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    Issue 3   Vol 20 Autumn 1402
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    • List of Articles Morteza Zendehdel

      • Open Access Article

        1 - The effect of intracerebroventricular injection of L-DOPA and 6-hydroxy-dopamine on noradrenaline-induced food intake in layer chickens
        F. Zanganeh, N. Panahi, M. Zendehdel,
        Food intake is regulated by a complex system of central and peripheral signals which ‎interact ‎together to modulate appetite. Noradrenaline has an essential role in the central ‎control of food ‎intake in birds. On the other hand, dopamine (DA) is a hyp More
        Food intake is regulated by a complex system of central and peripheral signals which ‎interact ‎together to modulate appetite. Noradrenaline has an essential role in the central ‎control of food ‎intake in birds. On the other hand, dopamine (DA) is a hypophagic ‎agent in birds. ‎The present ‎study aimed to investigate the effect of L-DOPA and 6-‎hydroxy-dopamine on noradrenaline-induced food intake in neonatal chickens. A total ‎of ninety-six neonatal female laying hens (Hy‎line) were randomly divided into two ‎experimental groups. Immediately after ‎intracerebroventricular (ICV) injection of ‎control diluent (normal saline) or drug solution, ‎cumulative food intake (g) was ‎measured based on the ‎percentage of the body weight (%BW). ‎Control solution (normal ‎saline, group1), L-DOPA (125 nmol, group 2), noradrenaline (300 nmol, ‎group 3), and ‎L-DOPA + noradrenaline (group 4) were injected in the first experiment.‎ In the ‎second ‎experiment, the control solution (group1), 6-hydroxy-dopamine (6-OH-DA, 2.5 nmol, ‎‎group 2), noradrenaline (300 nmol, group 3), and 6-OH-DA + noradrenaline (group 4) ‎were ‎injected. The results showed that ICV injection of noradrenaline decreased food ‎intake (P<0.05). ‎Furthermore, co-injection of L-DOPA and noradrenaline significantly ‎amplified noradrenaline-induced hypophagia in neonatal chicks (P<0.05). In contrast, ‎co-injection of 6-OH-DA and ‎noradrenaline significantly reduced hypophagia induced ‎by noradrenaline in chicks (P<0.05). ‎According to the results, noradrenaline-induced ‎food intake is probably mediated by the ‎dopaminergic system in neonatal chickens.‎ Manuscript profile
      • Open Access Article

        2 - The role of MC3/MC4 melanocortin receptors on food intake induced by nesfatin-1 in broilers
        A. Heidarzadeh, مرتضی Zendehdel, حسن Gilanpour وهاب Babapour,
        10.30495/jcp.2022.20938
        Food intake is a set of physiological mechanisms affecting different central nervous system areas. The melanocortin system plays an important role in the central control of food intake in birds. Nesfatin-1 reduces food intake in birds. The present study was conducted to More
        Food intake is a set of physiological mechanisms affecting different central nervous system areas. The melanocortin system plays an important role in the central control of food intake in birds. Nesfatin-1 reduces food intake in birds. The present study was conducted to investigate the effect of the melanocortin system on food intake caused by nesfatin-1 in broiler chickens. 36 broilers were randomly divided into three experimental groups. Each experiment included a control group and 3 treatment groups (12 chickens in each group). In all experiments, after 3 hours of food deprivation (FD3), chicks received either control diluent or drug solution by intracerebroventricular (I.C.V.) injection. Then the birds had ad libitum access to the ‎food and fresh water, and then cumulative food intake (gr) was measured based on the ‎percentage of the body (%BW). In the first experiment, chickens in the first group were given the control solution, the second group nesfatin-1 (40 ng), the third group SHU9119 (0.5 nmol, antagonist of MC3/MC4 receptors), and the fourth group nesfatin-1 + SHU9119 intracerebroventricularly was injected. In the second experiment, chickens in the first group were injected with the control solution, the second group with nesfatin-1 (40 ng), the third group with MCL0020 (0.5 nmol, MC4 receptor antagonist), and the fourth group with nesfatin-1+ MCL0020. In the third experiment, chickens in the first group were injected with the control solution, the second group with nesfatin-1 (10 ng), the third group with MTII (2.45 pmol, an agonist of MC3/MC4 receptors), and the fourth group with nesfatin-1+ MTII. The results showed that the injection of nesfatin-1 with a dose of 40 ng decreased food intake (p<0.05). Co-injection of nesfatin-1 and SHU9119 and co-injection of nesfatin-1 and MCL0020 inhibited the hypophagia caused by nesfatin-1 (p < 0.05). Injection of Nesfatin-1 with a dose of 10 ng and MTII with a dose of 2.45 pmol did not affect food intake (p > 0.05). While the co-injection of nesfatin-1 with a dose of 10 ng and MTII with a dose of 2.45 pmol reduced food intake (p < 0.05). According to the results, food intake caused by nesfatin-1 in broilers is probably mediated by the melanocortin system. Manuscript profile
      • Open Access Article

