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Open Access Article
1 - A deductive kinetic study of diclofenac release from chitosan-based magnetic nanocomposite hydrogels
Zargazi M. H. Ghadimi Yari M. Mehran Kurdtabar -
Open Access Article
2 - Density Functional Theory Calculations of Functionalized Carbon Nanotubes with Metformin as Vehicles for Drug Delivery
Morteza Keshavarz -
Open Access Article
3 - Theoretical Study of Drug Delivery Ability of Carbon INanotube
N. Dalill Mansour K. Zare A Elsagh -
Open Access Article
4 - Physicochemical Characteristics and Biomedical Applications of Hydrogels: A Review
R. Sariri -
Open Access Article
5 - Investigation of nuclear magnetic resonance (NMR) and Binding Energies Clonidine Drug-Carbon Nano Tube: A Theoretical Study
Z. Yousefian -
Open Access Article
6 - Development of exosome based drug delivery system for cancer treatment: a comprehensive review
shamseddin yousef amoli Razieh Yousefian molla Toktam Deylami Masoumeh Deylami Zahra shahab movahed Meghdad GhiyasiIn the present era, prevalence of cancer is increasing all over the world. So far, a variety of methods have been used to cure and stop cancer, but this disease resistance to current anticancer drugs has created a new need to new pharmaceutical compounds and drug delive MoreIn the present era, prevalence of cancer is increasing all over the world. So far, a variety of methods have been used to cure and stop cancer, but this disease resistance to current anticancer drugs has created a new need to new pharmaceutical compounds and drug delivery system. Immune deficiency can lead to tumor growth and progression. Therefore, cancer immunotherapy is amongst methods that prevent tumor growth. Exosomes are normal nano- carriers which have been distributed widely in the body fluids and are involved in various diseases processes, including tumorigenic. Exosomes have various advantages. They are non-toxic and non- immunogenic, they are capable of being designed to determine specific target and deliver drug. Therefore, they are used as a strong nano-structure to present anti-cancer drugs with the aim to treat cancer. This method has advanced to ease its usage in medical programs and biotechnology techniques. In this review paper, we investigate the development of Exosomes-based drug delivery systems over time and its advantages and functions. Effectiveness studies on exosome nano-particles using cancer cells and biological models as well as clinical trial are also discussed. Manuscript profile -
Open Access Article
7 - Investigating levothyroxine drug release on synthesized nanocomposite containing magnetic cores covered with alginate polymer and metal-organic framework
Zaynab Madadi Fadaeian Manochehr Mohammad Ali GhasemzadeObjectives: Levothyroxine drug is used to treat thyroid diseases, which is one of the most common chronic diseases in the world, and considering that levothyroxine is a hydrophobic drug with low solubility and low stability, it requires an advanced drug delivery system. MoreObjectives: Levothyroxine drug is used to treat thyroid diseases, which is one of the most common chronic diseases in the world, and considering that levothyroxine is a hydrophobic drug with low solubility and low stability, it requires an advanced drug delivery system. Among the targeted drug delivery systems, magnetically modified porous carriers have a high capacity to store drugs due to the presence of side groups, the adaptability of its porosity, and release it over a long period of time and instead of spreading throughout the body, it affects only the desired cell. he does.Materials and methods: The present research deals with preparing and identifying the metal-organic framework and investigating its performance in levothyroxine drug loading and release. First, MnCuFe2O4 nanoparticles were synthesized and covered by alginate polysaccharide. After that, the metal-organic framework 66-UiO was placed on it and the three-layer composite MnCuFe2O4@Alginate@UiO-66 was made.Findings: loading and release of levothyroxine drug on the synthesized nanocarrier was investigated at pH 7.4. The fabricated nanocomposite was examined by various methods such as SEM, EDX, FT-IR, BET. Nanocomposite was made with cheap and biodegradable raw materials such as alginate using an easy method with targeted drug delivery and magnetic strength.Conclusions: This nanocomposite with 87% loading capacity and 73% levothyroxine release can be used as a new and targeted drug delivery system. Manuscript profile -
Open Access Article
8 - Investigation of the Potential of Adsorption and Drug Delivery Application of the Duloxetine Antipsychotic by using its Molecular Imprinted Polymer
Seyyedeh Fatemeh Hoseini chehreghani Parviz Aberoomand Azar Maryam Shekarchi Bahram Daraei -
Open Access Article
9 - Fabrication of Graphene Oxide Nanocomposite Based on Poly(3-hydroxybutyrate)-Chitosan as a Useful Drug Carrier
Seyed Mohammadjafar Mousavi Mirzaagha Babazadeh Mahboob Nemati Moosa Esʼhaghi -
Open Access Article
10 - Investigation of the Drug Delivery Potential of a Transdermal Patch Based on Buprenorphine Templated Molecular Imprinted Polymer
Nasrin Behnia Parviz Aberoomand Azar Maryam Shekarchi Mohammad Saber Tehrani Noushin Adib -
Open Access Article
