Infertility

Open Access Article

1 - Social Ways and Consequences of Infertility in Shia and Sunni Women
parvane Afshari علی پژهان ehsan rahmani khalili

The present study focuses on this main goal to examine and identify some of the most important social factors and consequences associated with infertility.The theoretical framework of this research is based on theories of rational choice, structural explanation and theo More

The present study focuses on this main goal to examine and identify some of the most important social factors and consequences associated with infertility.The theoretical framework of this research is based on theories of rational choice, structural explanation and theories related to explaining cultural and social norms.Theories use new household economics, family system, feminist, gender-based psychology, self and me, and labeling.According to preliminary analysis based on indicators of social attitudes, social factors are affected by demographic variables, the number of years of infertility, infertility problems, treatment methods, type of job, household income and place of residence.There is a significant relationship between the type of religion of respondents and their attitude to technological conditions, mental norms, social stigma, social cohesion, social exclusion, lack of dynamism, family vitality, self-confidence, environmental conditions and separation of husband and wife.The biggest factor that causes men and women to suffer from infertility is the fear of losing their life together. Manuscript profile

Open Access Article

2 - Evaluation of E. coli On Testes Tissue study in Rat
Fallah, M., Khaki, A., Jafari, B. .

There is more kind of reproductive infectious diseases. Viruses and bacterial agents can cause to presents this disease that occurs by sexual contact. Syphilis and Gonorrhea are the most common old known diseases that affects urogenital tract system, in nowadays HIV and More

There is more kind of reproductive infectious diseases. Viruses and bacterial agents can cause to presents this disease that occurs by sexual contact. Syphilis and Gonorrhea are the most common old known diseases that affects urogenital tract system, in nowadays HIV and transmitted Antigens by sexual contacts are the others reasons of urinary infectious diseases. The aim of current study was to investigate the effects of E. coli on testis tissue, seminiferous tubules and semen parameters. Materials and methods: sixteen mature male Wistar rats with 200-220 grams’ weight and 2.5- 3 months’ ages, distributed to two of 8 rat’s groups and for 60 days of study period the lightning program was 12 hours’ light and 12 hours’ dark. Entro-toxigenic E coli (0114 serotype[n1] [PB2] ) was gained from Tehran Bouali reference laboratory for infect rats. After infection, samples were taken from testis tissue and Hematoxylin-eosin was used for histopathology. The motility, viability and semen count was evaluated. Results:  Histopathology studies indicated that in control group all seminiferous tubules were adhere together and all sexual germinal cells was seen. In E. coli infected group, seminiferous tubules were inconsecutive and germinal cells was not seen. Semen parameters evaluation showed that total count of sperm, viability and motility was decreased significantly in E. coli infected group in comparison to control group. The results indicated that the E. coli has undesirable effects on fertility rate and testis tissue and could decrease fertility rate. Manuscript profile

Open Access Article

3 - Take a look at assisted reproductive technology using freezing
mina ramezani shokoh chegini

Infertility has long been considered one of the important medical issues which by the passage of time and advances of knowledge and technology, many therapeutic strategies have been acquired. In cases where there are no natural fertility methods, assisted reproductive t More

Infertility has long been considered one of the important medical issues which by the passage of time and advances of knowledge and technology, many therapeutic strategies have been acquired. In cases where there are no natural fertility methods, assisted reproductive technologies are used. Researchers believe that the most common methods of fertility preservation, such as :Ovarian cortex, oocyte and embryo cryopreservation , depends on several parameters, including: the type of problem and treatment, the infertility cause and also the patient's age and marital status. Nowadays with the advances of medical science, infertile women or women with high risk of diseases such as cancer or who for various reasons postponed childbearing age can maintain their fertility using cryopreservation methods including egg, embryo and ovarian cortex freezing. Using these methods will be different based on the cause of infertility, infertile women conditions or specific diseases or cancer,. During the last years, vitrification techniques have been introduced as a clinical practice which constantly being reviewed, compared and changed. Manuscript profile

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4 - Correlation of Total Antioxidants Levels and Malondialdehyde with Sperm Parameters and Chromatin integrity in Asthenoteratozoospermia Men
rahil jannatifar Zahra Ebrahimi Hamid piroozmanesh seyedeh Saeideh Sahraei

Background and purpose: Sperm dysfunction caused by reactive oxygen species (ROSs) is one of the major causes of infertility in men, which leads to, lipid peroxidation (LPO) and the formation of stable peroxidation products like Malondialdehyde (MDA) in seminal plasma. More

Background and purpose: Sperm dysfunction caused by reactive oxygen species (ROSs) is one of the major causes of infertility in men, which leads to, lipid peroxidation (LPO) and the formation of stable peroxidation products like Malondialdehyde (MDA) in seminal plasma. MDA is effective factor in reducing fertility. The aim of this study is to determine two biochemical markers of oxidative stress; TAC and MDA, and correlation to sperm parameters and chromatin integrity at asthenoteratozoospermia men. Materials and methods: In this study, a case-control study was carried out in two groups of 50 fertilized men and 50 asthenoteratozoospermia men in Qom IVF center; Iran. Semen analysis was performed according to WHO (2010) guidelines. DNA damage, protamine deficiency and TAC, MDA levels in all patients were measured by kit methods, respectively. Results: According to our results, the percentage of sperm parameters in the infertile men were lower than the fertile men (p <0.05). Also, there was a significant difference in DNA damage and protamine deficiency between the two groups (p <0.05). Lower TAC levels (1.82± 0.11 vs. 2.25 ± 0.13) and higher MDA levels (2.36 ± 0.09 vs. 1.97 ± 0.10) were observed in infertile men with asthenoteratozoospermia compared to fertile men.Conclusion: These results suggest that decreasing TAC and increasing MDA lead to low sperm parameters and high DNA integrity in sperm of asthenoteratozoospermia men. Therefore, evaluation of oxidative status and antioxidant defenses system may be as a useful tool for diagnosis and treatment of male infertility especially in idiopathic male infertility Manuscript profile

Open Access Article

5 - The investigation of single nucleotide polymorphism rs2286663 in human Insulin-like 3 gene(INSL3),related to male infertility by RFLP PCR method
Asieh fotoohi رودابه بهزادی اندوهجردی مسعود زندی

ABSTRACT: Infertility is the inability of a couple to conceive after one year of consecutive sexual intercourses without birth control methods. Infertility is a multifactorial syndrome with several genetical or nongenetical reasons. The possible causes for infertility a More

ABSTRACT: Infertility is the inability of a couple to conceive after one year of consecutive sexual intercourses without birth control methods. Infertility is a multifactorial syndrome with several genetical or nongenetical reasons. The possible causes for infertility are still unknown for more than 25 percent of cases (idiopathic infertility). Recently a product of Leydig cells termed Leydig insulin –like hormone (INSL3)has been proposed as a putativa trophic hormone of the first part of descent.Absence of Insl3 in male mice results in bilateral cryptorchidism and mutations involving this gene may be a cause of azoospermia in man.this gene has several SNP .For this reason at this research rs2286663 is investigated. For this purpose, the number of 80 infertile men and 80 healthy men (as a control) was tested. Using a standardRFLP PCR method, the presence of the mutant was analyzed. The statistical results were not significant. Thus, no significant relationship between the mutation and idiopathic infertility in males has been detected. However, the results may be different by selecting the different genetic pool or significant changes in a population size. Manuscript profile

