List of Articles Mehdi Rahnema

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  1 - Study Effects Of Hydroalcoholic Extract Of Medicago sativa in the Treatment Of Acetic Acid Induced Gastric Ulcer in Rats
  Mojdeh Samari Mehdi Rahnema Shahrzad Nasiri Semnani Ali Shahnavaz
  Inroduction and Objective:Peptic ulcer, from histologicalpointisknownasmucosalnecrosisfactor. The purpose of this study was to investigate the effect of Alfalfa hydroalcoholicvegetivearial organs extract on gastric ulcer induced by acetic acid in Rat.Material and Method More

  Inroduction and Objective:Peptic ulcer, from histologicalpointisknownasmucosalnecrosisfactor. The purpose of this study was to investigate the effect of Alfalfa hydroalcoholicvegetivearial organs extract on gastric ulcer induced by acetic acid in Rat.Material and Methods: In this experimental study, 60 wistar rats weighting approximately (200-250g) were randomly divided into 4 groups; control, sham(normal salin), experiment 1 (extract of dose 250 mg/kg body weight) and experiment 2 (extract of dose 500 mg/kg body weight). Rats were deprived of food and then underwent surgeryand gastric wasby injecting60% acetic acid after 4,7,10,14 days gavage, the rats' stomach out and then measuring the wound and fixed with 10% formalin, the passage of the tissue section was stained And the number of neutrophils, macrophages and fibroblasts were counted.Results:Results showed that the hydroalcoholic extract of Alfalfacaused a significant increase in gastric ulcer healing in experimental groups 1 and 2 (PConclusion:Alfalfahydroalcoholic vegetive arial organs extract is effective in the treatment of peptic ulcer induced by acetic acid. Manuscript profile
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  2 - DeterEffects of Heracleum persicum Extract Prefeeding on the Blood-Brain Bajrriers Permeability and Brain Edema in Model Rats’ Cerebral Strokes
  Seyyed Lila Mirsalehi Mehdi Rahnema Mohammad Reza Bigdeli
  Inroduction & Objective:Ischemic brain damage has disabled a large number of patients, in some cases with death and in other cases with different forms of permanent disabilities. Ischemic edema is one of the most important stroke complications. The purpose of this study More

  Inroduction & Objective:Ischemic brain damage has disabled a large number of patients, in some cases with death and in other cases with different forms of permanent disabilities. Ischemic edema is one of the most important stroke complications. The purpose of this study is assessing the effects of heracleum persicum extract on the blood - brain barriers permeability and evaluating the caused reductions in brain edemas.Methodsand materialIn this experimental study, 7 male Wistar rat were under investigation. First and second groups (control mice and sham mice) were distilling water, while the other three groups were consuming heracleum persicum extract with doses of 30, 50, 100 mg/kg for per kilogram of their body weight, and this feeding procedure was orally by using gavage for 30 days. Two hours after taking the last dose; each major group had been divided to (Middle Cerebral Artery Occlusion) MCAO subgroups, in order to measure the permeability of the blood - brain permeability and also measuring the level of cerebral edema.ResultsPretreatment with heracleum persicum extracts reduced brain edema in groups which had received 50 and 100 mg/kgof the extract for per kilogram of their body weight. Rats pretreatment with heracleum persicum extract also reduced the permeability of blood - brain barriers after MCAO.ConclusionThis study suggests that heracleum persicum extract may reduce brain edema and also may reduce the permeability of the blood-brain barriers in cerebral ischemia - reperfusion in model rats and would cause neurological protection; but more work is needed to extend these observations. Manuscript profile
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  3 - Study Effects Of Hydroalcoholic Extract Of Melisa Officinalis in the Treatment Of Acetic Acid Induced Gastric Ulcer in Rats
  تکرخ اشتری توان دشتی مهدی رهنما شهرزاد نصیری سمنانی
  Inroduction and Objective:Peptic ulcer involved mucous extras and good heal under mucous in the wall of stomach. This decease usually is from the most known digest deceases, the plant drugs as compare with the chemical drugs had lower side effects and in contrast of che More

