Anti-inflammatory

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1 - Application of 3D-QSAR on a Series of Potent P38-MAP Kinase Inhibitors
Reihaneh Safavi-Sohi Jahan B. Ghasemi

One of the most applied methods in drug industry for development of new drugs is 3D-QSAR methodology. As p38-mitogen-activated protein kinase (p38-MAPK) plays a crucial role in regulating the production of such proinflammatory cytokines as tumor necrosis factor-α چکیده کامل

One of the most applied methods in drug industry for development of new drugs is 3D-QSAR methodology. As p38-mitogen-activated protein kinase (p38-MAPK) plays a crucial role in regulating the production of such proinflammatory cytokines as tumor necrosis factor-α (TNF-α) and interleukin-1, emerging as an attractive target for new anti-inflammatory agents, we used a 3D-QSAR based method of Comparative Molecular Field Analysis (CoMFA) on a series of 52 potent p38-MAP kinase inhibitors with IC50 ranging from 3.2 to 10,000 nM. An alignment rule for the compounds was defined using Distill in SYBYL 7.3. The best model was validated using a data set obtained by dividing the data set into a training set and test set using hierarchical clustering, based on the CoMFA fields and biological activities (pIC50). The best predictions were obtained with a CoMFA region-focusing model (R2 ncv = 0.952, q2 = 0.678, R2 Pred = 0.627). The statistical parameters from the model indicate that the data are well fitted and has high predictive ability. Moreover, the resulting 3D CoMFA contour maps provide useful guidance for designing highly active inhibitors. پرونده مقاله

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2 - Synthesis of Ibuprofen with Modified and Economical Process as an NSAID Drug
Abbas Ahmadi Marzie Daniali Sara Kazemi Samira Azami Noshin Alizade

Ibuprofen (I) is the most widely used non-steroidal anti-inflammatory drugs (NSAIDs) has been synthesized in recent years. NSAIDs are the first choice of drugs that are normally used for the treatment of pain and inflammation. There are many methods for synthesizing of چکیده کامل

Ibuprofen (I) is the most widely used non-steroidal anti-inflammatory drugs (NSAIDs) has been synthesized in recent years. NSAIDs are the first choice of drugs that are normally used for the treatment of pain and inflammation. There are many methods for synthesizing of I but each one has some difficulties as raw materials preparation, reaction conditions and etc. In an effort to establish modified method with improved and economical yield, I was synthesized by the mesylation of ethyl lactate in the presence of triethylamine or pyridine at 273 K to obtain the corresponding ethyl-2-(methylsulphonyloxy) propanoate (II). Then, Friedel-Crafts alkylation of II with isobutylbenzene for single step synthesis of ethyl-2-(4- isobutylphenyl) propanoate (III) was carried out by heating with AlCl3 under neat reaction conditions. Finally, ethyl-2-(4-isobutylphenyl) propanoate (I) formed in 50 % yield was hydrolyzed with KOH in methanol and acidified with HCl to afford the desired product. پرونده مقاله

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3 - Evaluation of antidiabetic, anti-inflammatory and LDL oxidation inhibitory potential of Alpinia galanga and Alpinia calcarata -An in vitro study
Suresh Nampoothiri Thirugnanasamy Esakkidurai Kasi Pitchumani

Alpinia galanga and Alpinia calcarata are two important aromatic medicinal plants belong to the family Zingiberaceae. In the present study, dried rhizomes of A. galanga and A. calcarata were extracted with water and then fractionated with different solvents. Among the v چکیده کامل

Alpinia galanga and Alpinia calcarata are two important aromatic medicinal plants belong to the family Zingiberaceae. In the present study, dried rhizomes of A. galanga and A. calcarata were extracted with water and then fractionated with different solvents. Among the various solvent fractions, ethyl acetate (EA) fraction of both the plants showed high polyphenolic content with better antioxidant activity. This polyphenol rich EA fraction is also screened for its antidiabetic and anti-inflammatory potential using in vitro assays. Results showed that EA fractions of these two plants had significant antihyperglycemic activity by inhibiting carbohydrate digesting enzymes (α-amylase and α-glucosidase) and by inhibiting glycation reaction. Inhibitory potential of EA fractions of both the plant against protein denaturation and xanthine oxidase validates its anti-inflammatory potential. Moreover, EA fractions also exhibited significant LDL oxidation inhibition .The observed antidiabetic and anti-inflammatory properties of A. galanga and A. calcarata could be due to the synergic effect of polyphenols such as gallic acid and ellagic acid as well as bioactive alkaloid, berberine. پرونده مقاله

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4 - A new pyrrolidinyl-piperazine alkaloid derivative from Oxyanthus speciosus DC. (Rubiaceae)
Judith Caroline Ngo Nyobe Désiré Mama Bikélé Matiedjie Becky Fodouop Emmanuel Mpondo Mpondo Jean Claude Ndom

A new pyrrolidinyl-piperazine alkaloid derivative named 2-(7’-methylhexyloxy)furan-5’-yl)-6- (pyrrolidin-7-yl)piperazine (1), along with five known compounds were isolated from methanolic extract of the roots of Oxyanthus speciosus DC. (Rubiaceae). The struc چکیده کامل

A new pyrrolidinyl-piperazine alkaloid derivative named 2-(7’-methylhexyloxy)furan-5’-yl)-6- (pyrrolidin-7-yl)piperazine (1), along with five known compounds were isolated from methanolic extract of the roots of Oxyanthus speciosus DC. (Rubiaceae). The structure of this new alkaloid was elucidated on the basis of the relevant NMR and MS analyses. Compound (1) possesses potent in vitro anti-inflammatory activity by protein denaturation assay with an IC50 value of 1.930 ± 0.9123 µg/mL. The obtained results indicated that the crude methanolic extract of O. speciosus DC. roots and its isolated pyrrolidinyl-piperazine alkaloid have potentials for further development as an effective and natural anti-inflammatory agents. پرونده مقاله

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5 - Phytochemical constituents and pharmacological potential of Solanum khasianum C.B. Clarke., extracts: Special emphasis on its skin whitening, anti-diabetic, acetylcholinesterase and genotoxic activities
Roktim Gogoi Neelav Sarma Sudin Pandey Mohan Lal

