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Open Access Article
1 - A review on pharmacological potentials of phenolic diterpenes carnosic acid and carnosol obtained from Rosmarinus officinalis L. and modern extraction methods implicated in their recovery
Dhananjay Singh Nishu Mittal Mohammed SiddiquiRosmarinus officinalis L. is a perennial herb, known for culinary as well as medicinal properties. It has been shown that bioactive compounds like rosmarinic acid, carnosic acid, and carnosol are responsible for the medicinal properties of this plant species. Carnosic a MoreRosmarinus officinalis L. is a perennial herb, known for culinary as well as medicinal properties. It has been shown that bioactive compounds like rosmarinic acid, carnosic acid, and carnosol are responsible for the medicinal properties of this plant species. Carnosic acid is a phenolic diterpene synthesized in young leaves of rosemary, whereas carnosol is produced after the oxidation of carnosic acid. Several studies have confirmed their antiangiogenic, anti-inflammatory, antimicrobial, antidiabetic, antioxidant, antitumor, neuroprotective, and gastroprotective properties. Ethanol, a mixture of ethanol-acetone, and hexane have been recommended as the best solvents for the extraction of carnosic acid, but advanced extraction techniques such as microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE), pressurized liquid extraction (PLE), supercritical fluid extraction (SFE), etc. have been used to extract these phenolic antioxidant compounds in higher yield. This report is a kind of first study that emphasizes the recent research on the pharmacological potentials of carnosic acid and carnosol and summarizes the studies on modern extraction procedures. Manuscript profile -
Open Access Article
2 - A review on biosynthesis, regulation, and applications of terpenes and terpenoids
Anjali Singh Dhananjay Singh Sapna Sharma Nishu MittalEssential oils (EOs) are concentrated liquids extracted from various parts of plants and can be classified based on their phytochemical compounds. Terpenes and terpenoids have a wide range of biological activities, including anticancer, anti-inflammatory, antimicrobial, MoreEssential oils (EOs) are concentrated liquids extracted from various parts of plants and can be classified based on their phytochemical compounds. Terpenes and terpenoids have a wide range of biological activities, including anticancer, anti-inflammatory, antimicrobial, antioxidant, and antiallergic properties. Terpenes are plant-based compounds commonly used in the pharmaceutical, food, biofuel, and chemical industries by humans. In synthetic biology, genomic resources and emerging tools facilitate the production of high-quality terpenoids in plants and microbes. Terpenoids, however, are difficult to produce in large quantities due to their complex chemical structures and the limited amounts found in plants. The regulation of terpenoid biosynthesis has gradually emerged as a research priority. This review presents an overview of the biological activities, synthesis pathways, and key enzymes involved in the biosynthetic pathways and regulation of terpenes or terpenoids. This review will also include references for further research on molecular regulation, biological advancements, and increasing the content of terpenes or terpenoids in plants. Manuscript profile
List of Articles Dhananjay Singh
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