  Inroduction and Objective:Peptic ulcer involved mucous extras and good heal under mucous in the wall of stomach. This decease usually is from the most known digest deceases, the plant drugs as compare with the chemical drugs had lower side effects and in contrast of chemical drugs that maybe had interfere with another compounds of  body or produced a poison in the body, hasn’t interfere effects. Melisa officinalis have biologic effects such as calmness and antioxidant effects. In this research studied the effects of hydroalcoholic nectar of leaf ofMelisa officinalis plant over the peptic ulcer result of acid acetic on the RatMaterial and Methods: In this experimental study prepared hydraulic nectar of melisa officinalis plant. 60heads of female mousse in weight of 250-200 divided accidently to four 15groups, control group, Sham group (normal receiver of Salin) experiment1 group (extract of does 200 mg/kg) experiment2 group (extract of does 400 mg/kg). Mousse suffered form peptic ulcer through injection of acid acetic. After a day the rats treated for 14days through nectar process. Then the sample of stomach in the forth, tenth seventh and fourteen days excited and after measuring the sizes of wounds and fitting with formalin 10% , passage stages,  performed tissue cut and coloring method and finally investigated the histology parameters.Results:the results showed that the nectar of Melisa officinalis result in meaningful increase of improving the wound in the experiment group 1 and 2 as compare with Sham and control groups, in the experiment group 2 improving the wound as compare with the experiment group 1 had meaningful increase. The inflammation factors and fibroblasts showed the meaningful decrease as compare with control and Sham group and showed meaningful reduction in the next days and the experiment group 2 showed meaningful reduction from froth day.Conclusion:Melisa officinalishas high recover ability in treatment of peptic ulcer result of acid acetic Manuscript profile
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  4 - IInvestigation of Synergistic Effects of Corticotropin and Melanocortin receptors with Sub-Effective Dose of Phoenixin-14 on Food Intake in Neonatal Chickens
  Sahar Rajaei Morteza Zendehdel Mehdi Rahnema Shahin Hassanpour Masoumeh Aslerousta
  20.1001.1.17359880.1401.15.4.1.1
  Introduction & Objective: Various peptides are involved in food intake regulation in the bird and mammalian brain. Melanocortin and corticotropin play an important role in food intake control. On the other hand, phoenixin-14 increases food intake. This study aimed t More

  Introduction & Objective: Various peptides are involved in food intake regulation in the bird and mammalian brain. Melanocortin and corticotropin play an important role in food intake control. On the other hand, phoenixin-14 increases food intake. This study aimed to investigate the synergistic effects of corticotropin and melanocortin with a sub-effective dose of phoenix -14 on food intake in neonatal chickens.Materials and Methods: A total of one hundred and ninety-two neonatal chicks were randomly divided into three experimental groups. Each experiment had a control group and three treatment groups (n=12 in each group). In all experiments, 3-hours food-deprived birds received intracerebroventricular ‎injections of either control diluent or drug solution. Then the birds had ad libitum access to the ‎food and fresh water, and then cumulative food intake (gr) was measured based on the ‎percentage of the body. In the first experiment, control solution, phoenixin-14 (0.8 nmol), Astressin-B (CRF1/CRF2 receptor antagonist; 30 µg), and phoenixin-14 + Astressin-B were injected. ‎  In the second experiment, control solution, phoenixin-14, Astressin-2B (CRF2 receptor antagonist; 30 µg), and phoenixin-14 + Astressin-2B were injected. In the third experiment, control solution, phoenixin-14 (0.8 nmol), SHU9119 (MC3/MC4 receptor antagonist; 0.5 nmol), and phoenixin-14 + SHU9119 were injected. In the fourth experiment, control solution, phoenixin-14 (0.8 nmol), MCL0020 (MC4 receptor antagonist; 0.5 nmol), and phoenixin-14 + MCL0020 were injected.Results: The results showed that co-inject ion of phoenixin-14 + Astressin-B and phoenixin-14 + Astressin-2B significantly increased food intake(p<0.05), while co-injection of phoenixin-14 + SHU9119 and phoenixin-14 + MCL0020 had no effect(p>0.05).Conclusion: According to the results of the present study, there is probably a synergistic effect between phoenixin-14 and corticotropin system on food intake control of neonatal chicks.  Manuscript profile
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  5 - THE EFFECT OF HYDROPHILIC EXTRACT OF MUSA SAPIENTUM ON ETHYLENE‌ GLYCOLl-INDUCED RENA STONE IN MALE WISTAR RATS
  samira babai norozi Parastoo Rahimi mehdi rahnema
  20.1001.1.17359880.1399.14.1.8.1
  Inroduction & Objective:Prevention of kidney stone formation is one of the important issues in preventing kidney disease. Banana’s peel has antioxidant, anti-inflammatory and tissue repairing properties, and due to its alkaline properties, it increases citrate More