11 - Modification of Polyvinyl Alcohol via Atom Transfer Radical Polymerization for Targeted Drug Delivery Applications
Sedigheh Ehsanimehr Peyman Najafi Moghadam Nasim Movagharnezhad Amir Reza Fareghi -
Open Access Article
12 - DFT-based study on Melphalan absorption on defective graphene-doped Si, Al and p
abolghasem shameli soha sabzalivandDue to growing demand of scientific society to targeted drug delivery for treatment of special diseases in which application of drugs results in various side effects,several studies were conducted with the aim of better understanding and optimizing experimental approach MoreDue to growing demand of scientific society to targeted drug delivery for treatment of special diseases in which application of drugs results in various side effects,several studies were conducted with the aim of better understanding and optimizing experimental approach for surveying capability of nano carriers and employing theoritical and computational methods. SaNano carriers improve the efficacy of a drug by changing the pharmacokinetic properties which leads to a reduction in side effects as well. In this study all investigations were obtained by means of density functional theory(DFT).optimization and frequency calculations were performed at B3LYP/6-311G(d) basis set.we have surveyed the adsorption of Melphalan on pure graphene and doped Graphene by Si,Al and P as well.According to the investigations, the adsorption energy has increased on doped graphene sheet which demonstrates that they could be applied as appropriate carriers for making complexion with Melphalan. Manuscript profile -
Open Access Article
13 - The Study of absorption of drug anticancer Chlorambucil on Graphene: A DFT Study
abolghasem shameli Ebrahim balaliRecently, increasing use of nanotechnology has moved to the delivery of chemotherapeutic drugs.Research extending is based to find novel targets in cancer cells, targeting methods, fixation of nanoparticles on the target site, drug delivery to the target cell and drug t MoreRecently, increasing use of nanotechnology has moved to the delivery of chemotherapeutic drugs.Research extending is based to find novel targets in cancer cells, targeting methods, fixation of nanoparticles on the target site, drug delivery to the target cell and drug therapeutic effects on the cancer tumors. Direct injection of anticancer drugs may cause side effects, such as harm to the nervous system, for this cause, it’s important to computational studies of its controlled release by graphene nano-plate. This study is based on the calculations of the density function theory with the basis sets B3LYP 6-31G*, which is the most suitable computational method. In this study are discussed the absorption of the Chlorambucil anticancer drug on the pristine graphene and doping graphene with Nitrogen (N) and Aluminium (Al). This research is discussed different effects on the parameters of the density of state (DOS) and natural bond orbital (NBO). With the comparative technique was chosen best and most reliable computational method. The conclusion was that the chemical properties of structures are highly dependent on the electron spaces the nucleus of the atoms. Manuscript profile -
Open Access Article
14 - Characterization of bio-hydrogels synthesized based on wild sage seed's gum by spectroscopic methods and evaluation of swelling and drug delivery with changes in temperature and pH
هما کوشکی محمد مهرشاد Seyed Hashem AkhlaghiMethods: In this research, composites based on Fe3O4 nanoparticles coated with silica gel and modified by vinyl groups were prepared. The modified nanoparticles were reacted with Mero grain gel to establish a covalent bond between the two compounds. Naproxen was then ad MoreMethods: In this research, composites based on Fe3O4 nanoparticles coated with silica gel and modified by vinyl groups were prepared. The modified nanoparticles were reacted with Mero grain gel to establish a covalent bond between the two compounds. Naproxen was then added to the final nanohydrogel. UV spectroscopy was used to ensure drug loading. After that, the drug release step was tested and UV spectroscopy was used again. FT-IR spectroscopy was also used to identify the modified nanoparticles. The surface morphology and dispersion of nanoparticles in maroon grain nanohydrogels were investigated using SEM scanning electron microscopy technique.Increasing the rate of water penetration into the hydrogel network reduces the release time of the drug. By placing the hydrogel in a buffer with a pH of 7.4, the buffer solution penetrates into the hydrogel network and the drug is released from it, so over time, the concentration of the drug in the buffer increases and the absorption of naproxen loaded: 2.1757, Absorption of naproxen released after 24 hours: 1.386 and drug release percentage after 24 hours: 63.7%. Manuscript profile -
Open Access Article
15 - Studying the π-π interaction between single-stranded oligonucleotides and single-walled carbon nanotubes by molecular dynamics simulation and density functional theory
