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Open Access Article
1 - Investigating the effect of Scenedesmus acuminates algae extract on healing wounds infected with Staphylococcus aureus in a rat model
هومن Akasheh, علیرضا Jahandideh امیر اقبال Khajerahimi شاپور Kakoolaki سعید HesarakiThe purpose of this study is to use a seaweed called Scenedesmus acuminates to reduce infection and heal wounds. Sixty rats were divided into four treatment groups, and sampling was done on the third, seventh, and fourteenth days after wound formation. No treatment was MoreThe purpose of this study is to use a seaweed called Scenedesmus acuminates to reduce infection and heal wounds. Sixty rats were divided into four treatment groups, and sampling was done on the third, seventh, and fourteenth days after wound formation. No treatment was done on the first group, the control group. The second group was treated with 25% zinc oxide as the drug of choice. The third and fourth groups were treated with 3% and 7% Scenedesmus acuminates seaweed ointment. The back wounds of mice were infected with 50 microliters of 2x108 CFU/mL Staphylococcus containing suspension. Histopathology and immunohistochemistry (CD68) were performed to compare the number of macrophages on tissue samples. On the third day after wounding, macrophages (CD68) were present in the algae group by 7% more than in the other groups. On the seventh day, fibroplasia and collagen synthesis in the algae group was 7% better than in the other two groups. On the 14th day, the accumulation of new blood vessels in the algae was 7% more than the others. The best result regarding the CD68 (macrophage) molecule expression level was seen in the 7% algae group on the 7th and 14th days. On the third, seventh, and fourteenth days, when macrophages are helpful, algae groups were better than others. The use of algae ointment can reduce the bacterial load of the wound and is better than the administration of zinc oxide. Manuscript profile -
Open Access Article
2 - Investigating the regenerative effects of PRP and polycaprolactone-hydroxyapatite zeolite nanocomposites on wound healing after tooth extraction
علیرضا Sagart علیرضا Jahandideh احمد Asghari ابوالفضل Akbarzadeh پژمان MortazaviWound healing after a tooth extraction is a complex process that helps repair wounds. Wound dressings are helpful for better healing. These agents should have the least inflammatory stimulation and the most antimicrobial properties. This study tried to investigate the e MoreWound healing after a tooth extraction is a complex process that helps repair wounds. Wound dressings are helpful for better healing. These agents should have the least inflammatory stimulation and the most antimicrobial properties. This study tried to investigate the effect of polycaprolactone-hydroxyapatite zeolite nanocomposites on the healing processes of the mucosa covering the alveoli after extraction. Fifteen healthy cats with lower premolar teeth caries were determined, and tooth extraction was performed. A biopsy sample was taken from the mucosa of the tooth extraction site on the 10th day after surgery. Premolar teeth of all 15 cats were extracted, and three groups were grouped as control, PRP, and nano polycaprolactone-hydroxyapatite zeolite. Histopathological analysis showed that unlike the control group and PRP, the nano group had a much better trend compared to the control group and the PRP group, with less presence of inflammatory cells, complete irregular epithelial tissue, more fleshy bud tissue, and more fibrosis. Polycaprolactone-hydroxyapatite zeolite nanocomposite accelerates wound healing after tooth extraction. Manuscript profile -
Open Access Article
3 - Effect of hydroalchoholic extract of Fraxinus extract in incisional wound healing in rats
narges nazari نسرین حیدریهPato physiological process of wound healing involves the interaction of cellular and biochemical processes. According to Ash anti-inflammatory effect Fraxinus extract the aim of this study was to evaluate the effect of Fraxinus extract ointment incisional wound healing MorePato physiological process of wound healing involves the interaction of cellular and biochemical processes. According to Ash anti-inflammatory effect Fraxinus extract the aim of this study was to evaluate the effect of Fraxinus extract ointment incisional wound healing in rats can be. Method: Ash fruits and leafy branches after identification by the university herbarium, extract by Soxhlet extraction using rotary powder was prepared.Then ointment 70% and 35% as a percentage of the volume using eucerin (ointment base) and the dried extract was created.To induce colitis in male Wistar rats first (g200 ± 230) were anesthetized with ether and In the middle of incisional wound to the back of the animals during 2 (cm) and the thickness of the dermis was created. Rats in four groups (n = 8), no treatment (negative control), eucerin treatment (positive control), treated with ointment were 35% and 70% Fraxinus extract .Treatment every other day for . 