Open Access Article

6 - A Novel Semi-Supervised Technique for Selecting Appropriate Sperm in Infertility Treatment
Asefeh Tavakkoli Seyed Abolghasem Mirroshandel Fatemeh Ghasemian

Introduction:Nowadays infertility is recognized as one of the most common clinical problems around the globe, and one of the most worrying social issues in different cultures and societies. In the meantime, efforts have always been made to prevent the progression of inf More

Introduction:Nowadays infertility is recognized as one of the most common clinical problems around the globe, and one of the most worrying social issues in different cultures and societies. In the meantime, efforts have always been made to prevent the progression of infertility caused by this factor by carefully examining the most effective male factor - as one of the potential parties in infertility problems - that is, analyzing the quantity and quality of sperm. On one hand, traditional methods have lots of problems such as inadequate accuracy, clinicians' disagreements, and prolonged treatment. On the other hand, the successes of machine learning in many areas prompted researchers to move toward automating sperm morphology analysis by means of machine learning.Methods:The ladder network as a semi-supervised learning algorithm, by using a small number of labeled samples and a larger part of unlabeled data, shows suitability and compliance with the real-world requirements in this field of study. In this regard, in order to implement ladder networks, the structure of stack noise removal auto-encoders with the architecture of two parallel encoders has been used to represent the samples and a decoder to reconstruct the samples. The present study by applying changes and improving various factors, especially input noise, has obtained good results in the analysis of low-resolution images without coloring.Results:The proposed model succeeded by extracting positive and fruitful features from the images of the head, acrosome, and vacuole of human sperm, showing an acceptable accuracy for classifying them into two natural and abnormal classes, and finally selecting the appropriate sperm to participate in the artificial insemination process. The study of the proposed model for all three sperm sections (head, vacuole, and acrosome) succeeded, despite low-quality images, achieving impressive results of more than 70% for the head and acrosome and more than 80% for the vacuole.Conclusion: In the future, we intend to improve the proposed model by finding ways to increase the accuracy and reduce the error of the test results and show that the change in the type of noise or how it is applied to the network will have a significant impact on the network performance. Manuscript profile

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7 - Effect of Ethanol and Hexane Extract of Tribulus terrestris on Quality of Sperm and Histology of Male's Rats
Bita Behbodian Majid Poursoltani

Inroduction & Objective: Infertility is a serious problem. About 10% of males are estimated facing the problem of fertility. Rapid growth and development of sciences within the pharmaceutical span and focus and rely on production of herbal medicines and the production o More

Inroduction & Objective: Infertility is a serious problem. About 10% of males are estimated facing the problem of fertility. Rapid growth and development of sciences within the pharmaceutical span and focus and rely on production of herbal medicines and the production of plant-based infertility drugs is growingToday, a lot of research regarding infertility and the effects of herbs on it and finding the best method for plant extraction takes place.Plant is the main source in discovery of novel medicine. Nearly 40% of modern medicines are originated from plants.Tribulusterrestris is also an important herb that used for infertility. Water extract of T.terrestris contains steroidal saponins and protodioscin that increased sexualhormones and testosterone. Water extract of T.terrestris increased sexual desire and weight of prostate. Material and Methods: In the present study, 80% hexane and ethanol extracts of Tribulusterrestris prepared and force feed to two groups of mice. Each group was consist of 4subgroups with 8 mice and extract with doses of 5, 10 and 20 mg per body weight was applied on them. After 45 days of treatment the mice were anesthetized and killed.Results: The present study showed that in comparison between ethanol and hexane extract of fruit ofT. terrestis, in dosages 5, 10, 20 mg per weight of body, hexane extract, increased sperm count, but didn’t show any significant effecton control group. Instead,ethanol extract of fruit of T. terrestis not only increased sexualhormones as LH and testosterone but also increased spermatogenesis in lumen of seminiferous and changed histological of testis.This extract didn’t changethe weight of testis and epididymis.Conclusion:According to the results, ethanol extraction of aloe vera as an antioxidant compound is able to reduce the levels of cardiovascular damage in mice treated with titanium dioxide nanoparticles. Manuscript profile

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8 - Evaluation of sperm parameters and oxidative stress level in asthenoteratozoospermia men by N-acetylcysteine treatment
rahil jannatifar kazem parivar Mohammad Hossein Nasr-Esfahani nasim hayati roodbari

Background Infertile men have higher levels of semen reactive oxygen species (ROS) than fertile men. High levels of semen ROS can cause sperm dysfunction, sperm DNA damage and reduced male reproductive potential. This study investigated the effects of supplementation wi More

Background Infertile men have higher levels of semen reactive oxygen species (ROS) than fertile men. High levels of semen ROS can cause sperm dysfunction, sperm DNA damage and reduced male reproductive potential. This study investigated the effects of supplementation with N-acetyl-cysteine (NAC) on sperm parameters; chromatin integrity and level of stress oxidative (ROS) in infertile men.Methods The study was carried out in the unit of ACECR Infertility Research Center, Qom, Iran. The patients consisted of 50 infertile men with asthenoteratozoospermia who received NAC (600 mg/d) orally for 3 months, after which they were compared with pre-treatment status. Sperm parameters according WHO (World Health Organization) guidelines, protamine deficiency (chromomycin A3 staining), sperm DNA damage (TUNEL assay), percentage and intensity of ROS (DCFH-DA staining) were assessed in infertile men.Results After NAC treatment, patients' sperm parameters improved (P Manuscript profile

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9 - Comparing the effects of cinnamon hydroalcoholic extract (Cinnamomum Zeylanicum) and lovastatin on sperm parameters in hyperlipidemic rats.
Hossein Mostafavi Mehdi Eskandari Farhad Mohammadi

Background & aims: Increasing evidence indicates the detrimental effects of obesity and hyperlipidemia on sperm quality. The degree of reversibility of these quality changes in studies is different. One of the properties attributed to cinnamon in traditional medicin More

Background & aims: Increasing evidence indicates the detrimental effects of obesity and hyperlipidemia on sperm quality. The degree of reversibility of these quality changes in studies is different. One of the properties attributed to cinnamon in traditional medicine is to reinforce fertility. This study was designed to investigate the effect of cinnamon extract on sperm parameters in hyperlipidemia conditions. Materials & methods: In order to conduct research, 36 male rats were allocated into six groups: control, model, vehicle, lovastatin, cinnamon with low dose (130 mg) and high dose (260 mg). Animals of all groups, except the control group, received high-fat diet for 8 weeks. Then the treated groups (groups 3 to 6) received their treatment intra-peritoneally for 6 weeks along with normal diet. At the end of the study, lipid profile and sperm parameters were evaluated. Results: Cinnamon extract with a low dose was effective in reducing serum cholesterol and triglyceride, and high dose of cinnamon was effective in reducing serum LDL. Using a high-fat diet had no effect on the number, motility and morphology of sperm, and pre-treatment with both doses of cinnamon extract had a decreasing effect on sperm count and had no effect on sperm motility and morphology. Conclusion: It seems that cinnamon as a pre-treatment has beneficial and reducing effects on serum lipid profile. But in this study, cinnamon had no improving effects on sperm parameters in hyperlipidemic conditions. The difference between the obtained results and the results of previous studies needs further investigation. Manuscript profile

