An Overview of Application of Diferent Nanoparticles in the Treatment of Various Types of Cancer and Investigation of their Cytotoxicity

Subject Areas : Journal of Animal Biology

Elham  Rostami ¹ (Department of Chemistry, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran)

Received: 2023-06-25 Accepted : 2023-09-03 Published : 2024-02-20

Keywords: nanoparticles, Chitosan, Cell toxicity, Targeting drug delivery,

Abstract :

Chitosan, made of deacetylated of chitin and the amino polysaccharide, is one of the greatest convenient biopolymers, which has large possibilities to be modified for new features of nano-medicine and being used in biomedical fields. Having responsibility of various features such as cationic nature and controlled drug release, are to the primary amine functional groups in chitosan. There are great properties, such as biocompatibility, biodegradability, loading capacity and an efficient way to avoid undesirable reactions, since the toxicity and side effects of systemic administration are reduced by adjusting Chitosan NPs, they are commonly synthesized as drug carriers. Achieving targeted delivery of drug is due to using peptides, antibodies, aptamer or small molecules. Mentioned methods lower using dosage of adequate drugs. Additionally, they lead the drugs to the targets. Also, the cytotoxicity studies of various nanoparticles and their pharmacokinetic studies have been carried out. The purpose of this review article is to show the importance of the characteristics of antibody-bound, magnetic, pH-sensitive conjugated chitosan nanoparticles in targeted drug delivery and to investigate the effect of these nanoparticles on different types of cancer cells.

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