10.30495/tpr.2021.1917249.1190

This study was designed to evaluate and compare the phytochemical constituents along with the bioactivities of Solanum khasianum C.B. Clarke. leaves (SKLME) and berries (SKBME) methanolic extracts. Alkaloids, flavonoids, saponins, steroids, terpenoids, phenols, oxalates چکیده کامل

This study was designed to evaluate and compare the phytochemical constituents along with the bioactivities of Solanum khasianum C.B. Clarke. leaves (SKLME) and berries (SKBME) methanolic extracts. Alkaloids, flavonoids, saponins, steroids, terpenoids, phenols, oxalates and cardiac glycosides were present in SKLME and SKBME. Considerable amounts of phenolic and flavonoids were found in SKLME and SKBME. SKBME showed better antioxidant activity with an IC50 value of 20.68 μg/mL vs SKLME (38.30 μg/mL). SKBME and SKLME respectively showed anti-inflammatory activity with IC50 of 20.96 and 23.37 μg/mL. Apart from this, the present investigation also reports SKBME skin whitening ability, anti-diabetic potential and anti-cholinesterase activity with IC50 values of 33.97, 28.24, and 32.42 μg/mL, respectively. Furthermore, SKLME showed herbicidal property with a total germination rate of 9.06% at a concentration of 80 μg/mL. Bioactivity analysis revealed higher pharmacological importance of the SKBME than SKLME, as well. پرونده مقاله

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6 - Chemical composition, insect antifeeding, insecticidal, herbicidal, antioxidant and anti-inflammatory potential of Ardisia solonaceae Roxb. root extract
Bahar Anjum Ravendra Kumar Randeep Kumar OM. Prakash R Srivastava D.S. Rawat A. Pant

The objectives of this research were to investigate the qualitative and quantitative analysis of Ethyl Acetate Root Extract of Ardisia solanacea Roxb. (EREAS) and estimation of its biological activities. Phytochemical screening of EREAS showed the abundance of total phe چکیده کامل

The objectives of this research were to investigate the qualitative and quantitative analysis of Ethyl Acetate Root Extract of Ardisia solanacea Roxb. (EREAS) and estimation of its biological activities. Phytochemical screening of EREAS showed the abundance of total phenolics, flavanoids, ortho-dihydric phenols, alkaloids, diterpenes and triterpenes etc. The quantitative analysis of EREAS was also carried out by GC/MS and α-amyrenone (13.3%) was found to be the major component. Antifeeding activity monitored through no choice leaf dip method against Spilosoma oblique. The results revealed dose and time dependent antifeeding activity, where the 100% mortality was observed signifying the intense insecticidal activity. The herbicidal activity of extracts was evaluated against the Raphanus raphanistrum seeds. Accordingly, EREAS showed effective herbicidal activity in terms of inhibition of seed germination, coleoptile length and the radical length. Evaluation of antioxidant activity was performed via DPPH radical scavenging, reducing power and metal chelating of Fe2+ activities. EREAS possessed potential antioxidant property and revealed good anti-inflammatory activity. پرونده مقاله

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7 - Phytochemical analysis and screening of antioxidant, antibacterial and anti-inflammatory activity of essential oil of Premna mucronata Roxb. leaves
Diksha Palariya Anmol Singh Anamika Dhami Anil K. Pant Ravendra Kumar Om Prakash

Premna mucronata Roxb. commonly known as agyon, is a plant of family Lamiaceae. This study dealt with the phytochemical analysis of leaves essential oil of Premna mucronata Roxb. (PMLO) using GC/MS technique and screening of its antioxidant activity using 2,2-diphenyl-1 چکیده کامل

Premna mucronata Roxb. commonly known as agyon, is a plant of family Lamiaceae. This study dealt with the phytochemical analysis of leaves essential oil of Premna mucronata Roxb. (PMLO) using GC/MS technique and screening of its antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH), metal chelating and reducing power assays, anti-inflammatory activity using in-vitro albumin denaturation assay and antibacterial activity using well diffusion method against pathogenic bacterial strains Escherichia coli and Staphylococcus aureus. The phytochemical analysis of PMLO revealed the presence of over 71 compounds. 3-octanone was found to be the major constituent that accounts for 23.6% of the total oil composition. The other major constituents identified were ethyl-hexanol (13.9%), 1-octen-3-ol (9.6%), linalool (5.5%), methyl salicylate (2.9%) and E-caryophyllene (2.9%). It was found that PMLO possessed antioxidant activity in terms of DPPH (IC50=11.18±0.03 µg/mL), metal chelating (IC50=18.82±0.46 µg/mL), and reducing power activities (IC50=21.69±0.02 µg/mL) and in-vitro anti-inflammatory activity was also shown by essential oil with IC50=30.27±0.005 µg/mL. Antibacterial activity of PMLO at higher concentration (1000ppm) showed zone of inhibition of 14.33±0.58mm against E. coli and 14.66±0.58mm against S. aureus. The essential oil of leave P.mucronata contains 3-Octanone, 1-octen-3-ol, ethyl-hexanol, linalool, and have antioxidant, anti-inflammation and antibacterial acitivities. پرونده مقاله

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8 - In vivo anti-inflammatory and anti-nociceptive activities, and chemical constituents of essential oil from the leaf of Gardenia jasminoides J. Ellis (Rubiaceae)
Nudewhenu Opeyemi Avoseh Oladipupo Adejumobi Lawal Isiaka Ajani Ogunwande Roberta Ascrizzi Guido Flamini Elizabeth Amoo

The chemical constituents, anti-inflammatory and anti-nociceptive activities of the leaf essential oil hydrodisitlled from the Gardenia jasminoides J. Ellis (Rubiaceae) were reported. The chemical constituents of the essential were analyzed using gas chromatography-flam چکیده کامل