Open Access Article

10 - Assessment Interleukins 3, 5 and 6 Concentration in Follicular Fluid and Their Diagnostic Value in Patients with Unexplained Infertility
mohmmad Ghodsi vida hojati armin atarzadeh bita Saifi

Inroduction & Objective: Our aim a cross-sectional study was to compare the follicular fluid level of interleukins 3, 5, and 6 and clinical factors in patients with unexplained infertility with healthy subjects in the outcome of In vitro fertilization (IVF).   More

Inroduction & Objective: Our aim a cross-sectional study was to compare the follicular fluid level of interleukins 3, 5, and 6 and clinical factors in patients with unexplained infertility with healthy subjects in the outcome of In vitro fertilization (IVF).  Material and Methods: Initiation of ovulation stimulating with ovulation stimulating drugs in different protocols started in 60 infertile patients with unexplained infertility and 40 fertile women. Subjects underwent antagonist and agonist protocol for ovarian stimulation.Then their follicular fluid was separated and the follicular concentration of interleukins 3, 5 and 6 determined by Enzyme-linked immunosorbent assay (ELISA) method. The diagnostic value of these 3 interleukins was also evaluated using the Roc curve. Results: Among the clinical factors, the endometrial thickness and testosterone levels significantly between the two groups (P <0.0001and P = 0.002), that the mean endometrial thickness was lower and the mean testosterone level was higher than the control group. So, hirsutism and hyperandrogenism significantly correlated between the patient and control groups (P = 0.046 and P = 0.046). Interleukin-3, 5, and 6 concentrations decreased in the patient, that the only reduction in IL-5 concentration significantly in the case group compared to the healthy group (P <0.0001). The diagnostic accuracy of IL-5 in the FF wasmoderate with the area under the curve (AUC) of 0.71. Conclusion: There is a significant difference in the follicular fluid interleukin-5 concentration between infertile and fertile women. This cytokine may be involved in the pathophysiology of unexplained infertility. Manuscript profile

Open Access Article

11 - Effect of sodium molybdate on Cadmium Chloride-induced Infertility in adult male Wistar rats
Hormat Khorami Akram Eidi Pejman Mortazavi Mehrdad Modaresi

Introduction & Objective: Molybdenum, as a trace and essential element has cofactor role in the structure of antioxidant enzymes. This study aimed at investigating the antioxidant role of sodium molybdate on cadmium chloride (CdCl2)-induced testicular toxicity in ad More

Introduction & Objective: Molybdenum, as a trace and essential element has cofactor role in the structure of antioxidant enzymes. This study aimed at investigating the antioxidant role of sodium molybdate on cadmium chloride (CdCl2)-induced testicular toxicity in adult Wistar rats.Materials and Methods: Eighty adult male rats were divided into ten groups, including healthy control, sodium molybdate alone, infertile control (3 mg/kg of CdCl2), and sodium molybdate plus CdCl2. The impacts of oral administration of sodium molybdate (0.05, 0.1, 0.2, and 0.4mg/kg) was evaluated in healthy and infertile animals. After the end of the period, serum levels of testosterone, FSH and LH and changes in body weight and testicular,the number of embryos obtained from fertility evaluation.Data were analyzed by analysis of variance (ANOVA) and Tukey test.Results: Final body weight, weight gained, testicular weight and ratio of testicular weight to body weight, serum level of male sex hormones and number of fertility fetuses in infertile experimental groups treated with sodium molybdate were significantly different from the infertile control group (P< 0.05).Conclusion: The current findings suggested that sodium molybdate performs as a strong protective agent from CdCl2-related testicular toxicity in rats. Manuscript profile

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12 - The roots of the refusal of modernity and the symbolic sterility of Iranians in the Qajar era
Arash Monshizadegan seyyeh hosseyn athari

Iran''s encounter with Western civilization is the most important cultural phenomenon in Iran''s history after Iran''s encounter with Islam. On the one hand, it was the West that was attacking and on the other hand, an old Illyrian empire with kings who believed it was More

Iran''s encounter with Western civilization is the most important cultural phenomenon in Iran''s history after Iran''s encounter with Islam. On the one hand, it was the West that was attacking and on the other hand, an old Illyrian empire with kings who believed it was good to maintain the old balance, and for this reason, there is a need to analyze the face of Iranians in the Qajar era with modernity and Its complications should be paid. This research has been organized using the library and documentary tools and phenomenological method, and it seeks to investigate the question of what effect has the gradual invasion of modernity had on Iranians'' perception of facing this new phenomenon? And it is based on the assumption that the complications of the entry of modernity have led to the functional-identity refusal of Iranians and the symbolic sterility of Iranians in adopting a suitable reaction. According to the findings of the research, the Iranian subject, affected by the entry of the western "other" and modernity, suffered infertility and started non-symbolic identification with it. Manuscript profile

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13 - The study of the association of two variants of MLH3(rs175080) andTEX11(rs6525433) in Iranian infertile men
Hanieh Sezavar Zahra Noormohammadi Masoud Sheidai

Infertility is one of the most common problems in human societies which estimated between 1 in 6 couples worldwide. It is a complex clinical condition caused by the interaction of genetic and environmental factors. The TEX11 and MLH3 gene plays a key role in the mechani More

Infertility is one of the most common problems in human societies which estimated between 1 in 6 couples worldwide. It is a complex clinical condition caused by the interaction of genetic and environmental factors. The TEX11 and MLH3 gene plays a key role in the mechanism of DNA repair and crossing over. Methods: In this study, the association of two SNPs of MLH3 (rs175080) and TEX11 (rs6525433) in Iranian infertile men was investigated. One hundred twenty infertile men with azoospermia and 115 healthy individuals were collected as a control. These two polymorphisms were investigated by using tetra-amplification refractory mutation system ((PCR), TETRA - ARMS – PCR), PCR – RFLP, and sequencing were used. Findings and Discussion: The frequency of GG and GA genotypes in MLH3 gene was 30.9% and 69.1% in azoospermia males and 31.3% and 68.7% in the control group (P = 0.619), respectively. The result showed that rs175080 polymorphism in the MLH3 gene and rs6525433 polymorphism in the TEX11 gene were not associated with the risk of Azoospermia. Manuscript profile

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14 - The correlation of rs4647269 and re1800734 SNPs in MLH1 gene with Iranian male infertility: Azospermia
Mehrdokht Dorpoosh Zahra Noormohammadi Masoud Sheidai

Introduction: Infertility and its problems are considered as one of the most important issues that affect 10-15% of couples. About half of all infertility is related to men. Human spermatogenesis depends on the activity of thousands of genes, and defects in repair mecha More

Introduction: Infertility and its problems are considered as one of the most important issues that affect 10-15% of couples. About half of all infertility is related to men. Human spermatogenesis depends on the activity of thousands of genes, and defects in repair mechanisms can stop spermatogenesis. One of the proteins involved in the repair system is the MLH1 protein. The aim of this study was to investigate the association of rs1800734 and rs4647269 polymorphisms in the MLH1 gene with male azoospermic infertility.Methods: In this case-control study, blood samples were collected from 113 men with azoospermia infertility as a patient and 101 healthy men as a control. After DNA extraction, the genotypes of rs4647269 and rs1800734 polymorphisms were determined by RFLP-PCR method using HPYCH4IV and PVUII enzymes, respectively, and confirmed by sequencing. Results: In rs1800734 polymorphism, no significant difference (p <0.05) was observed between the genotypic frequency of the patient and control groups. There was a significant difference between genotypic frequencies between the two groups (P = 0.024), P = 0.021, P = 0.036) Also in this polymorphism in terms of sperm volume in traits (P = 0.000).Conclusion: There is a significant relationship between rs4647269 rs polymorphism of MLH1 gene and azoospermia infertility in the study population of Iranian men and it can probably be effective in it. Manuscript profile

