Antiulcerogenic activity of stem extract and fractions of Homalium Letestui
الموضوعات : مجله گیاهان دارویی
لوییس آمازو
1
(Department of Pharmacology and Therapeutics, College of Medicine,Evans Enwerem University, Orlu Campus, Imo State)
جواد اکوکون
2
(Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria)
لوکی نوییدا
3
(Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Bayelsa State)
الکلمات المفتاحية: Homalium letestui, Gastric protective, Antiulcer,
ملخص المقالة :
Background & Aim: Homalium letestui Pellegr (Flacourtiaceae) used traditionally by the Ibibios of Southern Nigeria to treat stomach ulcer, malaria and other inflammatory diseases was evaluated for antiulcer properties. Experimental: The effects of ethanol stem extract of H. letestui (200 – 600 mg/kg) and fractions (Aqueous and Dichloromethane, 400 mg/kg) on experimentally induced ulcer were studied in rats using ethanol, indomethacin, reserpine and histamine –induced ulcer models. Results & Discussion: The extract (200 – 600 mg/kg) inhibited ethanol, indomethacin, reserpine and histamine –induced ulcer models in a dose dependent fashion. The various degrees of inhibitions were statistically significant (p<0.05, 0.01, 0.001). The effects of the extract/fraction were comparable to that of the standard drugs used in indomethacin and ethanol-induced ulcer models with the dichloromethane fraction having the highest activity. Industrial and practical recommendations: The present study demonstrates that stem extract of Homalium letestui might to be useful for the treatment of ulcer.
Agwu, C.N., Okunji, C.O. 1986. Gastrointestinal studies of Pyrenacantha staudii leaf extracts. Journal of Ethnopharmacology, 15: 45 – 55.
Ali, M., Latif, A., Zaman, K., Arfan, M., Maitland, D., Ahmad, H., Ahmad, M. 2014. Anti-ulcer xanthones from the roots of Hypericum oblongifolium Wall. Fitoterapia, 95: 258-65.
Alphin, R.S., Ward, J.W. 1967. Action of hexopyrronium bromide on gastric secretion in dogs and on gastric secretion and ulceration in rats. Archieves Internationales de Pharmacodynamie et de Therapie, 270: 128 -140.
Bhargava, K.P., Gupta, M.B., Tangri, K.K. 1973. Mechanism of ulcerogenic activity of indomethacin and oxyphenbutazone. European Journal of Pharmacology. 22: 191 – 195.
Borrelli, F., Izzo A.A. 2000. The plant kingdom as source of anti ulcer remedies. Phytotherapy Research, 14: 581 – 591.
Cho, C.H., Pfeiffer, C.J. 1981. Gastrointestinal ulceration in the guinea pigs in response to dimaprit, histamine and H1 and H2 blocking agents. Digestive Disease Science, 26: 306 – 311.
Di Carlo, G., Mascolo, N., Izzo, A.A., Capasso, F. 1999. Flavonoids:old and new aspects of a class of a natural therapeutic drug. Life sciences, 64: 337 – 353.
Evbuonwa, M.T., Bolarinwa, A.F. 1990. Effect of diet on indomethacin-induced peptic ulceration in pregnant rats. Nigerian Journal of Physiological Sciences. 6: 189 – 191.
Hayllar J., Bjarnason, I. 1995. NSAIDS,COX-2 inhibitor and the gut . Lancet, 346 - 522.
Hiruma-Lima, C.A., Calvo, T.R., Rodriguez, C. M., Andrade, F.D.P., Vilegas, W., Brito, ARM 2006. Antiulcerogenic activity of Alchornea castaneaefolia effects on somatostatin, gastrin and prostaglandin. Journal of Ethnopharmacology, 104: 215 – 224.
Hutchinson, J., Dalziel, J.M. 1973. Flora of West tropical Africa. 2nd edition.Crown Agents for Overseas Government and Administration. Vol.1. part.2. p.638.
Kamat, J. P., Ghosh, A. and Devasagayam, T. P. A. 2000. Vanillin as an antioxidant in rat liver mitochondria: inhibition of protein oxidation and lipid peroxidationinduced by photosensitization. Mol. Cell. Biochem. 209: 47-53.
Keay, R.W.J. 1989. Trees of Nigeria. A revised version of Nigerian trees (Vol 1 and 2), Keay RWJ, Onoche CFA, Stanfield DP (eds). Clarendon Press: Oxford.