The chemical constituents, anti-inflammatory and anti-nociceptive activities of the leaf essential oil hydrodisitlled from the Gardenia jasminoides J. Ellis (Rubiaceae) were reported. The chemical constituents of the essential were analyzed using gas chromatography-flame ionization detector (GC-FID) and gas chromatography coupled with mass spectrometry (GC/MS). The hot plate and carrageenan-induced models were used to determine the anti-nociceptive and anti-inflammatory activities. The main compounds of the oil were pentadecanal 17 (49.2%), geranial 4 (12.3%), ar-turmerone 14 (8.2%) and 10-epi-γ-eudesmol 10 (6.2%). The essential oil of G. jasminoides at 100 and 400 mg.kg-1 doses significantly (p < 0.001) increased the latency period for the reaction duration in the anti-nociceptive study. The carrageenan-induced edema model reveals the suppression of inflammatory mediators (p < 0.001) within 1st, 2nd and 4th h for 100 mg.kg-1 dose, 1st and 4th h (200 mg.kg-1) and 1st-3rd h (400 mg.kg-1). The results indicate the potential of G. jasminoides essential oil as a source of pain relieving agent. پرونده مقاله

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9 - Nutritional assessment, antioxidant, anti-inflammatory and antidiabetic potential of traditionally used wild plant, Berberis tinctoria Lesch.
Arumugam Vignesh Kumarasamy Pradeepa Veerakumari Subramaniam Selvakumar Rajan Rakkiyappan Krishnan Vasanth

10.30495/tpr.2021.1914719.1186

This study divulges a comparative analysis of Berberis tinctoria Lesch. leaf, stem, and fruit towards proximate contents assessment, e.g., moisture, crude-ash, crude-fibre, crude-lipid, crude-protein, nitrogen-free extract, energy followed by ICP-MS analysis w چکیده کامل

This study divulges a comparative analysis of Berberis tinctoria Lesch. leaf, stem, and fruit towards proximate contents assessment, e.g., moisture, crude-ash, crude-fibre, crude-lipid, crude-protein, nitrogen-free extract, energy followed by ICP-MS analysis which revealed that fruits have a higher amount of essential minerals. The primary metabolites were higher in the fruit extract, whereas more secondary metabolites were observed in the methanolic extracts in the hierarchy of leaf and fruit then stem, respectively. Likewise, a higher amount of antioxidant activities were observed in ethyl acetate and methanolic extracts. The fruit ethyl acetate extract showed a maximum of 95.27% anti-inflammatory activity. The fruit methanolic extract exhibited an antidiabetic activity with IC50 values of 75.5 ± 6.8 μg/mL and 45.4 ± 11.1 μg/mL for α-amylase and α-glucosidase, respectively. A significantly positive correlation was identified between the secondary metabolites and antioxidant activities. The principal component analysis implies ethyl acetate and methanolic extracts as pivotal extracts of B. tinctoria. پرونده مقاله

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10 - Phytochemical composition, antioxidant, and anti-inflammatory activities of essential oil of Acmella uliginosa (Sw.) Cass. grown in North India Terai region of Uttarakhand
Kanchan Gairola Shriya Gururani Ravendra Kumar Om Prakash Sanjeev Agarwal Shiv Dubey

10.30495/tpr.2021.680495

The plant Acmella uliginosa (Sw.) Cass. belonging to family Asteraceae was subjected to hydro distillation for essential oil extraction and was chemically analyzed by GC/MS for its phytochemical composition. Thirty-five compounds were identified comprising 88.1% of tota چکیده کامل

The plant Acmella uliginosa (Sw.) Cass. belonging to family Asteraceae was subjected to hydro distillation for essential oil extraction and was chemically analyzed by GC/MS for its phytochemical composition. Thirty-five compounds were identified comprising 88.1% of total essential oil composition. Limonene (12.2%) along with sesquisabinene isomer (7.3%) and caryophyllene oxide (5.9%) were the prominent compounds of the essential oil. In-vitro antioxidant activity of essential oil was investigated by DPPH free radical scavenging activity and metal chelating activity having IC50 value of 326.77 ± 5.34 μL and 14.853 ± 0.106 μL respectively whereas reducing power activity having RP50 value of 14.011 ± 0.0446 μL. The essential oil exhibited potent anti-inflammatory activity with IB50 value of 5.629 ± 0.0311 μL compared to standard Diclofenac sodium salt having IB50 value of 23.693 ± 0.306 μg/mL. The essential oil displayed exceedingly marked anti-inflammatory as well as antioxidant activities as compared to standard marketed drugs. پرونده مقاله

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11 - Anti-inflammatory potential of aqueous extract and ethyl acetate fractions of Munronia pinnata (Wall) Theob. and the isolated compound, Senecrassidiol
Swarna Hapuarachchi Thusharie Suresh Shiroma Hadunnetthi Wathuge Thamara Priyanthie Sandun Senarath Chandani Ranasinghe

10.30495/tpr.2022.1962166.1265

This study was designed to evaluate in vivo and in vitro anti-inflammatory potential of the different extracts of Munronia pinnata and compare it with the isolated compound, Senecrassidiol by using the carrageenan-induced paw edema animal model in Wistar rats. Munronia چکیده کامل

This study was designed to evaluate in vivo and in vitro anti-inflammatory potential of the different extracts of Munronia pinnata and compare it with the isolated compound, Senecrassidiol by using the carrageenan-induced paw edema animal model in Wistar rats. Munronia pinnata (Wall) Theob (Meliaceae) has been traditionally practiced for hundreds of years by traditional physicians as a home remedy for the treatment of inflammatory conditions in folk medicine in Sri Lanka. The tested ethyl acetate fractions of methanol extract and its isolated compound senecrassidiol exhibited significant anti-inflammatory activity in the tested models. It demonstrated the scientific rationale for the use of an anti-inflammatory agent in folk medicine. The MPaq showed a significant (p < 0.5) inhibition of infiltration of rat peritoneal cells, inhibition of NO production by rat peritoneal cells, and inhibition of membrane stabilization as well as the anti-histamine activity which are the probable anti-inflammatory mechanisms. پرونده مقاله

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12 - Molecular docking, anti-inflammatory, antimicrobial and antioxidant evaluation of Pterospermum rubiginosum B. Heyne
Rajamohanan Anish Fathima Rumaisa Thankamani Aswathy Velappan Nair Kalpana Arun Rauf