14 days was done Before treatment, the wound was photographed by a digital camera and then with the help of AutoCAD software and the percentage of wound healing, wound surface area was determined.Data analyzed by SPSS software and ANOVA and Tukey test were analyzed.The results showed ointment 35% and 70% Ash significant increase in the percentage of wound healing compared to the control group were positive.Result :Fraxinus extract extract is accelerated wound healing in rats. Manuscript profile -
Open Access Article
4 - Collagen Turnover in Healing of Cutaneous Wounds by Aloe vera Fresh Gel in Mouse: Involvement of Fibroblast Growth Factor Receptor
Mehran Arabi homeira JafarzadehInroduction & Objective: Using herbal products like Aloe vera (Aloe barbadensis Miller) plays an important role in wound healing. This study aimed to evalutea the curative influence of Aloe vera (AV) fresh gel on healing of open cutaneous wounds in mouse. Material MoreInroduction & Objective: Using herbal products like Aloe vera (Aloe barbadensis Miller) plays an important role in wound healing. This study aimed to evalutea the curative influence of Aloe vera (AV) fresh gel on healing of open cutaneous wounds in mouse. Material and Method: Mice were 1) pseudo-control (sham): wound treated with physiological serum; 2) wound treated with 2 gr AV fresh gel. Two equal full-thickness skin wounds were made on vertebral column in the sacral region. On 8th and 16th post wounding day, skin sampling for the purpose of gene expression of fibroblast growth factor receptor (FGF-R) under RT-PCR evaluation was taken place. Urine samples were used to determine the concentration of hydroxy proline (HP) as a marker of collagen turnover in wounds, using HP assay kit. Results: AV fresh gel could up-regulate the expression of FGF-R gene as compared to negative and pseudo-controls (P<0.05). In addition, HP concentration was incresed in AV gel-treated groups comparing to others. Conclusion: We revealed that AV fresh gel was capable of healing wounds via elevation in collagen turnover and represents a good candidate for a wound healing process in human and animals. Manuscript profile -
Open Access Article
5 - Green synthesis of zinc nanoparticles and investigation of changes in some biochemical parameters of blood and its effect on wound healing caused by burns in laboratory Wistar male rats
Zahra Sinaee pour Fard Nooshin Naghsh Nasrin Yazdanpanahi Gholam Reza AmiriIntroduction & Objective: Currently, zinc and its compounds are used as a suitable material for the treatment of infection in burns, open wounds and chronic wounds. This investigation, was designed and carried out with the aim the local effect of green zinc nanopart MoreIntroduction & Objective: Currently, zinc and its compounds are used as a suitable material for the treatment of infection in burns, open wounds and chronic wounds. This investigation, was designed and carried out with the aim the local effect of green zinc nanoparticles on blood biochemical parameters and skin tissue repair during wound healing in laboratory rat. Materials and methods: In this experimental study, 42 male Wistar rats were divided into 7 groups of 6. Then, by creating a 2 cm burn on the back of the rats, treatment was immediately performed with zinc nanoparticles ointment (1%, 4%, 16%) and zinc oxide ointment and pure Vaseline for 21 days. After sampling from the percentage of wound repair in the skin of rats was calculated. Similarly, blood sampling was done from the hearts of rats and serum was used to check biochemical parameters. Results: The percentage of wound healing in the 4% ointment group and zinc oxide ointment was significantly higher than the control group. In addition, all the concentrations of ointment were safe in terms of their effect on liver enzymes. Conclution: The results of investigation showed that the ointment of 4% zinc nanoparticles was the best treatment group, which accelerated the repair of skin wounds. Based on the results of the present experimental study, probably the ointment produced by the identified green nanoparticles could be suggested as a strong repair agent in skin lesions naturally. Manuscript profile -
