List of Articles Shabnam Movassaghi

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  1 - Effect of different times of ischemia/reperfusion on dentate gyrus cells of hippocampus in Wistar rat
  Zahra Nadia Sharifi shabnam movassaghi zahra kermaniha arefeh arafati amir ghasemi
  Stroke is the most important resalt of cerebral ischemia and followed  reperfusion produces  free radicales and can lead to apoptosis.  Granular cells of dentate gyrus are sensitive to ischemia. Whatever the time of ischemia gets longer and reperfusion st More

  Stroke is the most important resalt of cerebral ischemia and followed  reperfusion produces  free radicales and can lead to apoptosis.  Granular cells of dentate gyrus are sensitive to ischemia. Whatever the time of ischemia gets longer and reperfusion starts with delay, cell protection from oxidative damage and apoptosis will be less efficient. Since the percentage of tissue damage plays an important role in the study of neuroprotective drugs,We decide to study the  appropriate duration of   ischemia in order to use different drugs in ischemic animal models. In this experimental study, 30 male Wistar rat were divided  to 6 groups (5,10,15,20 and 30 minutes of ischemia. The ischemia was induced by ligation of  bilateral common carotid arteries followed by reperfusion. After four days, brains were removed and prepared for hematoxilin-eosin method and nissl staining . Our data showed that The number of degenerative cells with pyknotic nucleuses were increased especially in the30 minutes of ischemia and the number of the dentate gyrus granular cells were decreased significantly   in 15،20،30 ischemic groups.. It seems that more than 10 minutes of ischemia is the appropriate time for studying the effects of drugs in ischemic model.  Manuscript profile
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  2 - Effect of neurotrophic effect of Rifampicin on memory impairment in male Wistar Rat model of ischemia / reperfusion
  Sogol Shakibania Zahra Nadia Sharifi Shabnam Movassaghi
  Background: spatial memory impairment is seen after brain ischemic. The hippocampus is one of the most sensitive parts of the brain following ischemia. Oxidative stress and inflammation after cerebral ischemia damage the hippocampal neurons and cause spatial memory diso More

  Background: spatial memory impairment is seen after brain ischemic. The hippocampus is one of the most sensitive parts of the brain following ischemia. Oxidative stress and inflammation after cerebral ischemia damage the hippocampal neurons and cause spatial memory disorder. Rifampicin has anti-inflammatory and anti-oxidant effects. This study reviews the neurotrophic effects of the drug following post traumatic brain damage. Material and methods: Animals were divided into 4 groups: control, ischemic-vehicle and experimental. In the experimental group, rifampicin was injected intraperitoneally (20 mg / kg) at the onset of reperfusion and 24 hours after reperfusion. Ischemia / reperfusion was induced by bilateral closure of the common carotid artery for 20 minutes. Morris water maze and nissl staining were used for all groups. Results: Results showed that rifampicin (20 mg / kg) reduced the time and distance needed to find a platform in Morris water maze and increase the number of survival pyramidal cells following ischemia. There was a significant difference between the control group and the ischemic and vehicle groups, but this difference was not significant between the control group and the experimental group. Conclusion: In addition to the neurotrophic effects of Rifampicin on the tissue structure of the CA1 region of the hippocampus, this drug improves the spatial memory function after transient ischemia / reperfusion. Therefore it seems that rifampicin can be considered as one of the appropriate drug for treatment of brain-ischemic Manuscript profile
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  3 - Neuroprotective effect of Neurokinin 1 receptor antagonist on CA1 region of hippocampus in male Wistar rats following ischemic / reperfusion induction
  Shervin Eftekhari Shabnam Movassaghi Amir Ghasemi Zahra Nadia Sharifi
  Cerebral ischemia/reperfusion (I/R) injury is a critical factor leading to a poor prognosis for ischemic stroke patients. Substance P-mediated inflammation is reported to attenuate the neuroprotective PPAR-γ. In This study, we determined the effects of aprepitant, More

  Cerebral ischemia/reperfusion (I/R) injury is a critical factor leading to a poor prognosis for ischemic stroke patients. Substance P-mediated inflammation is reported to attenuate the neuroprotective PPAR-γ. In This study, we determined the effects of aprepitant, a substance P-NK1 receptor antagonist in bilateral common carotid arteries occlusion (BCCAO) induced I/R brain injury. 24 male Wistar rats were divided into4 groups ( Control- Ischemia - Vehicle and experimental). Ischemia model was induced by ligation of bilateral common carotid arteries. Aprepitant (40mg/kg) was administered twice, one hour beforethe ischemia and one hour after the reperfusion. After 72 hours, Brains were removed and prepared for Nissl staining.Data depicted that significant differences were seen in the number of viable Pyramidal cells in CA1 region between control and ischemia groups whereas there are no significant deference between experimental and control groups.It may be concluded that aprepitant can reduce post-ischemic tissue lesions, so may candidate for the treatment of I/R brain damage. Manuscript profile
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  4 - Evaluation of sperm morphology by stereology method in patients with different varicocele grades
  Narges ShoohaniZad Shabnam Movassaghi haniyeh Bayat shabnam Abdi
  10.30495/jdb.2021.686993
  20.1001.1.2008692.1400.13.4.1.1
  Introduction: Varicocele is one of the most common causes of male infertility in which testicular function and sperm production process are impaired. In this study, sperm parameters and sperm morphology were compared between patients with different varicocele grades.Met More

  Introduction: Varicocele is one of the most common causes of male infertility in which testicular function and sperm production process are impaired. In this study, sperm parameters and sperm morphology were compared between patients with different varicocele grades.Methods: This study was performed on 55 patients with grade 1, 2 and 3 varicocele as well as 32 fertile individuals (candidates for embryo donation or sex determination) as a control group. After collecting semen from patients, sperm parameters (number, motility and morphology of sperm) and sperm viability in different semen samples were examined. Also, sperm morphology (head, neck and tail length) was evaluated in different groups by stereology technique. Results: Sperm parameters including sperm count, motility and morphology were significantly lower in varicocele patients in comparison to control group and also sperm motility, survival, sperm count in the third degree varicocele group were significantly lower than other groups. There was no significant difference in sperm head volume and midline length between grade 1, 2 and 3 varicocele groups, but tail length in grade 3 varicocele group was significantly shorter than the other groups.Discussion and Conclusion: Varicocele, in all its degrees, is associated with a decrease in morphology and sperm count. Also, our study shows that the degree of varicocele affects sperm motility, morphology and viability, and sperm tail length. Manuscript profile