-
Open Access Article
1 - Adsorption Study of the Lysozyme from aqueous solution onto Hydroxyapatite Nanopowders
O. Moradi K. Zare -
Open Access Article
2 - Thermodynamic Study of Hg(II) Ion Adsorption onto Nano Hydroxyapatite from Aqueous Solution
S. Ghasemlou H. Aghaie M. Monajjemi -
Open Access Article
3 - Evaluation of β-tricalciumphosphate (β-TCP) nanocomposite granules compared with nanocomposite hydroxyapatite (HA) on healing of segmental femur bone defect in rabbits
Eftekhari, H., Jahandideh, A., Asghari, A., Akbarzadeh, A., Hesaraki, S. .The loss of bone fragments, often due to trauma, infection, mass loss, or even complete bone regeneration after complicated fractures, is one of the constant challenges in medicine and veterinary medicine. Over the last decades, many efforts have been made to obtain mat MoreThe loss of bone fragments, often due to trauma, infection, mass loss, or even complete bone regeneration after complicated fractures, is one of the constant challenges in medicine and veterinary medicine. Over the last decades, many efforts have been made to obtain materials that have the potential for high bone regeneration and to replace alternatives to autograft or zenografts. In this study, 45 adult male New Zealand male rabbits weighing 3-5 mg/kg, randomly divided into 3 groups of 15, were used. During surgery on the femur of each rabbit, a bilateral, 6 mm diameter defect was created. In the first group (control), no substance was used, in the second group, hydroxyapatite, and in the third group, nanocomposite tri-calcium phosphate (TCP) was used to fill the defect. Bone specimens were harvested for histopathologic evaluation on days 15, 30 and 45 and for evaluation of 4 indexes of union, spongiosa, cortex and bone marrow. The results showed that the results of using nanocomposite tricalcium phosphate in comparison with other groups were significantly different in all cases. Therefore, according to the results, it can be admitted that nanocomposite tri-calcium phosphate scaffold has a positive effect on the healing process and has good bone strength, so it can be widely used in orthopedic surgery as well as tissue engineering. Manuscript profile -
Open Access Article
4 - Evaluation of the performance of titanium dioxide nanocomposite scaffold compared to hydroxyapatite on the healing of rabbit femoral bone defects
حسین Sonbolekar علیرضا Jahandideh احمد Asghari سعید Hesaraki, ابوالفضل Akbarzadeh,This study was conducted with the aim of investigating the effectiveness of titanium dioxide nanocomposite scaffolds for the reconstruction of femur defects in rabbits. To investigate the effect of nanocomposites on the healing processes of broken bone (bone defect). 18 MoreThis study was conducted with the aim of investigating the effectiveness of titanium dioxide nanocomposite scaffolds for the reconstruction of femur defects in rabbits. To investigate the effect of nanocomposites on the healing processes of broken bone (bone defect). 18 New Zealand adult male white rabbits weighing 3 kg were studied. A cylindrical defect with a diameter of 6 x 5 mm was created in the femur of rabbits. The animals were divided into three experimental groups. The experimental groups after the defect were created included control, control (hydroxyapatite) and treatment (titanium dioxide). On the 15th and 45th days after surgery, the animals were killed and a sample was taken from the bone defect site and placed in 10% buffered formalin. 5 μm sections were evaluated after general and trichrome staining. Improvement of inflammation on day 15 and formation of new bone on day 45 in the nanocomposite group was the best in terms of ossification repair unit and reduction of inflammation. Nanocomposite had a significant recovery function in bone regeneration of defective areas. Manuscript profile -
Open Access Article
5 - Synthesis of Hydroxyapatite-Bioglass Nanocomposite Using Modified Sol-Gel Method
M. Taherian -
Open Access Article
6 - Micro-Finite Element Model to Investigate the Mechanical Stimuli in Scaffolds Fabricated via Space Holder Technique for Cancellous Bone
Sayed Alireza Hashemi Saeid Esmaeili Mazyar Ghadirinejad Saeed Saber-Samandari Erfan Sheikhbahaei Alireza Kordjamshidi Amirsalar Khandan -
Open Access Article
7 - Geological setting of iron oxide-apatite deposits in theBafq district, central Iran with an emphasis on mineralogical,petrographic, and geochemical study of the Sechahun deposit
Azat EslamizadehThe objective of this research is to determine all processes in the magmatic evolution and related hydrothermal activities that created the volcanic rocks and associated ore-forming systems of the Bafq ‎mining district. Several iron oxide-apatite (IOA) deposits were MoreThe objective of this research is to determine all processes in the magmatic evolution and related hydrothermal activities that created the volcanic rocks and associated ore-forming systems of the Bafq ‎mining district. Several iron oxide-apatite (IOA) deposits were investigated in this area with a focus on the Sechahun ore deposit. The Bafq ‎mining district is well known for hosting significant IOA ore deposits with several million tons of iron ore and with some economic resources of rare earth elements. To achieve the goals of this research, detailed petrographic, fluid inclusion microthermometry, and lithogeochemical studies were obtained and supported by geological investigations at both local and regional scales. Textural, mineralogical, and fluid inclusion evidence indicates the ore genesis by fluid mixing. Magmatic-hydrothermal iron oxide-apatite ore precipitated during circulation of deuteric solutions within the host rocks at the early stage of mineralization. The mesothermal iron oxide ore of the Sechahun deposit was emplaced at the relatively shallow depths, while the near-surface epithermal hematite-jaspilite ore formed in a subaqueous environment. The most likely source of iron oxide-apatite mineralization would be a combined magmatic hydrothermal to convective hydrothermal model ‎with magmatism originating from the upper mantle and related bimodal volcanism resulting in felsic volcanic rocks. Rifting of the continental lithosphere during the Early Cambrian was associated with emplacement of a highly fractionated bimodal ‎magmas along the regional ‎fracture-fault lines, a major controlling factor for mineralization processes in the Bafq district. ‎ Manuscript profile -
