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Open Access Article
1 - Evaluation of two different extraction techniques on determination of 〖Pb〗^(+2) contents of wastes of dye manufacturing industries
Maiid Mohammadhosseini Karim Zare Mohammad Saber Tehrani -
Open Access Article
2 - Flame atomic absorption spectrometric determination of Cd(II), Zn(II) and Ag(I) in different matrixes after solid phase extraction on sodium dodecyl sulfate (SDS)-coated alumina as their 2,3 Di Hydro 2,3 para tolyl Qinazoline (1 H)- 4 one (DPTQO)
Farveh Raoufi Saidah Bagheri Ebrahim Niknam Khodabakhsh Niknam Hamid Reza Farmani -
Open Access Article
3 - Sample preparation by Matrix Solid Phase Dispersion (MSPD)
زهرا آقاجانی راضیه بخشعلی دهکردیMatrix solid-phase dispersion (MSPD) is a sample-preparation process was first introduced in 1989 for the extraction of drug residues from animal tissue. By blending tissues with a polymeric phase bound to a solid support one obtains a semi-dry material which can be use MoreMatrix solid-phase dispersion (MSPD) is a sample-preparation process was first introduced in 1989 for the extraction of drug residues from animal tissue. By blending tissues with a polymeric phase bound to a solid support one obtains a semi-dry material which can be used as a column packing material from which one can isolate drugs in a stepwise manner based on the solubility characteristics of the drugs in this matrix.Matrix solid phase dispersion (MSPD) has found particular application as an analytical process for the preparation, extraction and fractionation of solid, semi-solid and/or highly viscous biological samples.MSPD is based on several simple principles of chemistry and physics, involving forces applied to the sample by mechanical blending to produce complete sample disruption and the interactions of the sample matrix with a solid support bonded-phase (SPE) or the surface chemistry of other solid support materials. These rules are discussed as important factors in the MSPD extraction. Manuscript profile -
Open Access Article
4 - Using Ghezeljeh Nanoclay for Measuring of Copper Ions Released from the Cooking Pot into Food Samples by FAAS and ICP-AES
Majid Soleimani Zahra Hassanzadeh Siahpoosh -
Open Access Article
5 - Solid-phase Extraction Using Modified Carbon Nanotube and Cupferron Ligand for Preconcentration and Determination of Trace Amounts of Copper in Real Samples
Maasoomeh Ghasemi Ali Moghimi Mohammad-Ali Karimi Shahla Mozaffari -
Open Access Article
6 - Magnetic Solid Phase Extraction of Triazine Herbicides from Environmental Aquatic Media using Polyaniline/ Fe3O4 Nanocomposite
Faezeh Khalilian Amir Adl Yekta -
Open Access Article
7 - Chemical Modification of Nanosilica Toward Dispersive Solid Phase Extraction of Trace Triazine Herbicides from Environmental Water Samples
Faezeh Khalilian Hadi Soori -
Open Access Article
8 - Application Molecularly Imprinted Solid Phase Extraction Method for Analysis and Determination of Bentazon as a Toxic Herbicide in Water
Alireza Geramizadegan Dadkhoda Ghazanfari Aliasghar Amiri -
Open Access Article
9 - Extraction of drugs in water Samples by Carbon Nanotubes modified and Measurement with Ultraviolet-Visible Spectrometry
ali moghimi Shaghayegh Donyagard Vajed Fariborz AziznejadIn this method, the use of drugs continues to increase which leads to an increase in environmental pollution; as a result, drug control is a common practice in many laboratories. This method is dedicated to improving a method to determine small amounts of Ciprofloxacin MoreIn this method, the use of drugs continues to increase which leads to an increase in environmental pollution; as a result, drug control is a common practice in many laboratories. This method is dedicated to improving a method to determine small amounts of Ciprofloxacin in a water and biological sample. In this study, new techniques were applied for solid phase extraction of insignificant amounts of Ciprofloxacin in water samples by carbon nanotubes and its measurement with ultraviolet-visible spectroscopy in biological samples. These techniques are two-phase systems in which donor phases are Ciprofloxacin-containing aqueous samples and acceptor phases are amino-functionalized carbon nanotubes. The experiments were carried out in two stages of extraction from desolate water samples of Ciprofloxacin using methanol as solvent and the desolate samples were taken to UV-Vis spectrophotometer for further analysis. This method is inexpensive, simple and fast, and is consistent with many of the existing machine methods. Extraction parameters such as the effect of desolating organic solvents, pH of donor and acceptor phases, extraction time, desolation time, mixing speed, volume of donor phase and surfactant effect were optimized and quantitative investigations and measurements were done under optimum conditions. The techniques mentioned enjoy many advantages including short extraction time, low consumption of organic solvents, deleting the effect of previous experiments, low detection limit, and high concentration factor. Concentration factor and detection limit for Ciprofloxacin were 10 and 9.51 μg, respectively. the relative standard deviation was 1.12% for Ciprofloxacin and R2=0.9958. Manuscript profile -