Mohammad Reza Bozorgmehr Maryam Ghanbari Ghanbarloo Ali MorsaliCarbon nanotubes are used in smart drug delivery due to their biocompatibility. However, due to the non-polar nature of these compounds, their use in the in vivo environment is limited. To solve this limitation, functionalization of nanotubes is used. Biological compoun MoreCarbon nanotubes are used in smart drug delivery due to their biocompatibility. However, due to the non-polar nature of these compounds, their use in the in vivo environment is limited. To solve this limitation, functionalization of nanotubes is used. Biological compounds such as nucleic acids are used to functionalize nanotubes. Understanding the interaction mechanism of nanotubes with biological compounds can help in smart drug delivery. In this research, the interaction of four homocopolymers of organic bases adenine, guanine, cytosine and thymine with carbon nanotubes was studied by molecular dynamics simulation and density functional theory. The distance between the two ends of each homocopolymer and the number of atoms of the organic base rings of the homocopolymers were calculated. These two quantities were used to calculate the probability of the system being in different states. Then, the Gibbs free energy for each interaction was calculated using the calculated probabilities. The results show that purine homocopolymers surround the carbon nanotube, while pyrimidine homocopolymers are placed on the surface of the nanotube. The number of monomers with π-π interaction in homocopolymer with guanine 4, adenine 3, cytosine and thymine 2 was obtained. Manuscript profile -
Open Access Article
16 - In vivo murine breast cancer targeting by magnetic iron nanoparticles involved L. GG cytoplasmic fraction
Salar Mokriyani Naser Harzandi Amir Tukmehchi Leila JabalameliInroduction & Objective: The use of chemical anti-cancer drugs frequently create serious side effects. However, probiotics are natural and treat different kinds of cancer without undesired effects. In this study, a nano delivery system was planned to transport the L MoreInroduction & Objective: The use of chemical anti-cancer drugs frequently create serious side effects. However, probiotics are natural and treat different kinds of cancer without undesired effects. In this study, a nano delivery system was planned to transport the Lactobacillus rhamnosus GG (L. GG) cytoplasmic fraction (Cf) to cancerous tissue in the mouse model. Material and Methods: Magnetic iron nanoparticles (MINPs) were synthesized and loaded with L. GG-Cf (0, 0.312, 0.625, 1.25, 2.5 mg/ml) and administrated for three weeks to treat experimentally induced murine breast cancer in a constant magnetic field. At the end of the trial, the treating efficacy of this complex molecule was evaluated via western blotting and qPCR. Results: Results showed MINPS can deliver and accumulate the L. GG-Cf in cancer tissue, also the size and volume of the tumors were reduced. Additionally, in cancer tissues of treated mice with 2.5 mg/ml of Cf-MINPs significant induced apoptosis was seen compared to untreated (control), and our data proved that this induction may be due to the caspase-3 pathway. Conclusion: In conclusion, L. GG-Cf could treat the murine breast cancer and MINPs are a suitable candidate for drug delivery because of their safety, uniformity, and magnetic properties. Manuscript profile -
Open Access Article
17 - Synthesis and Optimization of Human Serum Albumin Nanoparticles for Drug Delivery Application
rabi mehravar Mohsen JahanshahiAbstract In recent years, the application of protein nanoparticles has become of more and more interest to the pharmaceutical industry. In this study,Human Serum Albumin (HSA) was used for the synthesis of nanoparticles by desolvation method for application in drug deli MoreAbstract In recent years, the application of protein nanoparticles has become of more and more interest to the pharmaceutical industry. In this study,Human Serum Albumin (HSA) was used for the synthesis of nanoparticles by desolvation method for application in drug delivery system because of biodegradablity, owing to the high capacity of drug loading and nontoxiticty. Moreover, the effects of different parameters i.e. pH, HSA concentration, agitation speed, glutaraldehyde concentration, organic solvent adding rate, the ratio of organic solvent/HSA solution were examined in this research and Taguchi method with L16 orthogonal array was implemented to optimize experimental conditions. The best parameters for nanobioparticles production were obtained at pH=9, HSA concentration: 75 mg.ml-1 , ethanol adding rate: 1.5 ml.min-1 and the ratio of organic solvent/HSA solution: 4. Under these conditions, the software predicted the 46.625 nm for HSA nanoparticle size, which, in experiment 53 nm, was achieved for the nanoparticles. With respect to our study, the synthesis of human serum albumin nanoparticles was carried out for the first time and to the best of our knowledge, no reference has been found in the literature about using Taguchi method for optimization of HSA nanoparticles up to now. Manuscript profile -
Open Access Article
18 - Application of chitosan polymeric carriers as controlled drug delivery systems
