The purpose of this research was to study the effect of mindfulness on job performance and job stress with considering mediating role of meaning in work. The research method was correlation and the statistical population consisted of all employees of Parsian Ophthalmology Clinic, of which, 194 subjects were selected through convenience sampling method. Research questionnaires consisted of Mindfulness (Baer et al., 2006), Job Performance (Paterson, 1963), Job Stress (Babacas et al., 1992) and Meaning in Work (Ivtzan, Sorensen, & Halonen, (2013). Data were analyzed with use of Pearson's correlation coefficient and Structural Equation Modeling (SEM) and results revealed that mindfulness has a significant effect on meaning in work, job performance and job stress (p<0/05). Moreover, meaning in work has a significant effect on job performance and job stress (p<0/05). Furthermore, the results of structural equation modeling showed that mindfulness indirectly and through effect on meaning in work has a significant effect on job performance and job stress (p <0/05). Hence, based on the findings of the research, it could be concluded that, mindfulness due to the effect on meaning in work has an impact on job performance and job stress.
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