List of Articles موش صحرائی

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  1 - Evaluation of anti-cataleptic effect of Levodopa-Carbidopa and sertraline in the parkinsonian rats
  سیامک ریحانی راد جواد محمودی مجید خانمحمدی شلاله گنجی پیام سیفی
  Long-term administration of Levodopa in parkinsonian patients leads to development of somemotor disorders such as L-dopa induced dyskinesia and off-phenomena. Hence employment ofstrategy for effective treatment of this disease is of interest.In this investigation we att More

  Long-term administration of Levodopa in parkinsonian patients leads to development of somemotor disorders such as L-dopa induced dyskinesia and off-phenomena. Hence employment ofstrategy for effective treatment of this disease is of interest.In this investigation we attempted toevaluate the effect of sertraline on anti-cataleptic effect of L-dopa in 6-hydroxydopamine (6-OHDA) lesioned rats. Catalepsy was induced by infusion of 6-OHDA (8μg/2μl/rat) into theSubstantia nigra. These rats received intraperitoneally (i.p.) L-Dopa (15mg/kg) twice daily for20 consecutive days, and anti-cataleptic effect of L-dopa was evaluated by bar-test on days 5,10, 15 and 20. The results present that L-dopaexert anti-cataleptic effect only until day 15, andits effect was vanished on the day 20. On the day 21, these rats co-injected with three differentdoses of sertraline (0.5, 1and 2mg/kg, i.p.) and L-dopa (15mg/kg, ip). Sertralineat the dose of 2mg/kg improved the anti-cataleptic effect of L-dopa. Furthermore, the effect of sertraline (2mg/kg, i.p.) on anti-cataleptic effect of L-dopa (15mg/kg, ip) was antagonised by NAN-190 (0.5mg/kg, i.p.) as a 5-HT1A receptor antagonist. Theseresults showed that sertraline improvestheanti-cataleptic effect of L-dopa in the 6-OHDA-lesioned rats and probably this effect mediatedthrough activation of 5HT1A receptors. Manuscript profile
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  2 - Histopathological evaluation of the effect of Mentha piperita essential oil on cutaneous wound healing in rats infected with C. albicans
  N. Farhangi Ghaleh Joughi, M.R. Farahpour, M. Neiriz Naghadeh,
  Wound infections caused by Candida albicans has grown substantially in recent years.Expensive medications, side effects, and particularly, the development of drug resistance, led tothe use of biological materials may be considered as an alternative solution. Studies sho More

  Wound infections caused by Candida albicans has grown substantially in recent years.Expensive medications, side effects, and particularly, the development of drug resistance, led tothe use of biological materials may be considered as an alternative solution. Studies show thatMentha piperita essential oil contains flavonoids and menthol and hence it has antibacterialproperties. We used 100 male Wistar rats (weight 195-205 g). One square surgical wound withdimensions of 1.5×1.5 cm were performed on the back of each animal and immediately becameinfected whit 0.1 ml of 1.5×107 CFU Candida albicans suspension. Then the rats were dividedinto 4 groups (control, placebo, treatments 1.5% and 3%) each with 25 rats and randomlydistributed into 5 subgroups each whit 5 rats (sample groups on different days). Wound healingactivity was performed by histological studies and yeast counts at the end of 4th, 8th, 12th, 16thand 20th days after surgery. According to the pathological findings, Mentha piperita essential oiltopically, significantly reduces inflammation and migration of leukocytes, and also significantlyincrease in vascular regeneration, epithelialization and migration of fibroblasts, comparedcontrol group. Mentha piperita essential oil, especially in higher doses (3%), increasedpathological factors affecting wound healing in rats was infected with Candida albicans. Manuscript profile
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  3 - Protective effects of Silymarin on Cell-Phone Induced Liver Damage in Rats
  ََAmir Ashkan Mahjoor
  Inroduction & Objective: Different studies have demonstrated the effects of cell phone induced electromagnetic field on hepatic cells. The aim of this study was to investigate the hrpatoprotective effects of silymarin on this kind of damagesMaterial and MethodsSeventy r More