Open Access Article
6 - The effect of combining mord (Myrtus communis) leaf extract and olive oil (Olea europaea) in comparison with 1% silver sulfadiazine cream on skin wound healing in Balb/c mice
Farkhondeh Nemati Ramin Ataee Fatemeh Gorji Seyed Taleb Houseini Amin Lotfvarzi Ali Bagheri hashem abadMord (Myrtus communis) is a plant with antibacterial and anti-inflammatory properties. Ointment of ethanolic extract of the leaves of the mord was prepared in olive oil in a ratio of 1: 1. Wounds developed in the full thickness of the skin in the dorsal region of the mi MoreMord (Myrtus communis) is a plant with antibacterial and anti-inflammatory properties. Ointment of ethanolic extract of the leaves of the mord was prepared in olive oil in a ratio of 1: 1. Wounds developed in the full thickness of the skin in the dorsal region of the mice. The mice were then divided into control and experimental groups. The control group did not receive any treatment and the experimental group, which included the group receiving the combination of mord leaf extract and olive oil and the group receiving 1% silver sulfadiazine cream, were treated once a day. Finally, the percentage of recovery, average skin thickness, diameter of hair follicles, collagen formation, and angiogenesis were examined on the fifth, tenth, and fifteenth days. Data were analyzed using a one-way ANOVA test using SPSS software version 22. The results showed that the treatment with the combination of ethanolic extract of mord leaf and olive oil led to a significant increase in wound healing percentage, skin thickness, hair follicle diameter, compared to 1% silver sulfadiazine cream. There was also an increase in collagen formation and angiogenesis. These results have been a reason for accelerating the wound healing process in the samples treated with a combination of mord extract and olive oil. The results of this study showed that the use of mord leaf extract and olive oil accelerates the transition from the inflammatory stage to the stage of fibroblast hyperplasia due to the increase in collagen synthesis and blood vessels in this stage. Manuscript profile -
Open Access Article
7 - The effect of different concentrations of bee propolis on skin wound healing and immune response and survival of Common carp (Cyprinus carpio)
nasrin choubkar abbasali sari alireza bolandnazar hashem heshmati forough mohammadi nastaran shahbazian amirmohammad emamirad payam yari Antibiotics use to increase the immune and wound healing in many animals. But due to the residual effects of a drug, Antibiotics and used to increase the immune response and propolis wound healing is aquadic animals. But due to their residual, researchers a More Antibiotics use to increase the immune and wound healing in many animals. But due to the residual effects of a drug, Antibiotics and used to increase the immune response and propolis wound healing is aquadic animals. But due to their residual, researchers are looking to replace them with natural materials. One of these natural materials that has many health benefits is bee propolis. The aim of this study was to evaluate the effect of different concentrations of propolis on wound healing and immune system response in common carp (Cyprinus carpio). Propolis extracts were prepared from Kashan Barij essence with different concentrations of 0 , 2 , 5 and 10% with carrier substances (to dissolve the propolis in water), and were evaluated on wound healing and immune response and survival of common carp on a 21 –day cycle of short baths once a day . The results showed that, compared with the control group (0%), the use of bee propolis in concentration of 2% has statistically significant difference on wound healing and immune system response in common carp. The use of higher concentrations of propolis healed wound, but increased the number of blood cells (red blood cells, neutrophils, and eosinophils) and increased mortality of fish, so it is better to use lower concentrations of propolis in fish. The use bee propolis as additive in water is effective in low concentrations and stimulates the immune system. Manuscript profile -
Open Access Article
8 - اثر ترمیم کنندگی زخم معده توسط عصاره ساقه و فراکسیون های Homalium Letestui
