Fariba Khosravinejad Articles List

List of Articles Fariba Khosravinejad

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1 - A study on the inhibitory effects of taxifolin on amyloid fibrillation of hen egg white lysozyme
Mohsen Mahdavimehr Ali Akbar Meratan Ali Asghar Bagheri Fariba Khosravinejad

Among therapeutic approaches for amyloid-related diseases, attention has recently turned to the use of natural products as effective anti-aggregation compounds. Although a wealth of in vitro and in vivo evidence indicates some common inhibitory activity of these compoun More

Among therapeutic approaches for amyloid-related diseases, attention has recently turned to the use of natural products as effective anti-aggregation compounds. Although a wealth of in vitro and in vivo evidence indicates some common inhibitory activity of these compounds, they don’t generally suggest the same mechanism of action. In the present study, using a range of techniques including Thioflavin T and Nile red fluorescence assays, Congo red absorbance measurements, and atomic force microscopy the ability of taxifolin on the inhibition of HEWL amyloid fibrillation was investigated. Obtained results demonstrated that taxifolin exerts its inhibitory effect by binding to HEWL prefibrillar species. Furthermore, it’s binding results in diverting the amyloid pathway toward formation of very large globular, chain-like aggregates with low β-sheet content and reduced solvent-exposed hydrophobic patches. ThT fluorescence measurements show that the binding capacity of taxifolin is significantly reduced, upon generation of large protofibrillar aggregates at the end of growth phase. We believe these results may help design promising inhibitors of protein aggregation for amyloid-related diseases. Manuscript profile
Open Access Article
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2 - Inhibitory effects of Behind the scenes medicine extract (Physalis alkekengi) on prostate cancer caused by DMBA injection in mice
Maryam Teimouri fariba khosravinejad
10.30495/jdb.2021.683731

20.1001.1.2008692.1400.13.2.3.9

Introduction: Although many clinical and pre-clinical studies have widely demonstrated the therapeutic effects of hydroalcoholic extract of the puppet pup on several diseases, there is little information on the therapeutic properties of this plant's hydroalcoholic extra More

Introduction: Although many clinical and pre-clinical studies have widely demonstrated the therapeutic effects of hydroalcoholic extract of the puppet pup on several diseases, there is little information on the therapeutic properties of this plant's hydroalcoholic extract on prostate cancer. In this study, we evaluated the therapeutic effects of hydroalcoholic extract of Physalis alkekengi extract on prostate cancer induced by injection of 12.7-dimethylbenzanthracene (DMBA) (a carcinogenic drug) on mouse modelMaterials and Methods: After induction of anesthesia, DMBA was injected directly into the prostate gland of male rats and after 14 days, rats received different amounts of puppet extract every 48 hours and by the end of day 21, intraperitoneal injection of puppet extract. In the control group, intraperitoneal injection of normal saline was performed.Results: The results showed that the puppet extract significantly reduced prostate weight, especially at two concentrations (100 mg, 500, and 1000). Histopathological changes were also observed in the prostate tumors of p.alkekengi extract treated groups compared to the control group.Conclusion: It is suspected that the hydroalcoholic extract of the p.alkekengi inhibits abnormal growth, precancerous lesions, and DMBA-induced carcinoma in the BALB / c mouse prostate. Manuscript profile

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List of Articles Fariba Khosravinejad