Milad Ghezelsofloo Abdulhamid Dehghani Soheila GhasemiIn recent decades, natural polymers, especially polysaccharides, have been used as carrier to deliver a wide range of therapeutic agents. Chitosan, the second most abundant natural polysaccharide after cellulose, is a biocompatible, biodegradable, hydrophilic, non-toxic MoreIn recent decades, natural polymers, especially polysaccharides, have been used as carrier to deliver a wide range of therapeutic agents. Chitosan, the second most abundant natural polysaccharide after cellulose, is a biocompatible, biodegradable, hydrophilic, non-toxic, high bioavailability polymer with the ability to form films, gels, nanoparticles, microparticles, and granules. Chitosan is a linear polysaccharide obtained by deacetylation of chitin. Also, biodegradable chitosan in the human body is broken down into safe compounds (amino sugars) that are easily absorbed. Chitosan has hydroxyl and amine chemical functional groups that can be modified to achieve specific goals and turn it into a polymer with a wide range of potential applications. The aim of this paper is to provide insight into the potential applications of chitosan as a drug carrier. In the following, the use of chitosan to build deliverable sustainable delivery systems in other ways (oral, nasal, ocular, mucosal adhesion, buccal, and vaginal) is discussed. This report shows that research on chitosan-based systems containing different drugs for various therapeutic applications such as cancer treatment, gastrointestinal diseases, lung diseases, drug delivery to the brain and eye infections has increased in recent years. Manuscript profile -
Open Access Article
19 - A Review on Environment Responsive Hydrogels and their Advancement in Cancer Therapy
Mehrab Fallahi-Samberan Payam KazemianIn recent years, with the rise in research interest in new functional polymer materials and nanotechnology, drug delivery vehicles have become the focus of clinical medicine, especially for cancer treatment. Hydrogels, especially smart hydrogels, have received increasin MoreIn recent years, with the rise in research interest in new functional polymer materials and nanotechnology, drug delivery vehicles have become the focus of clinical medicine, especially for cancer treatment. Hydrogels, especially smart hydrogels, have received increasing attention due to their low toxicity, good biocompatibility, and biodegradability. Recent decades have witnessed numerous successful examples of hydrogel applications as anticancer drug delivery vehicles. Hydrogel carriers can cause fewer side effects than systemic chemotherapy, and these carriers also enable stable delivery of the drug to tumor sites. Intelligent hydrogels can respond to the environmental stimuli. Todays some internal and external stimuli are widely utilized for designing smart hydrogels for cancer therapies. smart hydrogels can undergo degradation or conformational changes under temperature, light, pH, redox potential, magnetic field and ultrasound stimulation, which can be utilized to achieve high drug delivery efficiency for in situ cancer treatment. In this research, the different sizes of hydrogels used for cancer treatment and their related delivery routes, the design strategies for stimuli- responsive hydrogels and the research concerning smart hydrogels reported in the past few years have been studied. In recent years, with the rise in research interest in new functional polymer materials and nanotechnology, drug delivery vehicles have become the focus of clinical medicine, especially for cancer treatment. Manuscript profile -
Open Access Article
20 - Drug delivery by nanotechnology for censer therapy
Saeideh Ebrahimiasl Mina NiushaNanotechnology in the field of drug delivery is rapidly developing to overcome several limitations of traditional drug delivery systems and to be used as a superior treatment for cancer treatment. Conventional chemotherapy has some serious side effects, including damage MoreNanotechnology in the field of drug delivery is rapidly developing to overcome several limitations of traditional drug delivery systems and to be used as a superior treatment for cancer treatment. Conventional chemotherapy has some serious side effects, including damage to the immune system and other organs due to non-specific targeting, lack of solubility, and the inability of the drug to penetrate the tumor core, which causes disruption in treatment. Nanotechnology has provided an opportunity to directly access cancer cells in a selective manner by increasing cellular uptake and drug effectiveness. Nanotechnology tools can be used to recognize cancer cells and deliver selective and precise drugs without avoiding interaction with healthy cells. In this study, the ability and application of nanotechnology tools with different strategies and with unique identification features in the detection of cancer cells and in the transfer of drugs and the delivery of specific drugs inside specific cells have been discussed, which is based on successful research in this field. It has been done, it shows that nanotechnology tools are suitable for removing the side effects of common cancer treatments and also increasing the effectiveness of the drug. Manuscript profile -
Open Access Article
21 - Preparation, Properties and Applications of Acrylic acid/ Acrylamide Based Hydrogels: A Review
