DeterEffects of Heracleum persicum Extract Prefeeding on the Blood-Brain Bajrriers Permeability and Brain Edema in Model Rats’ Cerebral Strokes

Subject Areas :

Seyyed Lila Mirsalehi ¹ , Mehdi Rahnema ² , Mohammad Reza Bigdeli ³

1 - کارشناس ارشد فیزیولوژی جانوری، مرکز تحقیقات بیولوژی دانشگاه آزاد اسلامی زنجان، زنجان. ایران.
2 - دانشیار گروه فیزیولوژی جانوری، مرکز تحقیقات بیولوژی واحد زنجان، دانشگاه آزاد اسلامی، زنجان. ایران.
3 - دانشیار گروه فیزیولوژی، دانشگاه شهید بهشتی تهران، دانشکده علوم زیستی، تهران. ایران.

Received: 2017-02-18 Accepted : 2018-08-04 Published : 2016-04-20

Keywords: Blood - Brain Barrier, Ischemia and Blood Reperfusion, Heracleum persicumExtract, Cerebral Edema,

Abstract :

Inroduction & Objective:Ischemic brain damage has disabled a large number of patients, in some cases with death and in other cases with different forms of permanent disabilities. Ischemic edema is one of the most important stroke complications. The purpose of this study is assessing the effects of heracleum persicum extract on the blood - brain barriers permeability and evaluating the caused reductions in brain edemas.Methodsand materialIn this experimental study, 7 male Wistar rat were under investigation. First and second groups (control mice and sham mice) were distilling water, while the other three groups were consuming heracleum persicum extract with doses of 30, 50, 100 mg/kg for per kilogram of their body weight, and this feeding procedure was orally by using gavage for 30 days. Two hours after taking the last dose; each major group had been divided to (Middle Cerebral Artery Occlusion) MCAO subgroups, in order to measure the permeability of the blood - brain permeability and also measuring the level of cerebral edema.ResultsPretreatment with heracleum persicum extracts reduced brain edema in groups which had received 50 and 100 mg/kgof the extract for per kilogram of their body weight. Rats pretreatment with heracleum persicum extract also reduced the permeability of blood - brain barriers after MCAO.ConclusionThis study suggests that heracleum persicum extract may reduce brain edema and also may reduce the permeability of the blood-brain barriers in cerebral ischemia - reperfusion in model rats and would cause neurological protection; but more work is needed to extend these observations.