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15 - Molecular docking and ADMET prediction of active compounds in Tualang honey against Sex hormone-binding globulin (SHBG) for the treatment of male infertility
Hamed Shahriarpour Mostafa Ghaderi-Zefrehei

10.30495/zisti.2023.1987659.1163

Introduction: Sex hormone-binding globulin (SHBG) is a protein that is synthesized by liver cells and binds to sex hormones to regulate their levels and bioavailability. Its binding to testosterone reduces bioavailable testosterone and causes diseases of the male reprod More

Introduction: Sex hormone-binding globulin (SHBG) is a protein that is synthesized by liver cells and binds to sex hormones to regulate their levels and bioavailability. Its binding to testosterone reduces bioavailable testosterone and causes diseases of the male reproductive tract such as infertility, erectile dysfunction and prostate cancer. Objective: In this in Silico study, the potential of several compounds present in Tulang honey against SHBG protein for the treatment of infertility has been investigated. Materials and methods: The six compounds in Tualang honey, Catechin, Ethyl oleate, Fisetin, Hesperetin, Kaempferol and Luteolin were obtained from previous studies and the PubChem pharmaceutical database. The binding energy and type of protein-ligand interactions were investigated by molecular docking of these compounds to SHBG protein. AutoDock Vina version 1.1.2 software was used to perform molecular docking and Discovery Studio v21.1.0.289 software was used to analyze molecular docking results. Then SwissADME and admetSAR 2.0 web servers were used to evaluate the pharmacokinetic properties of these compounds through ADMET predictions. Results: The binding energy obtained from molecular docking showed that Luteolin with a score of -10 kcal/mol binds to SHBG protein, and has more hydrogen-hydrophobic interactions than other studied compounds as well as compounds that have been worked on in recent papers. Catechin and Fisetin also showed an acceptable result. The study of ADMET and bioavailability radar showed that although these compounds have physicochemical properties for use as drugs, they have the potential to inhibit some cytochromes and toxicity for certain organs and DNA or other genetic material in the body that should be considered in the use of these compounds as drugs. Discussion and conclusion: Using this in silico study, several suitable molecules of natural origin against the SHBG protein were identified, which showed potential for the treatment of male infertility. Manuscript profile

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16 - Sociological examination of fertility biotechnologies in maternal issues
Amir Masoud Amir Mazaheri Mansore Sharifi

Motherhood experience is not unified in infertile women and it can be divided to three types of social motherhood, biological motherhood and genetic motherhood. In each of infertility treatments, the unified dimensions of this experience are flawed. This study examines More

Motherhood experience is not unified in infertile women and it can be divided to three types of social motherhood, biological motherhood and genetic motherhood. In each of infertility treatments, the unified dimensions of this experience are flawed. This study examines the help of fertility biotechnologies in maternal issue. Thus treatments in which the third person enters to the treatment process, have more complex social dimensions than treatments without the need for the third person. In this study, "fertility biotechnologies as the pain experience" was examined, and "donation intermediary" and "reasons and motivations of donation and its social consequences" were extended and analyzed. The study concludes that in the treatment of infertility whether with feminine or masculine origins, not only the main burden of physical side effects is for women, but also, the social burden of biotechnologies in treatment is affected women. So, what is considered as the motherhood phenomenon is also viewed in infertility treatments. However, due to the men's greater control over the economic resources of the family, in many cases, the final decision on starting or continuing the treatment process through fertility biotechnologies, is made by men.   Manuscript profile

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17 - The relationship between vitamin A, E, and some trace minerals and poor growth in replacement heifers
علی Sadeghi-nasab بهرام Dadmehr S.M Zolhavarieh علی Hassanpour A.A Bahari

One of the most important principles of cattle breeding is rearing and feeding of replacement calves. In this clinical survey three groups, consisting of 12-13 months old heifers, inseminated heifers up to 45 days of gestation and 4-5 months pregnant heifers suffering f More

One of the most important principles of cattle breeding is rearing and feeding of replacement calves. In this clinical survey three groups, consisting of 12-13 months old heifers, inseminated heifers up to 45 days of gestation and 4-5 months pregnant heifers suffering from nutritional problems which exhibited clinical signs of decreased growth rate, general debility, poor coat growth and discoloration and infertility were selected for pooled blood sampling and analysis of vitamin A, E and selenium, copper, zinc and manganese values. There was clear deficiency of vitamin E and manganese while selenium deficiency was slight correlating with clinical signs. It is suspected that improper and mouldy feeds presented to these non-lactating groups resulted in primary and secondary deficiencies of mentioned elements and finally have led to poor growth rate and fertility insufficiency in affected animals.       Manuscript profile

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18 - Protein- Protein Interaction network analysis for Discovering Potent Candidate Drugs in Female Infertility
Parinaz Tabrizi-Nezhadi Habib MotieGhader masoud Maleki

10.30495/ijbbo.2022.1963470.1013

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19 - The effect of low-power laser on the promotion of spermatogenesis in a mouse model of azoospermia (in-vivo)
habib tajalli Masoud Maleki Esmail Safavi Reza Shahi Fatemeh Firoozi Zahra Akbarpour Ali reza Sotoudeh Khyaban

10.30495/ijbbo.2022.1964975.1014

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20 - Protein- Protein Interaction network analysis for Discovering Potent Candidate Drugs in Female Infertility
Parinaz Tabrizi-Nejhadi Habib MotieGhader Masoud Maleki

10.30495/ijbbo.2022.696591

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21 - The effects of low-power laser on the promotion of spermatogenesis in a mouse model of azoospermia (in-vivo)
Habib Tajalli Masoud Maleki Esmail Safavi Reza Shahi Fatemeh Firoozi Zahra Akbarpour Alireza Sotoudeh Khyaban

10.30495/ijbbe.2022.698214

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22 - A sociological analysis on life experiences of infertile women being treated through modern methods in a pro-natalism environment
Narges Pirnia Shirin Ahmadnia Mohammad Jalal Abbasi-Shavazi

10.22034/ssyj.2023.1994999.1297

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23 - Classification and Analysis of Childlessness in Persian Love Poems
Azam Hosseini Hasan Zolfaghari

One of the narrative themes in love poems is the infertility of the lovers' parents. This theme is not one of the main themes, but it is the point of entry of lovers into the story So the author uses all his art to describe it as a beautiful and memorable event. This re More