Open Access Article
8 - Apatite Application to Investigate Magmatic Evolution of Zouzan Granites, NE Lut Block
S.A. Mazhari R. Sharifiyan AttarApatite minerals of I-type Zouzan granitoids and typical garnet-bearing S-type granites have been analyzed by electron microprobe to define trace element concentrations and compare them in different granites. Zouzan granites are composed of apatites with lower Fe, Mn, N MoreApatite minerals of I-type Zouzan granitoids and typical garnet-bearing S-type granites have been analyzed by electron microprobe to define trace element concentrations and compare them in different granites. Zouzan granites are composed of apatites with lower Fe, Mn, Na and HREE and higher REE and ∑REE relative to S-type ones. Trace elements abundances of apatite often vary with some parameters of the host rock, especially aluminum saturation index (ASI). Strontium content of apatite is very sensitive to whole-rock composition and binary diagrams of SrO- trace elements could be used to discriminate different granites and realize magmatic evolution in a single phase. The apatite concentration of Fe, Mn, Na and HREE increases during magmatic fractionation in Zouzan pluton, while Sr and REE decreases. The difference of REE concentrations in apatites of mafic and felsic rocks of Zouzan granitoids relates to the coeval or earlier crystallization of amphibole and titanite, respectively. Acicular apatites which are present in granodiorites and mafic microgranular enclaves show exceptionally dissimilar composition in comparison with other apatites in the same sample and host rock geochemistry. Extraordinary high levels of Fe, Mn, LREE, (Sr apatite /Sr bulk-rock )>1 and unusual low HREE indicate that a more mafic magma was involved in magma genesis of Zouzan pluton and confirms magma mixing Manuscript profile -
Open Access Article
9 - Geology and Mineralization of Bikilal phosphate deposit, Western Ethiopia, implication and outline of gabbro intrusion to East Africa zone
W. Mammo GhebreThe Bikilal layered gabbro-complex is composed of zones/layers of olivine/ pyroxene gabbro and hornblende gabbro. Within the hornblende gabbro, repeated lens-like thin and elongated bodies of hornblendite are found intimately associated with massive and disseminated ilm MoreThe Bikilal layered gabbro-complex is composed of zones/layers of olivine/ pyroxene gabbro and hornblende gabbro. Within the hornblende gabbro, repeated lens-like thin and elongated bodies of hornblendite are found intimately associated with massive and disseminated ilmenite-magnetite bodies, in places with apatite. Petrological examination of the hornblende gabbro shows 50-55% hornblende, 40-45% plagioclase, 5-7% opaque minerals/ilmenite + magnetite/, and 5-15% apatite and that of hornblendite shows 75% hornblende, 10-15% apatite, 10-15% ilmenite and rare sulphides, and traces of Uranium. Regardless of the type of lithological units, two main zones of phosphate mineralization ,the upper and lower zones, were identified and delineated entirely based on phosphate (P2O5) assay values of chip, channel and, core samples,The strike length of the upper zone is 1600m. There are two main layers of phosphate mineralization in the upper zone; the average thickness of each layer is 30m and 40m respectively. The strike length of the lower zone is 3000m having a thickness of 60m ─ 200m. The mineable reserve of Soji-Bikilal phosphate deposit is estimated to be 181 million tons, at a grade of 3.5% P2O5. Preliminary beneficiation trial reveals commercial grade concentrate, at which the overall weight recovery, is in the range of 3-5%. The Radioactivity of Uranium has not been determined and hence re-evaluation of the phosphate rock for Uranium content should be carried out. Similar Gabbro intrusions occur in Western Ethiopia and in East Africa which should be assessed for phosphate potential to develop the fertilizer potential of the East Africa Region. Manuscript profile -
Open Access Article
10 - Estimation of the mean grain size of mechanically induced Hydroxyapatite based bioceramics via artificial neural network
Mohammad Fahami Majid Abdellahi -
Open Access Article
11 - Hydroxyapatite Nano-Particles Extracted from Miscellaneous Bestial Resources: Study of Crystal Structure and Microstructure
Seyed Mehdi Rafiaei Mohammad Khodaei Fateme Eslami -
Open Access Article
12 - Survey and Evaluation of Diopside Nanostructure (DSN) Bioactivity in Biomedical Application
hassan gheisari -
Open Access Article
13 - Survey and Evaluation of Hardystonite Nanostructure (HTN) Bioactivity in Biomedical Engineering
hassan GHEISARIHardystonite (HT) is a monoclinic pyroxene mineral with composition Ca2ZnSi2O7. Lately, Hardystonite (HT) has been introduced as a bioceramics due to its best bioactivity and biocompatibility. It has a good strength and toughness than those of hydroxyapatite (HA). In th MoreHardystonite (HT) is a monoclinic pyroxene mineral with composition Ca2ZnSi2O7. Lately, Hardystonite (HT) has been introduced as a bioceramics due to its best bioactivity and biocompatibility. It has a good strength and toughness than those of hydroxyapatite (HA). In this project, bioactivity of hardystonite (HT) powder were evaluated and investigated. For synthesized of hardystonite (HT) powder, Zinc (Zn), calcite (CaCO3) and nano silicium (SiO2) powders was mechanically activate for different times. After that, the prepared powders were blended with ammonium chloride (NH4Cl) and put on various temperatures. In this part, for survey of bioactivity evaluation, the obtained hardystonite (HT) powders were pressed and immersed in Kukobo solution (SBF)The results indicated that nano-struacture hadystonite powder with crystalline size is 40 nm. The apatite formation ability,bioactivity and good mechanical behavior make it a good candidate in bone implant materials and open new insights in biomedical engineering. The apatite formation ability,bioactivity and good mechanical behavior make it a good candidate in bone implant materials and open new insights in biomedical engineering. Manuscript profile -
Open Access Article
14 - How we can prepare Hydroxyapatite Nano Crystal from Egg-Shell?