Open Access Article
10 - Solid Phase Extraction of Fluoxetine in water Samples by Carbon Nanotubes modified and its determination with Ultraviolet-Visible Spectrometry in Biological Samples
ali moghimi Leila Daemi Kabiri Nazanin FarhadyarIn this method, the use of drugs continues to increase which leads to an increase in environmental pollution; as a result, drug control is a common practice in many laboratories. This method is dedicated to improving a method to determine small amounts of fluoxetine in MoreIn this method, the use of drugs continues to increase which leads to an increase in environmental pollution; as a result, drug control is a common practice in many laboratories. This method is dedicated to improving a method to determine small amounts of fluoxetine in a water and biological sample. In this study, new techniques were applied for solid phase extraction of insignificant amounts of fluoxetine in water samples by carbon nanotubes and its measurement with ultraviolet-visible spectroscopy in biological samples. These techniques are two-phase systems in which donor phases are fluoxetine-containing aqueous samples and acceptor phases are amino-functionalized carbon nanotubes. The experiments were carried out in two stages of extraction from desolate water samples of fluoxetine using methanol as solvent and the desolate samples were taken to UV-Vis spectrophotometer for further analysis. This method is inexpensive, simple and fast, and is consistent with many of the existing machine methods. Extraction parameters such as the effect of desolating organic solvents, pH of donor and acceptor phases, extraction time, desolation time, mixing speed, volume of donor phase and surfactant effect were optimized and quantitative investigations and measurements were done under optimum conditions. The techniques mentioned enjoy many advantages including short extraction time, low consumption of organic solvents, deleting the effect of previous experiments, low detection limit, and high concentration factor. Concentration factor and detection limit for fluoxetine were 14.3 and 13.6 μg, respectively. The linear amplitude was between 1-10 mg.L-1 and the relative standard deviation was 3.33 for fluoxetine and R2=0.9958. Manuscript profile -
Open Access Article
11 - Preconcentration of Amlodipine using Fe3O4@MWCNT- chitosan compositeand determinated by UV-Visb in biologycal samples
ali moghimi Niloufar Tajodini Mohammad YariDrug consuming is increasing these days, which will lead to more environmental pollution. In this reesearch, technique is drug supervising which is used by many laboratories. This technique is about finding a way to determine small amount of Amlodipine in water and bilo MoreDrug consuming is increasing these days, which will lead to more environmental pollution. In this reesearch, technique is drug supervising which is used by many laboratories. This technique is about finding a way to determine small amount of Amlodipine in water and bilogical sample. In this study, innovative techniques to exploit small amount of Amlodipine in solid phase in water sample through Multi Wall Nanotube- NH2 its measurements by visible spectrophotometry and ultra violet in biological samples has been used. These techniques are di phasic system, which donor phases are watery samples and recipient phase is Fe3O4@MWCNT- chitosan. The experiments have been performed in two extraction stages of Amlodipine watery samples desorption by using Ammonia solvent and desorption samples were put to spectrophotometry device UV-Vis for analysis. This is quick and easy method and is consistent with many of available instrumental techniques. Exploitation parameters such as, desorption organic solvent, donor and recipient pH, extraction time, desorption time, stirring time, donor phase volume and surfactant effect were optimized and quantitative evaluation and measurements were performed in optimal conditions. The mentioned techniques have many advantages such as: short extraction time, consumption of organic solvent, deleting previous experiments effect, low diagnosis level and high-condensed factors and diagnosis level for Amlodipine are 12.5 - (LOD) 3.5 µgL-1 respectively. Linear range.0.01-7 mgL-1 and rational standard deviation for Amlodipine were % 1.5 and R2=0.9981. Manuscript profile -