One of the narrative themes in love poems is the infertility of the lovers' parents. This theme is not one of the main themes, but it is the point of entry of lovers into the story So the author uses all his art to describe it as a beautiful and memorable event. This research seeks to classify infertility in Persian love poems by describing and analyzing the content of the text. What role does each of these classifications and subspecies play in the narrative? For this purpose, the book "One Hundred Persian Love Poems" (Zolfaghari, 2015) is the basis of the work. According to the results, in thirty poems, the parents of lovers have suffered from infertility and in many cases, have been worried about the throne of their heirs. They have children in various ways (having children through prayer and charity, helping a dervish by eating blessings, having children outside the womb or with the presence of only one parent, hiding the birth or abandonment of a child, and predicting the birth of a child) has fallen. The evolution of this theme shows that its use began with mythology and was very primitive and naive in folk tales. The authors of Persian love poems of the fourth to ninth centuries, using their taste, have used it in various forms. From the ninth century onwards, nothing new is added to it and it is a repetition of the previous ones. Its peak was in the twelfth century due to the rise of Indian systematists and the rise of idealism. The role of this theme in the narrative structure of the love story is that the author, by portraying the difficult parenting of children, prepares the audience's mind for the events formed by these children in the continuation of the story, and increases the actions and thus the story's appeal. Manuscript profile

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24 - Investigation of Individual and Social Outcomes of Infertility on Couples in Masjed Soleyman
mahmoud yaghoubi doust

The main purpose of the present study was to investigate the social and individual consequences of infertile couples in Masjed Soleiman. The research method, the survey method and the statistical population of the present study included infertile couples referring to Ma More

The main purpose of the present study was to investigate the social and individual consequences of infertile couples in Masjed Soleiman. The research method, the survey method and the statistical population of the present study included infertile couples referring to Masjed-e Soleiman Medical Centers, which were selected using Cochran sampling of 109 couples. The researcher-made questionnaire and the standard questionnaire (BAK depression test) were used to measure the questionnaires. The data were analyzed by statistical, percentage, mean, standard deviation, Pearson correlation, Chi square, F, and variance analysis and SPSS software. The results of the hypothesis test showed that there is a meaningful relationship between couples' infertility and their willingness to divorce and job problems. But the results of the findings did not show the relationship between couples infertility with the variables of interactions and social relationships, depression, and duration of marital survival. The results of the hypothesis test showed that there is a meaningful relationship between couples' infertility and their willingness to divorce and job problems. But the results of the findings did not show the relationship between couples infertility with the variables of interactions and social relationships, depression, and duration of marital survival. Manuscript profile

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25 - Sociological explanation of the consequences and psychological problems of infertile women (Case study in Isfahan)
atefe kiani falavarjani sayed naser hejazi seyed ali hashemianfar

The issue of infertility and infertility and its consequences among families and human societies in general have such wide dimensions that in turn there is no room for any doubt. The study will look at the social consequences of infertility on the family and the extent More

The issue of infertility and infertility and its consequences among families and human societies in general have such wide dimensions that in turn there is no room for any doubt. The study will look at the social consequences of infertility on the family and the extent to which these effects will affect the families of infertile and childless families. This research is applied in terms of purpose and in terms of descriptive-survey nature. In this study, library studies were used and the main tool for collecting information was a researcher-made questionnaire. The statistical population of this study is all infertile women in Isfahan who have referred to the Infertility Treatment Center in Isfahan (located on Mushtaq II Street) in 2009. To obtain the reagent sample, the sampling method was used as available. The estimated sample size of Cochran's formula with unlimited population in this study is 384 people. The data required for this study were obtained through a researcher-made questionnaire. The end of this questionnaire was calculated through Cronbach's alpha coefficient and the result was a total of more than 0.70. Data analysis and analysis. SPSS software was done with version 24 and AMOS with version 24. Descriptive statistical methods (mean and standard deviation) were used for analysis and in the inferential statistical analysis, confirmatory factor analysis and structural equation modeling method (absolute fitness, adaptive, and fitness indicators) were used. There is a relationship between infertility problems and the components of psychological consequences (infertility stress, self-esteem and self-efficacy) in infertile women in Isfahan. Manuscript profile

Open Access Article

26 - Study of association between UBE2B variants with susceptibility to Idiopatic infertility in North Iranian male population
elham siasi Mohamad sadegh safai

 Infertility is a major clinical problem that involved about 10 to 15 percent of couples worldwide. Male infertility include 40 to 50 percent of all infertility cases and 37-58% of male infertility are unknown, as idiopathic male infertility. This disease is caused More

 Infertility is a major clinical problem that involved about 10 to 15 percent of couples worldwide. Male infertility include 40 to 50 percent of all infertility cases and 37-58% of male infertility are unknown, as idiopathic male infertility. This disease is caused by the interaction between genetic and environmental factors. UBE2B gene and its variations is one of the genetic factors in idiopathic male infertility. In this research was studied relation of T293G and A20016G polymorphism in UBE2B genes with the possibility of male infertility in Northern Iranian population. For this study, samples from 60 fertile men and 60 infertile men were selected. Then DNA was extracted from samples. Genotype and allele frequencies of the variants were determined by PCR- RFLP.  Statistical analysis in this study showed no significant association between patient and control groups for T293G (P = 0.66) and A20016G (P = 0.52) SNPs, in UBE2B gene. The results were indicated that two SNPs was not associated with idiopathic male infertility in Northern Iranian male population. Manuscript profile

Open Access Article

27 - The effect of Dacarbazine on the development of ovarian follicles and sex hormones and Estradiol in NMRI mice
nasim HAYATI simin mohamadi gorji kazem parivar zeinab ghaffari far

After cancer treatment occurs fertility problems and many birth defects, such as abortion, early delivery, low birth weight. Therefore, preserving fertility should be an integral part of improving the quality of life in survivors of cancer. Dacarbazine is an anti-cancer More

After cancer treatment occurs fertility problems and many birth defects, such as abortion, early delivery, low birth weight. Therefore, preserving fertility should be an integral part of improving the quality of life in survivors of cancer. Dacarbazine is an anti-cancer chemotherapy drug and this study focuses on the effects of dacarbazine on oogenesis and sex hormones and estradiol in NMRI mice. 30 adult female mice NMRI were divided into 5 groups: control, sham, 1, 2 and 3 experimental groups received 10-day solvent and doses of 20, 30 and 40 mg / kg by intraperitoneal injection dacarbazine. For analysis sex hormones and estradiol was drawn blood from heart and ovarian tissue was removed from the body to investigate Oogenesis. The results of this research work show that Dacarbazine reduces the number of Graafian follicle and blood vessel in comparison with the control group and the number of atretic follicle in the experimental groups 1, 2 and 3 has a significant increase compared to the control group. Also, the levels of FSH, LH and estradiol hormones show a significant decrease with dose increase. Manuscript profile

Open Access Article

28 - Association of single nucleotide polymorphisms T886C in TAS2R38 gene and C109869T in SLC6A14 gene with Idiopathic infertility in Iranian men
elham siasi ahmad aleyasin javad mowla

10.30495/jdb.2023.1963938.1321

Objective: Frequency of male infertility is 10-15% and there is not definite reason in 50% of infertility in men. This form of infertility is named idiopathic infertility and genetic factors are one of male infertility causes. Therefore, aim of this study was investigat More