Hassan Gheisari -
Open Access Article
15 - Preparation and characterization of fluorapatite-bioactive glass S53P4 nanocomposite
Sahebali Manafi Fatemeh Mirjalili Mahmood Hajisafari Faranak Orand -
Open Access Article
16 - Survey and Evaluation of Diopside Nanostructure (DSN) Bioactivity in Biomedical Application
Hassan Gheisari Ebrahim Karamian Ali Soheily -
Open Access Article
17 - Evaluating the Potential of Polycaprolactone/Heparinized Nano Fluoro Hydroxyapatite Composite Scaffolds for Advancing Bone Tissue Engineering: A Comprehensive Analysis of Biodegradability and Water Absorption
Nila Haghani Nahid Hasanzadeh Nemati Mohammad Taghi Khorasani Shahin BonakdarThe primary purpose of this study is to produce a composite scaffold using polycaprolactone (PCL) and heparinized nano-fluorohydroxyapatite for cancellous bone tissue engineering. The research investigated the impact of heparinized nano-fluorohydroxyapatite particles on MoreThe primary purpose of this study is to produce a composite scaffold using polycaprolactone (PCL) and heparinized nano-fluorohydroxyapatite for cancellous bone tissue engineering. The research investigated the impact of heparinized nano-fluorohydroxyapatite particles on various properties of the scaffold, including water absorption, biodegradability, and alkaline phosphatase activity. The scaffold was produced using the phase separation (solid-liquid) method in combination with freeze-drying, and two different concentrations of heparinized nano-fluorohydroxyapatite powder were utilized. Biodegradability was assessed by submerging the scaffolds in phosphate-buffered saline for 6 weeks, showing that increased nano-fluorohydroxyapatite content enhanced biodegradability. PCL/10%w(H-nFHA50) exhibited the highest biodegradability rate. Water absorption analysis revealed that PCL scaffolds had lower water absorption compared to composite samples with heparinized nano-fluorohydroxyapatite, with PCL/10%(H-nFHA50) demonstrating the highest water absorption. Alkaline phosphatase activity was assessed on day 14 of cell culture, showing higher activity in heparinized samples compared to heparin-free samples in the presence of nano-fluorohydroxyapatite. The presence of heparin and nano-fluorohydroxyapatite in the scaffold structure likely contributed to this difference. No significant difference was observed between heparinized scaffolds with different nano-fluorohydroxyapatite concentrations. The results emphasize that the constructed scaffolds possess the potential for utilization in cancellous bone tissue engineering. Manuscript profile -
Open Access Article
18 - Porous and Bifunctional ZnO-Hydroxyapatite Nanostructure for Photocatalytic Degradation of Paracetamol and Methylene Blue in Water
Jihane Labrag Chaimaa El Bekkali Abdeladim Oulguidoum D. Robert Abdelaziz Laghzizil J. M. Nunzi -
Open Access Article
19 - Synthesis and characterization of Fe-Doped hydroxyapatite by in-situ method for use in bone tissue engineering: scaffold application, Biocompatibility and degradation studies
Maryam Maskanati hamidreza Aghabozorg Masoumeh meskinfam Fereshteh MotieiIn the present study, calcium hydroxyapatite-Fe (Fe-HAp) nanocrystalline powder was prepared from a combination of iron ions, calcium nitrate and phosphorus pentoxide by in-situ method. The properties and structure of the synthesized nanocomposite were investigated usin MoreIn the present study, calcium hydroxyapatite-Fe (Fe-HAp) nanocrystalline powder was prepared from a combination of iron ions, calcium nitrate and phosphorus pentoxide by in-situ method. The properties and structure of the synthesized nanocomposite were investigated using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), vibrating sample magnetometry (VSM), and scanning electron microscopy (SEM), and energy-dispersive spectroscopy (EDS). The obtained results confirmed that the produced powder was hydroxyapatite-iron. The morphological properties of the scaffolds also confirmed that Fe-HAp particles distributed properly in the porous structure of chitosan (CS). The obtained samples were subjected to MTT in vitro test in terms of toxicity against fibroblast cells and also for quantitative evaluation of live cells attached and grown on the scaffolds. Therefore, according to the obtained results, this scaffold can be a suitable candidate for bone tissue reconstruction applications. Manuscript profile -
Open Access Article
20 - Evaluation on cross-linked nano microbial cellulose properties as bone scaffold
نیلوفر ادیب عشق ابوسعید رشیدی امین مفتاحی -
Open Access Article
21 - Synthesis of Hydroxyapatite/Ag/TiO2 Nanotubes and Evaluation of Their Anticancer Activity on Breast Cancer Cell Line MCF-7
Sara Rahimnejad Maryam Bikhof Torbati -
Open Access Article
22 - Electrochemical Evaluation of Hydroxyapatite/ZrN Coated Magnesium Biodegradable Alloy in Ringer Solution as a Simulated Body Fluid
Seyed Rahim Kiahosseini Abdollah Afshar Majid Mojtahedzadeh Larijani Mardali Yousefpour -
Open Access Article
23 - Electrochemical behavior and bonding strength of electrophoretically deposited HA-TiO2 nanostructured coatings
