polymerase and increasing rRNA synthesis and finally relief liver cell. Manuscript profile
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  19 - Comparison of the Effects of Flaxseed and Nigella Sativa Oils on Liver Enzymes and Some of the Inflammatory Factors in Male Rats with non-Alcoholic Fatty Liver
  Mozhgan Rahimi Seyed Ebrahim Hosseini Mohammad Amin edalatmanesh
  Fatty liver is a common metabolic disorder affecting millions of people all over the world. Due to the side effects of most of the chemical drugs used to treat this disease, this study has been performed aiming to investigate the effect of flaxseed and N. sativa oils on More

  Fatty liver is a common metabolic disorder affecting millions of people all over the world. Due to the side effects of most of the chemical drugs used to treat this disease, this study has been performed aiming to investigate the effect of flaxseed and N. sativa oils on serum levels of liver enzymes and some of the inflammatory factors in in male rats affected by non-alcoholic fatty liver disease (NAFLD). In this experimental study, 40 mature male rats were randomly assigned to 5 groups (8 rats in each group) include the control group (receiving no treatment), fatty liver (treated by fat emulsion), and the experimenta groups under 6-weeks by fat emulsion, and 28-day treatments by 0.75 ml/kg of flaxseed oil, 5 ml/kg of N. sativa oil, and the combined treatmnet of 0.75+ 5 ml/kg of flaxseed and N. sativa oils, respectively. At the end, after blood sampling and separation of the surface serum of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), BUN (blood urea nitrogen), creatinine, total protein, and interleukin 6 were measured.&nbsp; Data analysis was done by ANOVA and Tukey tests. The results showed that iduction of fatty liver caused significant increase of interleukin-6, total protein, blood urea nitrogen, ALP, ALT, AST enzymes, and creatinine compared to the control group (P˂0.01); while the use of flaxseed and N. Sativa oils alone and their combination caused a significant decrease in the level of the above mentioend (P˂0.01). factors The results showed that N. sativa and flaxseed oils and their combination can decrease the inflammatory serum factors and liver damage caused by fatty liver disorder. Manuscript profile
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  20 - The Effect of Curcumin on Testosterone and Liver Enzyme Levels in Varicocele-induced Rats
  Mohamad Reza Sadraie Marzieh Tavalaee Mohammad Hosein Nasr-Esfahani Mohsen Forouzanfar
  10.22034/ascij.2021.687831
  Varicocele is one of the most important causes of infertility in men, which in addition to negatively affecting spermatogenesis, can also affect the endocrine system. The link between varicocele and testosterone production is unclear. The liver is one of the most effect More

  Varicocele is one of the most important causes of infertility in men, which in addition to negatively affecting spermatogenesis, can also affect the endocrine system. The link between varicocele and testosterone production is unclear. The liver is one of the most effective organs in the metabolism of substances and hormones. This study aimed to evaluate serum testosterone levels and their association with liver enzymatic changes. Fifty male Wistar rats were divided into 5 groups, including sham control, varicocele induction, varicocele induction (50 mg/kg curcumin), and varicocele induction (100 mg / kg curcumin). After the treatment period, iron (Fe2 +), testosterone, direct bilirubin, total bilirubin and serum concentrations of ALT, and AST were assessed and liver tissue was isolated and examined. Varicocele caused a significant increase in iron levels (p &le; 0.05) and a non-significant decrease in testosterone levels (p = 0.242) and total bilirubin (T) (p = 0.639). The treatment resulted in a significant decrease in the levels of iron (p = 0.056) and total bilirubin (p = 0.639), as well as a significant increase in testosterone levels (p &lt; 0.05) compared to the varicocele. While the level of direct bilirubin (p &ge; 0.05) in the varicocele showed a significant increase compared to the sham and control. Using curcumin significantly reduced it compared to the varicocele (p = 0.03). Evaluation of ALT (p = 0.762) and AST (p = 0.367) levels did not show a significant difference among the groups. The levels of iron, testosterone, bilirubin, and liver enzymes are negatively affected by varicocele. Curcumin may lessen the harmful effects of varicocele on biochemical components linked with liver tissue in addition to preventing varicocele damage to testicular tissue. In varicocele rats, greater dosages of curcumin may lower the liver enzyme AST. Manuscript profile
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  21 - The effect of taurine amino acid addition on performance, carcass characteristics, blood factors and liver enzymes in broilers
  tahereh sandoghdar mehrdad irani Shahabodin Gharahveysi
  This research was conducted in order to study the effect of taurine amino acid addition on performance, carcass characteristics, blood factors and liver enzymes in broilers. The experiment was conducted in 45 days in the form of a completely random design with 300 piece More