Objective: Frequency of male infertility is 10-15% and there is not definite reason in 50% of infertility in men. This form of infertility is named idiopathic infertility and genetic factors are one of male infertility causes. Therefore, aim of this study was investigation on association between T886C polymorphism in TAS2R38 gene and C109869T polymorphism in SLC6A14 gene with Iranian idiopathic infertile male. Materials and Methods: For this study. DNA was extracted from 200 blood samples consist of 100 men with idiopathic infertility (oligospermic and azoospermia) and 100 fertile men as control groups. Genotyping of two studied polymorphisms were performed by using of molecular methods, HRM-PCR Corbett, PCR-RFLP and Sequencing, then results were statistical analyzed.Results: For T886C polymorphism in TAS2R38 gene statistical analysis showed no significant difference between patient and control groups (P=0.9) and results shown was not association between this polymorphism and idiopathic male infertility in Iranian population. Frequency of C109869T polymorphism in SLC6A14 gene was different in infertile patients and control groups (P=0.04) and is indicated significant relationship with idiopathic male infertility in studied Iranian men population.Conclusion: According to this research results, The C109869T polymorphism in SLC6A14 gene is actual in affected of idiopathic infertility in Iranian men population and could cause oligospermia and azoospermia and created infertility in Iranian male. For confirming these results is recommended study on more samples. Manuscript profile

Open Access Article

29 - A comparative study of the therapeutic effects of mesenchymal stem cells on polycystic ovary syndrome in various animal models
Umeh Leila Bakhshi Seyed Gholam Ali Jorsaraei Ramzan Khanbabaeia Maryam Gholamitabar tabari Seyedeh Zahra Babazadeh

10.30495/jdb.2023.1987322.1364

Infertility is a global health problem. One of the main causes of infertility in women is polycystic ovary syndrome (PCOS). Different methods are used to treat such people. Using stem cells and its products can be a good alternative for its treatment. There are differen More

Infertility is a global health problem. One of the main causes of infertility in women is polycystic ovary syndrome (PCOS). Different methods are used to treat such people. Using stem cells and its products can be a good alternative for its treatment. There are different models for inducing PCOS in animal models. Mesenchymal stem cells reduce ovarian dysfunction in PCOS mice. Tail injection of BM-MSC will improve the process of folliculogenesis. Intraovarian injection of BM-Hmsc and UC-MSC mesenchymal stem cells improves the process of folliculogenesis. AMSCs mesenchymal stem cell injection is associated with a positive result in fertility. MSC-EV stem cells improve fertility and increase folliculogenesis. One of the main causes of infertility in women is polycystic ovary syndrome (PCOS). The use of cell therapy for various diseases including PCOS is considered. The use of MSC in the treatment of infertility is in its preclinical research stages. The safety and efficacy of MSCs in the treatment of infertility needs further investigation. In this study, we have compared the therapeutic effects of mesenchymal stem cells on polycystic ovary syndrome in various animal models. Manuscript profile

Open Access Article

30 - Study on association of four polymorphisms in TNP2 gene with spermatogenesis and causes of male infertility
elham siasi Ahmad Aleyasin Javad Mowla

Protamines are DNA-binding proteins in the sperm nucleus, which cause differentiation of human spermatogenesis. Protamines required for packaging nucleus sperm by replacement of histones with protamines. Sperm protamine deficiency has been associated with spermatogenesi More

Protamines are DNA-binding proteins in the sperm nucleus, which cause differentiation of human spermatogenesis. Protamines required for packaging nucleus sperm by replacement of histones with protamines. Sperm protamine deficiency has been associated with spermatogenesis failed and caused male infertility.  In this study association of four SNPs in TNP2 gene were studied in Iranian idiopathic infertile men with azoospermia or oligospermia. Analysis of four SNPs include T1019G, G1272C،  G deletion at 1036 and 1046 in TNP2 gene  was performed by DNA extraction from blood samples of 96 idiopathic infertile men with azoospermia or oligospermia and 100 normal control men. Then using restriction fragment length polymorphism (PCR-RFLP) for detection of T1019G and G1272C, SNPs and for identification of G deletion at 1036 and 1046 used Single Strand Conformation Polymorphism (PCR- SSCP). Results were confirmed by DNA sequencing analysis. For (G1272C) in TNP2 gene, frequency of CC genotype was differented in fertile and infertile groups but statistical analysis showed no significant association related to this SNP in case and control groups. As also no polymorphisms were found for T1019G and G deletion at 1036 and 1046 nt. These results are consistent with previous studies and indicating that four tested SNPs was not associated with oligospermia and azospermia and idiopatic male infertility in Iranian population. Manuscript profile

Open Access Article

31 - The relationship between attachment styles and sexual problems among infertile couples
M. Ali Besharat S. Mahmoud Mirzamani

I nfertility, as a major source of crisis and loss, imposes many psychological and communication problems on couples. On the other hand, the quality and the dimensions of these problems are influenced by people’s attachment styles. In order to investigate the rela More

I nfertility, as a major source of crisis and loss, imposes many psychological and communication problems on couples. On the other hand, the quality and the dimensions of these problems are influenced by people’s attachment styles. In order to investigate the relationship between attachment styles and sexual dysfunctions among infertile couples, ninety and Shariati Hospitals were asked to completed the Adult Attachment Inventory (AAI) and the Golombok – Rust Inventory of Sexual State Questionnaire (GRISS-F, GRISSM). The results revealed that insecure infertile men and women had more sexual problems than secure infertile persons. Infertility was significantly related to the males’ but not to the females’ sexual problems; infertile men had more sexual problems than infertile women.     Manuscript profile

Open Access Article

32 - Isolation and molecular identification of Mycoplasma hominis from genital system of infertile men and women
Samaneh Jamalizadeh Bahaabadi Babak Kheirkhah Alireza Farsinezhad Victoria Habibzadeh

Background & Objectives: Mycoplasmas are one of the causative aetiologies of infertility in human beings. Genital Mycoplasmal infections can damage reproductive systems and lead to infertility infant mortalities. The aim of this study was molecular identification of More

Background & Objectives: Mycoplasmas are one of the causative aetiologies of infertility in human beings. Genital Mycoplasmal infections can damage reproductive systems and lead to infertility infant mortalities. The aim of this study was molecular identification of Mycoplasma hominis isolated from genital system of infertile men and women in Kerman. Materials & Methods: This descriptive study was performed on 100 infertile men and 100 infertile women with a six month purposive sampling from the patients who referred to Infertility Center of Kerman. Semen and vaginal swab were tested by PCR assay for the presence of M. hominis. PCR product of positive samples were selected for sequencing. Sequence alignment was performed using MEGA 5 software and Neighbor-joining method. Results: In this study 45% of the samples taken from men were infected to Mycoplasma. Among them, 33% of the isolates belonged to M. hominis. Furthermore, 43% samples taken from women were infected to Mycoplasma, among them 41.8% belonged to M. hominis. Based on sequencing analysis, these M. hominis isolated from the patients were categorized into 5 different strains. Conclusion: In this study, M. hominis was indicated as the main microbial reason of infertility in this group. Sequence analysis of different M. hominis showed significant variability among the isolates. Therefore, these isolates can be reported as the local strains of Iran. Manuscript profile

Open Access Article

33 - Comparison of the effectiveness of couple therapy based on acceptance and commitment of couple therapy based on compassion on marital conflicts and sexual intimacy of infertile couples in Kermanshah
elham hasani Shima Parandin

10.30495/hpsbjourna.2022.1956173.1077

Infertility and lack of reproduction of spouses is one of the important reasons for increasing marital conflicts and reducing sexual intimacy between couples. Among the third wave of psychology therapies is acceptance, commitment, and compassion therapy, which helps peo More

