Serum levels of malondialdehyde, glutathione peroxidase and superoxide dismutase in patients with non-Hodgkin's lymphoma in Zahedan

Subject Areas :

Hosnie Hoseini ¹ , Parichehreh Yaghmaei ² , Gholamreza Bahari ³ , Saeed Aminzadeh ⁴

1 - Department of Laboratory Sciences, Zahedan Branch, Islamic Azad University, Zahedan, Iran
2 - Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
3 - Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran |Children and Adolescent Health Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran
4 - Department of Animal and Marine Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran

Received: 2020-01-23 Accepted : 2020-05-19 Published : 2020-06-15

Keywords: Non-Hodgkin lymphoma, superoxide dismutase, Malondialdehyde, Glutathione Peroxidase,

Abstract :

Imbalance in the production of oxidative molecules and antioxidant activity plays an important role in carcinogenesis. This study was performed to evaluate the serum level of malondialdehyde (MDA) as oxidative damage marker, superoxide dismutase (SOD) as well as glutathione peroxidase (GPx) as an antioxidant defense system in non-Hodgkin's lymphoma (NHL). Twenty-five NHL patients and twenty-five healthy individuals were included in the study. The data showed that lower activity of enzymatic antioxidants (GPx, SOD) and higher MDA levels in NHL patients than in the control group. The results suggest that increased serum MDA and decreased SOD and GPx activity may be due to oxidative stress, which may play an important role in NHL formation. the role of oxidative stress in the pathogenesis of the NHL has not been extensively studied. Therefore, the present study aimed to measure the level of MDA as well as GPx and SOD activity in blood tissue collected from NHL patients compared with the control group.

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