اثر ترمیم کنندگی زخم معده توسط عصاره ساقه و فراکسیون های Homalium Letestui

Subject Areas : Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)

لوییس  آمازو ¹ (Department of Pharmacology and Therapeutics, College of Medicine,Evans Enwerem University, Orlu Campus, Imo State)
جواد  اکوکون ² (Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria)
لوکی  نوییدا ³ (Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Bayelsa State)

Received: 2014-03-28 Accepted : 2014-07-30 Published : 2015-04-01

Keywords: ترمیم زخم, Homalium letestui, محافظ معده,

Abstract :

مقدمه و هدف: Homalium letestui  که به طور سنتی توسط مردم ایبی بیو در جنوب نیجریه برای درمان زخم معده، مالاریا و سایر بیماریها استفاده می شود جهت بررسی ویژگیهای ممانعت کنندگی از ایجاد زخم معده مورد مطالعه قرار گرفت. روش تحقیق: تاثیر عصاره اتانولی ساقه (600-200 میلی گرم در کیلوگرم) و فراکشنها (آبی و دی کلرومتان؛ 400 میلی گرم در کیلوگرم) در زخم القا شده در شرایط آزمایشگاهی مورد مطالعه قرار گرفت. نتایج و بحث: عصاره (600-200 میلی گرم در کیلوگرم) از ایجاد زخم القا شده در مدلهای اتانول، ایندومتاسین، رزرپین و هیستامین به صورت وابسته به دوز ممانعت کرد و درجات ممانعت کنندگی از نظرآماری (p<0.05, 0.01, 0.001) معنی دار بودند. تاثیر عصاره قابل مقایسه با داروهای استاندارد مورد استفاده در مدلهای زخم القا شده توسط ایندومتاسین و اتانول بود و فراکشنهای به دست آمده توسط دی کلرومتان بیشترین فعالیت را داشتند. توصیه های کاربردی/صنعتی: این تحقیق نشان داد که عصاره ساقه Homalium letestui می تواند در درمان زخم موثر باشد.

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