Phytochemical composition, antioxidant, and anti-inflammatory activities of essential oil of Acmella uliginosa (Sw.) Cass. grown in North India Terai region of Uttarakhand
محورهای موضوعی : Natural Products: Isolation and Characterization
Kanchan Gairola
1
(Department of Biochemistry, G. B. Pant University of Agriculture and Technology, Pantnagar-263145, Uttarakhand, India)
Shriya Gururani
2
(Department of Biochemistry, G. B. Pant University of Agriculture and Technology, Pantnagar-263145, Uttarakhand, India)
Ravendra Kumar
3
(Department of Chemistry, G. B. Pant University of Agriculture and Technology, Pantnagar-263145, Uttarakhand, India)
Om Prakash
4
(Department of Chemistry, G. B. Pant University of Agriculture and Technology, Pantnagar-263145, Uttarakhand, India)
Sanjeev Agarwal
5
(Department of Biochemistry, G. B. Pant University of Agriculture and Technology, Pantnagar-263145, Uttarakhand, India)
Shiv Dubey
6
(Department of Biochemistry, G. B. Pant University of Agriculture and Technology, Pantnagar-263145, Uttarakhand, India)
کلید واژه: Essential oil, <i>Acmella uliginosa</i> (Sw.) Cass, Limonene, Anti-inflammatory activity, antioxidant activity,
چکیده مقاله :
The plant Acmella uliginosa (Sw.) Cass. belonging to family Asteraceae was subjected to hydro distillation for essential oil extraction and was chemically analyzed by GC/MS for its phytochemical composition. Thirty-five compounds were identified comprising 88.1% of total essential oil composition. Limonene (12.2%) along with sesquisabinene isomer (7.3%) and caryophyllene oxide (5.9%) were the prominent compounds of the essential oil. In-vitro antioxidant activity of essential oil was investigated by DPPH free radical scavenging activity and metal chelating activity having IC50 value of 326.77 ± 5.34 μL and 14.853 ± 0.106 μL respectively whereas reducing power activity having RP50 value of 14.011 ± 0.0446 μL. The essential oil exhibited potent anti-inflammatory activity with IB50 value of 5.629 ± 0.0311 μL compared to standard Diclofenac sodium salt having IB50 value of 23.693 ± 0.306 μg/mL. The essential oil displayed exceedingly marked anti-inflammatory as well as antioxidant activities as compared to standard marketed drugs.
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