  Inroduction & Objective: Different studies have demonstrated the effects of cell phone induced electromagnetic field on hepatic cells. The aim of this study was to investigate the hrpatoprotective effects of silymarin on this kind of damagesMaterial and MethodsSeventy rats were divided in five groups. One control group and four exposure groups that were exposed to cell phone radiation 5 times a day for 30 days each time 10 minutes. At the end of the study all of the rats were sacrificed and Alanine Aminotransferase (ALT), aspartate aminotransferase (AST) and Alkaline Phosphatase (ALP), total proptein, total bilirubin and albumin were measured. Liver samples were obtained for histopathological studiesResults: Cell phone radiation significantly (P≤005) increased levels of ALT, AST, ALP, total bilirubin  and decreased levels of total protein and albumin. In groups treated with silymarin improve in biochemical factors were noted. Histopathological findings were consistent with biochemical findingsConclusion:Our results suggest that silymarin has hepatoprotective effects on cell phone induced liver damaged due to free radical scavenger and antioxidant Manuscript profile
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  4 - The Effect Of Agonist Of Serotonergic ReceptoreAndagonist Of Cannabinoidergic Recepror (CB1) on Anxiety-Like Behaviors Of Central Amygdalein the Plus-Maze Model in Wistar Rat
  Saba Taheri Shahrbano Oryan Mohamad Reza Zarrindast Amaneh Rezayof
  Inroduction and ObjectiveAnxiety is a respond of anorganism to a likely treat which can disturb the cellular homstasis. Serotonergic and cannabinoidergic systems contribute in many physiologic behaviors like anxiety. This study was done to investigate the effect of cann More

  Inroduction and ObjectiveAnxiety is a respond of anorganism to a likely treat which can disturb the cellular homstasis. Serotonergic and cannabinoidergic systems contribute in many physiologic behaviors like anxiety. This study was done to investigate the effect of cannabinoidergic system on central amygdala and its interference with serotonergic system on anxiety in "Elevated Plus Maze"Materials and Methods:After a week resting , several doses of Arachidonile Cyclo Propyle Amide (ACPA) and selected Agonist of serotonergic receptore 1 (5-HT1) with commercial name of " CP94253 Hydrochloride" has been Microinjected into Central Amygdala of rat. The presence in Open Arms Time percent  (OAT%) and the number of entrance  into the open arms percent (OAE%) and locomotor activity (LA) was measured.Results: Injection of ACPA has no effect anxiety behaviors. Injection of high doses of agonist of serotonergic receptor has also got no effect of anxiety. microinjection of  non effective dose of CP94253 Hydrochloride into Central Amygdala could suppres the anxyolitic effect of ACPA.Conclusion: Presynaptic cannabinoid receptore of CB1 could inhibit many neurotransmitters secration like serotonin and it seems that serotonin agonist could replace the inhibited neurotransmitter by ACPA. nsi-language: EN-US;mso-fareast-language:EN-US;mso-bidi-language:FA'>ACPAباشد Manuscript profile
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  5 - Evaluation of the effect of aloe vera gel on ovarian tissue structure in nicotine-receiving rats
  Ali Mohammad Shahin Ali Mohammad Bahrami Aref Delkhosh Nematollah Shakarami
  10.30495/jvcp.2022.1942161.1331
  Exposure to nicotine and cigarette smoke has dangerous effects on pregnant women, fetal and neonatal health, and fertility rates. Aloe vera is one of the few medicinal plants that has maintained its popularity for a long time due to its many medicinal properties. Theref More