        3 - Synergistic effects of central glutamatergic and histaminergic systems on food intake in neonatal chickens: The role of NMDA receptors
        مینا Mobarhan مرتضی Zendehdel بیتا Vazir احمد Asghari
        10.30495/jcp.2022.21602
        Appetite modulation is a set of complex physiological mechanisms affecting different central nervous system areas. Glutamate and histamine play an important role in the central control of food intake in birds and reduce food intake in birds. The present study was conduc More
        Appetite modulation is a set of complex physiological mechanisms affecting different central nervous system areas. Glutamate and histamine play an important role in the central control of food intake in birds and reduce food intake in birds. The present study was conducted to investigate the synergistic effects of central glutamatergic and histaminergic systems on feeding behavior in neonatal chicks. 36 chickens were randomly divided into three experimental groups. Each experiment included a control group and 3 treatment groups (12 chickens in each group). In all experiments, after 3 hours of food deprivation (FD3), chicks received either control diluent or drug solution by intracerebroventricular (ICV) injection. Then the birds had ad libitum access to the ‎food and fresh water, and then cumulative food intake (gr) was measured based on the ‎percentage of the body (%BW) ‎. In the first experiment, glutamate (75 nmol), histamine (75 nmol), and histamine + glutamate was injected. In the second experiment, chlorpheniramine (H1 receptor antagonist, 300 nmol), MK-801 (NMDA glutamate receptor antagonist, 15 nmol), and chlorpheniramine + MK-801 was injected. In the third experiment, MK-801, α-FMH (histamine synthesis inhibitor, 250 nmol), and α-FMH + MK-801 was injected. The results showed that the injection of sub-effective doses of histamine with a dose of 75 nmol (sub-effective dose) and glutamate with a dose of 75 nmol (sub-effective dose) did not affect food intake (p > 0.05). However, co-injection of glutamate and histamine decreased food intake (p < 0.05). Injection of chlorpheniramine with a dose of 300 and MK-801 with a dose of 15 had no effect on food intake (p > 0.05). However, co-injection of chlorpheniramine and MK-801 increased food intake (p < 0.05). Injection of α-FMH with a dose of 250 and MK-801 with a dose of 15 did not influence food intake (p > 0.05). However, co-injection of α-FMHs and MK-801 increased food intake (p < 0.05). According to the results, there is probably a synergistic effect between histaminergic and glutamatergic systems in the control of food intake in neonatal chicks. Manuscript profile
      • Open Access Article

        4 - Synergistic effects of L-dopa and dopamine with melanocortin receptors (MC3/MC4) agonist on food intake in chickens
        محمد Bameri مرتضی , Zendehdel بیتا Vazir نگار Panahi احمد asghari
        10.30495/jcp.2022.21928
        Appetite modulation includes a set of complex physiological mechanisms that affect different areas of the central nervous system. Previously, the role of dopaminergic and melanocortinergic systems in the central control of food intake in birds has been proven. The curre More
        Appetite modulation includes a set of complex physiological mechanisms that affect different areas of the central nervous system. Previously, the role of dopaminergic and melanocortinergic systems in the central control of food intake in birds has been proven. The current study was conducted with the aim of investigating the synergistic effects of dopaminergic system and melanocortinergic system on feeding behavior in layer chickens. In this study, three experiments were designed, so that each experiment included one control group and three treatment groups(n=12 in each group). In all groups, birds received intracerebroventricular injection of diluent solution or drug solution after 3 hours of food deprivation. In the first experiment, in order to determine the sub-effective dose of dopamine, normal saline and dopamine were injected with doses of 10, 20 and 40 nmol respectively in the test groups. In the second experiment, normal saline, L-dopa (dopamine precursor, 250 nmol), MTII (2.45 pmol, MC3/4 receptor agonist) and L-dopa + MTII were injected, and the third experiment was conducted as second experiment, but instead of L-dopa, dopamine (10 nmol) was injected either alone or in combination with MTII. After the injection, water and food were freely available to the birds and food consumption (gr) was measured based on the percentage of body weight. Based on the obtained results, the dose of 10 nmol of dopamine was determined as the sub-effective dose. It was also observed that the injection of sub-effective doses of dopamine, L-dopa and MTII alone had no effect on the food intake of chickens (p > 0.05), and only co-injections of L-dopa + MTII and dopamine + MTII caused a significant decrease in food intake in chickens (p<0.05). Based on the findings, it seems that there is probably a synergistic effect between the dopaminergic system and the melanocortinergic system in the control of food intake in chickens. Manuscript profile

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