Magnetite -silica-quantum dot carbon nano composite to use in melatonin drug delivery

Subject Areas :

aida faeghinia ¹ , hossein nouranian ² , Hossein eslami ³

1 - merc
2 - asoc.prof
3 - student

Received: 2020-04-27 Accepted : 2024-01-08 Published : 2023-11-22

Keywords: Silica, melatonin, Carbon, Magnetite, Drug delivery,

Abstract :

In targeted drug delivery, the drug is released at specific points and conditions, and in this study, magnetite nuclei were used to target the drug system. First, magnetite nanoparticles were synthesized by co-precipitation of two- and three coordinated iron chloride salts (FeCl2 and FeCl3).Carbon dioxide quantum dots, which had been hydrolyzed by citric acid and whose surface was ineffective by diethylamine, were then placed in silica cavities by physical absorption. The effective drug melatonin was also loaded on the system by physical absorption, and the method of releasing this drug by dialysis bag was carefully examined in the simulated environment of blood and cancer tissue, and the quantum yield of the system was determined. The accuracy of the operations performed by electron microscopy, nitrogen uptake and absorption, factor characterization, X-ray diffraction, magnetometry and infrared spectroscopy were investigated. The results showed that the loading of melatonin and carbon quantum dots was well performed on silica nanoparticles with magnetite nuclei, and the system also releases the drug well at room temperature.

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