لوییس آمازو جواد اکوکون لوکی نوییدامقدمه و هدف: Homalium letestui که به طور سنتی توسط مردم ایبی بیو در جنوب نیجریه برای درمان زخم معده، مالاریا و سایر بیماریها استفاده می شود جهت بررسی ویژگیهای ممانعت کنندگی از ایجاد زخم معده مورد مطالعه قرار گرفت. روش تحقیق: تاثیر عصاره اتانولی ساقه (600-200 میلی Moreمقدمه و هدف: Homalium letestui که به طور سنتی توسط مردم ایبی بیو در جنوب نیجریه برای درمان زخم معده، مالاریا و سایر بیماریها استفاده می شود جهت بررسی ویژگیهای ممانعت کنندگی از ایجاد زخم معده مورد مطالعه قرار گرفت. روش تحقیق: تاثیر عصاره اتانولی ساقه (600-200 میلی گرم در کیلوگرم) و فراکشنها (آبی و دی کلرومتان؛ 400 میلی گرم در کیلوگرم) در زخم القا شده در شرایط آزمایشگاهی مورد مطالعه قرار گرفت. نتایج و بحث: عصاره (600-200 میلی گرم در کیلوگرم) از ایجاد زخم القا شده در مدلهای اتانول، ایندومتاسین، رزرپین و هیستامین به صورت وابسته به دوز ممانعت کرد و درجات ممانعت کنندگی از نظرآماری (p<0.05, 0.01, 0.001) معنی دار بودند. تاثیر عصاره قابل مقایسه با داروهای استاندارد مورد استفاده در مدلهای زخم القا شده توسط ایندومتاسین و اتانول بود و فراکشنهای به دست آمده توسط دی کلرومتان بیشترین فعالیت را داشتند. توصیه های کاربردی/صنعتی: این تحقیق نشان داد که عصاره ساقه Homalium letestui می تواند در درمان زخم موثر باشد. Manuscript profile -
Open Access Article
9 - Therapeutic effect of cold plasma on burnt skin in adult mice
Shadi Dorehlo simin mohamadi Gorji Nasim Hayati RodbariBurn wounds significantly heal the patient and these wounds are prone to infection with electrical energy and scar formation. The use of CO2 laser or nitrogen plasma along with the old methods of sterilization and whisper dressing to accelerate the process of blood clot MoreBurn wounds significantly heal the patient and these wounds are prone to infection with electrical energy and scar formation. The use of CO2 laser or nitrogen plasma along with the old methods of sterilization and whisper dressing to accelerate the process of blood clotting and wound healing. It may repair the natural process and be more effective than other treatments. Therefore, the aim of this study was to evaluate the effect of cold plasma on heat burn wound on the skin of adult Syrian mice in vivo. 24 adult male mice were randomly divided into control, fuel control, sham and experimental groups. After anesthesia and under sterile conditions, a circular wound with a diameter of 8 mm was created on the back of the mice's neck through hot body contact and caused burns as a zero day. Mice in experimental groups 1 to 3 were then treated daily for 30, 60 and 120 seconds, respectively, by cold or plasma irradiation of helium gas for one week. At the end of the treatment period, the sample bed was tested. The samples were tagged in Bowen and after molding with paraffin, 5 micron thick sections were prepared and stained with hematoxylin and stained. Wound healing is achieved by examining parameters such as the thickness of the stratum corneum, epidermis, dermis, hypodermis, the number of hair follicles and the diameter and number of blood vessels in the skin. Macroscopic examination of the wound site showed that the team of mice with cold plasma reduced the diameter of the burned area. Also, the thickness of skin layers (horny layers, epidermis, dermis and hypodermis) in experimental groups increased significantly (P <0.001) compared to the control group of fuel, as well as the number (P <0.001) and diameter of vessels. Dermal (P <0.01) was also increased compared to the control group of the fuel group. Wound area also decreased significantly (p <0.001) compared to the control group of fuel on the seventh day. The results showed that cold plasma irradiation of helium gas is effective in all performance indicators and by inducing it during burns can help accelerate wound healing. Manuscript profile -
Open Access Article
10 - Evaluation of the Effect of Sedar (Ziziphus spina-christi) Extract on Biochemical Parameters of Skin Lesion in NMRI Mice