  Exposure to nicotine and cigarette smoke has dangerous effects on pregnant women, fetal and neonatal health, and fertility rates. Aloe vera is one of the few medicinal plants that has maintained its popularity for a long time due to its many medicinal properties. Therefore, in the present study, the protective effect of aloe vera gel on ovarian histological changes in nicotine-receiving rats was investigated. For this purpose, 32 female Wistar rats into 4 control groups (normal diet), nicotine (6 weeks nicotine at 0.2 mg / kg body weight of animals injected intra peritoneal), nicotine-aloe vera (6 weeks nicotine injection + gel) Aloe vera plant (400 mg / kg body weight of animals orally), Aloe vera group (6 weeks aloe vera gel by the above method and amount) were divided. At the end of the course, the mice were facilitated and the ovaries were transferred to a histological laboratory to prepare a tissue slide and perform hematoxylin-eosin staining. The results showed that after nicotine treatment, weight loss, ovarian weight, number of healthy and active follicles, new corpus luteum and increase in the number of atretic follicles were observed. But the use of aloe vera gel was able to improve all the microscopic complications and disorders and macroscopic changes caused by nicotine injection. Therefore, oral consumption of aloe vera gel can reduce or inhibit the harmful effects of nicotine in tobacco or drugs on the ovaries and fertility in women. Manuscript profile
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  6 - Effect of Malva sylvestris hydroethanolic leaf extract on the healing of full-thickness, excisional skin wounds in the rat
  mohammadreza Farahpour saro Sedaghat
     The healing of full-thickness wounds has always attracted attention due to disruption of the healing process that leads to prolonged recovery period. Therefore, the quest for finding clinically effective wound-healing agents is important in the medical mana More

     The healing of full-thickness wounds has always attracted attention due to disruption of the healing process that leads to prolonged recovery period. Therefore, the quest for finding clinically effective wound-healing agents is important in the medical management of full-thickness wounds. The present study was conducted to investigate the effects of Malva sylvestris hydroethanolic leaf extract on wound healing process in 54 male rats. Two standardized circular surgical full-thickness excisional wounds with a diameter of 7mm were created in the dorsal skin of vats in all three groups. The rats in the two treatment groups were treated with ointments containing 1.5% and 3% of the extract mixed with yellow soft paraffin, whereas the rats in the control group were only treated with yellow soft paraffin. Treatments were applied immediately after wounding and also for 16 consecutive days post-wounding. Wound-healing was assessed microscopically in terms of the initiation of neo-dermal tissue deposition and wound closure over a 16-day period. Significant increase in wound contraction rate was seen in the treatment groups, especially the 3% group, compared to the control group (P<0.05). Moreover, the inflammatory cell score showed a decrease, whereas new vessel formation, fibroblast distribution, collagen production and epidermis thickness increased in Malva sylvestris hydroethanolic leaf extract-treated animals. These results suggest that the topical application of Malva sylvestris hydroethanolic leaf extract has beneficial effects on full-thickness excisional wound healing. Manuscript profile
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  7 - The effect of coenzyme Q10 on the prevention of testicular tissue damages in Alloxan-induced diabetic rats
  seyyed sajjad hejazi ramin jahangirfard
  Coenzyme Q10 is considered as a vitamin or a vitamin-like substance which is found in food resources naturally like other vitamins. In recent years, several drugs have been used effectively for treatment of diabetes, but the treatment or protective effect of few of them More