Open Access Article
12 - Dispersive solid-phase extraction for preconcentration of Amlodipine in aqueous samples using Fe3O4@MWCNT- β cyclodextrin composite
ali moghimi Mostafa Shojai Milad AbnikiIn this reasearch, innovative techniques to exploit small amount of Amlodipine in solid phase in water sample through Multi Wall Nanotube- NH2 its measurements by visible spectrophotometry and ultra violet in biological samples has been used. These techniques are di pha MoreIn this reasearch, innovative techniques to exploit small amount of Amlodipine in solid phase in water sample through Multi Wall Nanotube- NH2 its measurements by visible spectrophotometry and ultra violet in biological samples has been used. These techniques are di phasic system, which donor phases are watery samples and recipient phase is Fe3O4@MWCNT- β cyclodextrin. The experiments have been performed in two extraction stages of Amlodipine watery samples desorption by using Ammonia solvent and desorption samples were put to spectrophotometry device UV-Vis for analysis. This is quick and easy method and is consistent with many of available instrumental techniques. Exploitation parameters such as, desorption organic solvent, donor and recipient pH, extraction time, desorption time, stirring time, donor phase volume and surfactant effect were optimized and quantitative evaluation and measurements were performed in optimal conditions. The mentioned techniques have many advantages such as: short extraction time, consumption of organic solvent, deleting previous experiments effect, low diagnosis level and high-condensed factors and diagnosis level for Amlodipine are 14.5 - (LOD) 7.5 µgL-1 respectively. Linear range.0.02-7.9 mgL-1 and rational standard deviation for Amlodipine were % 1.9 and R2=0.9989. Manuscript profile -
Open Access Article
13 - Deltamethrin and Chloropyrifosresidue determination on greenhouse tomato in Karaj by Solid Phase Extraction
Shahrzad Mohammadi Sohrab ImaniConsidering the abundant application of pesticides, the subject of pesticides and their exceeded residues on harvested crops is important issue in agriculture. For this purpose, comprehensive and several studies on agricultural products should be done to prevent of ente MoreConsidering the abundant application of pesticides, the subject of pesticides and their exceeded residues on harvested crops is important issue in agriculture. For this purpose, comprehensive and several studies on agricultural products should be done to prevent of entering of contaminated samples in using cycle. In this study, among 29 fruits and vegetable markets in Karaj, 10 of them in different parts of the city were considered, and 25 samples were randomly prepared for each specimen, weighing 2 kg. Samples in laboratory were extracted by using Solid Phase Extraction (SPE) and with the help of N method were concentrated and extracts were injected into High Performance Liquid Chromatograph (HPLC), Gas Chromatograph (GC/NPD), GC/Mass Spectrometer (GC/MS) devices for measuring the residue. Obtained data were compared with WHO/FAO and national Maximum Residue Limit (MRL) codex by T-test.The results showed that for chlorpyrifor 6 and 20 numbers (24 and 80%) of samples based on WHO/FAO and MRL codex respective, and for deltamethrin 14 numbers (56%) of samples based on WHO/FAO codex have had exceeded contamination of insectides. Manuscript profile -
Open Access Article
14 - Extraction of trigonelline from plasma using a new magnetic composite through the application of experimental design
mahdieh Abbasi meymand maryam kazemipour mehdi ansari dogahe Mehdi shahidizandiBentonite-β-cyclodextrin-iron nanoparticles (Ben-βCD-INP) composite was synthesized,characterized, and utilized like an innovative magnetic solid-phase extraction ( MSPE) adsorbent to separate and preconcentrate trigonelline . Experiment conditions to find imp MoreBentonite-β-cyclodextrin-iron nanoparticles (Ben-βCD-INP) composite was synthesized,characterized, and utilized like an innovative magnetic solid-phase extraction ( MSPE) adsorbent to separate and preconcentrate trigonelline . Experiment conditions to find important variables of trigonelline adsorption on the Ben-βCD-INP were A: time, B: Adsorbent amount, C: pH and for desorption were A: temperature, B: concentration, C: time, and D: Volume .. The adsorbent contributes significantly in the extraction process. The INP in the nano composite makes it easy to remove the adsorbent with the help of a magnet. Scanning electron microscopy( SEM ), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), vibrating sample magnetometry (VSM), and X-ray diffraction (XRD) were used to characterize the synthesized adsorbent. Experimental design was used to optimize the factors affecting extraction. trigonelline in plasma samples was extracted and evaluated by a reversed-phase HPLC–UV method. The findings have shown that MSPE was able to extract trigonelline efficiently. The developed HPLC–UV procedure for the determination of trigonelline in human plasma, showed linear relation shipin the concentration interval of 0.05-10 mg/L (r = 0. 