Mehrab Fallahi-Samberan Tannaz Soltanolzakerin- SorkhabiHydrogels are among the well-liked biomaterials due to their biocompatibility, biodegradability and non-toxic properties which can be used in various applications in the field of engineering and medicine such as agriculture, pharmaceuticals, biomedical and cosmetic indu MoreHydrogels are among the well-liked biomaterials due to their biocompatibility, biodegradability and non-toxic properties which can be used in various applications in the field of engineering and medicine such as agriculture, pharmaceuticals, biomedical and cosmetic industry. Hydrogels are hydrophilic components that have the capability to absorb water or biological fluid. Hydrogels can be synthesized by polymer crosslinking. Applications, common synthesis and physical, chemical, mechanical and morphological properties of hydrogels are targeted to be understood through this review, focusing on acrylic acid and acrylamide based hydrogels and their application in medicine. Hydrogels have been used as a drug delivery system in varying medical areas from cardiology, oncology, immunology and wound healing to pain management. The main objective of this review is to gather information about the hydrogels such as acrylic acid, acrylamide, and preparation method of these hydrogels using N,N-methylenebisacrylamide (MBAA-crosslinker), ammonium persulfate (APS-initiator), tetramethylethylenediamine (TEMEDA-catalyst), and Fe+3 (ionic cross linker). future perspective of hydrogel materials is also considered in this review. Manuscript profile -
Open Access Article
22 - Application of near-infrared responsive nano-carrier for controlled drug delivery: synthesis, isotherm and kinetic studies
Mohammadreza Mahdavijalal Homayon Ahmad Panahi Ali Niazi Atefeh Tamaddon Elham Moniri -
Open Access Article
23 - Numerical Simulation of Fluid Flow over a Ceramic Nanoparticle in Drug Delivery System
Mina Alafzadeh Shahram Talebi Mojdeh Azizi -
Open Access Article
24 - Biological application of Layered double hydroxides in drug delivery systems
nahid shahabadi Mahtab Razlansari -
Open Access Article
25 - Potential of magnetite nanoparticles with biopolymers loaded with gentamicin drug for bone cancer treatment
Ehsan Nassireslami Mehdi Motififard Bahareh Kamyab Moghadas Zahra Hami Amir Jasemi Amin Lachiyani Reza Shokrani Foroushani Saeed Saber-Samandari Amirsalar Khandan -
Open Access Article
26 - Preparation and Characterization of Silica Coated Magnetic Cu Based MOF as a Nanocarrier for Gradual Release of the Capecitabine Anticancer Drug
Azar Asgari Pari Susan Samadi Mohammad Reza__Allahgholi__Ghasri Mohammad Reza__Allahgholi__Ghasri Maryam Torbati Mohammad YousefiThis study developed a novel silica-coated magnetic nanoparticle (Fe3O4@SiO2@Cu BTC) based on a metal-organic framework (MOF) for targeted anticancer medication delivery. Using a co-precipitation method, the Fe3O4@SiO2 core was coated with Cu(OH)2 shell, which was then MoreThis study developed a novel silica-coated magnetic nanoparticle (Fe3O4@SiO2@Cu BTC) based on a metal-organic framework (MOF) for targeted anticancer medication delivery. Using a co-precipitation method, the Fe3O4@SiO2 core was coated with Cu(OH)2 shell, which was then converted to CuBTC in a hydroethanolic mixture. Finally, a post-synthetic approach was used to manufacture a 3-(mercaptopropyl) trimethoxysilane functionalized Fe3O4@SiO2@Cu BTC nanocomposite. The resulting material is characterized using SEM-EDX, TEM, VSM, XRD, TGA, BET, UV–Vis, and FTIR techniques. TEM and SEM micrographs confirmed the core-shell structure. The resulting nanocomposite has high thermal stability, according to TGA findings. Because of their great biocompatibility and drug loading capability, coated Fe3O4@SiO2@Cu BTC nanoparticles might be perfect for drug delivery. Capecitabine (CAP), an anticancer medication, was successfully dispersed through MOF pores. The acquired data revealed that 91 percent of the CAP was adsorbed on the constructed framework, and that the release of capecitabine in PBS buffer solution (pH 5.7) at 37 °C took up to 60 hours to complete. The findings show that nano-sized MOFs-based magnetic NPs with high drug loading and acceptable biocompatibility are viable options for targeted drug delivery. Manuscript profile -
Open Access Article
27 - Theoretical insights into the encapsulation of anticancer Oxaliplatin drug into single walled carbon nanotubes
Mahyar Rezvani Iran Ahmadnezhad Masoud Darvish Ganji Maria Fotukian -
Open Access Article
28 - Hollow Mesoporous Silica Nanoparticles (HMSNs) Synthesis and in vitro Evaluation of Cisplatin Delivery
Zohreh Jomeh Farsangi Seyed Mehdi Rezayat Ali Beitollahi Saeed Sarkar Mahmoudreza Jaafari Amir Amani -
Open Access Article
29 - Potential of magnetite nanoparticles with biopolymers loaded with gentamicin drug for bone cancer treatment
Ehsan Nassireslami Mehdi Motififard Bahareh Kamyab Moghadas Zahra Hami Amir Jasemi Amin Lachiyani Reza Shokrani Foroushani Saeed Saber-Samandari Amirsalar Khandan -
Open Access Article
30 - Fluorouracil functionalized Pt-doped carbon nanotube as drug delivery nanocarrier for anticarcinogenic drug: a B3LYP-D3 study
Zahra Khalili Masoud Darvish Ganji Maryam Mehdizadeh -
Open Access Article
31 - Biological Application of Layered Double Hydroxides in Drug Delivery Systems
Nahid Shahabadi Mahtab Razlansari -
Open Access Article