Shokooh Sharbatdar Nasim Hayati Roodbari Parichehr YaghmaeeThe skin is one of the largest organs of the body and acts as a protective barrier against external harmful factors including microorganisms. It can be damaged and sometimes if the damage is too much, the hypoderm is also involved, so more time is needed for restoration MoreThe skin is one of the largest organs of the body and acts as a protective barrier against external harmful factors including microorganisms. It can be damaged and sometimes if the damage is too much, the hypoderm is also involved, so more time is needed for restoration. The purpose of this research is to investigate cedar plant on skin wound healing in NMRI laboratory mice. 24 mice with a weight of approximately 25-35 grams were bought and after wounding the skin on days 3, 6, 12, 21 they were treated with ointment prepared from cedar and oserin. Mice were randomly divided into three groups: sham, experimental 1, experimental 2. These groups were treated with oserin and Cedar ointment with a dose of 2 mg and 4 mg respectively. Wounds were measured after 3 weeks and their tissue was evaluated by hematoxylin-eosin staining. Biochemical indices of SOD, MDA and TAC were also investigated. Data analysis was done by SPSS version 22 software and Tukey's test. The wound size in Cedar 1 and 2 groups had a significant decrease compared to oserin (p < 0.05). The concentration of MDA in cedar groups 1 and 2 had a significant decrease compared to oserin (p < 0.05). In addition, the activity of SOD and TAC were significantly increased in cedar groups 1 and 2 compared to oserin (p < 0.05). Also, there was a significant increase in the thickness of epidermis and dermis in cedar 1 and 2 compared to oserin (p < 0.05). There was a significant increase in the number of fibroblasts and blood vessels in cedar 1 and 2 compared to oserin (p < 0.05). According to the results of the present study, it can be concluded that cedar extract was effective in wound healing by increasing SOD, TAC and decreasing MDA. Manuscript profile -
Open Access Article
11 - The Effect of Ethanolic Extract of Quercus persica on Gastric Ulcer Healing in Rats
فهیمه مطیع میترا حیدری نصرآبادی عبدالحسین شیروی فریما زاهدیToday there is great interest in using traditional medicine for ulcer healing has been increased.Quercus persica is used in Iranian traditional medicine to treat some gastric diseases. The present study was undertaken to evaluate the Quercus persica ethanolic extract fo MoreToday there is great interest in using traditional medicine for ulcer healing has been increased.Quercus persica is used in Iranian traditional medicine to treat some gastric diseases. The present study was undertaken to evaluate the Quercus persica ethanolic extract for gastric ulcer healing in rats. Extractedfrom theskin of oakfruit soakedin90%ethanoland extractswere measuredby therotarydevice. To determine the effect of this extract from Quercus persica, 56 wistar male rats divided into 2 groups; experimental and control (n=7).Gastric ulcers were induced by luminal application of 0.12 ml acetic acid solution (40% v/v). One day after ulcer induction, the experimental groups Ethanolic extract of Quercus persica at concentration 100 mg/kg w.b.and the control groups received 1 ml normal salin through oral gavage for few consecutive days. On days 1, 3, 5 and 7 rats were killed and wound samples were collected for histological and statistical studies. Results analysis by one way Anova demonstrated that ethanolextract ofthe fruitskinof Quercus persica at concentration 100 mg/kg w.b.significantly increased gastric ulcer area compared to control group and decreased ulcer healing. Also, inflammation cells such as neutrophil and macrophage in the third and fifth days in the experimental groups compared with control groups had significantly increased, which is prolonged inflammation stage.On the seventh day, in the experimental groups a significant reduction in the amount of fibroblast was seen that indicates the delay in wound healing and collagen-synthesis process.The current study showedsignificant increase of inflammation and decrease wound healinginrats treated with ethanolextract ofthe fruitskinof Quercus persica at concentration 100 mg/kg w.b.as compared to control group Manuscript profile -
Open Access Article
12 - The Effects of Chitosan/Polyvinilalchol Nanofibers Scaffold on Skin Burns in Adult Male NMRI Mouse
لیلا ریاحی نسیم حیاتی رودباری سهیلا سلحشور کردستانی کاظم پریورTo repair the wounds of burns a wide range of research including the use of bio-scaffolds due to ability to achieve the desired characteristics has been done. According to favorable biological properties of chitosan such as biocompatibility, antimicrobial properties and MoreTo repair the wounds of burns a wide range of research including the use of bio-scaffolds due to ability to achieve the desired characteristics has been done. According to favorable biological properties of chitosan such as biocompatibility, antimicrobial properties and the ability to improve wound healing in biomedical applications, and also due to biocompatibility and lack of