10.30495/tpr.2023.1977515.1316

Pterospermum rubiginosum B.Heyne ex G.Don (PR) is a traditional medicinal plant used by the tribal people of the Western Ghats to treat bone fractures, inflammation, and sprain. Being an under-explored medicinal plant, the mechanism behind the anti-inflammatory activity چکیده کامل

Pterospermum rubiginosum B.Heyne ex G.Don (PR) is a traditional medicinal plant used by the tribal people of the Western Ghats to treat bone fractures, inflammation, and sprain. Being an under-explored medicinal plant, the mechanism behind the anti-inflammatory activity of PR is unknown to the scientific community. FTIR analysis was done to recognize the functional groups in PR bark extract, and LCMS elucidated the phytochemical characterization. Molecular docking studies showed an excellent ligand and protein (inflammatory mediators) binding and their interactive mechanism. Total phenolic and total flavonoid contents were found to be 46.7 and 37.4 g/100 g for PRME. PRME showed hydrogen peroxide and DPPH (1,1diphenyl-2-picryl hydrazyl) radical scavenging activity with IC50 values of 48.33 and 42.70 µg/mL, respectively. Gene expression study of COX-1 and COX-2 enzymes confirmed the anti-inflammatory activity of PRME. The present study justifies the potential use of PR in the traditional medicine as an anti-inflammatory agent. پرونده مقاله

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13 - The anti-inflammatory and antitumor potential of Cryptocarya concinna Hance and its phytoconsituents
Christian Bailly Gerard Vergoten

10.30495/tpr.2022.1970912.1283

The tree Cryptocarya concinna Hance is largely distributed in southeast Asia and essentially used for its robust wood. Alcoholic extracts made from the leaves or roots of the plant have revealed anti-inflammatory and anticancer properties. The DNA-damaging dihydrochalco چکیده کامل

The tree Cryptocarya concinna Hance is largely distributed in southeast Asia and essentially used for its robust wood. Alcoholic extracts made from the leaves or roots of the plant have revealed anti-inflammatory and anticancer properties. The DNA-damaging dihydrochalcone derivative cryptocaryone accounts for the anti-proliferative and pro-apoptotic activities observed with the extracts. Other bioactive products have been isolated, including α-pyrone derivatives such as cryptoconcatones A-L and flavonoids such as cryptoconones A-E. A structural analogy is underlined between cryptoconcatone D and two known compounds with an α,β-unsaturated δ-lactone: pironetin and the styryl-lactone goniothalamin which targets the peroxisomal protein MFE2 (multifunctional enzyme type2). Pironetin is a potent α-tubulin binder with robust anticancer properties. By analogy, the binding of cryptoconcatone D to the pironetin-site of α-tubulin is proposed. The review shed light on the phytochemical constituents of Cryptocarya concinna and the biological properties of α,β-unsaturated lactone compounds isolated from this little studied plant. پرونده مقاله

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14 - Anti-inflammatory and Analgesic Effects of Aqueous Extracts of Vitex agnus castus L. and Cymbopogon nardus L. Against Carrageenan-Induced Inflammatory Inflammation in Rats
Fatima El Kamari Driss Ousaaid Laila Lahrizi Abdelfattah El Moussaoui Badiaa Lyoussi

Vitex agnus cactus and Cymbopogon nardus are widely used in traditional and conventional medicine as natural anti-inflammatory agents. Within this framework, the current study was undertaken to examine in vivo the anti-inflammatory and analgesic effects of aqueous extra چکیده کامل

Vitex agnus cactus and Cymbopogon nardus are widely used in traditional and conventional medicine as natural anti-inflammatory agents. Within this framework, the current study was undertaken to examine in vivo the anti-inflammatory and analgesic effects of aqueous extracts of the leaves and seeds of V.agnus and C.nardus. To do this, aqueous extracts of the leaves and fruits of V.agnus and C.nardus were prepared. The inflammatory process was induced using the carrageenan method. The analysis of the obtained results revealed that the aqueous extract of leaves of V.agnus exhibited the highest antioxidant content (80.22±11.7 mg GAE/g for TPC, 72.14±9 mg RE/g for TFC, 680±19.6 mg QE/g for flavones and flavonols, 355.33±23.36 mg AAE/g for TAC, 0.33±0.04 mg/ml for IC50-DPPH, and 0.97±0.04 mg/ml for EC50-FRAP) and anti-inflammatory effect with dose-dependent manner. These results show that these plants can reduce pain and inflammation when used therapeutically. پرونده مقاله

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15 - A review on biosynthesis, regulation, and applications of terpenes and terpenoids
Anjali Singh Dhananjay Singh Sapna Sharma Nishu Mittal

10.30495/tpr.2023.1989410.1358

Essential oils (EOs) are concentrated liquids extracted from various parts of plants and can be classified based on their phytochemical compounds. Terpenes and terpenoids have a wide range of biological activities, including anticancer, anti-inflammatory, antimicrobial, چکیده کامل

Essential oils (EOs) are concentrated liquids extracted from various parts of plants and can be classified based on their phytochemical compounds. Terpenes and terpenoids have a wide range of biological activities, including anticancer, anti-inflammatory, antimicrobial, antioxidant, and antiallergic properties. Terpenes are plant-based compounds commonly used in the pharmaceutical, food, biofuel, and chemical industries by humans. In synthetic biology, genomic resources and emerging tools facilitate the production of high-quality terpenoids in plants and microbes. Terpenoids, however, are difficult to produce in large quantities due to their complex chemical structures and the limited amounts found in plants. The regulation of terpenoid biosynthesis has gradually emerged as a research priority. This review presents an overview of the biological activities, synthesis pathways, and key enzymes involved in the biosynthetic pathways and regulation of terpenes or terpenoids. This review will also include references for further research on molecular regulation, biological advancements, and increasing the content of terpenes or terpenoids in plants. پرونده مقاله