حمیدرضا فرنوشIn the present study, the HA-TiO2 nanostructured composite coatings with 0, 10 and 20 wt% TiO2 were fabricated by electrophoretic deposition at 20 V for 3 min. Electrochemical corrosion behavior of the samples was conducted in SBF solution at 37oC by potentiodynamic pol MoreIn the present study, the HA-TiO2 nanostructured composite coatings with 0, 10 and 20 wt% TiO2 were fabricated by electrophoretic deposition at 20 V for 3 min. Electrochemical corrosion behavior of the samples was conducted in SBF solution at 37oC by potentiodynamic polarization tests. For the effect of titania on apatite formation, electrochemical impedance spectroscopy after in-vitro tests were conducted on coatings. The variation of electrochemical parameters in equivalent circuit with different times of apatite formation was discussed for each sample. The lowest corrosion current density (icorr) and the highest corrosion potential (Ecorr) and linear polarization resistance (Rp) were obtained for HA-20 wt% TiO2 sample. The EIS analysis revealed that the total resistance of HA-20 wt% TiO2 sample is higher than that of other samples. The ICP analysis of Ca2+ concentration of SBF solution showed that the highest dissolution rate was achieved for HA sample. The concentration of Ca2+ of HA-20 wt% TiO2 sample remained almost constant after 15 days immersion which indicated the accelerated apatite formation. Moreover, the bonding strength of coating was increased by a factor of 2 with the addition of titania in HA-20 wt% TiO2 sample. Manuscript profile -
Open Access Article
24 - Characterization of functionally graded hydroxyapatite/TiO2 multilayer coating on Ti-6Al-4V titanium alloy by electrophoretic deposition
محمد جعفر هادیان علیرضا عراقی طاهره طلایی مهسا ثانیSingle layer and functionally graded coatings of hydroxyapatite and TiO2 particles were deposited on Ti-6Al-4V titanium alloy substrate by electrophoretic deposition technique (EPD). The coatings chemical composition and morphology were investigated using energy dispers MoreSingle layer and functionally graded coatings of hydroxyapatite and TiO2 particles were deposited on Ti-6Al-4V titanium alloy substrate by electrophoretic deposition technique (EPD). The coatings chemical composition and morphology were investigated using energy dispersive X-ray spectroscopy (EDX), scanning electron microscope (SEM) and X-ray diffraction (XRD) methods. The results showed in HA/TiO2 functionally graded coating, the composition varied from inner layer to top layer as 100 %wt TiO2 to 100 %wt HA. To investigation biocompatibility of the coatings, the culture Wharton’s Mesenchymal Stem Cells was used. The results showed the HA/TiO2 functionally graded coating and HA single layer coating were more biocompatible in comparison to TiO2 single layer coating. The adhesion strengths of the coatings were measured by shear testing and the results showed that the HA/TiO2 functionally graded coating has more adhesion strength (~31 MPa) compare to HA single layer. Manuscript profile -
Open Access Article
25 - Investigation of mechanical and biological properties of functionalized polycaprolactone and polyethylene glycol diacrylate based scaffold reinforced with hydroxyapatite
نرجس کوپائی Akbar KarkhanehThe purpose of this study is synthesised of functionalized polycaprolactone and polyethylene glycol diacrylate based scaffold in the presence of hydroxyapatite (HA) particles and investigated of mechanical and biological properties of scaffolds. . At the first step, PCL MoreThe purpose of this study is synthesised of functionalized polycaprolactone and polyethylene glycol diacrylate based scaffold in the presence of hydroxyapatite (HA) particles and investigated of mechanical and biological properties of scaffolds. . At the first step, PCL diol was acrylated with acryloyl chloride and confirmed using fourier transform infrared (FTIR).Then, the scaffolds were synthesized by radical crosslinking reaction of polycaprolacton acrylate and polyethylene glycol diacrylate (PEGDA) in the presence of hydroxyapatite (HA) particles and particulate technique with sodium chloride. The prepared samples were characterized using techniques such as scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FTIR), and dynamic mechanical thermal analysis (DMTA). Results show that increasing the ratio of PEGDA to polycaprolactone diacrylate (PCLDA) led to increase of tan δ peak and decrease of compressive modulus of the network, respectively. It was found that the incorporation of HA particles with the polymer matrices resulted in an increased of compressive modulus and a decrease of tan δ peak. Cytocompatability of the scaffolds were assessed by direct contact test and staining cell. Results indicated no toxicity, and cells attached and spread on the pore walls offered by the scaffols. Thus, the results indicated that the PCLDA/PEGDA/HA scaffolds have the potential of being used as promosing substrates in bone tissue engineering. Manuscript profile -
Open Access Article
26 - Wear characterization of different hydroxyapatite based coatings on Ti-6Al-4V titanium alloy by electrophoretic deposition
