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Open Access Article
1 - UPLC in phytochemical analysis
Lutfun Nahar Satyajit D. SarkerUltra Performance Liquid Chromatography (UPLC), which has been around just over one and a half decade, is an advanced liquid chromatographic technique that offers a significantly short analysis time and small amount of solvent(s) as a mobile phase. It also provides much MoreUltra Performance Liquid Chromatography (UPLC), which has been around just over one and a half decade, is an advanced liquid chromatographic technique that offers a significantly short analysis time and small amount of solvent(s) as a mobile phase. It also provides much better separation efficiency and resolution of analyte mixtures. Manuscript profile -
Open Access Article
2 - Cannabidiol (CBD) – An update
Satyajit D. Sarker Lutfun NaharCannabinoids are synthetic, semisynthetic or natural organic molecules that bind to cannabinoid receptors, and they have similar pharmacological properties as produced by the plant,Cannabis sativaL..Of the 113 naturally occurring cannabinoids identified to date, D9-tetr MoreCannabinoids are synthetic, semisynthetic or natural organic molecules that bind to cannabinoid receptors, and they have similar pharmacological properties as produced by the plant,Cannabis sativaL..Of the 113 naturally occurring cannabinoids identified to date, D9-tetrahydrocannabinol (D9-THC or simply, THC) and cannabidiol (CBD) are the two major cannabinoids, biosynthesized byC. staiva. While D9-THC is the main contributor to the psychoactive property ofC. sativa, interestingly, the other major compound, CBD, possesses antipsychoactive property as well as other beneficial medicinal properties, because of which, this compound has been in the lime light for its potential pharmaceutical/medicinal and cosmeceutical applications. However, because of various legislative bottlenecks and restrictions regarding the use, sell and possession ofCannabisandCannabisproducts including CBD have made difficult to its breakthrough in the market in many countries, especially in the UK. Manuscript profile -
Open Access Article
3 - A mini-review on oxysporone
Satyajit D. Sarker Lutfun Nahar Tauhidur Rahman Nurunnabi S.M. Mahbubur Rahman Md. Hossain Sohrab Md. Morsaline Billah Fyaz M. D. Ismail George P. SharplesOxysporone, possessing a 4H-furo(2,3-b)pyran-2(3H)-one structure, is a fungal metabolite, first isolated from Fusarium oxysporum. Later, this compound was also reported from the fungal genera, Diplodia, Pestalotia and Pestalotiopsis. Oxysporone was patented as an antibi MoreOxysporone, possessing a 4H-furo(2,3-b)pyran-2(3H)-one structure, is a fungal metabolite, first isolated from Fusarium oxysporum. Later, this compound was also reported from the fungal genera, Diplodia, Pestalotia and Pestalotiopsis. Oxysporone was patented as an antibiotic for the treatment of dysentery, and its phytotoxic property has been well-established. Interesting biological and chemical properties of oxysporone make this compound attractive for its potential biotechnological applications in agriculture, especially as a new agrochemical with a lower environmental impact. However, it requires further extensive bioactivity screening looking at beyond its established phytotoxicity and preliminary antifungal property. It has a simple chemical structure (C₇H₈O₄), and the hydroxyl group at C-4 provides options for synthesising numerous analogues by simply incorporating various functionalities at C-4, whilst keeping the main skeleton intact. This mini-review provides a critical overview on the occurrence, production, synthesis, structure elucidation and bioactivities of oxysporone. Manuscript profile -
Open Access Article
4 - Automated structure elucidation of phytochemicals
Lutfun Nahar Satyajit D. SarkerPlants produce a variety of chemical compounds, and plants have been the main source of new chemical entities and novel chemical scaffolds or templates, unfolding new challenges for organic synthetic chemists to explore appropriate synthetic routes for their total synth MorePlants produce a variety of chemical compounds, and plants have been the main source of new chemical entities and novel chemical scaffolds or templates, unfolding new challenges for organic synthetic chemists to explore appropriate synthetic routes for their total synthesis. Because of the unique chemical diversity offered by plants, it is often a tedious and complicated process when it comes to structure elucidation of phytochemicals. Recent advances in spectroscopic techniques, particularly in NMR and MS methodologies, have provided various tools that assist phytochemists with the structure elucidation