9998) with the limit of detection (LOD), the limit of quantitation (LOQ) and recovery (%) of 0.005, 0.018 mg/L, and 114%, respectively. The procedure was successfully used to determine the concentration of trigonelline in human plasma. This study offers a promising hybrid nano bio material adsorbent in biomedical nanotechnology to selective measurement of the drug or supplements such as trigonelline from plasma. Manuscript profile -
Open Access Article
15 - Survey of Diazinon and Chlorpyrifos Pesticide Residues in the Corp of Apple (Red Delicious Variety) of Miyandoab’s Springhouses by Using HPLC-PDA
H. Shahyan H. SheikhloieIn this research to investigate the probable contamination of the apple tree to pesticides that is used by farmers in Miandoab, the residues of Diazinon and Chlorpirifos were investigated in this crop. First, the sampling is carried out by using the simple random sampli MoreIn this research to investigate the probable contamination of the apple tree to pesticides that is used by farmers in Miandoab, the residues of Diazinon and Chlorpirifos were investigated in this crop. First, the sampling is carried out by using the simple random sampling method and then, after Solid Phase Extraction (SPE) through High-Performance Liquid Chromatography (HPLC), the residues of Diazinon and chlorpirifos were measured. So that, the pesticides residues in apples that were washed with skin, without skin and, in peeled apples were measured 0.08, 0.31, 0.68 ppm for Diazinon and 0.24, 0.54, 0.98 ppm for Chlorpirifos, respectively. Comparison of the statistical results with global standards reveals that the residues of Diazinon in Apples with the skin, and the residues of Chlorpirifos in three modes: Unwashed with the skin, washed with the skin and peeled is more than global standards (Diazinon 0.5 ppm and Chlorpirifos 0.01 ppm) Therefore, it is required that the authorities and farmers of this region pay special attention to residues and the time of applying pesticides; thereby, they can prevent endangering health society. Manuscript profile -
Open Access Article
16 - Nano Analysis in Biochemistry: In Vitro Separation and Determination of Aluminium in Blood of Dialysis Patients Based on Graphene Oxide Nanoparticles Dispersed to Ionic Liquid
Farnaz Hosseini Hamid Shirkhanloo Negar Motakef Kazemi -
Open Access Article
17 - Spectrophotometric Determination of Mefenamic Acid in Biological Samples Using Magnetic Iron Oxide Nanoparticles as a Sorbent for Solid Phase Extraction
Ali Niazi Mahtab D. Torkman Neda Khorshidi -
Open Access Article
18 - Magnetic solid-phase extraction and Uv/vis Spectrophotometric determination of trace amount of Copper in vegetable and fruit samples after preconcentration of its Pentetate complex
Hojjat Veisi Fatemeh Parvizi Mohammad Reza Abdi -
Open Access Article
19 - Application of Nanoanalysis: Amine-Functionalized Mesoporous Silica nanoparticles for Mercury Speciation in Human Samples
Sara Davari Hamid Shirkhanloo Negar Motakef Kazemi -
Open Access Article
20 - Preparation of Magnetite Nanocomposites based on Azolla Filiculoides fern with Environmental Applications for Organic Pollutants
Reyhaneh Kouchakinejad Shahab Shariati Jafar Abolhasani Ebrahim Ghorbani-Kalhor Mohammad Taghi VardiniAzolla Filiculoides fern was utilized as a natural adsorbent to develop a magnetic solid phase extraction method for the preconcentration and determination of trace amounts of chlorpyrifos pesticide, which is a primary environmental concern. In this study, the magnetic MoreAzolla Filiculoides fern was utilized as a natural adsorbent to develop a magnetic solid phase extraction method for the preconcentration and determination of trace amounts of chlorpyrifos pesticide, which is a primary environmental concern. In this study, the magnetic solid phase extraction (MSPE) method using magnetite-modified azolla nanocomposites (azolla@Fe3O4 NCs) was developed to preconcentrate trace amounts of chlorpyrifos pesticide prior to UV-Vis spectroscopy. The structural characteristics of the synthesized nanocomposites (NCs) were investigated by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy (FT-IR), and vibrating sample magnetometry (VSM) methods. In the proposed MSPE method, after optimizing the adsorption/desorption variables in MSPE and obtaining the optimum level of each variable (adsorption step: Vsample = 50 mL, contact time = 15 min, solution pH = 3, adsorbent mass = 0.05 g, ionic strength = 0.01 mol L-1; desorption step: eluent type and volume = ethanol (2 mL) for 10 min), the desorbed ethanolic solution was spectrophotometrically investigated in the UV-Vis region. The results confirm the developed MSPE method can be used for the preconcentration and determination of trace amounts of chlorpyrifos in the aqueous samples. Manuscript profile -