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16 - Phytochemical study and anti-inflammatory activity of the roots of Mangifera indica L. in lipopolysaccharide (LPS)-stimulated peritoneal macrophages
Yolande Nangue Eulogio José Llorent-Martínez Maria Luisa Fernández-de Córdova Douglas Alphonse M. Ngangoum Télesphore Benoit Nguelefack Anatole Guy Blaise Azebaze Alain Bertrand Dongmo

This study deals with the identification of secondary metabolites of methanol extract of the roots of Mangifera indica L and the assessment of plant in vitro anti-inflammatory activity. High-performance liquid chromatography with electrospray ionization mass spectrometr چکیده کامل

This study deals with the identification of secondary metabolites of methanol extract of the roots of Mangifera indica L and the assessment of plant in vitro anti-inflammatory activity. High-performance liquid chromatography with electrospray ionization mass spectrometric detection (HPLC-ESI-MSn) using the negative ion mode was performed to establish the chromatographic fingerprint and identify various chemical components of the plant extract. The anti-inflammatory effect of the MeOH extract (3, 30 and 300 μg/mL) was assessed through cell viability and nitric oxide (NO) production on non-stimulated and LPS-stimulated peritoneal macrophages. Phytochemical analysis indicated the presence of a number of phenolic compounds where galloyl derivatives, mangiferin and its derivatives were the major constituents. The methanol extract exhibited significant concentration-dependent inhibitory effect on NO production, both on stimulated and non-stimulated macrophages. The concentration 300 μg/mL showed significant cell toxicity. The methanol extract of Mangifera indica is rich in phenolic compounds and possesses potent in vitro anti-inflammatory activity, but its higher concentrations are cytotoxic. پرونده مقاله

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17 - Anti-Inflammatory/Bacteria Potential of Gelatin/ZnO Nano Fiber Scaffold
Hamed Zare Shahnaz Nayebzadeh Abolfazl Davodiroknabdi Seyedhasan Hataminasab

10.30495/ijtnbm.2023.1976229.1019

Based on healthy properties of gelatin, strengthening it for using as multi functional material is essential. In this paper nano scaffold of gelatin was doped with nano zinc oxide (ZnO) (with different percent) and electrospun. The morphology of obtained nano scaffold w چکیده کامل

Based on healthy properties of gelatin, strengthening it for using as multi functional material is essential. In this paper nano scaffold of gelatin was doped with nano zinc oxide (ZnO) (with different percent) and electrospun. The morphology of obtained nano scaffold was study by Field Emission Scanning Electron Microscope (F E S E M) and elemental mapping proved the present and distribution of nano zinc oxide (ZnO) in scaffold. Also, X ray Fluorescence (XRF) test was done to confirm the amount of used nano material. The anti bacterial property of the obtained scaffold was investigated against both gram negative and gram positive bacteria (Shigella and Staphylococcus Aureus respectively) and the results show that the nano scaffold has more than 96% anti bacterial property. On the other hands, the anti inflammatory effect of nano scaffold was investigated on rats and the results illustrated that nano scaffold is effective for edema decrease. پرونده مقاله

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18 - بررسی مقایسه‌ای خواص فیتوشیمیایی، آنتی‌اکسیدانی و ضدالتهابی عصاره گیاهان شوید، زیره سیاه، بومادران و میخک
روح الله فرامرزی دوزین افشین کریمی احسان کریمی‌ احسان اسکوئیان محسن قاسمی

10.30495/ejmp.2021.1936350.1644

این آزمایش به منظور مقایسه و ارزیابی خاصیت فیتوشیمیایی، آنتی اکسیدانی و ضدالتهابی عصاره های شوید[1]، زیره سیاه[2]، بومادران[3]، و میخک[4] در قالب یک طرح کامل تصادفی در مرکز تحقیقات و آموزش کشاورزی و منابع طبیعی مشهد در سال 1400 انجام شد. عصاره متانولی گیاهان به روش رفلا چکیده کامل

این آزمایش به منظور مقایسه و ارزیابی خاصیت فیتوشیمیایی، آنتی اکسیدانی و ضدالتهابی عصاره های شوید[1]، زیره سیاه[2]، بومادران[3]، و میخک[4] در قالب یک طرح کامل تصادفی در مرکز تحقیقات و آموزش کشاورزی و منابع طبیعی مشهد در سال 1400 انجام شد. عصاره متانولی گیاهان به روش رفلاکس استخراج و با استفاده از کروماتوگرافی مایع با کارایی بالا (HPLC) ترکیبات شیمیایی آنها آنالیز شد. فنل کل و ظرفیت آنتی اکسیدانی عصاره ها به ترتیب از طریق فولین-سیکالتو و رادیکال های آزاد DPPH و نیتریک اکسید (NO) بررسی و سپس پتانسیل عصاره ها در مهار آنزیم های زانتین اکسیداز، هیالورونیداز، استیل کولین استراز، الاستاز و تیروزیناز بررسی گردید. نتایج نشان داد که بیشترین میزان فنل کل (40/9 mg GAE/g.DW ) و ساپونین (94/8 mg diosgenin /g.DW) در عصاره میخک و کمترین میزان فنل کل ( mg GAE/g.DW 2/7) و ساپونین (mg diosgenin /g.DW 7/72) در عصاره بومادران مشاهد شد. نتایج ارزیابی HPLC نشان داد که غلظت ترکیبات فنولیکی در عصاره گیاه میخک در مقایسه با بقیه عصاره های گیاهی بیشتر بود. عصاره گیاه میخک در مقایسه با بقیه عصاره _های مورد بررسی خاصیت آنتی اکسیدانی قویتری داشت به طوری که مقادیرIC50 بدست آمده برای عصاره میخک از دو روش DPPH و NO به‌ترتیب برابر μg/ml 82/95 وμg/ml 104/34 بود. سه عصاره میخک، بومادران و زیره سیاه به‌ترتیب در غلظت‌های 55/3 μg/ml ، 98/5 μg/ml و 198 μg/ml بیشترین اثر گذاری را بر روی مهار آنزیم زانتین اکسیداز داشتند. نتایج حاصل از خاصیت ضدالتهابی نشان داد که که عصاره گیاه میخک با بیش از 61 درصد، بالاترین مهار نیتریت اکساید را نشان داد. به نظر می رسد عصاره میخک این پتانسیل را دارد که به عنوان ماده ضدالتهاب، روشن کننده پوست و جلوگیری کننده از چروک پوست مورد استفاده قرار گیرد. پرونده مقاله

