Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease of central nervous system and commonly used as an animal model for multiple sclerosis (MS). Multiple sclerosis is a disabling neurodegenerative disease in human being. Inflammatio More
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease of central nervous system and commonly used as an animal model for multiple sclerosis (MS). Multiple sclerosis is a disabling neurodegenerative disease in human being. Inflammation is a key event in both EAE and MS, which leads to demyelination and subsequent disability. It is shown that Crocus sativus L. stigma (saffron) extracts have anti-inflammatory activity in rats and mice. There are modern pharmacological evidences for anti-tumour, chemopreventive and genoprotective effects as well as radical scavenger properties of saffron extracts or its constituents. We observed that both therapeutic doses of dexamethasone and methanol extracts of saffron stigma at 100 mg/kg and more prevented EAE from progression significantly in pMOG-immunized female C57BL/6 mice. Aqueous maceration extract of Crocus sativus L. did not prevent EAE progression. These results suggest that saffron may attenuate symptoms of EAE by its anti-inflammatory activity. Experimental data analyzed by one-way ANOVA.
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