  Coenzyme Q10 is considered as a vitamin or a vitamin-like substance which is found in food resources naturally like other vitamins. In recent years, several drugs have been used effectively for treatment of diabetes, but the treatment or protective effect of few of them have been studied microscopically. In the present study, the complementary effect of Q10 on testicular structure in alloxan-induced diabetic rats was studied. Forty male Wistar rats were randomly divided into four groups of 10 rats. The first group was the control group; the second group was the control group treated with 75 mg/kg Q10 for one month, orally (gavage); the third one was the alloxan-induced diabetic treatment group in which a single dosage of 120 mg/kg alloxan was administered intra peritoneally, and the fourth group was the diabetic treatment group treated with Q10. The rats’ weight, testis weight, seminiferous tubule diameter, testicular capsule thickness and seminiferous tubular epithelium thickness were measured. Statistical analysis was performed using ANOVA and Duncan,s multiple range test. Q10 demonstrated a modifying effect on the diabetic rats’ testicular damage such that damages in tissue structure and the sex cells, as well as shrinkage of the seminiferous tubules were observed very slightly. Furthermore, Q10 could inhibit the infiltration of the vessels into and under the capsule space which was significant in diabetic group. The use of Q10 as an antioxidant significantly protected the spermatogenic cells, testicular capsule, testis weight, and seminiferous tubule diameter from the damage of diabetes in rats. Manuscript profile
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  8 - Study of teratologic effects of zonisamide on neonatal rat skeletal system
  seyyed sajjad hejazi hossain Erikaghaji hassan Gilanpour
  Zonisamide is one of the most effective medications for epilepsy, which has teratogenic properties; and is widely administrated in patients. The present study aimed to evaluate the teratogenic effects of zonisamide on newborn rats’ skeletal system during fetal per More

  Zonisamide is one of the most effective medications for epilepsy, which has teratogenic properties; and is widely administrated in patients. The present study aimed to evaluate the teratogenic effects of zonisamide on newborn rats’ skeletal system during fetal period. Therefore, 12 mature male rats were mated with 36 female rats and the female rats became pregnant. The pregnant rats were randomly divided into two equal groups of treatment and control.. The treatment group received 200 mg/kg zonisamide on days 9, 10, and 11 of pregnancy via gavage. The control group also received the same amount of normal saline solution on the same days of pregnancy via gavage. Length and weight of the newborn rats were measured using caliper and digital weigh. Then, the newborns were evaluated in terms of apparent anomalies under the stereomicroscope. Eventually, Alizarin Red staining was conducted in order to study bones. Data were analyzed using T-test. The mean length of arm, ulna, radius, thigh, tibia, and fibula was significantly different between the two groups. Alizarin Red results suggested that the treatment group had anomalies such as scoliosis, wavy rib, imperfectly formed bones of the skull. The results of the study indicated that administration of zonissamide during pregnancy causes fetal growth disorders and retards fetal growth therefore it is considered as a risk factor for fetal development in this species. Conflict of interest: None declared. Manuscript profile
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  9 - Protective Effect of Curcumin on Hormones of Spermatogenesis and DNA Breaks in Rats Exposed to Gamma-radiation
  زهرا حمزوی جهرمی سمانه ذوالقدری جهرمی وحید حمایت خواه جهرمی
  Radiation therapy is a stage of therapeutic in the management of tumors that causes normal cells damage. So compounds with name Radio protective drugs injected before of radiotherapy that reduce cell damages and death against ionizing radiation. Curcumin is an antioxida More