Kumar, S., Priyadarsini, K. and Sainis, K. 2002. Free radical scavenging activity of vanillin and o-vanillin using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical. Redox Rep, 7: 35-40.
Lirdprapamongkol, K., Kramb, J. P., Suthiphongchai, T., Surarit, R., Srisomsap, C., Dannhardt, G. and Svasti, J. 2009. Vanillin suppresses metastatic potential of human cancer cells through PI3K inhibition and decreases angiogenesis in vivo. J. Agr. Food Chem, 57: 3055-3063.
Lewis, D.A., Hanson, D. 1991.Anti-ulcer drugs of plants origin. Progress in Medicinal Chemistry, 28: 208 – 210.
Maity, S., Vedasiromoni, J.R., Ganguly, D.K. 1995. Anti-ulcer effect of the hot water extract of black tea (Camellia sinensis). Journal of Ethnopharmacology, 46: 167 – 174.
Matsunaga, T., Hasegawa, C., Kawasuji, T., Suzuki, H., Saito, H., Sagioka, T., Takahashi, R., Tsukamoto, H., Morikawa, T., Akiyama, T. 2000. Isolation of the anti-ulcer compound in essential oil from the leaves of Cryptomeria japonica. Biol Pharm Bull, 23: 595-598.
Nwafor, P.A., Effraim, K.D., Jacks,T.W. 1996. Gastroprotective effects of acqeous extracts of Khaya senegalensis bark on indomethacin – induced ulceration in rats. West African Journal of Pharmacology and Drug Research, 12: 46 – 50.
Nwafor, P.A., Okwuasaba F.K., Binda l.G. 2000. Antidiarrhoeal and antiulcerogenic effects of methanolic extracts of Asparagus pubescens root in rats. Journal of Ethnopharmacology, 72: 421 – 427.
Souza, R.H.L., Cardoso, M.S.P., Menezes, C.T., Silva, J.P., De Sousa, D.P., Batista, J.S. 2011. Gastroprotective activity of α-terpineol in two experimental models of gastric ulcer in rats. DARU, 19(4): 277 – 281.
Okokon, J.E.,Antia, B.S., Ita, B.N. 2007. Antidiabetic effects of Homalium letestui (Flacourtiaceae) in streptozotocin induced diabetic rats.Res J Med Plants,1(4): 134 - 138.
Okokon, J.E., Dar, A., Choudhary, M.I. 2013b. Cellular antioxidative, anticancer and antileishmanial activities of Homalium letestui. Aviccena J Phytomed, 3(1): 35 - 44.
Okokon, J.E., Ita, B.N., Udokpoh, A.E. 2006. Antimalarial activity of Homalium letestui.Phytother Res, 20(11): 949 - 951.
Okokon, J.E., Okokon, P.J., Dar, A., Choudhary, M.I. 2013a. Antiinflammatory and analgesic activities of Homalium Letestui. Pharmaceutical Biology, 51(11): 1459 – 1466.
Okokon, J.E., Davies, K. 2014. Psychopharmacological studies of Homalium letestui stem extract. Journal of Pharmaceutical Biology, 4(3): 158 – 164.
Pihan, G., Regillo, C., Szabo, S. 1987. Free radicals and lipid peroxidation in ethanol or aspirin – induced gastric mucosa injury. Digestive Diseases and Sciences, 32: 1395 – 1401.
Rainsford, K.D. 1987. The effects of 5- lipoxygenase inhibitors and leukotriene antagonists on the development of gastric lesions induced by nonsteroidal anti-inflammatory drugs in mice. Agents and Action, 21:316 – 319.
Salim, A.S. 1990. Removing oxygen derived free radicals stimulates healing of ethanol induced erosive gastritis in the rats. Digestion, 47: 24 – 28.
Whittle, B. J. R., Oren-Wolman, N., Guth, P. H. 1985. Gastric vasoconstrictor actions of leukotriene C4 and PGF2α and thromboxane mimetic (U-4669) on rats submucosal microcirculation in vivo..American Journal of Physiology, 248: G580 – G586
Zaidi, S.H., Mukerji, B. 1958. Experimental peptic ulceration. Part 1. The significance of mucus barrier. Indian Journal of Medical Research, 46: 27 – 37.
Zayachkivska, O. S., Konturek, S. J., Drozdowicz, D., Konturek P.C., Brzozowski T., Ghegotsky, M.R. 2005. Gastroprotective effects of flavonoids in plants extracts. Journal of Physiology and Pharmacology, 56: 216 - 231.