علیرضا عراقی محمد جعفر هادیانفردIn the present study, hydroxyapatite (HA) Single layer TiO2 single layer, HA-TiO2 double layer and functionally graded HA/TiO2 coatings were deposited on Ti-6Al-4V titanium alloy substrate by electrophoretic deposition technique (EPD). Impact resistance of coatings were MoreIn the present study, hydroxyapatite (HA) Single layer TiO2 single layer, HA-TiO2 double layer and functionally graded HA/TiO2 coatings were deposited on Ti-6Al-4V titanium alloy substrate by electrophoretic deposition technique (EPD). Impact resistance of coatings were measured by ball drop impact test and the results showed that the HA/TiO2 functionally graded coating has more impact resistance compare to HA single layer and HA-TiO2 double layer coatings. The wear resistance of coatings were investigated by pin on disc method. The normal load and sliding distance were 0.5 N and 50 m respectively and the worn surface was observed using scanning electron microscope (SEM) and analyzed by ImageJ software. The results showed that the HA/TiO2 functionally graded coating has more wear resistance compare to HA single layer. Additionally, investigation of worn surface of coatings showed that all of the coatings have abrasive mechanism but wear mechanism for functionally graded coating, changed and delamination was added to abrasive mechanism. Manuscript profile -
Open Access Article
27 - Evaluation of the thermal properties of PLLA/HA and PLLA/45S5 composites for application in bioabsorbable interference screws
mohammad khorsand-ghayeni علیرضا صادقی اول شهر سمیرا نوخاسته امیر مهدی مولوی حسین امینی مشهدیReplacement of metals with bioabsorbable polymers has shown promising results for fabrication of biomedical implants. But polymers themselves have some restrictions such as inability in osteoconduction and integration with surrounding tissue, induce foreign body reactio MoreReplacement of metals with bioabsorbable polymers has shown promising results for fabrication of biomedical implants. But polymers themselves have some restrictions such as inability in osteoconduction and integration with surrounding tissue, induce foreign body reactions, reducing of pH by degradation products which can results in unwanted inflammatory reactions in related place, and weak mechanical properties in compare to metallic types. In order to alleviate these problems using of polymeric composites including bioactive particles is taken into consideration. In the present work 45S5 bioactive glass and hydroxyl apatite (HA) ceramic particles were used for fabrication of poly(L-Lactic acid) (PLLA) composite screws. Microstructure and thermal properties of produced samples were evaluated by differential thermal analysis (DTA), thermogravimetry (TG), scanning electron microscopy (SEM) and particle size analysis (PSA). Also for evaluation of osteogenic activity of produced samples, alkaline phosphatase (ALP) and Alizarin Red Staining assays were carried out and cytotoxicity was conducted through MTT assay. In compare to PLLA screws, PLLA/HA and PLLA/45S5 composites showed more and less thermal stability respectively. The results of cell analysis assays showed no cytotoxicity and both composites revealed proper osteogenesis potentials. Manuscript profile -
Open Access Article
28 - Effect of Hydroxyapatite Nanoparticles on Differentiotion of Mesenchymal Stem Cells into Bone cells in Polycaprolacton/Keratin/Hydroxyapatite Scaffolds
Mahboobeh Mahmoodi Mina Kalantari Marjan MirhajThe human body process can spontaneously repair small bone defects, while large bone defects cannot be repaired without medical interventions. Efforts to eliminate these shortcomings have led to the foundation of bone tissue engineering. In this research, polycaprolacto MoreThe human body process can spontaneously repair small bone defects, while large bone defects cannot be repaired without medical interventions. Efforts to eliminate these shortcomings have led to the foundation of bone tissue engineering. In this research, polycaprolactone/keratin scaffold and Polycaprolactone/keratin/hydroxyapatite scaffold were fabricated using electrospinning method and were evaluated. Then, in order to evaluate the cellular differentiation, adipose tissue-derived mesenchymal stem cells were cultured on scaffolds and the process of differentiation of mesenchymal stem cells into bone cells for 7 and 14 days was investigated by alkaline phosphatase and alizarin red test. Increase of the activity of the enzyme alkaline phosphatase, the presence of the minerals and the red-orange-color extended on the scaffolds containing hydroxyapatite nanoparticles that confirmed the presence of Ca + 2 , demonstrated the differentiation of mesenchymal cells into bone cells. Therefore, the results of this study suggest that the polycaprolactone/keratin/hydroxyapatite scaffold is a suitable substrate for proliferation and differentiation of stem cells for bone tissue engineering. Manuscript profile -
Open Access Article
29 - Comparison of in vitro physico-chemical and antibacterial properties of 68S and 58S bioactive glasses synthesized by sol-gel method
Amirhossein Moghanian mohammad amin zohour fazeliThe major aim of this study was to evaluate the effect of CaO content on in vitro hydroxyapatite formation, MC3T3cells cytotoxicity and proliferation as well as antibacterial efficiency of sol-gel derived SiO2–CaO–P2O5 ternary system. For this purpose, first MoreThe major aim of this study was to evaluate the effect of CaO content on in vitro hydroxyapatite formation, MC3T3cells cytotoxicity and proliferation as well as antibacterial efficiency of sol-gel derived SiO2–CaO–P2O5 ternary system. For this purpose, first two grades of bioactive glass (BG); BG-58s (mol%: 60%SiO2–36%CaO–4%P2O5) and BG-68s (mol%: 70%SiO2–26%CaO–4%P2O5)) with the fixed P2O5 content were synthesized by sol-gel method. Second, the effect of CaO content in their composition on in vitro bioactivity was investigated by soaking the BG-58s