Infertility and lack of reproduction of spouses is one of the important reasons for increasing marital conflicts and reducing sexual intimacy between couples. Among the third wave of psychology therapies is acceptance, commitment, and compassion therapy, which helps people deal with the issues in their lives in a proper way. The aim of this study was to compare the effectiveness of acceptance and commitment based therapy and compassion based treatment on marital conflicts and sexual intimacy of infertile couples in Kermanshah. This research is a quasi-experimental type. The statistical population of the present study includes all infertile couples in Kermanshah who have referred to the infertility treatment clinics of Motazedi Hospital in Kermanshah annually and have shown the available type using pre-test, post-test design with control group and sampling method. It is found that couple therapy based on acceptance and commitment and couple therapy based on compassion at a significant level (p≤0.01) has been effective in increasing sexual intimacy. Also, at a significant level (p≤0.01), comparing the difference between the mean effectiveness of commitment therapy based on commitment and acceptance and couple therapy based on compassion, did not show a significant effect on marital conflicts. Manuscript profile

Open Access Article

34 - Effect of Red Clover Leaf Extract on Expression of Genes Involved in Follicogenesis and Proliferation of Ovarian Granulosa Cells of NMRI Mice
Farzaneh Rangamiz Javad Baharara Khadijeh Shahrokhabadi

Infertility is one of the major medical problems in today’s world. Today, some studies have addressed the effects of phytoestrogenic compounds in the treatment of infertility. Red clover is one of the herbs containing phytoestrogenic compounds. In the present stud More

Infertility is one of the major medical problems in today’s world. Today, some studies have addressed the effects of phytoestrogenic compounds in the treatment of infertility. Red clover is one of the herbs containing phytoestrogenic compounds. In the present study, the effect of red clover leaf extract on expression of genes involved in follicogenesis and proliferation of granulosa cells in NMRI mice was investigated. In this experimental in vitro study, 30 NMRI 18-20 immature female rats were used. For experiments, follicular granulosa cells were isolated, and in vitro cells were randomly divided into 6 groups.Control (untreated) and experimental groups with concentrations (10, 15, 20, 40, 80 μg/ml) of treated red clover leaf extract and cell viability were evaluated by trypan blue staining and MTT staining. Expression changes of BMP15 and FOXO1 genes were evaluated by Real Time PCR. The results of trypan blue staining and MTT assay showed that cell viability decreased with increasing concentration and time of treatment with clover leaf extract. Moreover, the expression level of BMP15 and FOXO1 genes was significantly increased in the 10 μg/ml red clover leaf extract compared to the control group (p < 0.05). Due to the effect of red clover leaf extract on granulosa cell proliferation and expression of genes involved in follicogenesis, this plant can be considered as a suitable candidate for clinical studies in infertility treatment.   Manuscript profile

Open Access Article

35 - The Comparison of Sperm Parameters and DNA Damage among Infertile Men with Varicocele and Obesity
Mahshid Elahi Vida Hojati Mahmoud Hashemitabar Mahsa Afrough Hossain Pourkargar

10.22034/ascij.2022.1954994.1375

Varicocele and obesity are common causes of male infertility that negatively influence spermatogenesis. This study aims at investigating sperm parameters and the correlation between the amount of DNA damage in obese patients and patients with varicocele compared with no More

Varicocele and obesity are common causes of male infertility that negatively influence spermatogenesis. This study aims at investigating sperm parameters and the correlation between the amount of DNA damage in obese patients and patients with varicocele compared with normal subjects. Generally, there were 210 samples, which respectively included 95 semen samples from obese infertile men, 50 semen samples from infertile men with varicocele, and 65 normal men with an age range from 27 to 50 years who met the conditions to be included in the study. It was separated from other samples and the semen was analyzed based on the parameters of the World Health Organization (WHO). The fragility of sperm DNA was evaluated for the mentioned samples. Compared with normal subjects, obese infertile men showed a significant decrease in sperm count, sperm motility, sperm morphology and a significant increase in DNA damage (p < 0.001). Also, a significant negative correlation was observed between DNA Fragmentation Index (DFI) and sperm parameters in obese infertile men, so that with the increase in DFI, other parameters showed a decrease. In obese infertile subjects, DFI had a negative correlation with sperm parameters including number (r = -0.171), movement (r = -0.467) and sperm morphology (r = -0.314). Infertile people with varicocele compared with normal people, a significant decrease in sperm count, sperm motility, sperm morphology and a significant increase in DNA damage were observed. Also, a significant negative correlation was observed between parameters and DFI. In this way, with the increase in DFI, other parameters decreased. In varicocele patients, DFI had a negative correlation with sperm parameters including number (r = -0.466), movement (r = -0.413) and morphology (r = -0.484). The results showed that varicocele and obesity have a negative effect on the health of sperm DNA in addition to reducing the quality of sperm parameters. Also, a significant negative correlation was observed between the amount of DFI and sperm parameters, which shows that these items may adversely influence the process of spermatogenesis.   Manuscript profile

Open Access Article

36 - Protective Effect of Coenzyme Q10 on Rat Sperm and Testicular Tissue after Exposure to Diazinon
Sima Ebadi Naftchali Ramezan Khanbabaei Abasali Dehpour Jouybari Roya Bishekolaei Esmaeil Fattahi

10.22034/ascij.2023.1991460.1512

Diazinon (DZN) is an organophosphate insecticide that causes a wide range of pathological effects on the male reproductive system, disturbances in sperm production and quality, and fertility problems. This study investigated the protective effect of coenzyme Q10 treatme More

Diazinon (DZN) is an organophosphate insecticide that causes a wide range of pathological effects on the male reproductive system, disturbances in sperm production and quality, and fertility problems. This study investigated the protective effect of coenzyme Q10 treatment on sperm quality, oxidant/antioxidant system, and histopathology of testicular tissue in male rats after exposure to diazinon. This experimental study was carried out on 16 adult male Wistar albino rats with an approximate weight of 150 to 230 gr, which were obtained from the animal care center.The animals were randomly divided into four groups (n=4) and were tested by intraperitoneal injection for 30 days which including the diazinon exposure group (50 mg/kg of diazinon dissolved in sesame oil intraperitoneally injected), the coenzyme Q10 and diazinon exposure group (50 mg/kg of diazinon and 10 mg/kg of coenzyme Q10 dissolved in sesame oil intraperitoneally injected), group of coenzyme Q10 (10 mg/kg of coenzyme Q10 dissolved in sesame oil intraperitoneally injected), and the control group (1.5 mg/kg of sesame oil intraperitoneally injected). After treating coenzyme Q10 with diazinon, a significant increase in the number and motility of sperm and a decrease in sperm mortality were observed (P<0/05). Exposure to diazinon with coenzyme Q10 treatment was able to decrease the level of malondialdehyde (MDA) and increase the activity of superoxide dismutase (SOD) compared to the diazinon group (P<0/05). Simultaneous exposure to diazinon and coenzyme Q10 treatment led to a decrease in testicular histopathological damage after exposure to diazinon. It seems that coenzyme Q10 can have a good protective effect against oxidative damage in the male reproductive system caused by exposure to diazinon. Manuscript profile