  This research was conducted in order to study the effect of taurine amino acid addition on performance, carcass characteristics, blood factors and liver enzymes in broilers. The experiment was conducted in 45 days in the form of a completely random design with 300 pieces of one-day-old broilers of the Ras strain, including 4 treatments, 5 repetitions and 15 birds in each repetition with the same energy and protein diets with the same rearing conditions. The experimental treatments included: the first treatment (basic diet) and the second, third and fourth treatments respectively: the basic diet along with 1 g/kg taurine amino acid, 3 g/kg taurine amino acid and 6 g/kg taurine amino acid. The results showed that body weight gain, feed consumption and food conversion ratio were significant between the experimental treatments and the control treatment during the breeding period (P0.05). But numerically, a better performance was observed with the addition of taurine supplement to the diet in these enzymes. (P > 0.05). In general, the results of this experiment showed that adding 6 grams/kg of taurine amino acid leads to an improvement in the titer of blood parameters and liver enzymes without negatively affecting the performance and characteristics of the carcass. Manuscript profile
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  22 - The Effect of Different Levels of Dietary Manganese on Antioxidant Activity, Liver Enzymes and Liver Histology in Reared Young Beluga (Huso huso)
  Fatemeh Hemmati Hossein Khara Habib Vahabzadeh Roudsari Rezvanollah Kazemi
  This research aims to determine the effect of different amounts of dietary manganese on antioxidant activity, liver enzymes and, liver tissue of rearing young beluga (Huso huso) from October to December 2022 at the Dr. Beheshti Reproduction and Genetic Stock Restoration More

  This research aims to determine the effect of different amounts of dietary manganese on antioxidant activity, liver enzymes and, liver tissue of rearing young beluga (Huso huso) from October to December 2022 at the Dr. Beheshti Reproduction and Genetic Stock Restoration Center of Sturgeon in Rasht, Guilan province. For this study, 180 pieces of beluga with an average initial weight of 266 ± 3.05 grams underwent a two-week adaptation period in the breeding environment, in six treatment groups and each treatment with three repetitions, with concentrations of 5 (Mn1), 10 (Mn2), 15 (Mn3), 20 (Mn4) and 25 (Mn5) mg of manganese sulfate monohydrate (MnSO4H2O) per kilogram of food and control treatment (Mn0) without adding manganese sulfate supplement were carried out in two months. At the end of each month, three pieces of fish were selected from each repetition, blood was collected and their livers were sampled for histological studies. The results revealed a significant difference in catalase and glutathione peroxidase levels among the experimental treatments (p<0.05) and their maximum amount was the control treatment fish, while superoxide dismutase levels did not differ significantly (p<0.05). Among the liver enzymes, Alkaline-phosphatase and aspartate-aminotransferase had a significant difference between the control treatment and other experimental treatments (p<0.05), but the alanine-aminotransferase enzyme had no significant difference (p<0.05). Also, different forms of tissue damage were observed in the liver tissue of all treatments, even the control (atrophy, biliary stagnation, Fat degeneration and, cellular necrosis). Based on the results of this research, the levels of 10-15 mg of dietary manganese could improve antioxidant activities, liver enzymes and reduce liver tissue damage in breeding young beluga. Manuscript profile
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  23 - Protecting Effect Extracts of Satureja bachtiarica and Thymus daenensis Celak against Hepatic Fibrosis Induced by Thioacetamide on Rat
  H. Sazegar F. Fadaei Sh. Mashadizadeh N. Ziajahromi F. Sadeghi Samani
  nowadays, one of the problems of human societies is liver diseases and using chemical drugs with their side effects, causing the researchers change their approaches towards new sources of herbal drugs .The aim of this study was to investigate the effect of Satureja bach More

  nowadays, one of the problems of human societies is liver diseases and using chemical drugs with their side effects, causing the researchers change their approaches towards new sources of herbal drugs .The aim of this study was to investigate the effect of Satureja bachtiarica and Thymus daenesis Celak the liver damage is caused by injection thioacetamide. 54 male wistar rats were randomly selected and divided into 9 groups of 6 each groups the (first sahed, second of positive control, third of negative control, fourth, fifth, sixth extracts of Satureja bachtiarica with 5, 10 and 20 miligram per kilogram ,seven , eight and nine &nbsp;extract of Thymus daenensis Celak with 5, 10 and 20 mg/kg extract were given by gavage.Thioacetamide first for three week and twice weekly a rats of 1cc to all groups except the control group were injection then gavage for 14 days savory and thyme extract groups were treated with the extract and the positive drug control group treated with 8 mg/kg capsule sibilinin slap for 14 days.then the blood samples were taken and liver of rats. Histopathologic study suggests that liver lesions compared to the control group is related to the negative control group .Aspartate aminotransferase and alanine aminotransferase well as in the study were assessed and showed that extracts of thyme daenensis has a positive effect on liver fibrosis. By studying the findings, it seems that Flavonoid compounds and phenolic in Thymus daenesis Celak and Satureja bachtiarica can decrease the toxic effects induced By thioacetamide In liver tissue of Mice. Manuscript profile
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  24 - Protective Effects of Chicory (Cichorium intybus) Hydroalcoholic Extract on Hepatotoxicity of Vincristine Sulfate in Rats
  Neda Dehasht Bostan Roudi Vida Hojati
  Vincristine is an anti-cancer drug which fights the growth and spread of cancer cells in the body. This study aimed to investigate the protective effects of hydroalcoholic extract of chicory plant (Cichorium intybus)on hepatotoxicity of vincristine sulfate in rats. Adul More