  Radiation therapy is a stage of therapeutic in the management of tumors that causes normal cells damage. So compounds with name Radio protective drugs injected before of radiotherapy that reduce cell damages and death against ionizing radiation. Curcumin is an antioxidant compound. The aim of this study is to investigate the possible protective effect of curcumin on Hormones of spermatogenesis and DNA strand break against Gamma-Radiation in rats. 70 adult male Wister rats randomly divided in to 10 groups including: control, sham, Experimental 1(treatment with maximum of cur cumin in amount of 100 mg/ml), Experimental 2 (treatment with medium of cur cumin in amount of 50 mg/ml), Experimental3(treatment with minimum of curcumin in amount of 25 mg/ml), Experimental 4 (treatment with curcumin + radiation in amount of maximum), Experimental 5 (treatment with curcumin+radiation in amount of medium), Experimental 6 (treatment with curcumin+radiation in amount of minimum), Experimental 7 (treatment with solvent+ radiation), Experimental 8 (exposure to irradiation). All of animals received for 15 days respectively as Intraperitonealinjection. Then the animals were euthanized and blood collection for FSH, LH and tesostrone hormones and extraction of DNA from bone marrow slides for molecular biology studies. ELISA hormone assay for measuring of hormones levels and agarose gel electrophesis with Ethidium Bromide-stained for separating of DNA breaks was used. Data were analyzed by SPSS 15 software and statistical tests including two-way ANOVA and Duncan test. This study showed that Gamma-radiation with dose of 2 Gy caused significantly decreased of plasma testosterone level and significantly increased of plasma LH, FSH hormones levels (pandlt; 0.05) and many breaks in DNA molecule in irradiation and solvent + radiation groups with control. So treatment with curcumin balances these adverse effects of Gamma-radiation on testis hormones of spermatogenesis and DNA molecule and leads toward normal position.These results suggest curcumin have an ameliorative effect on concentration of plasma hormones of spermatogenesis and DNA molecule breaks against Gamma-radiation Manuscript profile
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  10 - The Effect of Q10 on Reducing of Induced Diabetic Kidney Tissue Injury and Improvement of the Serum Levels of Renal Functional Factors in Rat
  سید سجاد حجازی
  The present study was conducted to evaluate the protective effects of Q10 on the damage of kidney tissue as well as serum factor levels due to diabetes induction in Alloxan-induced diabetic rats. The experimental model of diabetes type A in rats was induced by intraperi More

  The present study was conducted to evaluate the protective effects of Q10 on the damage of kidney tissue as well as serum factor levels due to diabetes induction in Alloxan-induced diabetic rats. The experimental model of diabetes type A in rats was induced by intraperitoneally injection of 120 mg Alloxan monohydrate per kg/bw. Physiology serum was used as Alloxan solvent. Control group rats received buffer citrate 0.05 M (pH= 4.5), intraperitoneally. The Q10- treatment group received 75 mg/kg Q10 via gavage for one month. In Alloxan-Q10 treatment group, the rats at first were diabetic and then they received 75 mg/kg Q10 via gavage for one month. Severe tissue damage was observed in the obtained tissue samples from diabetic rats. The tissue damages were in the forms of acute tubular necrosis, interstitial tubular nephrosis, vacuolar alterations, and atherosclerosis. The obtained results from urea, uric acid, and creatinine levels in understudied rats demonstrated a significant difference between diabetic-treatment group and diabetic-Q10 group (p Manuscript profile
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  11 - Histopathological effects of flowering shoot hydroethanol extracts of Hypericumperforatum on experimental full-thickness skin wound healing in rats
  , M AsghariehAhary M.R Farahpour,
  Wound healing has always been of great concern for the surgeon and therefore using different effective biologicalsubstances of either plant or animal origin for a faster and more effcient wound healing (repair) has been considered.The aim of this study was to investigat More

  Wound healing has always been of great concern for the surgeon and therefore using different effective biologicalsubstances of either plant or animal origin for a faster and more effcient wound healing (repair) has been considered.The aim of this study was to investigate the accelerating effects of Hypericumperforatumhydroethanolextracton open wound healing in rats. Study design: thirty-six adult male Wistar-albino rats (weight 200±10 g) wererandomly allocated to three groups (one control and two treatment groups). Two seven-mm, circular, fullthicknesses, skin wounds were created on the back of each rat (2 on the left and 2 on the right side). In the controlgroup, wounds were treated by an ointment with no extract. The treatment groups were treated by standardizedointment containing 1% and 2% Hypericumperforatum extract. For histopathological studies, the 3 groups weresubdivided into 4 subgroups with 4 rats in each. Samples were taken from the groups 1 to 4 on days 3, 7, 14, and21, respectively. After taking the sample, the rats were euthanized. The sequential wound biopsies were evaluatedhistopathologically for their heamorrage,neutrophils and lymphocyte, new vascularization and re epithelialization.According to the results of this study, the ointment with 2% extract was much better and slightly better than thecontrol and 1% extract ointments, respectively. Manuscript profile