Effect of sodium molybdate on Cadmium Chloride-induced Infertility in adult male Wistar rats

Subject Areas :

Hormat Khorami ¹ , Akram Eidi ² , Pejman Mortazavi ³ , Mehrdad Modaresi ⁴

1 - Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
2 - , Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
3 - Department of Pathology, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
4 - , Department of Physiology, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.

Received: 2020-12-25 Accepted : 2021-05-12 Published : 2022-09-18

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Abstract :

Introduction & Objective: Molybdenum, as a trace and essential element has cofactor role in the structure of antioxidant enzymes. This study aimed at investigating the antioxidant role of sodium molybdate on cadmium chloride (CdCl2)-induced testicular toxicity in adult Wistar rats.Materials and Methods: Eighty adult male rats were divided into ten groups, including healthy control, sodium molybdate alone, infertile control (3 mg/kg of CdCl2), and sodium molybdate plus CdCl2. The impacts of oral administration of sodium molybdate (0.05, 0.1, 0.2, and 0.4mg/kg) was evaluated in healthy and infertile animals. After the end of the period, serum levels of testosterone, FSH and LH and changes in body weight and testicular,the number of embryos obtained from fertility evaluation.Data were analyzed by analysis of variance (ANOVA) and Tukey test.Results: Final body weight, weight gained, testicular weight and ratio of testicular weight to body weight, serum level of male sex hormones and number of fertility fetuses in infertile experimental groups treated with sodium molybdate were significantly different from the infertile control group (P< 0.05).Conclusion: The current findings suggested that sodium molybdate performs as a strong protective agent from CdCl2-related testicular toxicity in rats.