Studying MiR-133 influencing the process of apoptosis of Cardiomyocytes floating in blood serum of patients suffering from acute Myocardial Infarction
Subject Areas : Developmental biology of plants and animals , development and differentiation in microorganisms
shiva
kasiolkheir
1
(1Department of biology, Ahar Branch, Islamic Azad University, Ahar,Iran)
changiz
ahmadizadeh
2
(1Department of biology, Ahar Branch, Islamic Azad University, Ahar,Iran)
hoshang
hosseinzadeh mogbeli
3
(Department of Molecular genetic ,Islamic Azad University, Tabriz Branch, Tabriz,Iran)
Keywords: Myocardial Infarction, Apoptosis, miR-133,
Abstract :
Abstract Background and goals: Myocardial Infarction is known as one of the most common disabling and threatening heart diseases resulted from irrevocable and degenerative cellular death in a part of heart muscle. After the discovery of miRNA in 1990 and the discovery of more than 2500 types of miRNA, gradually the importance of these mechanism regulators and molecular signals and gene routes were identified in the processes and the cellular mechanisms, specifically in cardiovascular system. The goal of this research is Studying MiR-133 influencing the process of apoptosis of Cardiomyocytes floating in blood serum of patients suffering from acute Myocardial Infarction Methods: To achieve our goals in this case-observation study type regarding miR-133, 70 patients in Shahid Madani Hospital in Tabriz in the year 2017 were investigated by Real time PCR and the data were compared with those of the healthy persons. The statistical analyses were carried out using SPSS (version19) and a t-test method. The amounts for P>0.05 were considered meaningful. Findings: The expression levels of miR-133 among patients suffering from MI have had a considerable increase compared with control group and it was meaningful statistically. (P=0.009). Also the results showed that miR-133expression among fat and normal people did not have a meaningful difference statistically (P=0.06). Conclusion: The present study showed that the expression of miR-133among individuals suffering from MI has been greater than healthy people and it can be utilized as an identification factor and also prognosis of the patients suffering from MI.
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