Open Access Article
21 - Evaluation of adsorption potential of Buprenorphine drug from blood plasma by its molecular imprinted polymer; a joint experimental and theoretical study
Maryam Khanlari Bahram Daraei Leila Torkian Maryam Shekarchi Mohammad Reza Manafi -
Open Access Article
22 - The possibility of adsorption of Duloxetine antipsychotic drug from blood plasma by using its molecular imprinted polymer
Naghmeh Ali Kahi Bahram Daraei Leila Torkian Maryam Shekarchi AmirHossein Monzavi -
Open Access Article
23 - Microextraction and preconcentration of nickel in chocolate samples by SrFe12O19@CTAB magnetic nanoparticles and determination by electrothermal atomic absorption spectroscopy
vahid mortazavi nik elahe kanoz Alireza Feizbakhsh Amir Abdullah Mehrdad SharifCocoa beans contain unsaturated fats and a nickel catalyst is used to hydrate the unsaturated fats. Nickel can be present in high concentrations in chocolate. In this research, dispersion solid phase extraction combined with electrothermal atomic absorption method as a MoreCocoa beans contain unsaturated fats and a nickel catalyst is used to hydrate the unsaturated fats. Nickel can be present in high concentrations in chocolate. In this research, dispersion solid phase extraction combined with electrothermal atomic absorption method as a new method for measuring nickel in chocolate samples. First, strontium hexaferrite magnetic nanosorbents were synthesized. Then its surface was modified with acetyl trimethylammonium bromide (CTAB) surfactant and magnetic nanosorbent SrFe12O19@CTAB was prepared. The characteristics of the synthesized adsorbent were studied by thermogravimetric analysis-differential scanning calorimetric (TGA-DSC), X-ray diffraction spectroscopy (XRD), Fourier-transform infrared spectroscopy (FTIR), vibrating sample magnetometer (VSM), and field emission scanning electron microscopy (FESEM). The optimum amount of effective parameters of extraction (pH=8, adsorbent amount of 50 mg, and type of eluent solvent of 2% (v/v) methanol in nitric acid with a volume of 2 ml) were obtained. Finally, nickel was preconcentrated in real chocolate samples under optimal conditions. It was measured by electrothermal atomic absorption spectrometer. Analytical parameters such as linear working range of the calibration curve 1-100 µg l-1, the detection limit (LOD) 0.45 µg kg-1, the recovery values ranged from 97.8 to 100.2%, relative standard deviation of 0.22-0.68% for all samples and preconcentration factor of 50 were found. This method is a simple, fast, low-cost, effective, high sensitivity, and environmentally friendly method for measuring nickel in chocolate samples. Manuscript profile -
Open Access Article
24 - Determination of nitrite in various aqueous samples using magnetic solid phase extraction and image analysis via a mobile phone
leila khoshmaram ali karimi fatemeh sadeghiIn this study, an image analysis method using a homemade colorimeter for determination of trace amount of nitrite in various water samples is provided. The proposed method is based on using a smartphone to obtain RGB values of digital images. 4-nitroaniline and α- MoreIn this study, an image analysis method using a homemade colorimeter for determination of trace amount of nitrite in various water samples is provided. The proposed method is based on using a smartphone to obtain RGB values of digital images. 4-nitroaniline and α-naphthol were used to convert nitrite to a colored product. Magnetic solid phase extraction was then used to extract azo dye. In magnetic solid phase extraction, magnetic graphene was used as adsorbent and acetone as a desorption solvent. After taking the extraction phase digital images using a cell phone and their analyzing using Color Grab software, R values were used to obtain analysis signal related to nitrite concentration. The experimental parameters affecting the reaction and extraction efficiency were investigated. Under optimum conditions, the detection limit and the quantitative limit of the method were obtained 1.2 and 4 μg l-1, respectively. The calibration graph was linear in the range of 10-300 μg l-1 with a correlation coefficient of 0.993. The relative standard deviations for 100 and 30 μg l-1 were 2.2 and 3.9, respectively. The proposed method was successfully applied for the determination of nitrite in various water samples. Manuscript profile -