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19 - آنالیز این-سیلیکو از فضای برهمکنش شیمیایی ایجاد شده توسط دیکلوفناک سدیم و رسپتورهای کوروم سنسینگ Las در سودوموناس آئروژینوزا
شیرین شاهنگیان

10.30495/bioem.2024.2004055.1025

بیشتر خصوصیات بیماری زایی سودوموناس آئروژینوزا که یک باکتری گرم منفی فرصت طلب است، توسط سیستم های سنجش حد نصاب آن کنترل می شود. بنابراین، مسدود کردن مسیرهای سنجش حد نصاب می تواند به عنوان یک استراتژی مناسب برای مقابله با سودوموناس آئروژینوزا استفاده شود. داروهای ضد الته چکیده کامل

بیشتر خصوصیات بیماری زایی سودوموناس آئروژینوزا که یک باکتری گرم منفی فرصت طلب است، توسط سیستم های سنجش حد نصاب آن کنترل می شود. بنابراین، مسدود کردن مسیرهای سنجش حد نصاب می تواند به عنوان یک استراتژی مناسب برای مقابله با سودوموناس آئروژینوزا استفاده شود. داروهای ضد التهاب غیر استروئیدی از جمله محبوب ترین مواد شیمیایی مورد استفاده در درمان عفونت های میکروبی هستند. در مطالعه حاضر، فضای برهمکنش شیمیایی دیکلوفناک سدیم، یک داروی ضدالتهاب غیراستروئیدی معروف، در مقابله با دو گیرنده اصلی سیستم سنجش حد نصاب در سودوموناس آئروژینوزا (LasI و LasR) بررسی شده است. ساختارهای بهینه شده لیگاندها و گیرنده‌ها با استفاده از AutoDock Vina که بخشی از نرم‌افزار PyRx است، تحت شبیه‌سازی داکینگ مولکولی قرار گرفتند. نتایج به ‌دست‌آمده از داکینگ مولکولی و تحلیل فضای برهمکنشی، انرژی‌های اتصال مناسبی را برای دیکلوفناک سدیم در مقابله با هر دو گیرنده نشان داد. اگرچه، انرژی اتصال دیکلوفناک سدیم برای گیرنده LasR منفی تر بود که نشان دهنده میل ترکیبی بالاتر دیکلوفناک سدیم برای این گیرنده است. در نهایت، بر اساس نتایج بدست آمده، پیشنهاد می‌شود که دیکلوفناک سدیم پتانسیل خوبی برای اتصال به هر دو گیرنده دارد، که این به نوبه خود می تواند با کاهش بیان برخی از ژن های مربوط به فاکتورهای بیماری زایی همراه باشد. بنابراین، دیکلوفناک سدیم را می توان به عنوان یک مهارکننده بالقوه برای سیستم حد نصاب در سودوموناس آئروژینوزا در نظر گرفت. پرونده مقاله

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20 - Analgesic and anti-inflammatory activities of Zea mays leaves
جود اکوکون کوفره دیویز باسی آنتیا

Background & Aim:Zea mays leaf used traditionally in Ibibio ethno medicine in Southern Nigeria to treat malaria and other inflammatory diseases. These anti-inflammatory and analgesic properties were evaluated against experimentally induced inflammation and pains usi چکیده کامل

Background & Aim:Zea mays leaf used traditionally in Ibibio ethno medicine in Southern Nigeria to treat malaria and other inflammatory diseases. These anti-inflammatory and analgesic properties were evaluated against experimentally induced inflammation and pains using standard models. Experimental: The effects of ethanol leaf extract of Zea mays (170 -510 mg/kg) on experimentally induced inflammation and pain were studied in rats using Carrageenin, egg albumin and xylene-induced inflammation as well as acetic acid-induced writhing and thermal induced pain models. The GCMS analysis of the most active fraction was carried out. Results: The extract (170 -520 mg/kg) inhibited inflammation and pains caused by different phlogistic agents used in a dose dependent fashion. The various degrees of inhibitions were statistically significant (p<0.05, 0.01, 0.001), though incomparable to that of the standard drugs used (ASA and indomethacin). The GC-MS revealed the present of polyunsaturated fatty acids and phenolic compounds which may be responsible for the observed activities of the extract. Recommended applications/industries: The present study demonstrates that leaf extract of Zea mays might to be useful for the treatment of inflammation and pains. پرونده مقاله

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21 - The antinociceptive and anti-inflammatory effects of hydro alcoholic extract of Satureja bachtiarica on mouse
فیروزه سقایی صادق معتمدی

10.14196/JHD.2018.179

Background & Aim: The use of anti-nociceptive and anti-inflammatory drugs in clinical medicine is necessary and unavoidable. Since the use of synthetic drugs is associated with numerous side effects, the application of complementary therapies such as herbal medicine چکیده کامل

Background & Aim: The use of anti-nociceptive and anti-inflammatory drugs in clinical medicine is necessary and unavoidable. Since the use of synthetic drugs is associated with numerous side effects, the application of complementary therapies such as herbal medicine can accompany with less side effects while having anti-inflammatory and analgesic properties. Satureja bachtiarica contains different active compounds such as Thymol, Para syman, Menton and Carvacrol which may be involved in the control of nociception and/or inflammation. Experimental: 75 male mice (weighing 30 -20 g) were divided to 15 groups. Analgesic and anti-inflammatory effects of hydroalcoholic Satureja bachtiarica extract at doses of 400, 600, 800 mg/kg were evaluated by writhing, formalin and xylene tests. Morphine (10 mg /kg) and dexamethasone (10 mg/kg) were considered as positive controls in analgesic and anti-inflammatory tests, respectively. Results & Discussion: Different doses of hydroalcoholic extract of Satureja bachtiarica significantly reduced pain in comparison to control groups, however, the anti-inflammatory effect of this drug evaluated by xylene test, has not been established which needs further examination through other tests. Industrial / Practical recommendation: According to present results, the analgesic effect of Satureja bachtiarica was comparable to morphine. However, it seems that further research is needed in the future to take advantage of this plant in relieving pain. پرونده مقاله