and BG-68s powders in simulated body fluid (SBF) for time periods up to 14 days. The evolution of the SBF composition was monitored by inductively coupled plasma atomic emission spectrometry (ICP-AES) analyses. Additionally, Fourier transform infrared (FTIR), X-ray diffraction (XRD) and scanning electron microscopy (SEM) were performed to characterize formed hydroxyapatite on BG's surface. On the other hand, Live/dead staining, 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and alkaline phosphatase (ALP) activity assays were conducted respectively, as qualitatively and quantitatively assess for cell viability, proliferation and differentiations of MC3T3cells in presence of 58s and 68s BGs. Eventually, BG-58s with enhanced MC3T3 cells proliferation and ALP activity, acceptable bioactivity and significant high antibacterial effect against MRSA bacteria is suggested as a suitable candidate in comparison to BG-68S in order to further functionalizing for delivery of therapeutic ions and growth factors in bone tissue engineering. Manuscript profile -
Open Access Article
30 - Investigation of the Ways of Purification of Apatite Stone and Its using in the Ceramic Glazes
Davoud Ghahremani صاحبعلی منافی E. فرح بخش Fariborz ForohandehIn the current research, within purification of apatite stone of Bafg investigated its using in the formulation of white glaze of Single firing of fast fired Wall Tile (Monoporosa Tile). The results of the investigations done on the purificated apatite of Bafg determine MoreIn the current research, within purification of apatite stone of Bafg investigated its using in the formulation of white glaze of Single firing of fast fired Wall Tile (Monoporosa Tile). The results of the investigations done on the purificated apatite of Bafg determined that this matter showing good thermal stability under the temperature of 1400 degress centigerate and isn’t any unfavorabale element in its compositon for using in ceramic glaze formulations exception of iron. Nevereless the problem of low Thermal Expansion Coefficient of the white glazes of Monoporosa, The Dilatometry results of the glaze containing Apatite dictated higher Thermal Expansion Coefficient. The images of SEM showed both the safe adhering of glaze to engobe and increment of amount of insoluble fine particles of zircon in the base phase of glaze that with the safe results of colourimetry was the explanatory of increment of the whitness of current glaze. Also by considering the low price of this matter, it wills reduce the final price of glaze. Manuscript profile -
Open Access Article
31 - Investigation of the Effect of Strontium Ion Content on Thermal, Bioactivity, Antibacterial Properties and Behavior of MC3T3-E1 Osteoblast Cells in Silicate-Based Bioactive Glass
Noushin Nankali Amirhossein Moghanian Morteza Saghafi YazdiBioactive glass (BG), is able to bind to body tissues, in this regard, it can be considered suitable material for applications such as bone tissue engineering. In this study, we first synthesized and studied the structural changes, biocompatibility, in vitro bioactivity MoreBioactive glass (BG), is able to bind to body tissues, in this regard, it can be considered suitable material for applications such as bone tissue engineering. In this study, we first synthesized and studied the structural changes, biocompatibility, in vitro bioactivity, biological behavior and antibacterial properties of silicate-based BG containing with strontium. To evaluate the bioactivity, the BG powder was placed in a simulated body fluid (SBF) solution for 1, 3, 7 and 14 days and then before and after the mentioned time periods, the changes and the process of forming a hydroxyapatite (HA) layer on their surface was studied by using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), release rates of various ions elements, pH changes and scanning electron microscopy (SEM). The results of X-ray diffraction tests and infrared spectroscopy studies confirmed the formation of crystalline HA layer on the BG surface. Moreover, the results of live/dead assay, nucleus microstructure and actin microfilaments of MC3T3-E1 osteoblast cells showed that 5% of strontium in silicate-based bioactive glass led to the growth, proliferation and activity of MC3T3-E1 osteoblast cells. The results of cytotoxicity test and evaluation of alkaline phosphate activity showed that substitution of strontium instead of calcium in silicate-based bioactive glass composition not only did not cause cytotoxicity but also caused significant proliferation and activity of MC3T3-E1 osteoblast cells. Meanwhile, improvements in the antibacterial properties of strontium-containing bioactive glass against MRSA bacteria were observed in comparison with strontium-free bioactive glass. Manuscript profile -
Open Access Article
32 - On the use of Response Surface Methodology for Optimization of Scaffold Composite of the Hydroxyapatite and Diopside