32 - Evaluation of adsorption potential of Buprenorphine drug from blood plasma by its molecular imprinted polymer; a joint experimental and theoretical study
Maryam Khanlari Bahram Daraei Leila Torkian Maryam Shekarchi Mohammad Reza Manafi -
Open Access Article
33 - Preparation and characterization of biodegradable magnetic nanoparticles biodegradable based on polyurethane for gene delivery into MCF-7 cells
Zhale Alirezazad hashem yaghoubi Somayeh Javid Zahra AjamThe folate receptor (FR) is known to be over-expressed extracellularly on a variety of human cancers. Therefore, this molecule is an ideal candidate for targeting nanoparticles to drug delivery using these nanoparticles to cancer cells or cancer tissues. In this study, MoreThe folate receptor (FR) is known to be over-expressed extracellularly on a variety of human cancers. Therefore, this molecule is an ideal candidate for targeting nanoparticles to drug delivery using these nanoparticles to cancer cells or cancer tissues. In this study, we designed an amphiphilic cationic Fe3O4-PEI-PU-PEG-FA nanoparticles. The prepared nanoparticles were characterized by FTIR, VSM, TEM measurements. FTIR indicated that the synthesis of Fe3O4-PEI-PU-PEG-FA nanoparticles have been performed successfully. Vibrating sample magnetometry (VSM) showed that the biodegradable-magnetic nanoparticles were superparamagnetic at room temperature. The morphology of the Fe3O4 and Fe3O4-PEI-PU-PEG-FA nanoparticles were evaluated using a transmission electron microscopy. TEM showed the nanoparticles were spherical in shape. Moreover biocompatibility assay of Fe3O4-PEI-PU-PEG-FA nanoparticles was performed using MTT test. Also the ability of Fe3O4-PEI-PU-PEG-FA nanoparticles to DNA delivery into MCF-7 cells were analysis using MTT test and flow cytometry respectively. Interestingly, due to the incorporation of PU and PEG segments, this Fe3O4-PEI-PU-PEG-FA nanoparticles showed less toxicity but better gene transfection efficiency than PEI. Manuscript profile -
Open Access Article
34 - PEGylation of polyamidoamine-G3 dendrimer bonded with silica-coated magnetic nanoparticles as a pH-sensitive targeted drug delivery system
seyed esmaeil mhamadi mehr Mehdi Faramarzi seyed abotaleb mosavi parsaThis research, reports the fabrication of a new pH-responsive nanocarrier based on iron oxide nanoparticle with dendrimer coating and PEG conjugated for targeted and controlled delivery of chemotherapy drugs to cancer cells. The structure of the nanocarrier was confirme MoreThis research, reports the fabrication of a new pH-responsive nanocarrier based on iron oxide nanoparticle with dendrimer coating and PEG conjugated for targeted and controlled delivery of chemotherapy drugs to cancer cells. The structure of the nanocarrier was confirmed by Fourier transform infrared (FT-IR) spectra analysis. transmission electron microscope (TEM), Field Emission Scanning Electron Microscopy (FE-SEM) and vibrating sample magnetometer (VSM) analysis showed that the nanocarrier has a spherical structure with super paramagnetic properties. The efficiency of nanocarrier was evaluated with cyclophosphamide chemotherapy drug. The in vitro drug release studies at different pH proved the pH-sensitivity of the nanocarrier. Due to the open state of dendritic structure in acidic pH, the maximum release observed at pH 4.5 (lysosomal pH). Mass transfer studies showed that drug release from nanocarrier is rapid in short contact time and slow in long contact time. These results indicate that cyclophosphamide-loaded magnetic nanocarrier is promising for targeted delivery and controlled drug release. Manuscript profile -
Open Access Article
35 - The role of metal and non-metal nano oxides in improving the physical properties of drugsin drug formulation
Somaye Golsanamlou Aliakbar TarlaniIn this review article, the role of porous inorganic oxide compounds as drug carriers in order to improve the physical properties of drugs is discussed. Solubility and permeability of drugs in the digestive system is one of the determining factors of oral bioavailabilit MoreIn this review article, the role of porous inorganic oxide compounds as drug carriers in order to improve the physical properties of drugs is discussed. Solubility and permeability of drugs in the digestive system is one of the determining factors of oral bioavailability of drugs. There have always been drugs whose solubility needed to be optimized to prepare a suitable oral formula. Today, as a result of extensive research and the emergence of new drugs, the number of drugs that have solubility problems has increased, including some cardiac drugs that are in the second class of drugs and have low solubility. The low solubility of these types of drugs has caused therapeutic limitations because to increase the effectiveness of these drugs, a higher dose of them has to be prescribed which causes the drug to accumulate in the blood and deposit in the blood vessel wall. Therefore, drugs need a drug carrier to improve their performance. Drug delivery systems (DDS) including biodegradable polymer nanoparticles, polymer micelles, solid nanoparticles, nanoliposomes, dendrimers, magnetic nanoparticles and quantum dots have been used for this purpose for decades. However, in recent years, the use of metal and non-metal oxides in modern drug delivery systems has attracted the attention of scientists. Compared to other conventional compounds, these inorganic porous compounds have many advantages, including improving solubility and stability, the possibility of controlling the drug dosage, controlling the kinetics of drug release, delivering the drug to the target tissue, reducing side effects, increasing the biocompatibility of the drug, etc. Therefore, the use of new drug delivery systems based on the new generation of metal and non-metal oxides in order to improve the solubility, permeability and biocompatibility of drugs is an important and essential step in the formulation of drugs, which has been discussed in this article. Manuscript profile -