  Inroduction & Objective:Prevention of kidney stone formation is one of the important issues in preventing kidney disease. Banana’s peel has antioxidant, anti-inflammatory and tissue repairing properties, and due to its alkaline properties, it increases citrate and decreases urinary calcium, urea and blood creatinine.Material and Method:In this study, 32 males of Wistar divided into 6 groups. Healthy control used only food and water, negative control group rats, used food, water, and 1% ethylene glycol solution. The control group 1, used food, water and solution of banana’s peel at concentrations of 100 mg / kg and 150 mg / kg orally. Experimental  1  used  food , water, and 100 kg concentration of banana's  skin extract solution  with 1% ethylene glycol .Experimental  2 rats, used  food , water,  solution of banana's peel extract at concentration of 150 mg / kg with 1% ethylene glycol solution. At the end   24 urine, blood kidneys of samples were collected. Kidney tissue was histological examined with hematoxylin-eosin for accumulation of calcium oxalate.Results: Significant differences were observed in creatinine and blood uric acid in the negative control group   compared to experimental 2.The highest urea levels in the blood were observed in the negative control Negative control had significant difference with experimental 1. Urea and urinary citrate in the negative control had significant difference compared to all groups. Urinary oxalate in the negative control  a statistically significant difference was observed compared to  healthy control .Also, the amount of crystals in  total renal tissue between experimental groups 1 and experimental group 2 with negative control group and other groups significant statistical differences were observed (P <0.05). Renal histological examinations showed improvement of renal tissue .Conclusion: The results show the effectiveness of banana peel extract on preventing kidney stones and improving tissue complications due to ethylene glycol consumption by inhibiting the formation of calcium oxalate due to its antioxidant and anti-inflammatory properties. Manuscript profile
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  6 - Synergistic Effects of Noradrenalin, Serotonin, and Oxytocin with Nesfatin on Central Control of Food Intake in Broiler Chickens
  Takrokh Ashtari tavandashti , Morteza , Zendehdel Mehdi Rahnema Shahin Hasanpour , Masoumeh Asle-Rousta
  Introduction & Objective: Appetite modulation is a set of physiological mechanisms that influence the various areas of the central nervous system. Noradrenaline, serotonin, and oxytocin have an important role in the central control of food intake in birds. On the ot More

  Introduction & Objective: Appetite modulation is a set of physiological mechanisms that influence the various areas of the central nervous system. Noradrenaline, serotonin, and oxytocin have an important role in the central control of food intake in birds. On the other hand, nesfatin decreases food intake in birds. Therefore, the aim of this study was to explain the synergistic effects of noradrenalin, serotonin, and oxytocin with nesfatin on food intake in neonatal broiler chickens.Materials and Methods: A total of one hundred and forty-four neonatal chicks were randomly divided into three experimental groups. Each experiment had a control group and three treatment groups (n=12 in each group). In all experiments, 3-hour food-deprived birds received intracerebroventricular ‎injections of either control diluent or drug solution. Then, the birds had ad libitum access to the ‎food and fresh water, and then cumulative food intake (gr) was measured based on the ‎percentage of the body. In the first experiment, normal saline, noradrenalin, nesfatin, and noradrenalin plus nesfatin were injected.‎ In the second experiment, normal saline, serotonin, nesfatin, and serotonin + nesfatin were injected. In the third experiment, normal saline, oxytocin, nesfatin, and oxytocin plus nesfatin were injected.Results: The results of the present study showed that co-injection of noradrenalin and nesfatin, serotonin plus nesfatin, and oxytocin plus nesfatin significantly reduced food intake in broiler chickens (P<0.05).Conclusion: According to the results of the present study, there is probably a synergistic effect between noradrenalin, serotonin, and oxytocin with nesfatin on food intake control of neonatal broiler chickens.  Manuscript profile
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  7 - Effect of Viola tricolor hydro-ethanolic extract on serum glucose and lipids in streptozotocin-nicotinamide-induced diabetic rats
  Abbas Vakilian Masoumeh Asle Rousta مهدی رهنما
  Background & Aims: Viola tricolor is one of the medicinal plants of the Violaceae family, which possesses antioxidant and anti-inflammatory properties. This study aims to investigate the effect of V. tricolor hydro-ethanolic extract on glucose levels and serum lipid More

  Background & Aims: Viola tricolor is one of the medicinal plants of the Violaceae family, which possesses antioxidant and anti-inflammatory properties. This study aims to investigate the effect of V. tricolor hydro-ethanolic extract on glucose levels and serum lipid profile in diabetic rats.Materials & Methods: The rats were injected intraperitoneally with streptozotocin and nicotine to induce diabetes. Diabetic rats were divided into four groups. The first group received no treatment, and the second to fourth groups received glibenclamide and extract of V. tricolor with doses of 300 and 600 mg/kg for 30 consecutive days by gavage. Blood glucose level, lipid profile, and body weight were assessed at the end of the period.Results: When administered at a dose of 600 mg/kg, V. tricolor extract significantly reduced the levels of glucose, cholesterol, triglycerides, and low-density lipoprotein in the serum of diabetic rats. It also increased high-density lipoprotein and body weight in these animals.Conclusion: The results indicate that the Viola tricolor is beneficial in reducing complications caused by type 2 diabetes. Manuscript profile
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  8 - Investigating the effects of injecting intravenous anesthetics Propofol, sodium thiopental, fentanyl during implantation on the rate of abnormalities in rats.
  Shiva Shojaifard Mohamad Reza Jamshidi Elham Hosseini Somayeh Abdollahi sabet مهدی رهنما
  Background & Aim: Background and purpose: Anesthesia is very important for assisted reproductive technology to provide minimal adverse effects on the oocyte. Defects in the development of the embryo or abnormality in its growth phenomenon lead to IVF failure in most More

