Trace Analysis of Pharmaceutical Residues in Wastewater Treatment Plants in Rio de Janeiro, Brazil

Subject Areas : Journal of Chemical Health Risks

Aldo  Pacheco Ferreira ¹ (Rua Leopoldo Bulhões, 1480, Manguinhos, Rio de Janeiro, 21041-210, Brasil)

Received: 2014-04-20 Accepted : 2018-10-29 Published : 2018-10-29

Keywords:

References:

1. Aga D.S., 2008. Fate of pharmaceuticals in the environment and in water treatment systems, CRC Press, Boca Raton.
2. Neto M.L.F, Ferreira A.P., 2007. Perspectivas da sustentabilidade ambiental diante da contaminação química da água: desafios normativos. Interfacehs 2(4), 1-15.
3. Al Aikido M., Verlicchi P., Jelic A., Petrovic M., Barcelò D., 2012. Monitoring release of pharmaceutical compounds: occurrence and environmental risk assessment of two WWTP effluents and their receiving rivers in the Po Valley, Italy. Science of Total Environment 438, 15-25.
4. Fent K., Weston A.A., Caminada D., 2006. Ecotoxicology of human pharmaceuticals. Aquatic Toxicology 76, 122-159.
5. Palomo M.E., Ballesteros M.P., Frutos P., 1999. Analysis of diclofenac sodium and derivatives. Journal of Pharmaceutical and Biomedical Analysis 21(1), 83-94.
6. Baumgarten S., Schroder H.F., Charwath C., Lange M., Beier S., Pinnekamp J., 2007. Evaluation of advanced treatment technologies for the elimination of pharmaceutical compounds. Water Science and Technology 56(5), 1-8.
7. Bell K.Y., Wells M.J.M., Traexler K.A., Pellegrin M.L., Morse A., Bandy J., 2011. Emerging Pollutants. Water Environment Research 83(10), 1906-1984.
8. Bends D., Paxeus N.A., Ginn T.R., Loge F.J., 2005. Occurrence and fate of pharmaceutically active compounds in the environment, case study: Hoje River in Sweden. Journal of Hazardous Materials 122(3), 195-204.
9. Kimura K., Hara H., Watanabe Y., 2007. Elimination of selected acidic pharmaceuticals from municipal wastewater by an activated sludge system and membrane bioreactors. Environmental Science & Technology 41(10), 3708-3714.
10. Heberer T., 2002. Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicology Letters 131(1-2), 5-17.
11. David L.S., Frederick W., Tom W.J.H., 2010. Rheumatoid arthritis. Lancet 376 (9746), 1094-1108.
12. Félix-Cañedo T.E., Durán-Álvarez J.C., Jiménez-Cisneros B., 2013. The occurrence and distribution of a group of organic micropollutants in Mexico City's water sources. Science of Total Environment 454-455, 109-118.
13. Blot L., Marcelis A., Devogelaer J.P., Manicour D.H., 2000. Effects of diclofenac, aceclofenac and meloxicam on the metabolism of proteoglycans and hyaluronan in osteoarthritic human cartilage. British Journal of Pharmacology 131(7), 1413-1421.
14. Green R.E., Newton I., Shultz S., Cunningham A.A., Gilbert M., Pain D.J., Prakash V., 2004. Diclofenac poisoning as a cause of vulture population declines across the Indian subcontinent. Journal of Applied Ecology 41(5), 793-800.
15. Brozinski J.M., Lahti M., Meierjohann A., Oikari A., Kronberg L., 2013. The Antiââ‚‌ inflammatory drugs diclofenac, naproxen and ibuprofen are found in the bile of wild fish caught downstream of a wastewater treatment plant. Environmental Science & Technology 47(1), 342-348.
16. Subedi B., Du B., Chambliss C.K., Koschorreck J., Rüdel H., Markus Quack M., et al., 2012. Occurrence of pharmaceuticals and personal care products in German fish tissue: A national study. Environmental Science & Technology 46(16), 9047-9054.
17. Schwaiger J., Ferling H., Mallow U., Wintermayr H., Negele R.D., 2004. Toxic effects of the non-steroidal anti-inflammatory drug diclofenac. Part I: histopathological alterations and bioaccumulation in rainbow trout. Aquatic Toxicology 68(2), 141-150.
18. Triebskorn R., Casper H., Heyd A., Eikemper R., Köhler H.R., Schwaiger J., 2004. Toxic effects of the non-steroidal anti-inflammatory drug diclofenac. Part II: cytological effects in liver, kidney, gills and intestine of rainbow trout (Oncorhynchus mykiss). Aquatic Toxicology 68(2), 151-166.
19. Hoeger B., Köllner B., Dietrich D.R., Hitzfeld B., 2005. Water-borne diclofenac affects kidney and gill integrity and selected immune parameters in brown trout (Salmo trutta f. fario). Aquatic Toxicology 75(1), 53-64.
20. Mehinto A.C., Hill E.M., Tyler C.R., 2010. Uptake and biological effects of environmentally relevant concentrations of the nonsteroidal anti-inflammatory pharmaceutical diclofenac in rainbow trout (Oncorhynchus mykiss). Environmental Science & Technology. 44(6), 2176-2182.