Open Access Article
25 - Application of calibration transfer method exploiting multivariate standardization for detection and quantification of parabens in aquatic environments using gas-mass spectrometry chromatography
Maryam Vosough Maryam Torbati Kourosh Tabar HeydarParabens are widely used as preservatives in pharmaceuticals, food, and personal care products. Solid phase extraction (SPE) is one of the most frequently used methods for monitoring parabens in aqueous samples. However, SPE is a costly and time consuming method. In thi MoreParabens are widely used as preservatives in pharmaceuticals, food, and personal care products. Solid phase extraction (SPE) is one of the most frequently used methods for monitoring parabens in aqueous samples. However, SPE is a costly and time consuming method. In this study, the application of piecewise direct standardization (PDS) method for transfer of direct calibration of gas chromatography -mass spectrometry (GC-MS) data to SPE-based calibration and quantification of methyl, ethyl, propyl, and butyl parben derivatives in aqueous environmental samples has been evaluated. In this method, at first, a multivariate model is constructed using different chromatographic regions based on only two subsets of direct and extracted calibration data, and then a transformation matrix is obtained, which in the next step it can correct all direct calibration samples to be matched with SPE-based data. Modeling validation was confirmed using altrernating trilinear decomposition (ATLD) method, and the recovery values were 81-106% and the mean relative prediction error was 2.1-6.4% for validation samples. Finally, modified direct calibration samples were used to detect and predict pollutants (at low µg/l values) in several real water samples. Manuscript profile -
Open Access Article
26 - Trace Analysis of Pharmaceutical Residues in Wastewater Treatment Plants in Rio de Janeiro, Brazil
Aldo Pacheco Ferreira -
Open Access Article
27 - Selective Dispersive Solid Phase Extraction of Ser-traline Using Surface Molecularly Imprinted Polymer Grafted on SiO2/Graphene Oxide
Faezeh Khalilian Feloria Khajoie Kermani -
Open Access Article
28 - Preparation of Modified Magnetic Nanocomposites Dithiooxamide/Fe3O4 for Preconcentration and Determination of Trace Amounts of Cobalt Ions in Food and Natural Water Samples
Ali Mirabi Nafiseh Aliakbari -
Open Access Article
29 - Perconcentration of Mercury (II) from Natural Water by Activated Charcol -loaded Schiff’s Base 2-Propylpiperidine-1-Carbodithioate (PPCD) Phases
A. Moghimi -
Open Access Article
30 - Preconcentration and Determination of Theophylline in Water Samples using Magnetic Nano-Cellulose with Dispersive Solid Phase Extraction
Parastoo Molaei ali moghimi Shahin Ahmadi seyedali sobhanianTheophylline (1,3-dimethyl-2,3,6,7-tetrahydro-1-hydrogen-purine-6,2-dione) is a bronchodilator drug used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). Due to the narrow therapeutic strip of this drug, it is important to measure its blood l MoreTheophylline (1,3-dimethyl-2,3,6,7-tetrahydro-1-hydrogen-purine-6,2-dione) is a bronchodilator drug used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). Due to the narrow therapeutic strip of this drug, it is important to measure its blood level.To achieve a simple, safe and sensitive method based on dispersive solid phase extraction (DSPE) using magnetite nanoparticles covered with nanocellulose and beta-cyclodextrin for preconcentration and measurement of theophylline in aqueous samples and its validation, this method was used. In this research, variables affecting the extraction such as pH, ionic strength, and amount of adsorbent, temperature, time, limit volume and type of solvent were optimized. After extraction, the adsorbent was easily separated from the aqueous sample using an external magnetic field without filtration or centrifugation. The results showed that optimum conditions were obtained with pH=5, 1 mg of sodium chloride, 0.2 g of adsorbent with a capacity of 0.53 mg/g, temperature of 40 degrees Celsius, 20 minutes of contact between the adsorbent and the sample and 5 mL of methanol as the desorption solvent. In optimal conditions, the suitable concentration factor is 12, low detection limit (0.17 mg/L), wide linear range and in accordance with the therapeutic strip of the drug (5-50 mg/L), good correlation coefficient (R2=0.9991) and good accuracy (RSD=1.03%) was obtained.Urine sample was used to validate the above method. Also, it was found that the proposed method is suitable, efficient and usable for measuring of theophylline. Manuscript profile
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