stimulation of the immune system of polyvinyl alcohol, the authors decided to investigate the in-vivo effect of Nanofiber scaffolds on the mix of these two polymers on damaged skin.30 NMRI male mice were randomly divided in to a control group and three experimental groups (Scaffolding chitosan: polyvinylalcohol ratio of 0.100, 20.80, 30.70).Under sterile conditions and anesthesia, a 1 cm in diameter and full thickness skin wounds was created on the back of each mouse. Electrospinning nanofiber scaffolds were applied as wound dressing to cover the burn. The burn area was sterile every day and scaffolding was dressing on the wound. After 21 days histological studies have been done on the wound. The results showeda significant meaningful reduction in wound diameter in the experimental group in comparison to control group(p Also increase in the rate of wound shrinkage has been seen in samples containing scaffolds compared to control samples. Manuscript profile -
Open Access Article
13 - The Effect of Hydroalcoholic Extract Internal Layer of Iranian Oak (Quercus persica) on the Process of Wound Healing and Collagen Synthesis in Wistar Rats
Azadeh Kakoie Akbar karimi shima toghianiDue to their lower complications than chemical compounds, herbal medicines have received attention from doctors. In this study, Internal Layer of Persian Oak (Quercus persica), which is used in traditional medicine for chronic dermatologic disorders and eczema, wa MoreDue to their lower complications than chemical compounds, herbal medicines have received attention from doctors. In this study, Internal Layer of Persian Oak (Quercus persica), which is used in traditional medicine for chronic dermatologic disorders and eczema, was utilized to investigate cutaneous ulcer healing. Thirty adult male Wistar rats in 5 groups were treated while kept under normal laboratory conditions by creating a wound with dimensions of 1.5 × 1.5 cm2 and a depth of 2 mm in the back. The control group, the sham group, and the experimental groups consist of hydro-alcoholic extract of Internal Layer of Quercus persica at a dose of 250 mg / kg, hydro-alcoholic extract of Quercus persica at a dose of 500 mg / kg, and hydro-alcoholic extract of Quercus persica extract at a dose of 1000 mg / kg, respectively. Topical treatment of ulcers was performed in a 10-day interval every other day, and on the 6th, 8th and 10th days, tissue samples were prepared from the scars. After samples were washed, they were fixed in 10% formalin and hematoxylin-eosin staining of samples, epidermal thickness, wound healing percent, and collagen density were assessed and data were analyzed using SPSS software. In the experimental groups, there was a significant increase (at the level of p < 0.05 and p < 0.01) in the epidermal thickness and the wound healing percent, indicating the significant effect of Internal Layer of Iranian oak Jaft extract on the wound reconstruction, but no significant effect was observed on collagenization in this study Internal Layer of Iranian oak hydroalcoholic extract may have an effective role in accelerating skin wounds healing. Manuscript profile -
Open Access Article
14 - The Effect of Cornus mas Extract on the Wound Healing of the Diabetic Male Wistar Rats
S. Alhooei-Nazari A. Shiravi Vida HojatiDiabetes is one of the reasons for delayed wound healing; as the fruit of blueberries, Cornus mas, possesses high content of antioxidants, therefore, this study aims to investigate the extract of this fruit on wound healing in a male rat of Wistar strain affected by dia MoreDiabetes is one of the reasons for delayed wound healing; as the fruit of blueberries, Cornus mas, possesses high content of antioxidants, therefore, this study aims to investigate the extract of this fruit on wound healing in a male rat of Wistar strain affected by diabetes.In this study, 48 male rats of Wistar strain were divided into 4 groups of 12. After affecting these groups to diabetes (except control group), there was created a wound at the back of the rat in all 4 groups; the length of the wounds in the groups were investigated up to 21 days; (1) control group: with no blueberries extract and ocerin treated on their wounds, called as healthy group; (2) Shem Group: they include a group of diabetics rats who were treated by ocerin (twice per day); (3) Experimental Group 1: they included a group of diabetics rats who received no ocerin and extract; (4) Experimental Group 2: they include the diabetics group who treated by the ointment of blueberries extract (twice a day).Results of comparing the mean of wounds length in the investigated groups indicate that the experimental group 2 had significant reduction up to p ≤ 0.01 than Shem and experimental1 groups. By reducing the blood glucose and modifying some biochemical factors, blueberries makes treatment effect on diabetes. According to the results of this study, blueberries ointment may accelerate skin wound healing in the healthy and diabetic samples. Manuscript profile -
