Effect of neurotrophic effect of Rifampicin on memory impairment in male Wistar Rat model of ischemia / reperfusion

Subject Areas : Developmental biology of plants and animals , development and differentiation in microorganisms

Sogol Shakibania ¹ , Zahra Nadia Sharifi ² , Shabnam Movassaghi ³

1 - 5. School of Medicine, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
2 - Department of anatomy-Islamic Azad university- Tehran medical sciences branch
3 - Anatomy Department, Tehran Medical sciences Branch, Islamic Azad University, Tehran, Iran

Received: 2017-11-15 Accepted : 2018-04-09 Published : 2017-11-22

Keywords: Ischemia, Rifampicine, spatial memory,

Abstract :

Background: spatial memory impairment is seen after brain ischemic. The hippocampus is one of the most sensitive parts of the brain following ischemia. Oxidative stress and inflammation after cerebral ischemia damage the hippocampal neurons and cause spatial memory disorder. Rifampicin has anti-inflammatory and anti-oxidant effects. This study reviews the neurotrophic effects of the drug following post traumatic brain damage. Material and methods: Animals were divided into 4 groups: control, ischemic-vehicle and experimental. In the experimental group, rifampicin was injected intraperitoneally (20 mg / kg) at the onset of reperfusion and 24 hours after reperfusion. Ischemia / reperfusion was induced by bilateral closure of the common carotid artery for 20 minutes. Morris water maze and nissl staining were used for all groups. Results: Results showed that rifampicin (20 mg / kg) reduced the time and distance needed to find a platform in Morris water maze and increase the number of survival pyramidal cells following ischemia. There was a significant difference between the control group and the ischemic and vehicle groups, but this difference was not significant between the control group and the experimental group. Conclusion: In addition to the neurotrophic effects of Rifampicin on the tissue structure of the CA1 region of the hippocampus, this drug improves the spatial memory function after transient ischemia / reperfusion. Therefore it seems that rifampicin can be considered as one of the appropriate drug for treatment of brain-ischemic

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