of known or new phytochemicals. However, spectroscopic data interpretation manually requires significant experience and expertise, knowledge, intellectual ability and patience; often the manual process can be quite time consuming and even be frustrating. Over the last several decades, especially with the phenomenal progress in computation and applications of artificial intelligence and various mathematical modelling, several automated spectral data interpretation and structure elucidation software have become available to the phytochemists. These automated tools, not necessarily have replaced human intelligence or efforts, but certainly have facilitated the process, and improved the accuracy of structure elucidation of phytochemicals. Manuscript profile -
Open Access Article
5 - Phytochemicals and phyto-extracts in cosmetics
Satyajit D. Sarker Lutfun NaharPhytochemicals are generally secondary metabolites produced by plants, and they often possess various biological and pharmacological properties, which have long been exploited to find new drug molecules for the treatment of human ailments. However, because of the proper MorePhytochemicals are generally secondary metabolites produced by plants, and they often possess various biological and pharmacological properties, which have long been exploited to find new drug molecules for the treatment of human ailments. However, because of the properties like antioxidant, emollient and antimicrobial, and also as a colour and fragrance, some of the phytochemicals are used in a number of cosmetic products available to date. Manuscript profile -
Open Access Article
6 - Sonneratinone: A new antimicrobial benzofuranone derivative from the endophytic fungus Aspergillus niger isolated from the mangrove plant Sonneratia apetala Buch.-Ham
Tauhidur Rahman Nurunnabi Shaymaa Al-Majmaie Lutfun Nahar Ismini Nakouti S. M. Mahbubur rahman MD. Hossain Sohrab MD. Morsaline Billah Fyaz MD. Ismail George P. Sharples Satyajit D. SarkerA new antimicrobial benzofuranone derivative, named, sonneratinone (1), was isolated from the endophytic fungus Aspergillus niger, obtained from the leaves of Sonneratia apetala, a mangrove plant from the Sundarbans. Whilst the fungal strain was identified by macroscopi MoreA new antimicrobial benzofuranone derivative, named, sonneratinone (1), was isolated from the endophytic fungus Aspergillus niger, obtained from the leaves of Sonneratia apetala, a mangrove plant from the Sundarbans. Whilst the fungal strain was identified by macroscopic, microscopic and molecular techniques, the structure of the new compound was elucidated by spectroscopic means, e.g., 1D and 2D NMR, and HRESIMS. Sonneratinone (1) showed considerable antimicrobial activity against Micrococcus luteus, Staphylococcus aureus and Candida albicans in the resazurin 96-well microtitre plate antimicrobial assay. Manuscript profile -
Open Access Article
7 - Flavonoids from two Turkish Centaurea species and their chemotaxonomic implications
Sharmeen Uddin Lillian Alnsour Peter Segun Huseyin Servi Sezgin Celik R. Süleyman Göktürk Afaf Al-Groshi Shaymaa Al-Majmaie Stephanie T. Guetchueng Lutfun Nahar Nicola M. Dempster Fyaz M. D. Ismail Kenneth J. Ritchie Satyajit D. SarkerCentaurea asutro-anatolica Hub.-Mor. and C. kizildaghensis Uzunh., E. Doğan & H. Duman, two indigenous perennial herbs from the Turkish flora, belong to the medicinally important genus Centaurea L. (fam: Asteraceae), which comprises ca. 600 species worldwide. While MoreCentaurea asutro-anatolica Hub.-Mor. and C. kizildaghensis Uzunh., E. Doğan & H. Duman, two indigenous perennial herbs from the Turkish flora, belong to the medicinally important genus Centaurea L. (fam: Asteraceae), which comprises ca. 600 species worldwide. While various Centaurea species are well-known for producing alkaloids, flavonoids, lignans and terpenoids, there is no report on any thorough phytochemical work on any of these two species available to date. In continuation of our phytochemical and bioactivity studies on the Turkish Centaurea species, four flavonoids apigenin (1), apigenin 7,4’-dimethyl ether (2), genkwanin (3) and quercetin (4) were isolated from the methanol extracts of the aerial parts of C. austro-anatolica and C. kizildaghensis, for the very first time. The structures of the flavonoids were elucidated conclusively by spectroscopic means, i.e., UV, MS and 1D and 2D NMR data analyses. The distribution of these flavonoids (1-4) within the genus Centaurea and their possible chemotaxonomic implications within the genus Centaurea or the family Asteraceae have been discussed. Manuscript profile
List of Articles Satyajit D. Sarker
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