Nasrin Rafiee Saeid Karbasi amirabas nourbakhsh kamran aminiThe response surface methodology is a statistical approach to design the experiments, modeling and analysis of the effective factors as well as to help optimizing the process. In this study, we use the central composite design technique to select the optimum scaffold co MoreThe response surface methodology is a statistical approach to design the experiments, modeling and analysis of the effective factors as well as to help optimizing the process. In this study, we use the central composite design technique to select the optimum scaffold composite of the Hydroxyapatite and Diopside. This method suggested twenty different scaffold specimens by optimizing the suitable percentage of porosity via determining the percentage weight concentrations of the three effective parameters. After making the scaffold and determining their porosity, the optimum case for composite scaffolds was 77.57 wt% nHA (22.43wt% Di), 0.64wt% lubricant (STPP) and heat treatment temperature 1200. Also, the results of SEM, FTIR, and XRD confirm that the scaffold specimen made with the response method is an ideal specimen for use in bone tissue engineering. In general, according to the results of this research, the response surface methodology can be a useful tool for optimizing composite scaffolds in tissue engineering. Manuscript profile -
Open Access Article
33 - Characterization and investigation of biocompatibility of bioactive glass 60 mol%SiO2-36 mol%CaO-4 mol%P2O5-5 mol%SrO containing zinc
Amirhossein Moghanian Noushin Nankali Morteza SaghafiyazdiIn this research, bioactive glasses 60mol%SiO2-36mol%CaO-4mol%P2O5-5mol%SrO containing 0, 5, and 8 mol% zinc were synthesized by sol-gel method, and the effect of adding ZnO microstructure, in vitro bioactivity and biocompatibility was investigated. To investigate the i MoreIn this research, bioactive glasses 60mol%SiO2-36mol%CaO-4mol%P2O5-5mol%SrO containing 0, 5, and 8 mol% zinc were synthesized by sol-gel method, and the effect of adding ZnO microstructure, in vitro bioactivity and biocompatibility was investigated. To investigate the in vitro bioactivity, glass powders were placed in the simulated body solution (SBF) for 14 days, and before and after the mentioned periods, the changes and process of hydroxyapatite (HA) phase formation on BGs surfaces, using characterization methods. Fourier transform infrared (FTIR), checking the release rate of different ions by inductively coupled plasma spectroscopy (ICP_AES), pH changes, and microstructure studies using a scanning electron microscope (SEM) were investigated. In the infrared Fourier transform spectroscopic analysis of the surface of the synthesized bioactive glasses after immersion in SBF solution, phosphate and carbonate bands were detected, indicating the synthesized glasses' bioactivity. Also, the scanning electron microscope images showed that the microstructure of HA created was spherical. Finally, among all the bioactive glasses synthesized in this research, S5Z5 bioactive glass was introduced as a new multi-functional biological bio-material in bone tissue engineering due to its osteogenic, biocompatibility, and bioactivity in vitro properties. Manuscript profile -
Open Access Article
34 - Study of Biological, compound and Surface Topography if Granule Scaffold Hydroxyapatite/Ostrich Eggshell for Bone Tissue Engineering
Farideh Alahgahi Esmail Fattahi Mohsen Saeedi Mir Mahmoud Mortazavi RoudmianeThis study aimed to investigate the topography surface and ability of this scaffold in combination with the mesenchymal and fibroblast cells. In this regard, several different ratios of hydroxyapatite / ostrich eggshell scaffold were created to determine the surface pro MoreThis study aimed to investigate the topography surface and ability of this scaffold in combination with the mesenchymal and fibroblast cells. In this regard, several different ratios of hydroxyapatite / ostrich eggshell scaffold were created to determine the surface properties and responsiveness to the cells with different types of hydroxyapatite/ostrich eggshell (OsE/HA) combinations (ratios 0-1, 1-2, 1-1, 2-1, 1-0). Natural biomaterials including ostrich eggshells which contain the minerals such as calcium carbonate, play a major role in the fabrication of hard tissue scaffolds. Surface characterization was investigated using SEM and recognizing the scaffold properties by XRD, FTIR. Finally, direct contact (toxicity) test with fibroblast-like cells (L929) was performed to study the cytotoxicity response. After the scaffold toxicity test, the material was ready for in vitro acceptance test, which mesenchymal stem cells isolated from the adipose tissue of New Zealand white rabbit (RADMSCs) which kept with this bioscaffold. This study's results showed that this scaffold has the best biocompatibility and the highest surface lacuna for cell adsorption and attachment with hydroxyapatite / ostrich eggshell. Bioscaffold OsE/HA with the ratio of 1-2 has the best cell attachment among other groups. Natural biomaterials with synthetic materials can promote the bone tissue engineering in many ways. Manuscript profile -
Open Access Article
35 - Evaluation of the Potential of 3D Printed Polycaprolactone Scaffolds Coated with Bioceramics in the Proliferation and Osteogenic Differentiation of Human Adipose Tissue-derived Mesenchymal Stem Cells