  Vincristine is an anti-cancer drug which fights the growth and spread of cancer cells in the body. This study aimed to investigate the protective effects of hydroalcoholic extract of chicory plant (Cichorium intybus)on hepatotoxicity of vincristine sulfate in rats. Adult male Wistar rats were used in this study. 56 mice were divided into 7 groups of eight. Treatments were intraperitoneally performed for 15 days. The control group contained healthy mice. Experimental groups 1 and 2, each contains three subgroups with defined concentrations: Experimental group a1 received 15 mg/kg of chicory extract, 0.05 mg/kg of vincristine sulfate and again chicory extract. Experimental group b1 received 20 mg/kg of chicory extract, 0.1 mg/kg of vincristine and chicory extract again. Experimental group c1 received 25 mg/kg of chicory extract; then, vincristine at a dose of 0.2 mg/kg, and then chicory extract again. Experimental group a2: first 0.5 mg/kg vincristine then chicory extract at 15 mg/kg dose, and received Wayne Christian. Experimental b2: First, they received 0.1 mg/kg of vincristine; then, 15 mg/kg of chicory extract and again of vincristine. Experimental c2: first, they received 0.2 mg/kg vincristine, then 15 mg/kg chicory extract, and again vincristine. After performing the above steps by anesthetizing the animals, blood sampling from mice, serum isolation, liver isolation, the measurement of the level of biochemical parameters, and liver enzymes, and their liver tissue were tested. In this study, a significant increase in ALT and AST enzymes was observed in experimental groups 1 compared to the control group, and also a significant decrease was observed in experimental groups 2 compared to experimental groups 1. The results showed that the subcutaneous injection of vincristine had additive effects on the number of liver enzymes in experimental group 1, the chicory extract had high antioxidant properties and significantly reduced liver enzymes. Manuscript profile
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  25 - Effect of Nano-curcumin on the Treatment of Non-alcoholic Fatty Liver Disease (NAFLD) in Hypercholesterolemia Mice
  Sahar Farzaneh Sepideh Farahinia
  According to the widespread use of nanoparticles in medicine, the pathological study seems to be necessary. Important properties of nanoparticles are their small size. Accumulation of fat and inflammation of the liver are the beginning stage of liver cirrhosis. We aimed More

  According to the widespread use of nanoparticles in medicine, the pathological study seems to be necessary. Important properties of nanoparticles are their small size. Accumulation of fat and inflammation of the liver are the beginning stage of liver cirrhosis. We aimed to determine the effect of nano-curcumin on fatty liver disease. Sixty male mice were divided into 6 groups (n=10): control, gavaged with normal food. The second group were fed cholesterol, third group were fed cholesterol and curcumin. Other groups were fed different dose of nano-curcumin. Then, lipid profile and liver enzymes were measured and liver tissues were fixed in formalin buffer, staining with hematoxylin-eosin. Data were analyzed using SPSS. Evaluation of serum cholesterol showed that treatment with curcumin significantly decreased cholesterol, TG, and LDL of plasma level. Histopathological changes of the liver in the group received cholesterol showed vacuoles of fat, in groups which were fed low doses of the nano-curcumin did not show fat vacuoles of fat. Nano-curcumin may be used in the safe doses for treatment of nonalcoholic fatty liver disease. Manuscript profile
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  26 - Evaluation of Hematological and Biochemical Parameters in Infected Mehraban Sheep with Hydatid Cyst and Hepatitis Trematoda in Hamadan Industrial Slaughterhouse 2015
  Heydar Heydari Hamidreza Zahiri Azam Hosseini Parmis Notghi Saeideh Ayneh Azadeh Hosseini Elaheh Shams Hossein vazini
  Background; Livestock is the most important source of human food chain and the main source of protein. Parasitic diseases cause economic damage and have adverse effects on the health of animals and humans.Study plan; In this study, hematologic and biochemical parameters More

  Background; Livestock is the most important source of human food chain and the main source of protein. Parasitic diseases cause economic damage and have adverse effects on the health of animals and humans.Study plan; In this study, hematologic and biochemical parameters in hepatocyte infected sheep at Hamedan industrial slaughterhouse in 2015 were investigated.Animals studied; 220 Mehraban sheep breed by different ages were randomly collected from Hamedan slaughterhouses. The sheep were divided into four groups: 50 sheep infected with fasciolopsis (first infected group), 50 cases infected with hydatid cyst (second infected group), 20 cases infected with dicrucylose (three infected group) and 100 healthy sheep (control group).Method; The sheep were examined for macroscopic examination for hydatid cyst and hepatic trematoda. The blood sample was taken from the jugular vein of sheep. Blood and serum samples were tested. SPSS software was used to analyze the data.Results; The results showed that between the total number of red blood cells (RBC), mean corpuscular hemoglobin concentration (MCHC), hemoglobin (Hb), Mean Corpuscular Hemoglobin (MCH), mean cell volume (MCV), white blood cell (WBC) ) And aspartate transferase (AST), alanine transferase (ALT), alkaline phosphatase (ALP) enzymes were significantly different in the infected groups than the healthy group (P Manuscript profile