Anti-inflammatory potential of aqueous extract and ethyl acetate fractions of Munronia pinnata (Wall) Theob. and the isolated compound, Senecrassidiol
محورهای موضوعی : Natural Products: Isolation and Characterization
Swarna Hapuarachchi
1
(Unit of Pharmacology and Pharmaceutics, Department of Ayurveda, Institute of Indigenous Medicine, University of Colombo, Sri Lanka)
Thusharie Suresh
2
(Department of Biochemistry, Faculty of Medical Sciences, University of Sri Jayewardenepura, Sri Lanka)
Shiroma Hadunnetthi
3
(Institute of Biochemistry, Molecular Biology, and Biotechnology, University of Colombo, Sri Lanka)
Wathuge Thamara Priyanthie Sandun Senarath
4
(Department of Botany, Faculty of Applied Sciences, University of Sri Jayewardenepura, Sri Lanka)
Chandani Ranasinghe
5
(Department of Chemistry, Faculty of Natural Sciences, The Open University of Sri Lanka)
کلید واژه: <i>Munronia pinnata</i>, Wistar Rats, Anti-inflammatory, Membrane stabilization, Folk medicine, Senecrassidiol,
چکیده مقاله :
This study was designed to evaluate in vivo and in vitro anti-inflammatory potential of the different extracts of Munronia pinnata and compare it with the isolated compound, Senecrassidiol by using the carrageenan-induced paw edema animal model in Wistar rats. Munronia pinnata (Wall) Theob (Meliaceae) has been traditionally practiced for hundreds of years by traditional physicians as a home remedy for the treatment of inflammatory conditions in folk medicine in Sri Lanka. The tested ethyl acetate fractions of methanol extract and its isolated compound senecrassidiol exhibited significant anti-inflammatory activity in the tested models. It demonstrated the scientific rationale for the use of an anti-inflammatory agent in folk medicine. The MPaq showed a significant (p < 0.5) inhibition of infiltration of rat peritoneal cells, inhibition of NO production by rat peritoneal cells, and inhibition of membrane stabilization as well as the anti-histamine activity which are the probable anti-inflammatory mechanisms.
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