Open Access Article

37 - The Effect of Season and Age on Sperm Parameters in Infertile Men
Sh. Bakhshesh M. Tavalaee M.H. Nasr-Esfahani

Approximately 15% of couples are infertile. Male factor infertility is reported in half of infertile couples. Several factors including age, and season are effective on the quality of sperm parameters, which can have different results in different geographic locati More

Approximately 15% of couples are infertile. Male factor infertility is reported in half of infertile couples. Several factors including age, and season are effective on the quality of sperm parameters, which can have different results in different geographic locations. In this study, the effect of these two factors on sperm parameters in infertile men was investigated. Overall, 659 semen samples from infertile men referred to the Isfahan Fertility and Infertility Center, Isfahan, central Iran were collected. Semen analysis included assessment of volume, concentration, motility and morphology carried out according to WHO (2010). Statistical analyses were performed using SPSS software. Quality of sperm parameters, especially sperm motility and count were affected by the age and seasonal changes. Negative significant correlations between male age with sperm count and motility were observed (P<0.05). As the age increases, the mean of sperm count and motility in infertile men are reduced, and the reduction in these two parameters are more pronounced in the first half of the year than in the second half of the year. However, age and seasonal variations do not affect sperm morphology.   Manuscript profile

Open Access Article

38 - Effects of Lavandula officinalis Aqueous Extract on Ovaries Balb/c Adult Female Mouse
F. Soheili P. Torabzadeh M. Ramezani

Lavendula officinalis has sedative properties of aqueous extract. It is effective on diabetes and depression and has antimicrobial properties and manage. However, its effect on reproductive system has not been reviewed yet. Therefore, in this study, the effect of L. off More

Lavendula officinalis has sedative properties of aqueous extract. It is effective on diabetes and depression and has antimicrobial properties and manage. However, its effect on reproductive system has not been reviewed yet. Therefore, in this study, the effect of L. officinalis aqueous extract on ovaries BALB/c adult female mouse was stdied. After preparation of aqueous extract and when we observed lack of lethal symptoms, experiments were continued with selected doses as follows: 6 (group1: 15 mice), 12 (group2: 15 mice), 18 (group3:15mice) g/kg.bw. Intraperitoneally injections were done for 12 d on 65 mice. Results were compared with the control group (non-injection: 10 mice) and sham (injection of normal saline: 10 mice). For reliability, experiences were repeated 2 times. Data was checked with SPSS 20 and Duncan test and ANOVA with condition (P<0.05) and (P<0.001). The experimental groups1 and 2, showed a significant decrease in large and small diameters of ovaries (P<0.05). In experimental group3 showed a significant increase in numbers of primary follicles (P<0.05). All experimental groups showed a significant decrease of growing, Graafian follicle and corpus luteum.L. officinalis aqueous extract has detrimental effect on female ovaries and may be use as a contraceptive pill in the future. Manuscript profile

Open Access Article

39 - Investigate the relationship between serum hormone anti-mullerian and results of assisted reproductive technology cycles in infertile patients referred to an Infertility center in 2012 to 2013
Mahmud Erfanian Ahmad pour Mahbub Keramati Jamal Hekmat Khalili Far

Background: IVF is one of the most important means of assisted reproductive technology treatment of infertility. There is Known association serum hormone anti-mullerian between and fertility rates. Methods: A cross-sectional study of 71 case patients 2011 to 2012 years More

Background: IVF is one of the most important means of assisted reproductive technology treatment of infertility. There is Known association serum hormone anti-mullerian between and fertility rates. Methods: A cross-sectional study of 71 case patients 2011 to 2012 years in Novin center of  infertility undergoing IVF were investigated. Patient information including age, number and quality of oocytes and embryos, AMH levels And thus the cycle ultrasound then confirmed as positive HCG was extracted., then the data was analyzed.  Finding: In our study, patients were given the hormone AMH four groups were classified (less than 0/3 or the first group، 0/3 to 0/7 or The second group, 0/7 to 3 or the third  group، more three or the fourth group) of the 14 women in group three had positive results in 46.7% of cycles result in pregnancy.,there is  a statistically difference between the mean number and quality of oocytes and pregnancy and the average number of the embryos with Different levels of AMH were observed. Conclusion: IVF results، there is  a statistically difference between the mean number and quality of oocytes and pregnancy and the average number of the embryos with Different levels of AMH were observed. But there is not a statistically difference between the mean frequency of embryo quality and mean age at different in the levels of AMH.    Manuscript profile

Open Access Article

40 - Prevalence of BVD in bovine aborted fetuses of dairy cattle herds by RT� PCR in Tehran province
آریا Badii, فرهاد Mousakhani, علی Zolfaghari, محسن Zafari, , M Malekan

Bovine viral diarrhea disease virus (BVDV) from ﬂaviviridae family and pestiviruses can cause reproductive complications including abortion, stillbirth, infertility, congenital defects and many other economic losses. Becauseof diffcult clinical diagnosis, many laborator More

Bovine viral diarrhea disease virus (BVDV) from ﬂaviviridae family and pestiviruses can cause reproductive complications including abortion, stillbirth, infertility, congenital defects and many other economic losses. Becauseof diffcult clinical diagnosis, many laboratory methods including reverse transcriptase polymerase chain reaction(RT-PCR) can be used to exact diagnosis.In this study, 251 samples of aborted fetuses were referred from industrial dairy farms of Tehran province andevaluated in a reference laboratory during one year. samples tested were tissues, including liver, kidney, spleenand heart were the fetus.Based on the results, the estimated prevalence of abortion due to BVD in Tehran province was 25.2% and basedon the season, respectively, spring 33.3%, summer 18%, atom 34.2%, winter 23.7%.In order to reduce the prevalence of BVD abortions the following points should be noted: identifcation and elimination PIs, vaccination, application of bio-security principles and etc Manuscript profile

Open Access Article

41 - Prevalence of Leptospira spp. In bovine aborted fetuses of dairy cattle herds by PCR in Tehran province
آریا Badii فرهاد Mousakhani محمد Malekan محسن Zafari

Leptospirosis is a zoonotic disease that can cause heavy economic losses through complications including abortion, stillbirth, infertility, reduced milk production, etc. In this study, 251 referred samples of aborted fetuses inindustrial dairy herds of Tehran province e More

Leptospirosis is a zoonotic disease that can cause heavy economic losses through complications including abortion, stillbirth, infertility, reduced milk production, etc. In this study, 251 referred samples of aborted fetuses inindustrial dairy herds of Tehran province evaluated in MABNA laboratory during one year. Tested samples included a homogenous tissue mixture of fatal heart, kidney, liver and spleen. For DNA extraction, the ProteinaseK Method was used. Then polymerase chain reaction (PCR) was performed to recognize Leptospira Spp. by using specifc 16s rRNA gene primers. Samples with 331bp band in electrophoresis gel were considered positive.Prevalence of leptospiral abortion in average was 12.8 % in Tehran province during a year and based on season,respectively, the amount in spring was 15%, summer 9.08 %, autumn 10 % and winter 19.2 %. Based on theseresults, it was most prevalent in spring and winter that is probably due to higher environmental humidity, hydrophilic nature of leptospira and more bacterial activities. Generally according to the prevalence of 12.8 %, the majorcause of abortion in Tehran province in industrial dairy herds is leptospiral infection so that any activities in orderto eradicate and control the disease is essential. Manuscript profile

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