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22 - Anti-inflammatory and antimicrobial studies of biosensitive Knoevenagel condensate β-ketoanilide Schiff base and its Co(II), Ni(II), Cu(II) and Zn(II) complexes
Natarajan Raman Ramaraj Jeyamurugan Jeyasekaran Joseph

A new series of transition metal complexes of Co(II), Ni(II), Cu(II) and Zn(II), has beensynthesized from the Knoevenagel condensate Schiff base ligand(L) derived from β-ketoanilideand furfural with o-phenylenediamine and diethylmalonate. Structural features were d چکیده کامل

A new series of transition metal complexes of Co(II), Ni(II), Cu(II) and Zn(II), has beensynthesized from the Knoevenagel condensate Schiff base ligand(L) derived from β-ketoanilideand furfural with o-phenylenediamine and diethylmalonate. Structural features were determinedby spectral and analytical techniques. Square-planar geometry has been adopted by thecomplexes except cobalt complex which has an octahedral geometry. The synthesized ligand andits complexes were screened for their anti-inflammatory activity in male albino rats(Carrageenan-induced rat paw oedema model). Among these complexes, copper complex showssignificant anti-inflammatory activity. It exhibits significant dose dependent activity in acuteinflammation. The doses of 100 and 200 mg kg-1 bw produced 38.3 % and 42.8 % inhibitionrespectively after 3 h as compared with that of the standard drug (indomethacin) which showed48.5 % inhibition. The in vitro antimicrobial activity of the ligand and its complexes wasmonitored by disc diffusion method. It has been found that complexes have higher antimicrobialactivity than that of free ligand. پرونده مقاله

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23 - Comparing the Effect of Herbal Drugs and Non-steroidal Anti-Inflammatory Drugs on Primary Dysmenorrhea in Iran: a Systematic Review and Meta-Analysis
Razhan Chehreh Kourosh Sayehmiri Masoumeh shohani Saeed Vahidnia Hamed Tavan

10.22034/jchr.2020.1882587.1061

Several studies have been conducted to investigate the effects of herbal drugs and Non-steroidal anti-inflammatory drugs on the primary dysmenorrhea, but their results have been different.The aim of this study was to compare the effects of herbal drugs and NSAIDon the p چکیده کامل

Several studies have been conducted to investigate the effects of herbal drugs and Non-steroidal anti-inflammatory drugs on the primary dysmenorrhea, but their results have been different.The aim of this study was to compare the effects of herbal drugs and NSAIDon the primary dysmenorrheausing meta-analysis method.A literature search was conducted in Scopus, Pub med, and Google scholar databases from1996 to December 2016 in English and Persian languages using the search keywordsof primary dysmenorrhea combined with herbal and NSAID. The random effect model was adoptedto combine the results of the studies, and I2 index was used to check heterogeneity. One hundred and ninety-nine studies were obtained, and after reading the abstracts, 21 articles were included in the study. The total number of samples was 2041 people. The standard mean difference(SMD)betweenherbal drugs and Non-steroidal anti-inflammatory drugs in the pain reduction in the first intervention was estimated atSMD= 0.2(95%CI:(-0.340.74 ), z=0.73, p=0.463), and in second intervention it was SMD=-0.59(95%CI: (-1.650.47),Z=1.09 and p=0.278). also, the SMD for the duration of menstrual variable SMD=0.18(95%CI:( 0.02 0.34) , z=2.20, p=0.027) in favor of NSAID drugs and interval cycle of menstrual variable was SMD=0.07(95%CI:(-0.140.28), z=0.68, p=0.496).Mean difference of pain intensity reduced relatively better by administering herbal medicines, which is supported by the majority of studies, and the herbal drugs were found to be more effective than the NSAIDs drugs. Finally, given the many side effects of non-steroidal anti-inflammatory drugs, herbal drugs can be used at the standard dosageand considering the side effects. پرونده مقاله

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24 - ارزیابی خواص ضد اکسیدانی، ضد التهابی و ضد باکتریایی نانوذرات پلی‌لاکتیک کو گلیکولیک اسید (PLGA) بارگذاری شده با عصاره دود عنبرنسارا
رویا مهدی زاده محسن فیروزرای مسعود همایونی تبریزی سید جواد حسینی

10.22034/ascij.2023.1979768.1465

هدف از این مطالعه سنتز و بررسی اثرات ضد اکسیدانی، ضد التهابی و ضد باکتریایی نانوذرات پلی لاکتیک کو گلیکولیک اسید (PLGA) حاوی عصاره دود عنبرنسارا است. برای این منظور دود عنبر نسا با استفاده از روش W1/O/W2 توسط نانوذرات PLGA محصور شد و با تکنیک‌های DLS، پتانسیل زتا، FESEM چکیده کامل