Open Access Article
36 - Skin drug release and antifungal activity of econazole-containing silica nanoparticles
maryam montazeri Saman Ahmad Nasrollahi Alireza Feizbakhsh, , Mehdi Razzaghi-AbyanehBackground & Objectives: Silica Nanoparticles (MCM41) are silica mesopores (MSNs), which have large pores and relatively low density. The purpose of this study was to load Econazole onto silica nanoparticles (MCM41-NH2 and MCM41) And release of econazole in human sk MoreBackground & Objectives: Silica Nanoparticles (MCM41) are silica mesopores (MSNs), which have large pores and relatively low density. The purpose of this study was to load Econazole onto silica nanoparticles (MCM41-NH2 and MCM41) And release of econazole in human skin (Ex-Vivo) then the antifungal effect of loaded econazole on silica nanoparticles was investigated. Materials & Methods: In this study, MCM41 was prepared, then MCM41-NH2 nanoparticles were provided by using amine cetyltrimethylammonium bromide and finally, the drug econazole was loaded on it. The morphology of the nanoparticles was determined by SEM and drug loading by FT-IR. Francescell and UV-Vis were used to measure the release. The release cream from the skin containing 1/1 drug and nanoparticles was prepared. Finally, the anti-fungal effect of ECO/MSNs was investigated in three ways. Francescell device was also used to check skin release. Results: Silica nanoparticles were prepared about 300 nanometers Release of the drug into the skin showed that during the first 8 hours 80% release and then up to 24 hours of continuous drug release. Antifungal effect by disk diffusion method showed that ECO/MCM41 had a larger inhibitory effect and also minimal inhibition of fungal growth (MIC) 75 mg/ml. Antifungal tests showed that no fungus grew after 72 hours.the antifungal effect as well as ECO / MCM41 (MIC) was greater in methanol. Conclusion: The antifungal effect of the newest agar method was not suitable for this drug. Therefore, as a suitable drug in the cream, a drug loaded with methanol is recommended. Manuscript profile -
Open Access Article
37 - Controlled Release of Amoxicillin from Bis(2-hydroxyethyl)amine Functionalized SBA-15 as a Mesoporous Sieve Carrier
Nafiseh Yaghobi Leila Hajiaghababaei Alireza Badiei Mohammad Reza Ganjali Ghodsi Mohammadi Ziarani -
Open Access Article
38 - Synthesis and characterization of mesoporous magnesium silicate for controlled release drug applications
اشکان بی غمIn the present study, mesoporous magnesium silicate (m-MS) was synthesized via non-ionic surfactant-assisted sol-gel method. The m-MS was produced into an acidic medium and calcined at 550 ºC temperature to remove the organic template (P123). The aim of this study MoreIn the present study, mesoporous magnesium silicate (m-MS) was synthesized via non-ionic surfactant-assisted sol-gel method. The m-MS was produced into an acidic medium and calcined at 550 ºC temperature to remove the organic template (P123). The aim of this study was to evaluate the ability and application of drug loading and controlled release from m-MS. In addition, the effect of drug loading and release on textural properties of m-MS such as surface area, pore diameter and pore volume was investigated. The synthesized compound was studied by X-ray diffraction (XRD), Fourier transform infrared spectra (FTIR), Brunauer–Emmett–Teller (BET) surface area analysis, transmission electron microscopy (TEM) and Uv-vis spectrophotometer. The low angle XRD, BET and TEM results showed that magnesium silicate contained 2D hexagonal honeycomb pore channels with uniform and homogeneously distributed mesopores of the same size. The m-MS demonstrated large specific surface area by about 504 m2/g and after adsorption of ibuprofen, the N2 adsorbed volume decreased obviously, and the corresponding BET surface area, pore size and pore volume changed from the 504 m2/g, 4.6 nm, 0.44 cc/g (550 ºC) to 225 m2/g, 1.2 nm, 0.21 cc/g (550 ºC drug loaded) respectively. This study revealed that m-MS has the ability to drug loading and controlled release of ibuprofen and can be used as a novel drug delivery system. Manuscript profile -
Open Access Article
39 - Magnetite -silica-quantum dot carbon nano composite to use in melatonin drug delivery
