Cannabidiol (CBD) – An update

Subject Areas : Phytochemistry: Isolation, Purification, Characterization

Satyajit D.  Sarker ¹ (Centre for Natural Products Discovery (CNPD), School of Pharmacy and Biomolecular Sciences, John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, United Kingdom)
Lutfun  Nahar ² (Centre for Natural Products Discovery (CNPD), School of Pharmacy and Biomolecular Sciences, John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, United Kingdom|Laboratory of Growth Regulators, Institute of Experimental Botany ASCR & Palacký University, Šlechtitelů 27, 78371 Olomouc, Czech Republic)

Received: 2020-01-20 Accepted : 2020-01-20 Published : 2020-03-01

Keywords: Cannabis, Cannabinoids, Cannabidiol (CBD), D9-THC, Pharmacological properties,

Abstract :

Cannabinoids are synthetic, semisynthetic or natural organic molecules that bind to cannabinoid receptors, and they have similar pharmacological properties as produced by the plant,Cannabis sativaL..Of the 113 naturally occurring cannabinoids identified to date, D9-tetrahydrocannabinol (D9-THC or simply, THC) and cannabidiol (CBD) are the two major cannabinoids, biosynthesized byC. staiva. While D9-THC is the main contributor to the psychoactive property ofC. sativa, interestingly, the other major compound, CBD, possesses antipsychoactive property as well as other beneficial medicinal properties, because of which, this compound has been in the lime light for its potential pharmaceutical/medicinal and cosmeceutical applications. However, because of various legislative bottlenecks and restrictions regarding the use, sell and possession ofCannabisandCannabisproducts including CBD have made difficult to its breakthrough in the market in many countries, especially in the UK.

References:

Corroon, J., Kight, R., 2018. Regulatory status of cannabidiol in the United States: A perspective. Cannabis Cannabinoid Res. 3, 190-194.

Lafaye, G., Karila, L., Blecha, L., Benyamina, A., 2017. Cannabis, cannabinoids, and health. Dialogues Clin. Neurosci.19, 309-316.

MedlinePlus, 2019. Cannabidiol. US National Library of Medicine. https://medlineplus.gov/druginfo/natural/1439.html (accessed on 22 December 2019).

Nahar, L., Onder, A., Sarker, S. D., 2020. A review on the recent advances in HPLC, UHPLC and UPLC analyses of naturally occurring cannabinoids (2010-2019). Phytochem. Anal. DOI: 10.1002/pca.2906