Nasrin Fazeli Ehsan Arefian Shiva Irani Abdolreza Ardeshirylajimi Ehsan SeyedjafariIn recent years, the focus of researches in the field of tissue engineering has been on the preparation of scaffold materials and methods. 3D printing is an emerging technology that can accurately and quickly prepare bone tissue engineering scaffolds with specific shape MoreIn recent years, the focus of researches in the field of tissue engineering has been on the preparation of scaffold materials and methods. 3D printing is an emerging technology that can accurately and quickly prepare bone tissue engineering scaffolds with specific shapes and structures. One of the most common 3D printing methods is fused deposition modeling (FDM), the materials used in this method are polymers such as polycaprolactone (PCL). In this study, 3D printed PCL scaffolds were made and due to the hydrophobic and non-osteogenic nature of PCL, the surface of the scaffolds was coated with a 1% solution of hydroxyapatite (HA) and bioactive glass (BG) bioceramics. Surface modification of PCL scaffolds was done to increase hydrophilicity and improve cell attachment. Field emission scanning electron microscop (FeSEM) images, Energy-dispersive X-ray spectroscopy (EDS) and mapping of the surface elements of the scaffolds confirmed the proper coating of PCL scaffolds with HA and BG bioceramics. The biocompatibility of PCL/HA/BG scaffolds and the cell viability and attachment on the surface of the scaffolds were investigated by seeding of human adipose mesenchymal stem cells (hAMSCs) and using MTT test and FeSEM images. Also, the potential of PCL/HA/BG scaffolds in osteogenic differentiation of hAMSCs was evaluated by alkaline phosphatase activity measurement test and immunocytochemical staining. The results showed that the three-component PCL/HA/BG scaffolds improved the proliferation and osteogenic differentiation of hAMSCs, so the PCL/HA/BG scaffolds can be a suitable candidate for bone tissue engineering applications. Manuscript profile -
Open Access Article
36 - سنتز آلیاژ تیتانیوم (Ti-6Al-4V)به روش آلیاژسازی مکانیکی و بررسی رفتار مکانیکی و زیست فعالی نانوکامپوزیت (Ti-6Al-4V/HA-Clay)
محمدعلی مطلبی ابراهیم کرمیان مجید کریمیان ایمپلنتهای تیتانیمی به علت سبکی و مقاومت در مقابل خوردگی در محیطهای بیولوژیکی و همچنین دانسیته نزدیک به استخوان بدن، کاربردهای پزشکی خاصی دارند. یکی از آلیاژهای تیتانیم در این زمینه Ti-6Al-4V است، که روش آلیاژسازی مکانیکی به علت نقطه ذوب و شرایط سخت ریختهگری ا More ایمپلنتهای تیتانیمی به علت سبکی و مقاومت در مقابل خوردگی در محیطهای بیولوژیکی و همچنین دانسیته نزدیک به استخوان بدن، کاربردهای پزشکی خاصی دارند. یکی از آلیاژهای تیتانیم در این زمینه Ti-6Al-4V است، که روش آلیاژسازی مکانیکی به علت نقطه ذوب و شرایط سخت ریختهگری این آلیاژها روش تولید متداولتری است. هیدروکسی آپاتیت به دلیل زیست سازگاری و زیست فعالی بالا، ترکیبی مشابه با ترکیب استخوان درترمیم استخوان بسیار مورد توجه قرار گرفته است. همچنین کلی به علت حضور یون Si که میتواند به عنوان جوانهزنی در آپاتیت سازی (استخوانسازی) عمل کند مورد توجه است. هدف از این پژوهش بررسی زمان و شرایط آسیاکاری جهت آلیاژسازی؛ همچنین بررسی اثرات زمان، دما و شرایط زینترینگ در مرحله متالورژی پودر (PM) بوده است که تأثیر آنها بر روی خواص مکانیکی و رفتار زیست بررسی میگردد. در این پژوهش، ابتدا از استخوان گاو، هیدروکسی آپاتیت طبیعی به دست آمده، سپس با استفاده از نانو پودر کلی و روش آسیا کاری پر انرژی نانو کامپوزیت کلی- هیدروکسی تبدیل گردید. در نهایت نمونههای بالک آلیاژ تیتانیم محتوی 0%، 10%، 20% و 30% درصد وزنی مخلوط سرامیکی هیدروکسی آپاتیت-کلی تهیه گردید. جهت بررسی خواص مکانیکی، آزمون اندازهگیری استحکام فشاری سرد و همچنین ارزیابی زیست فعالی، آزمون زیست فعالی بر روی نمونههای متراکم شده انجام گرفت. بررسی نتایج نشان میدهد که بهترین خواص مکانیکی و رفتار زیست فعالی در نمونه کامپوزیتی تیتانیمی محتوی 20% وزنی مخلوط نانو کامپوزیت سرامیکی مشاهده گردید؛ بنابراین این نانوکامپوزیت تیتانیمی میتواند به عنوان یک کاندیدای مناسب جهت مقاصد مهندسی پزشکی معرفی میگردد. Manuscript profile -
Open Access Article
37 - Review of Micro-Particles of Hydroxyapatite Nanoparticles by Ball Milling
F. Fardi Pour M. Najafi Anaraki M. Karmian -
Open Access Article
38 - Manufacturing High-Strength HA-Ti Surface Composites by Friction Stir Processing with Different Filler Mixtures
A Shahbaz Mehrdad Abbasi H SabetIn recent years, a wide range of studies have focused on the surface modification of titanium, especially in terms of its biomedical applications. However, comparatively less researches have been conducted on the fabrication of titanium surface composites in bulk form MoreIn recent years, a wide range of studies have focused on the surface modification of titanium, especially in terms of its biomedical applications. However, comparatively less researches have been conducted on the fabrication of titanium surface composites in bulk form. The primary objective of this investigation is to successfully produce hydroxyapatite (HA)-Ti surface composites with a homogenous dispersion of nano hydroxyapatite particles through friction stir processing (FSP). The secondary aim is to investigate the effect of FSP parameters, specifically filler mixture, on the microstructure and mechanical properties of the composites. Two different mixtures of HA and FSP parameters, traverse speeds of 30 and 45 mm min-1, rotational speed of 1200 rpm, and a conical tool shape, were used. It was found that the samples obtained by a filler mixture of HA-polyvinyl alcohol (PVA) showed better dispersion of HA in the Ti base, as well as higher tensile strength. Also, a 30 mm min-1 traverse speed led to higher strength in both filler mixtures. Therefore, the sample produced by a traverse speed of 30 mm min-1 and HA/PVA filler mixture was selected as the optimum sample. Manuscript profile
Sanad
Sanad is a platform for managing Azad University publications
Links
Related Centers
Technical Support
Official pages
The rights to this website are owned by the Raimag Press Management System.
Copyright © 2021-2024