هدف از این مطالعه سنتز و بررسی اثرات ضد اکسیدانی، ضد التهابی و ضد باکتریایی نانوذرات پلی لاکتیک کو گلیکولیک اسید (PLGA) حاوی عصاره دود عنبرنسارا است. برای این منظور دود عنبر نسا با استفاده از روش W1/O/W2 توسط نانوذرات PLGA محصور شد و با تکنیک‌های DLS، پتانسیل زتا، FESEM و میکروسکوپ الکترونی FTIR مشخص شد. فعالیت ضد اکسیدانی نانوذرات سنتز شده با استفاده از تست های ABTS و FRAP و همچنین اندازه گیری سطح بیان ژن‌های آنتی اکسیدانی کاتالاز (CAT) و سوپراکسید دیسموتاز (SOD) و بیان اینترلوکین 6 (IL-6) و اینترلوکین 10 IL-10)) همچنین برای تعیین پتانسیل ضد التهابی نانوذرات با آزمون Real time PCR مورد تجزیه و تحلیل قرار گرفت. فعالیت ضد باکتریایی نانوذرات سنتز شده بر روی دو سویه باکتریایی اشریشیا کلی و باسیلوس سوبتیلیس مورد ارزیابی قرار گرفت. نتایج تشکیل نانوذراتی کروی با متوسط اندازه 2/51 نانومتر، شاخص پراکندگی 22/0، دارای شارژ سطحی 37/35- میلی ولت و راندمان کپسوله سازی 74 درصد را نشان داد. خواص ضد اکسیدانی نانوذرات PLGA سنتز شده با کاهش Fe+3، مهار تشکیل رادیکال‌های آزاد و افزایش سطح بیان ژن‌های CAT و SOD تایید گردید. سطح بیان IL-6 و IL-10 نیز تحت تأثیر نانوذرات PLGA بارگذاری شده با عصاره آلی دود عنبرنسارا افزایش یافت که نشان دهنده خواص ضد التهابی نانوذرات پیشنهادی است. نانوذرات PLGA بارگذاری شده با عصاره آلی دود عنبرنسارا بر باکتری Bacillus subtilis اثر ضد باکتریایی داشت، اما بر E. coli تأثیری نداشت. نانوذرات PLGA بارگذاری شده با عصاره آلی دود عنبرنسارا دارای خواص ضد اکسیدانی، ضد التهابی است و می‌تواند به عنوان ترکیبی با پتانسیل ضد بکتریایی در نظر گرفته شود. پرونده مقاله

دسترسی آزاد مقاله

25 - بررسی اثرات ضددردی و ضدالتهابی عصاره الکلی برگ اسفناج (Spinacia oleraceal) در موش کوچک آزمایشگاهی NMRI
سمیه میرعزیزی غلامحسن واعظی علی حائری روحانی

طبق تحقیقات انجام شده، عصاره اسفناج اثرات فارماکولوژیکی متنوعی از قبیل ضدالتهابی، آنتی‌اکسیدانی و ضداضطرابی دارد. مطالعه حاضر به بررسی اثر ضددردی و ضدالتهابی عصاره اتانولی برگ اسفناج در موش کوچک آزمایشگاهی نر بالغ با استفاده از آزمون فرمالین، صفحه داغ وآزمون زایلن می‌پر چکیده کامل

طبق تحقیقات انجام شده، عصاره اسفناج اثرات فارماکولوژیکی متنوعی از قبیل ضدالتهابی، آنتی‌اکسیدانی و ضداضطرابی دارد. مطالعه حاضر به بررسی اثر ضددردی و ضدالتهابی عصاره اتانولی برگ اسفناج در موش کوچک آزمایشگاهی نر بالغ با استفاده از آزمون فرمالین، صفحه داغ وآزمون زایلن می‌پردازد. در این پژوهش که روی 36 موش کوچک آزمایشگاهی نر بالغ نژاد NMRI با وزن 25 تا30 گرم انجام شد، حیوانات به طور تصادفی به 6 گروه 6تایی شامل: گروه کنترل (سالم)، گروه شاهد (دریافت‌کننده نرمال سالین) و همچنین سه گروه دریافت‌کننده دوزهای 150، 300 و 600 میلی‌گرم بر کیلوگرم وزن بدن عصاره اتانولی برگ اسفناج وگروه استاندارد (دریافت‌کننده دگزامتازون با دوز 10 میلی‌گرم بر کیلوگرم یا مورفین با دوز 10 میلی‌گرم بر کیلوگرم) تقسیم شدند. پس از انجام تیمار حیوانات به وسیله آزمون فرمالین و هات پلیت از نظر واکنش به درد، مورد بررسی قرار گرفتند. همچنن فعالیت ضدالتهابی توسط آزمون زایلن یا التهاب گوش در حیوان بررسی گردید. تمامی داده‌ها از نظر آماری با استفاده از آنالیز واریانس یک‌طرفه و سپس آزمون توکی مقایسه و بررسی شدند. نتایج این مطالعه نشان داد که عصاره اتانولی برگ اسفناج موجب کاهش معنی‌دار درد در فاز مزمن تست فرمالین و تست صفحه داغ می‌شود. همچنین عصاره اتانولی برگ اسفناج درآزمون ادم گوش دارای فعالیت معنادار ضدالتهابی است. تحقیق حاضر نشان داد عصاره اتانولی برگ اسفناج دارای خواص ضددردی و ضدالتهابی در موش کوچک آزمایشگاهی است. پرونده مقاله

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26 - Anti-inflammatory and analgesic effects of aqueous extracts of Vitex agnus cactus L. and Cymbopogon nardus L. against carrageenan-induced inflammation in rats
Fatima El Kamari Driss Ousaaid Laila Lahrizi Abdelfettah El Moussaoui Badiaa Lyoussi

Vitex agnus cactus and Cymbopogon nardus are widely used in traditional and conventional medicine as natural anti-inflammatory agents. Within this framework, the current study was undertaken to examine in vivo the anti-inflammatory and analgesic effects of aqueous extra چکیده کامل

Vitex agnus cactus and Cymbopogon nardus are widely used in traditional and conventional medicine as natural anti-inflammatory agents. Within this framework, the current study was undertaken to examine in vivo the anti-inflammatory and analgesic effects of aqueous extracts of the leaves and seeds of V. agnus cactus and C. nardus. In this relation, aqueous extracts were prepared from the leaves and fruits of V. agnus cactus and the leaves of C. nardus. The inflammatory process was induced using the carrageenan method. The analysis of the obtained results revealed that the aqueous extract of leaves of V. agnus cactus exhibited the highest antioxidant content (80.22 ± 11.7 mg GAE/g for TPC, 72.14 ± 9 mg RE/g for TFC, 680 ± 19.6 mg QE/g for flavones and flavonols, 355.33 ± 23.36 mg AAE/g for TAC, 0.33 ± 0.04 mg/mL for IC50-DPPH, and 0.97 ± 0.04 mg/mL for EC50-FRAP) and anti-inflammatory effect with dose-dependent manner. These results suggest that these plants have the potential to alleviate pain and inflammation when used for therapeutic purposes. پرونده مقاله

فهرست مقالات Anti-inflammatory

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