  Background & Aim: Background and purpose: Anesthesia is very important for assisted reproductive technology to provide minimal adverse effects on the oocyte. Defects in the development of the embryo or abnormality in its growth phenomenon lead to IVF failure in most cases. The number of abnormalities in laboratory rats is RAT.Materials & methods: Propofol, Nestonal, and Fentanyl were used for single and combined anesthesia. The sham group was studied to control injection stress by injecting distilled water and the control group without receiving drugs. In the next step, the fertility conditions of the mice were provided. The effectiveness of the drugs is relatively similar to the selected doses, and after counting, cesarean surgery is performed on each fetus, and after the placenta is carefully separated from the fetus, both are carefully weighed, measured, and recorded.Results: The difference in the number of births was not observed, but the weight of the placenta and the weight of the fetus were investigated as indicators determining the effect of drugs on the fetus, which can be a symbol of fetal abnormalities. The results showed that the drugs used had no effect on conception and its success rate, but they were effective on fetal growth, and propofol had the least effect on abnormalities, and there was a significant difference in placenta and fetal weight between this group and the other group. The birth weight of mice was based on the type of drug, the highest birth weight was related to the drug Nestonal (TP) and the lowest birth weight was related to the drug Fentanyl (PH). Based on the type of drug, the live birth weight of the mice was the highest weight of the live mice related to Nestonal drug (TP) and the lowest was related to Fentanyl drug (PH).Conclusion: Examining anesthetic drugs to find the safest and best drug is of great clinical and research importance. The study of chromosomal abnormalities is one of the main programs of future studies for the analysis of fetal abnormalities. Manuscript profile
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  9 - Evaluation of the Effects of Q10 on Neural Protection and Behavioral Disorders in Cell Culture and Mice Models of Parkinson’s Disease
  mahdieh Aazarshab mehdi rahnema Ramin Hajikhani Jalal Solati mohammad Reza Bigdeli
  Inroduction & Objective: Oxidative stress which is responsible for pathophysiology of hypertension, causes decrease in total antioxidant capacity. PON 1 is an antioxidant enzyme present on the surface of HDL also which is responsible for prevention of HTN and it&rsq More

  Inroduction & Objective: Oxidative stress which is responsible for pathophysiology of hypertension, causes decrease in total antioxidant capacity. PON 1 is an antioxidant enzyme present on the surface of HDL also which is responsible for prevention of HTN and it’s complications. The aim of this study was to investigate the Effect of Isosorbide and Garlic Supplementation on Protein levels and Gene expression of PON1 at the Heart tissue in Female rats with hypertension After a period of aerobic training. Materials and Methods: In the experimental study,30 female Wistar rats weighing 180-220 g were randomly divided into 8 groups: healthy control, sham, blood pressure induction (Hyper), garlic, endurance training, endurance training -garlic. The rats suffered from hypertension of 6 days a week for 8 weeks after dietary period and 10 mg/kg body weight L_NAME injection. Experimental groups received 50 mg/kg body weight garlic supplement for six weeks.The endurance training program was performed at speeds of 20-30 m/min and 20 to 35 minutes, 5 sessions per week for 6 weeks. Protein levels and expression of PON1 heart tissue were measured using ELISA kit and Real Time PCR. Data were analyzed by t-test, One-way ANOVA and post hoc tokey at the significant level P<0.05. Results: The results showed that there was no significant difference between the mean protein and the expression of paraoxonase-1 in the heart tissue of the female rats with hypertension in the different groups of the study (P> 0.05).Also, there was no difference between the levels of protein paraoxonase-1 heart tissue in different groups than the group of blood pressure induction (P> 0.05). Conclusion: According to the findings, it seems to that the inadequacy of the training period (frequency and intensity of exercise) and the dose rate of Garlic Supplementation can be one of the possible causes of ineffectiveness in the present study.   Manuscript profile
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  10 - بررسی تنوع مورفولوژیک در جمعیت های مختلف ساردین رنگین کمان(Clupeidae: ,Dussomieria acuta) موجود در خلیج فارس و دریای عمان
  پرستو رحیمی مهدی رهنما
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