aida faeghinia hossein nouranian mojtaba eslamiIn targeted drug delivery, the drug is released at specific points and conditions, and in this study, magnetite nuclei were used to target the drug system. First, magnetite nanoparticles were synthesized by co-precipitation of two- and three coordinated iron chloride sa MoreIn targeted drug delivery, the drug is released at specific points and conditions, and in this study, magnetite nuclei were used to target the drug system. First, magnetite nanoparticles were synthesized by co-precipitation of two- and three coordinated iron chloride salts (FeCl2 and FeCl3).Carbon dioxide quantum dots, which had been hydrolyzed by citric acid and whose surface was ineffective by diethylamine, were then placed in silica cavities by physical absorption. The effective drug melatonin was also loaded on the system by physical absorption, and the method of releasing this drug by dialysis bag was carefully examined in the simulated environment of blood and cancer tissue, and the quantum yield of the system was determined. The accuracy of the operations performed by electron microscopy, nitrogen uptake and absorption, factor characterization, X-ray diffraction, magnetometry and infrared spectroscopy were investigated. The results showed that the loading of melatonin and carbon quantum dots was well performed on silica nanoparticles with magnetite nuclei, and the system also releases the drug well at room temperature. Manuscript profile -
Open Access Article
40 - Recent Biotechnological Advances in the Preparation of Wound Dressings for Diabetics
Sayed Rasoul Zaker Shahrbanoo Jafari Rahman EmamzadehIn the last two decades, given the importance of biotechnological drugs and their important role in the treatment of chronic wounds, studies have predicted that the market for advanced wound care targeting surgical wounds and chronic wounds is likely to reach $15-22 bil MoreIn the last two decades, given the importance of biotechnological drugs and their important role in the treatment of chronic wounds, studies have predicted that the market for advanced wound care targeting surgical wounds and chronic wounds is likely to reach $15-22 billion by 2024. Therefore, in the present study, the recent advances in biotechnology in the field of preparing wound dressings from compounds obtained from plants and animals for people with diabetic foot ulcers have been discussed. In this research, the methods and approaches of delivery of therapeutic agents for the treatment of DFUs and in fact the recent results of in vitro and in vivo studies, emphasizing the unique potential of wound dressings based on natural polymers in the treatment of DFUs, have been collected and analyzed. This expansion is expected to be driven by advances in technology, increased incidence of chronic wounds, and an increasing elderly population. A review of the challenges ahead in the treatment of chronic wounds reveals the inadequacy of the effectiveness of some wound care products, suggesting that families and governments must contend with medical challenges for longer periods. Diabetic foot ulcer (DFIU) is a chronic ulcer that can cause severe infections and even amputation. Biomaterials that are currently used as matrices for wound healing can be classified into natural and synthetic types according to their origin. Natural biomaterials such as chitosan, alginate, cellulose, hyaluronic acid, silk fibroin, and collagen have been widely recommended for diabetic foot wound healing due to their easy degradability, remarkable biocompatibility, reduced inflammatory responses, and non-immunogenic nature. Biotechnology guarantees the possibility of using natural biomaterials to develop advanced wound dressings with appropriate and patient-friendly therapeutic results. Manuscript profile -
Open Access Article
41 - An Overview of Application of Diferent Nanoparticles in the Treatment of Various Types of Cancer and Investigation of their Cytotoxicity
Elham RostamiChitosan, made of deacetylated of chitin and the amino polysaccharide, is one of the greatest convenient biopolymers, which has large possibilities to be modified for new features of nano-medicine and being used in biomedical fields. Having responsibility of various fea MoreChitosan, made of deacetylated of chitin and the amino polysaccharide, is one of the greatest convenient biopolymers, which has large possibilities to be modified for new features of nano-medicine and being used in biomedical fields. Having responsibility of various features such as cationic nature and controlled drug release, are to the primary amine functional groups in chitosan. There are great properties, such as biocompatibility, biodegradability, loading capacity and an efficient way to avoid undesirable reactions, since the toxicity and side effects of systemic administration are reduced by adjusting Chitosan NPs, they are commonly synthesized as drug carriers. Achieving targeted delivery of drug is due to using peptides, antibodies, aptamer or small molecules. Mentioned methods lower using dosage of adequate drugs. Additionally, they lead the drugs to the targets. Also, the cytotoxicity studies of various nanoparticles and their pharmacokinetic studies have been carried out. The purpose of this review article is to show the importance of the characteristics of antibody-bound, magnetic, pH-sensitive conjugated chitosan nanoparticles in targeted drug delivery and to investigate the effect of these nanoparticles on different types of cancer cells. Manuscript profile
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