Open Access Article
15 - Effects of Alcoholic Extract of Artemisia inflorescence on Wound Healing of Diabetic Wistar Rats
F. Harasani Gh. Vaezi Vida HojatiSkin ulcers and diabetic foot ulcers are an important issue in medicine. Diabetes is one of the most common metabolic diseases of the endocrine system. Artemisia pharmacological, particularly effects on diabetes. The aim of this study was to compare the healing effects MoreSkin ulcers and diabetic foot ulcers are an important issue in medicine. Diabetes is one of the most common metabolic diseases of the endocrine system. Artemisia pharmacological, particularly effects on diabetes. The aim of this study was to compare the healing effects of alcoholic extract of Artemisia in the process of healing and skin wounds in normal and diabetic rats is quickly closing. Overall, 20 adult male Wistar rats were used. The rats were divided into four groups of five controls (without diabetes and treatment), sham (diabetes treatment Eucerin), Experimental 1 (diabetes without treatment), Experimental 2 (diabetes treated with alcoholic extract of Artemisia) were divided. Three groups of rats were made diabetic using STZ. Over 2 cm wound on the skin of spinous were created in all groups. The experimental group and the experimental group 2 with wormwood extract 1 Eucerin day with a dose of 100 mg Barba topical treatment over a period of 21 d, respectively. Wound healing was evaluated by macroscopic and microscopic. Wound healing in experimental groups 1 and 2 was treated with than the alcoholic extract of Artemisia control group showed the highest rate. Wormwood extract leads to topical wound healing in diabetic rats and material contained in Artemisia cause, faster wound contraction, and the healing. Manuscript profile -
Open Access Article
16 - Clinical and microscopic study of the effect of different concentrations of cardamom extract (Elettaria cardamomum) on the healing of skin wounds in diabetic rabbits with alloxan
Fatemeh Tavakoli Rad loghman Akradi Mahdieh RaeeszadehIn this study, 30 male rabbits weighing 900 - 1000 g were randomly divided into 6 groups (positive control, negative control and test). After general anesthesia using a combination injection of ketamine 50 mg / kg and xylazine 5 mg / kg intraperitoneally to create ulcer MoreIn this study, 30 male rabbits weighing 900 - 1000 g were randomly divided into 6 groups (positive control, negative control and test). After general anesthesia using a combination injection of ketamine 50 mg / kg and xylazine 5 mg / kg intraperitoneally to create ulcers in the rabbit skin a 10 mm circular punch was made. The wounds was measured with the aid of millimeter papers on the first, third, sixth, ninth, twelfth, fifteenth, eighteenth, and twenty-first days after surgery. This measurement is made at a specific time of day by a specific person. Complete recovery time was measured in negative, positive control and test samples. Then, on day 21, the wound was sampled. The specimens were subjected to histopathological studies after fixation of dewatering and staining.According to the results, there was no significant difference between control group and T1 group (P <0.05), but there was a significant difference between control group and T2, T3, T4, T5 group (P <0.05). The highest difference was between T5 and control group. It can be said that methanolic extract of cardamom at a dose of 400 mg / kg topical and feeding on cardamom powder pellets was more effective than all groups. Also, migration of epithelial tissue and reduction of wound openings in group T5 on days 15 to 21 were higher than other groups. Also, cardamom powder as the last plate of food significantly decreased glucose in diabetic groups (P <0.05). Cardamom lowers blood sugar by antioxidants such as flanoids. According to the results of this study, cardamom extract has a high ability to heal full-thickness wounds compared to chemical drugs. Manuscript profile
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