21. Pain D.J., Bowden C.G.R., Cunningham A.A., Cuthbert R., Das D., Gilbert M., Jakati R.D., Jhala Y., Khan A.A., Naidoo V., Oaks J.L., Parry-Jones J., Prakash V., Rahmani A., Ranade S.P., Baral H.S., Senacha K.R., Saravanan S., Shah N., Swan G., Swarup D., Taggart M.A., Watson R.T., Virani M.Z., Wolter K., Green R.E., 2008. The race to prevent the extinction of South Asian vultures. Bird Conservation International 18(S1), S30-S48.
22. Moura A., Tacão M., Henriques I., Dias J., Ferreira P., Correia A., 2009. Characterization of bacterial diversity in two aerated lagoons of a wastewater treatment plant using PCRââ‚‌“DGGE analysis. Microbiological Research 164(5), 560-569.
23. Yasui H., Shibata M., 1994. An innovative approach to reduce excess sludge production in the activated sludge process. Water Science and Technology 30(9), 11-20.
24. American Public Health Association, 2005. Standard Methods for the Examination of Water and Wastewater. 21st Edt., American Water Works Association, Water Environment Federation, Washington DC.
25. Soulet B., Tauxe A., Tarradellas J., 2002. Analysis of acidic drugs in Swiss wastewaters. International Journal of Environmental Analytical Chemistry 82, 659-667.
26. Ternes T.A., 1998. Occurrence of drugs in German sewage treatment plants and rivers. Water Research 32 (11), 3245ââ‚‌“3260.
27. Koutsouba V., Heberer T., Fuhrmann B., Schmidtbaumler K., Tsipi D., Hiskia A., 2003. Determination of polar pharmaceuticals in sewage water of Greece by gas chromatography-mass spectrometry. Chemosphere 51(2), 69-75.
28. Vieno N.M., Tuhkanen T., Kronberg L., 2005. Seasonal variation in the occurrence of pharmaceuticals in effluents from a sewage treatment plant and in the recipient water. Environmental Science & Technology 39(21), 8220-8226.
29. Sultan D., Zühlke S., Lamshöft M., Spiteller M., 2008. Occurrence of diclofenac and selected metabolites in sewage effluents. Science of Total Environment 405(1-3), 310-316.
30. Zorita S., MÃ¥rtensson L., Mathiasson L., 2009. Occurrence and removal of pharmaceuticals in a municipal sewage treatment system in the south of Sweden. Science of Total Environment 407, 2760-2770.
31. Thomas P.M., Foster G.D., 2005. Tracking acidic pharmaceutical, caffeine, and triclosan through the wastewater treatment process. Environmental Toxicology and Chemistry 24(1), 25-30.
32. Ying G.G., Kookana R.S., Kolpin D.W., 2009. Occurrence and removal of pharmaceutically active compounds in sewage treatment plants with different technologies. Journal of Environmental Monitoring 11, 1498-1505.
33. Zhang Y., Geiben S.U., Gal C., 2008. Carbamazepine and diclofenaco: Removal in wastewater treatment plants and occurrence in water bodies. Chemosphere 73(8), 1151-1161.
34. Klavarioti M., Mantzavinos D., Kassinos D., 2009. Removal of residual pharmaceuticals from aqueous systems by advanced oxidation processes. Environment International 35(2), 402-417.
35. Daughton C.G., Ternes T.A., 1999. Pharmaceuticals and personal care products in the environment: agents of subtle change? Environmental Health Perspectives 107(6), 907-938.
36. Lindqvist N., Tuhkanen T., Kronberg L., 2005. Occurrence of acidic pharmaceuticals in raw and treated sewages and in receiving waters. Water Research 39(11), 2219-2228.
37. Vieno N.M., Harkki H., Tuhkanen T., Kronberg L., 2007. Occurrence of pharmaceuticals in river water and their elimination in a pilot-scale drinking water treatment plant. Environmental Science & Technology 41(14), 5077-5084.
38. Daneshvar A., Svanfelt J., Kronberg L., Prévost M., Weyhenmeyer G.A., 2010. Seasonal variations in the occurrence and fate of basic and neutral pharmaceuticals in a Swedish riverââ‚‌lake system. Chemosphere 80(3), 301-309.
39. Perez S., Barcelo D., 2008. First evidence for occurrence of hydroxylated human metabolites of diclofenac and aceclofenac in wastewater using QqLITââ‚‌MS and QqTOFââ‚‌MS. Analytical Chemistry 80(21), 8135-8145.
40. European Medicines Agency, 2008. Guideline on the environmental risk assessment of medicinal products for human use. Document Reference EMEA/VHMP/DEP/4447/00, European Medicines Agency, London.
41. Petrovic M., Gros M., Barcelo D., 2006. Multi-residue analysis of pharmaceuticals in wastewater by ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry. Journal of Chromatography A 1124(1-2), 68-81.
42. Gebhardt W., Schroeder H.F., 2007. Liquid chromatography-(tandem) mass spectrometry for the follow-up of the elimination of persistent pharmaceuticals during wastewater treatment applying biological wastewater treatment and advanced oxidation. Journal of Chromatography A 1160(1-2), 34-43.
43. Zhang Y., Giessen S.U., Gal C., 2008. Carbamazepine and diclofenac: removal in wastewater treatment plants and occurrence in water bodies. Chemosphere 73(8), 1151-1161.