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1 - Anti-plasmodial diterpenes from the roots of Hypoestes forsskaolii (Vahl) R.Br (Acanthaceae)
Fred Wanyonyi Sawenja Ruth Anyango Omole Peter Gakio Kirira Hamisi Masanja Malebo Alex Kingóri Machocho Richard Maveke Musau Isalah Omolo Ndiege

Ethno-pharmacological surveys previously revealed that Hypoestes forskalei (Vahl) Sol. Roemer & Schl.(Acanthaceae), a local medicinal plant, is one of the most widely used herbs in traditional malaria therapy by the Marakwet and Kisii communities in Kenya. This stud More

Ethno-pharmacological surveys previously revealed that Hypoestes forskalei (Vahl) Sol. Roemer & Schl.(Acanthaceae), a local medicinal plant, is one of the most widely used herbs in traditional malaria therapy by the Marakwet and Kisii communities in Kenya. This study was aimed at validating the indigenous medicinal knowledge claims on the efficacy of H. forskalei and its safety as a traditional anti-malarial drug. It involved the sequential solvent extraction of plant material, bioassay-guided separation and isolation of components, identification of anti-plasmodial principles of H. forskalei and determination of their cytotoxicity and selectivity. From the roots of H. forskalei, (3, 4a, 7, 7,10a-pentamethyl-1, 3-vinyl-dodecahydro-benzo[f]chromene (1) and (3,4a,7,7,10a-pentamethyl-3-vinyl-dodecahydrobenzo[f]chromen-8-ol (2) with moderate and mild anti-plasmodial activity at IC50 2.39±0.0 µg/mL (7.81 µM) and 4.34±0.03 µg/mL or 15.0 µM), respectively, were isolated plus the inactive kaur-16-en-19-oic acid (IC50 19.75±0.11 µg/mL or 65.40 µM) against Plasmodium falciparum D6 (CQ-sensitive) strain. Manuscript profile

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