Characterization of bio-hydrogels synthesized based on wild sage seed's gum by spectroscopic methods and evaluation of swelling and drug delivery with changes in temperature and pH
Subject Areas :
هما کوشکی
1
(سبزوار)
محمد مهرشاد
2
(سبزوار)
Seyed Hashem Akhlaghi
3
(Department of Chemistry, Islamic Azad University, Sabzevar Branch)
Keywords: : Bio nano-hydrogel, swelling and drug delivery, pH, Temperature Changes, Mero seed gum,
Abstract :
Methods: In this research, composites based on Fe3O4 nanoparticles coated with silica gel and modified by vinyl groups were prepared. The modified nanoparticles were reacted with Mero grain gel to establish a covalent bond between the two compounds. Naproxen was then added to the final nanohydrogel. UV spectroscopy was used to ensure drug loading. After that, the drug release step was tested and UV spectroscopy was used again. FT-IR spectroscopy was also used to identify the modified nanoparticles. The surface morphology and dispersion of nanoparticles in maroon grain nanohydrogels were investigated using SEM scanning electron microscopy technique.Increasing the rate of water penetration into the hydrogel network reduces the release time of the drug. By placing the hydrogel in a buffer with a pH of 7.4, the buffer solution penetrates into the hydrogel network and the drug is released from it, so over time, the concentration of the drug in the buffer increases and the absorption of naproxen loaded: 2.1757, Absorption of naproxen released after 24 hours: 1.386 and drug release percentage after 24 hours: 63.7%.
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